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At least 163 records · Page 9Linked to original sources
PubMed2003

Evaluation of in vitro antiviral activity in methanol extracts against in fl uenza virus type A from Korean medicinal plants.

Methanol extracts from 101 Korean medicinal plants were tested for inhibitory activity against influenza virus type A by means of a modified haemagglutination inhibition (HI) test. MM-57, MM-72, MM-104 and MM-110, four of 101 extracts tested exhibited strong anti-influenza virus type A activity at concentration ranges of 0.78-6.25 mg/mL, 0.78-3.13 mg/mL, 0.78-1.56 mg/mL and 0.0975-0.39 mg/mL, respectively. The extracts MM-57, MM-72 and MM-110 showed very strong anti-influenza virus type A activity in the range 1.56-6.25 mg/mL, 1.56-3.13 mg/mL and 195-390 micro g/mL, respectively. The four methanol extracts were weakly cytotoxic to red blood cells. These results demonstrated that four methanol extracts of Korean medicinal plants exhibit strong anti-influenza virus type A activity, and weak cytotoxic effects. They may inhibit attachment of the virus to the cell and may therefore be used for prophylaxis.

Antiviral Agents↗
PubMed1980

Age and susceptibility of Swiss mice for mouse adenovirus, strain FL.

NMRI mice of different ages (24 hours, 10 to 12 days old, adults) were inoculated intraperitoneally with varying doses of mouse adenovirus. The susceptibility to disease was high in newborn mice (1 LD50 equalled 7 TCID50, as measured in mouse kidney cell cultures), medium in 10 days' old mice and almost nil in adult animals. The survival time was not greatly influenced by the virus dose. The susceptibility to infection is greatest in adults and lowest in 10 day old mice; these show a susceptibility equal to kidney cell cultures. In newborn mice, the virus spreads via the blood to all organs tested except for the intestinal tract, peak titers being reached in kidney and liver for at least 52 days, together with a sustained viruria. Adult mice could be infected by oral or intranasal installation.

Adenoviridae↗
PubMed1975

Clinical evaluation of a novel beta-lactam antibiotic: pivmecillinam (FL 1039).

Pivmecillinam, a new penicillin-like antibiotic, is a member of the amidinopenicillanic acid group. Its mode of action differs from that of the classical penicillins and it exhibits no cross-resistance with them. Fifty-two gerontopsychiatric patients, median age 81 years, with E. coli, Klebsiella, and Proteus bacteriurias were divided into three comparable groups. In a ten week open clinical trial the patients were treated with pivmecillinam, pivampicillin or the two drugs given alternately in doses reduced in stages. The bacteriuria in all groups cleared almost completely in three days. Pivmecillinam compared favourably with pivampicillin especially at the end of the reduced medication. The alternating treatment seemed to be superior to treatment with either drug administered separately. No development of resistance was observed. No toxic effect on the liver, kidney, or bone marrow was seen in any of the three groups. In the group receiving pivmecillinam alone, no ampicillin-like skin rashes occurred.

Aged↗