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PubMed1990

[Transcutaneous oxygen partial pressure measurement in follow-up of patients with erysipelas].

In 24 patients with erysipelas, skin oxygen tension (tcPO2) was measured in the centre, at the border and outside the area of skin inflammation before, during and after antibiotic treatment. At the same time ESR, leucocytes and body temperature were determined. Skin erythema persisted over a period of about 7 days. Leucocytes and body temperature showed normal values after 3 days, while ESR was raised continuously in the first 3 weeks. Skin oxygen tension showed a good correlation with the clinical picture, but was still reduced at the end of therapy. About 2 weeks after disappearance of the clinical signs of inflammation, tcPO2 values were back to normal. The measurement of transcutaneous oxygen pressure can supplement the classic parameters of inflammation as a valuable tool for follow-up examinations in patients with erysipelas.

Adult↗
PubMed1989

[The immunopathological mechanisms of the skin lesion in erysipelas patients].

The localization of bound IgG, IgA, IgM and component C3 of the complement in the focus of skin lesion in patients with different forms of erysipelas has been studied by the method of direct immunofluorescence. The presence of fixed immune complexes and component C3 in the affected areas of the skin at the acute period of the disease and their absence in the healthy areas of the skin have been established, which seems to be indicative of the presence of the local immunocomplex process in erysipelas. This process is one of the mechanisms of erysipelatous inflammation.

Acute Disease↗
PubMed1977

Erysipelas: facial lymphangitis.

Two cases of facial lymphangitis have been described, and the pathophysiology of erysipelas has been discussed. Now rarely observed by hospital residents, this potentially serious infection can create considerable diagnostic confusion in medical as well as dental services. Rapid response of erysipelas to penicillin therapy is the modern expectation.

Child, Preschool↗
PubMed1989

[Treatment of chronic recurrent erysipelas with streptococcal vaccine].

One hundred patients suffering from relapsing erysipelas were treated with streptococcal vaccine consisting of a phenol- und heat-inactivated mixture of 12 different types of streptococci. Simultaneously the entry point was cured and general disposition and local terrain factors were treated. In the majority of cases further relapses were avoided or their frequency reduced. The results of the treatment with streptococcal vaccine were compared with those of long-term benzathine-penicillin therapy in 47 patients. The vaccine has proved to be equivalent to the penicillin therapy and can be recommended as a real alternative to it for prevention of further infections and late sequelae, especially those of chronic lymphedema. The beneficial therapeutic effect of the vaccine is probably attributable to a non-specific immune stimulation. A partial cellular immune defect involving the protective M-antigen together with simultaneous partial abnormalities of immune reactivity is discussed as a cause of relapsing erysipelas.

Adult↗
PubMed1985

[Circulating immune complexes in the pathogenesis of recurrent erysipelas].

The dynamics of circulating immune complexes (CIC) in comparison with the level of SH-groups of serum deproteinate and other characteristics of cell-mediated and humoral immunity (the reaction of the inhibition of antibodies, the levels of T-cells and their main subpopulations) was studied in 103 erysipelas patients and in 46 persons having had the disease at the acute period of this infection and at the periods between relapses. The elevated levels of CIC and SH-groups of serum deproteinate were found to be directly correlated with the inhibition index. The study showed that, as a rule, in patients with the elevated level of CIC the frequently relapsing form of erysipelas, accompanied by the formation of relative hypersuppressor-type secondary immunodeficiency and by a decrease in the functional activity of dermal macrophages, was observed.

Acute Disease↗
PubMed1988

[The pathogenesis of erysipelas arthritis].

Experimental chronic erysipelas polyarthritis in rat, induced by living erysipelas bacteria, histologically can be divided into four different phases. In the phase of population bacteria are distributed diffusely within the whole joint but accumulate in the transitional zones and entheses by multiplication within the ground substance of cartilage. In the phase of acute destruction a severe inflammation of all joint tissues predominates. Bacterial antigen is eliminated by a pannus tissue destroying the cartilaginous structures. In the following phase a diffuse dystrophy of articular cartilage dominates. The reason for this process is not clear; within the cartilage bacterial antigen can seldom be demonstrated, but it accumulates intracellularly in the periphery of the joints (e.g. dense connective tissue, muscles). In the chronic phase we find a lymphoplasmacytic infiltration of the subsynovium, a lining cell hyperplasia, and pannus formation arising from the epiphyseal bone marrow cavity. The relation between chronic inflammation and destruction in the central and antigen persistence in the outer parts of the joints is a matter of current investigation.

Animals↗
PubMed1986

[Cytotoxic effect of lymphocytes on autologous blood monocytes in the presence of streptococcal group A antigens in patients with primary erysipelas].

The present work deals with a modification of the cytotoxic test for the determination of the cytotoxic activity of lymphocytes in infectious diseases. This modification is based on the use of the suspension of mononuclear blood cells, simultaneously containing effector cells (sensitized lymphocytes) and target cells (autologous monocytes). The cytotoxic effect on monocytes is observed after the preliminary incubation of nonadhering cells (lymphocytes) with the antigen of microorganisms causing the infectious process. A statistically significant increase in the cytotoxic activity of lymphocytes was recorded in patients with primary erysipelas at the acute period of the disease. The cytotoxic effect has been found to persist at a high level for two weeks. By the end of the disease this effect drops to the level characteristic of clinically normal persons. An elevated level of the cytotoxic activity of lymphocytes in the presence of streptococcal antigens of one type has been detected in 72% of patients with primary erysipelas. This indicates that type-nonspecific streptococcal antigens take part in the formation of delayed hypersensitivity, which is also confirmed by the data obtained in animal experiments.

Animals↗
PubMed1987

[Swine erysipelas: from yesterday to today].

The history of swine erysipelas in the Netherlands is reviewed, with special reference to the significance of vaccination and the views on epidemiology. The paper of D. A. de Jong Jzn. (1891) is discussed. The activities of the National Serum Institute in Rotterdam in this regard are discussed in detail. In conclusion, it is stated that vaccinations designed to prevent swine erysipelas are no longer required under conditions prevailing in the Netherlands.

Animals↗
PubMed1986

[Treatment of phlegmonous and necrotic forms of erysipelas].

Clinical observations, bacteriological examinations in 220 patients operated upon for phlegmonous and necrotic erysipelas and investigation of the immunological background (in 48 of them) have shown that phlegmono-necrotic erysipelas develops due to the displacement of streptococci from the inflammatory center of the secondary infection against the background of the venous and lymphostasis with reduced local immunity.

Adolescent↗
PubMed1985

[Possibility of increasing the efficacy of antibiotic therapy of erysipelas using combinations of methyluracil with prodigiozan].

Two hundred and six patients with erysipelas were examined. Of these, 100 patients were subjected to the routine therapy and 106 were additionally treated with methyluracil and prodigiosan. It was noted that the use of methyluracil and prodigiosan in the combined treatment of erysipelas promoted an increase in the efficacy of the antibiotic therapy owing to acceleration of the local inflammation regression and the favourable effect of the treatment on the cell immunity.

Adult↗
PubMed1983

[Free and bound antigen of Streptococcus group A L forms and the circulating immune complex level of erysipelas patients].

The level of circulating immune complexes in the blood serum of patients with relapsing erysipelas was found to be correlated with the level of the antigen of group A S. haemolyticus L-forms, this antigen entering in to the composition of the immune complexes. In 68% of cases the antigen of the streptococcal L-forms was bound and only in 20% of cases, free. High titers of antibodies to group A S. haemolyticus L-forms in patients with relapsing erysipelas at the absence of free antigen indirectly suggests that the antigen is incorporated into antigen-antibody complexes.

Antibodies, Bacterial↗
PubMed1978

Effects of aflatoxin on the development of acquired immunity to swine erysipelas.

The effect of aflatoxin consumption on the development of acquired immunity to swine erysipelas was studied. Twenty-four pigs were divided into 4 groups (6 pigs/group). Two groups were fed a normal diet and 2 groups were fed the same diet but containing aflatoxin. One group from each diet treatment was given a single injection of an erysipelas bacterin, and 21 days later all pigs were given a challenge inoculum of virulent Erysipelothrix rhusiopathiae organisms. On the basis of the response to the challenge inoculation, pigs were classified as immune, partially immune (PI), or susceptible. Three of the vaccinated pigs fed the normal diet were immune, 2 were PI, and 1 was susceptible, whereas none of the vaccinated pigs given the aflatoxin diet were immune, only 1 was PI, and the remainder were susceptible. Two of the nonvaccinated pigs fed the normal diet were PI and 4 were susceptible; all of the nonvaccinated pigs fed the aflatoxin diet were susceptible. It was concluded that aflatoxin consumption interfered with the development of acquired immunity and apparently increased the severity of the E rhusiopathiae infection in unvaccinated pigs.

Aflatoxins↗
PubMed1982

[Necrotizing erysipelas--connections with angiological diseases].

Necrotizing erysipelas (NE) is a variant of erysipelas with a relatively severe course. 12 patients were examined for predisposing factors of necrotizing. In only one of them, the face was involved, and in the rest the lower extremities. In 10 cases, a chronic arterial occlusive disease was detected by the Doppler-ultrasound. In 5 patients we found a diabetes mellitus, simultaneously. In a further diabetic patient, it was not possible to measure the regional blood pressure, because of the location of the NE in the face. In two cases we found a diabetic retinopathy. Only in one patient the arterial ankle pressure was normal.

Adult↗
PubMed1981

[The erysipelas as complication of a lymph oedema after therapy of mastocarcinomas (author's transl)].

1812 patients with mastocarcinomas were submitted to a combined therapy (surgery and radiotherapy); 34.2% of them developed an oedema. This inflammation is a complicating factor because it may increase the oedematous tendency. The authors discuss the correlations between a disturbed defluxion and an erysipelas tendency as well as the risks of a chronic stasis. These correlations necessitate an immediate and intensive treatment of the erysipelas.

Adult↗
PubMed1980

[Aerosol immunization of ducks with Spirovak erysipelas vaccine "Dessau"].

A method for active immunisation of ducklings during the raising period (between the first and 20th days of age) was devised in another attempt to control erysipelas septicaemia of duck on freeland fattening sites. Spirovak erysipelas vaccine "Dessau" was aerogenically applied through vortex injector nozzles, when the animals were between five and 20 days of age. Immunisation took place in groups of 5,000 animals each. The vaccine concentrations were four doses per cubic metre in the first immunisation and eight doses per cubic metre in the second. Exposures were 30 minutes in the first immunisation and 20 minutes in the second. Ten man-hours were required to immunise 10,000 ducks. Benefits of the method are substantive improvement of working conditions, higher labour productivity, and lower production cost.

Aerosols↗
PubMed1981

Facial erysipelas in the immunocompromised host. Report of two cases.

Two cases of facial erysipelas in immunologically altered hosts are reported herein. The unusual presentation with absence of erythema in the skin lesion is emphasized. Atypical fever patterns were also noted. In one patient, the facial lesion followed the onset of fever by 48 hours, and, in the other, the facial swelling preceded the fever. Various aspects of the patient's altered host status are discussed in light of the atypical clinical presentation. Recognition of facial erysipelas as a potential source of group A beta-hemolytic streptococcemia in immune-altered hosts is important to ensure rapid and appropriate therapeutic intervention.

Adult↗
PubMed1994

Secondary milia following bullous erysipelas.

Secondary milia associated with bullous erysipelas developed in the right leg of a 64-year-old woman. The milia, measuring up to 6 mm, appeared one month after healing of the erysipelas. Findings of histopathologic and immunohistochemical studies showed that the milia were related to dilated eccrine ducts and not to the hair follicle. Topical treatment with 0.05 percent tretinoin cream resulted in almost full resolution of the lesions.

Eccrine Glands↗
PubMed1993

[Dermatoplasty in the treatment of necrotic mastitis and breast erysipelas].

The authors had 15 female patients aged from 20 to 35 years with various diseases of the breast which were marked by necrosis of the skin and subcutaneous fat with involvement of 18 to 100% of the breast surface. The necrosis was caused by phlegmonous and infiltrative abscess producing forms of mastitis in 18 and by erysipelas in 7 cases. Necrotic mastitis and erysipelas developed in the first 2 weeks after delivery, as a rule, in patients with marked concomitant diseases of the heart and vessels. The patients were hospitalized 7 to 29 days after the onset of the disease. The development of severe forms of breast diseases was promoted by intensive manual abstraction of milk from the breast and retromammary antibiotic-novocaine blockades. After an operative intervention a complex of therapeutic measures was applied including semisynthetic antibiotics, agents containing protein globulin fractions, and dry and native blood plasma, and artificial polyuria with preceding hemodilution was produced. All patients underwent dermatoplasty with the use of a free split perforated skin graft. Lactorrhea in the region of the granulations was not a contraindication for surgical closure of the wound. Perforation of the skin graft was regarded a forced measure because the secretion of milk led to inevitable rejection of the transplant. The applied treatment produced quite satisfactory cosmetic and functional results.

Abscess↗