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Results for “Foreign-Body Reaction”

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At least 163 records · Page 9Linked to original sources
PubMedDate not supplied

The Herbert total knee replacement: a longer than three year follow-up.

Thirty personally performed Herbert total knee replacements, evaluated during a 3-year follow-up, were found not to function well. At the end of one postoperative year 6 knees had symptomatic metal synovitis and required replacement. By the end of 3 years the Herbert total knee replacement had functioned in only 12 patients. The largest single follow-up complication was foreign body synovitis, inflammation of the synovium secondary to small free metal fragments produced by the 2 components rubbing against each other during gait.

Arthritis↗
PubMed1978

Adaptive responses of the pulmonary macrophagic system to carbon. I. Kinetic studies.

The adaptive capacity of the lung to increase the output of alveolar macrophages is vital to its handling of foreign material, particularly in an overload situation. In previous papers we demonstrated the role of pulmonary intersititial cells in providing a pool of precursor cells that may be available for this purpose. We now extend these observations to a study of pulmonary cytodynamics in mice subjected to a single large load (4 mg.) of carbon delivered by endotracheal tube. The output of free macrophages over a period of 14 days was correlated with DNA synthesis of pulmonary cells as measured by their uptake of 3H-thymidine. The initial increase of macrophagic output, 5 times in 12 hours and 10 times in 24 hours occurred before any increase in mitotic activity or cellularity was demonstrated in the pulmonary interstitium. The high level of macrophagic cell output which was maintained over the next week was accompanied by increased thymidine uptake in the lung. Increased mitotic activity was confined to the interstitial cell population; no mitoses were observed in free macrophages. The results indicate a biphasic macrophagic response to inhaled particulates, an early phase apparently unrelated to a local cellular response and a later phase of interstitial cell proliferation which appears to be concerned with the maintenance of the high output of macrophages.

Animals↗
PubMed1978

[Contractile connective tissue cells and wound healing. Function of myoid fibroblasts in reparative regeneration of mesenchymal tissue].

The present survey deals with processes of wound healing with special regard to fibroblast proliferation. Comparative experimental studies on reparative and regenerative fibroblastic proliferates and findings from the literature point to the importance of a fibroblast modification with myoid structure in certain phases of the reparative regeneration of the connective tissues. The ultrastructural picture of the myoid fibroblasts and their functional significance are discussed with regard to wound healing in man.

Achilles Tendon↗
PubMed1978

[Suture threads in the pathology of the operated stomach].

Endoscopy following operations on the stomach showed inflammation or ulceration attributable to no-absorbable suture threads in a number of cases. The pathogenetic and clinical features of this picture are described. Complete remission was obtained after endoscopic removal of the foreign body.

Dyspepsia↗
PubMed1979

Schistosomiasis--cancer: etiological considerations. A review.

Evidence for a causal connection between Schistosoma haematobium-infection and carcinoma of the urinary bladder is discussed. A group relationship of schistosomiasis cancer to cancers as+sociated with asbestosis, foreign body implants, and cicatrization is suggested on the basis of several criteria. Results of experimental foreign body tmuorigenesis in mice are presented and elaborated in relationship to schistosomiasis cancer. Carcinogenic development at the cellular level is discussed with emphasis on the essential role of tissue-environmental conditions, especially fibrotic changes and macrophage quiescence.

Adult↗
PubMed1978

Polyvinylchloride (PVC) particles implantation in mouse liver. A technique for experimental study of schistosome eggs-induced liver pathology.

An injection of suspended PVC particles in the caecal vein of mice induces a foreign-body portal granuloma reaction in the liver. Plastic casts of the portal system, after PVC particles implantation, show modifications in the portal bed and are compared with plastic casts obtained in mice infested by Schistosoma mansoni. This technique can be useful to study the cellular dynamics of the portal granuloma and can be a model for schistosomal eggs induced liver pathology.

Animals↗