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At least 163 records · Page 9Linked to original sources
PubMed2001

Garbage catastrophe theory of aging: imperfect removal of oxidative damage?

Increasing evidence suggests an important role of oxidant-induced damage in the progress of senescent changes, providing support for the free radical theory of aging proposed by Harman in 1956. However, considering that biological organisms continuously renew their structures, it is not clear why oxidative damage should accumulate with age. No strong evidence has been provided in favor of the concept of aging as an accumulation of synthetic errors (e.g. Orgel's 'error-catastrophe' theory and the somatic mutation theory). Rather, we believe that the process of aging may derive from imperfect clearance of oxidatively damaged, relatively indigestible material, the accumulation of which further hinders cellular catabolic and anabolic functions. From this perspective, it might be predicted that: (i) suppression of oxidative damage would enhance longevity; (ii) accumulation of incompletely digested material (e.g. lipofuscin pigment) would interfere with cellular functions and increase probability of death; (iii) rejuvenation during reproduction is mainly provided by dilution of undigested material associated with intensive growth of the developing organism; and (iv) age-related damage starts to accumulate substantially when development is complete, and mainly affects postmitotic, cells and extracellular matrix, not proliferating cells. There is abundant support for all these predictions.

Aging↗
PubMed1990

Are you feeding the patient or the garbage can?

In a question and answer format, frequent clinical and food production problems that occur in long term care facilities are addressed. Subject matter includes the handling of food complaints, accommodating food preferences, maintaining safe food temperatures despite a wide variety of food consistencies, accommodating a resident's small appetite and maintaining the nutritional adequacy of the puree diet. The emphasis is on simplified food production which utilizes menu items that fit many diet consistencies. Various tested solutions to these problems are offered. The authors welcome additional questions.

Aged↗
PubMed1991

Garbage wars '91. Report from the front.

In this first of a three-part series examining the status of waste management strategies available to non-commercial foodservice operators, Food Management looks at the use and recycling of polystyrene in light of the McDonald's Corp.'s decision to replace polystyrene with paper and paper-based packaging.

Environmental Pollutants↗
PubMed1991

Garbage wars '91. Report from the front. Part three.

This final installment in Food Management's three-part series on solid waste management highlights the effective strategies independent foodservice operators and contract companies are employing to promote recycling and waste reduction and to educate customers and employees about responsible waste management.

Environmental Pollution↗