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Incontinence.

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Disposable Equipment↗

[Urological complications in patients with multiple sclerosis (author's transl)].

63 patients with multiple sclerosis underwent urodynamic evaluation. Hyperreflexia of the bladder was found in 64% and areflexia in 8%. Hypertrophy or sclerosis of the bladder neck (internal sphincter) was detected in 27% of the patients and a spastic external sphincter (dyssynergia) was encountered in 57%. 16 patients were admitted for surgery: 9 for TUR of the bladder neck, 5 for percutaneous selective sacral nerve block, 2 for ileal diversion, 2 for prolonged bladder distension and 1 for nephrectomy for staghorn calculi of the renal pelvis. Highly effective conservative therapy is available in the form of Lioresal for treatment of the hyperactive detrusor muscle and Dibenzyran - an alpha-adrenergic blocking agent - to relieve bladder neck spasticity.

Adolescent↗

[Drug induced esophageal ulcers].

Drug induced esophageal ulcers are more frequent than supposed. Four ulcerative lesions of the esophagus, two after ingestion of doxycycline-hydrochloride, one after metacycline-hydrochloride, and one after emeproniumbromide were detected at the department of Internal Medicine of a medium-sized standard-hospital during the last six years. Symptoms develop suddenly after taking the drug with minimum fluid, usually before going to bed. Retrosternal burning, odynophagia and dysphagia are pathognomonic features. The cause of ulceration is discussed to be a matter of the drug remaining in the esophagus and of its local cytolytic and corrosive effect. Cytomegalo and herpes-simplex-infections can be excluded as etiologic factor of such ulcers. The clinical diagnosis is verified by endoscopy only.

Adult↗

Pharmacological studies of the uninhibited neurogenic bladder. II. The influence of cholinergic excitatory and inhibitory drugs on the cystometrogram of neurological patients with normal and uninhibited neurogenic bladder.

In order to elucidate the parasympathetic activity of the uninhibited neurogenic bladder, controlled cystometry before and during influence of cholinergic and anticholinergic drugs has been performed on patients with normal and uninhibited neurogenic bladder. Cholinergic stimulation proved to increase the intravesical pressure to a great extent; to a higher degree in the normal than in the uninhibited bladder. In two patients with normal bladder, uninhibited detrusor contractions were induced by cholinergic stimulation. Cholinergic inhibition had only minor influence on the intravesical pressure during the filling phase. Opposite effects were obtained on the uninhibited detrusor contractions which are regarded as a part of the expulsive phase. Cholinergic stimulation increased the amplitude of the uninhibited bladder to some degree, but cholinergic inhibition markedly reduce the amplitude. Conclusively, the uninhibited neurogenic bladder is at least partly caused by an overactivity in cholinergic stimulation.

Adult↗

[Ulcer of the esophagus after intake of emeproniumbromide (author's transl)].

Two female patients were treated because of pollakiuria with emeproniumbromide tablets. They developed extended ulcers of the esophageal mucosa. The tablets had been taken late in the evening with only little fluid. Ulcer formation is thought to be due to prolonged passage time and to a locally damaging effect of the hygroscopic compound. There may be lesions of the esophageal musculature as well, as demonstrated by considerable disturbance of esophageal motility. Ulcers tend to be painfull; they heel fast without formation of scars.

Adult↗