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At least 163 records · Page 9Linked to original sources
PubMed1990

Familial subluxation of the metacarpophalangeal and proximal interphalangeal joints of the little finger in two consecutive siblings: the "serpentine little finger".

Two consecutive siblings, both males, presented with congenital curly little finger ('serpentine finger') caused by subluxations at the metacarpo-phalangeal and the proximal interphalangeal joints. Literature on this phenomenon is scant, and to the best of the authors' knowledge it is probably a new entity. A theory of the possible aetiology is presented.

Child↗
PubMed2026

Genome-wide identification of CHY zinc finger and RING finger (CHYR) genes in pepper and functional characterization of CaCHYR5 in response to Phytophthora capsici infection.

CHY zinc finger and RING finger (CHYR) proteins play crucial roles in the growth and development, as well as stress response. To date, no systematic or comprehensive analysis of the CHYR gene family has been performed in pepper (Capsicum annuum L.). In this study, we identified 8 CaCHYR genes (CaCHYR1-CaCHYR8), which were classified into 3 groups based on phylogenetic relationships. CaCHYR members within the same group exhibited similar distributions of conserved motifs and exon-intron structures. Chromosomal localization analysis showed that 8 CaCHYR genes were unevenly distributed on 6 chromosomes. Segmental duplication, rather than tandem duplication, was found to be the major contributor to the expansion of this gene family. CaCHYR genes feature a variety of cis-elements involved in developmental processes, phytohormone responses, and stress adaptation. Expression analysis based on RNA-seq data revealed that CaCHYR genes exhibited distinct spatial expression patterns across different tissues and in response to Phytophthora capsici infection (PCI), and quantitative real-time PCR (qRT-PCR) further confirmed that three of them (CaCHYR2, CaCHYR3, and CaCHYR5) exhibited altered expression under PCI. Furthermore, transient overexpression of CaCHYR5 in pepper leaves increased susceptibility to PCI, suggesting its potential negative regulatory role in pepper defense against P. capsici. Collectively, these findings reveal the expression patterns and regulatory functions of pepper CHYR genes in growth and development, laying a groundwork for breeding pepper cultivars tolerant to PCI.

Phytophthora capsici infection (PCI)↗
PubMed1987

Reduction of grip strength, finger flexion pressure, finger pinch pressure and key pinch following flexor tendon repair.

67 patients with 176 repaired flexor tendons have been reviewed after a mean follow-up interval of 26.4 months. After repair, mean grip strength was 74.5%, mean finger flexion pressure 76.8% and mean finger pinch pressure 74.7% of that of the opposite uninjured hand or digit. For 16 patients with repaired flexor pollicis longus tendons, mean key pinch was 78.7%. Grip strength was reduced after injury to tendons alone, but was especially reduced when there was concomitant damage to the median or ulnar nerves.

Adolescent↗
PubMed2000

Osseointegrated finger prosthesis: An alternative method for finger reconstruction.

Three patients had traumatic amputation of the index and middle fingers at the base of the proximal phalanx. A 2-stage reconstruction procedure with osseointegrated titanium implants was performed in each patient to fix a finger prosthesis to the proximal phalanx. The first stage included implantation of the titanium fixture into the medullary canal of the proximal phalanx. After a 3-month rest period to allow the fixture to firmly osseointegrate with the proximal phalanx, a skin-penetrating abutment was placed on top of the fixture, to which the prosthesis was firmly attached. The follow-up period ranged from 16 to 24 months. There were minimal skin problems. Some tactile sensibility, better motor function, and good cosmetic results were achieved. (J Hand Surg 2000; 25A:86-92.

Adolescent↗
PubMed1975

[Construction of a finger substitute with sensation following the loss of all fingers].

On a patient with traumatic loss of all of the fingers a light but satisfactory grip was obtained by the construction of an opposition post with sensation. This was achieved by a tubed abdominal pedicle flap containing iliac bone graft. A neurovascular cross-finger flap was transfered from the uninjured hand in such a way that an anastomosis to a branch of the nerve of the injured hand was possible, allowing for the development a satisfactory sensation.

Abdominal Muscles↗
PubMed2005

Feasibility and validity of a modified finger-nose-finger test.

In essential tremor (ET) research, it is important to obtain standardized, objective data on tremor severity. Often, it is not possible to carry out in-person or videotaped neurological examinations. In place of these, handwriting samples can be collected, but they do not capture all of the variance in tremor severity. Although additional tests of tremor severity (finger-nose-finger [FNF] test) might be of use, these would need to be modified to allow ET patients to mail their results to the study investigator for rating. We modified the standard FNF test (sFNF) by asking subjects to hold a pen during this activity and mark a paper target. The purpose of this report was to determine whether the modified FNF (mFNF) test was feasible and valid. Of 70 subjects, 65 (92.9%) were able to complete the mFNF, demonstrating that it was feasible. The scores of the mFNF correlated highly with those of the sFNF (r = 0.56-0.85; all P < 0.001), indicating the mFNF is a valid measure of tremor severity. In addition, using the regression equation, sFNF = 0.174(mFNF) + 0.743, a sFNF score can be derived easily from the mFNF score. The mFNF may be used to collect valuable data on tremor severity in pathological, genetic, and epidemiological field studies of ET, in which in-person or videotaped neurological examinations are not possible.

Essential Tremor↗
PubMed2000

Molecular cloning of ring finger protein 21 (RNF21)/interferon-responsive finger protein (ifp1), which possesses two RING-B box-coiled coil domains in tandem.

We have cloned the full length of a novel cDNA, named ring finger protein 21 (RNF21), composed of the RING finger-B box-coiled coil (RBCC) domain and the B30.2 domain, which are characteristic of the RBCC-B30.2 family. As a structural feature, the RNF21 cDNA possessed at least three kinds of isoforms, due to alternative splicing, consisting of the long form with the RBCC-RBCC-B30.2 domain, the medium form with the RBCC-B30.2 domain, and the short form with only the RBCC domain. Moreover, respective transcripts corresponding to the three isoforms were detected in various human organs by reverse transcription-PCR and Northern blot analyses. Interestingly, the medium form of the RNF21 mRNA expressed most predominantly was dramatically up-regulated within 8-16 h by interferon stimulation of HeLa cells. These findings suggest that RNF21 is a downstream gene that may mediate interferon's biological action.

Alternative Splicing↗
PubMed1992

Evolution of zinc finger-Y and zinc finger-X genes in oryzomyne-akodontine rodents (Cricetidae).

Zinc finger-Y (Zfy) and zinc finger-X (Zfx) genes were analyzed by Southern blotting in male and female specimens of 10 species belonging to the oryzomyne-akodontine stock of Cricetidae rodents. DNA fragments were used as characters to construct a parsimony tree of the genes. Zfx and Zfy trees in general coincide with the evolutionary history of the taxa. Both trees show Oryzomys longicaudatus genes as the outgroup whereas Akodon xanthorrhinus genes are also distant from those of the other species. Oxymycterus rufus and Bolomys obscurus share related sequences, while genes from the other six Akodon species form a group of their own. It was found that 9 out of the 10 species analyzed show Zfy amplification in a range varying from 2 to 24 copies and with a pattern that is clade specific. The estimation of the average changes per character strongly suggests that Zfy has evolved more rapidly than Zfx; our estimates of the rate of nucleotide substitution are 4.6 times higher for Zfy than for Zfx.

Animals↗
PubMed1993

Evaluation of methods of claw finger correction using the finger dynamography technique.

Finger dynamography is a bedside technique for evaluation of the moving abilities and working space of the hand. Various operative procedures used for correcting the claw finger deformity restore the functional abilities to a varying extent. The palmaris longus transfer with insertion into A1-A2 pulley appears to be a better procedure than lateral band insertion, extensor diversion or extensor many-tail procedures. The use of palmaris longus as a motor seems to have advantages over flexor digitorum superficialis transfer where removal of FDS as a motor produces local deficits.

Adolescent↗
PubMed1979

Open complex metacarpophalangeal joint dislocation. Two cases: index finger and long finger.

Two patients with open complex dislocation of a metacarpophalangeal joint were treated by cleansing of the wound, open reduction, primary wound closure, and early motion. One dislocation occurred in the index finger, the other in the long finger which is only the second such case to be described. Antibiotics were given before and continued for 5 days after operation. There were no infections, and both patients regained an excellent range of motion without pain.

Adolescent↗
PubMed1988

Rotational deformity of the index finger caused by reversed finger sucking.

Five patients with deformities of the index finger are presented. We believe all five are due to finger sucking. The deformity usually consists of a combination of rotation, radial deviation in the metacarpal phalangeal joint, and hyperextension in the proximal interphalangeal joint; one of these is more pronounced. In our series the rotational deformity and deviation were the most prominent features. Cause, incidence, and other factors influencing this deformity as well as spontaneous regression and therapy are discussed.

Adult↗
PubMed1994

Direct control of transcription of the Drosophila morphogen bicoid by the serendipity delta zinc finger protein, as revealed by in vivo analysis of a finger swap.

Determination of the anterior structures of the Drosophila embryo is under control of the maternal gene product Bicoid (bcd), which specifies distinct domains of embryonic gene expression in a concentration-dependent manner. We show here that bcd transcription is controlled by serendipity delta (sry delta), a zygotic-lethal zinc finger protein gene. This sry delta germ-line function was revealed by transgenic expression of a modified Sry delta protein, Sry DB56, carrying a two-finger swap. Although it almost fully rescues sry delta lethality, Sry DB56 does not substitute for the wild-type protein in activating bcd transcription. Two overlapping sites binding the Sry delta protein were identified in the bcd promoter region, a few base pairs upstream of the putative TATA box. Mutating one site impairs bcd transcription in vivo, indicating that Sry delta acts directly upstream of bcd. The specific requirement of sry delta for bcd transcription in the female germ line constitutes an unexpected link between a zygotic gene with pleiotropic functions and the establishment of coordinates of the Drosophila egg. It highlights the fundamental role of ubiquitous transcription factors in bringing about a specific developmental program.

Amino Acid Sequence↗
PubMed2005

Crystallization and preliminary X-ray crystallographic analysis of Aart, a designed six-finger zinc-finger peptide, bound to DNA.

Crystals of a designed six-finger zinc-finger protein, Aart, bound to a 22-base-pair duplex DNA containing a consensus binding site have been obtained. Crystals grew by hanging-drop vapor diffusion from solutions containing polyethylene glycol 4000 as the precipitating agent. The irregularly shaped crystals belong to space group P1, with unit-cell parameters a = 41.95, b = 71.76, c = 74.73 A, alpha = 100.87, beta = 96.22, gamma = 106.33 degrees . There are most likely to be two protein-DNA complexes in the asymmetric unit. A complete native data set has been collected from a high-energy synchrotron source to a resolution of 2.95 A at 100 K, with an Rmerge of 9.3%.

Amino Acid Sequence↗
PubMed1977

Movement patterns of intrinsic minus fingers. Role of intrinsic and extrinsic muscles in finger posture control.

A detailed study of the patterns of two movements (pure metacarpophalangeal flexion and pure interphalangeal extension) in intrinsic minus fingers shows that the long extensors and long flexors produce simultaneous movement at the metacarpophalangeal and interphalangeal joints. A comparison of the patterns of these movements in totally intrinsic minus and interosseous minus fingers shows that in the latter the lumbricals are probably largely inactive during attempted pure metacarpophalangeal flexion and contribute to restrain metacarpophalangeal extension considerably during attempted pure interphalangeal extension. Active participation by the interosseous muscles appears necessary for completing these movements.

Fingers↗