Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “ERGOT ALKALOIDS”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 163 records · Page 9Linked to original sources
PubMed1979

[From ergot alkaloids to nicergoline/Chemical points of view (author's transl)].

The author reports the rationale of a line of research that has led to pharmacologically active ergoline derivatives from the more complex ergot alkaloids. Specific compounds showing oxytocic, alpha-adrenolytic and antiserotoninic activity were synthesized and the relationship between structure and activity discussed. Out of the compounds, 10-methoxy-1,6-dimethyl-ergoline-8 beta-methanol-(5-bromonicotinate) (nicergoline) was chosen as the most interesting product for a detailed further development.

Chemical Phenomena↗
PubMed2005

The influence of ergot-contaminated feed on growth and slaughtering performance, nutrient digestibility and carry over of ergot alkaloids in growing-finishing pigs.

Diets containing 0, 1 and 10 g ergot (Claviceps purpurea) per kg, corresponding to mean total alkaloid contents of 0.05, 0.60 and 4.66 mg/kg (sums of ergometrine, ergotamine, ergocornine, alpha-ergocryptine, ergocristine, ergosine and their -inine isomers analysed by a HPLC-method), were each fed ad libitum to 12 pigs in the BW range of 30-115 kg to study the effect of ergot-contaminated feed on growth and slaughtering performance and the carry over of ergot alkaloids. Additionally, balance trials were conducted to investigate the digestibility of nutrients. Tendencies towards reduced feed intake and BWG were observed at a feeding level of 4.66 mg total alkaloids per kg diet. Typical symptoms of ergot poisoning were not observed. Heart and spleen weights showed significant linear increases. Differences in carcass quality due to dietary treatment were not detected. No genuine ergot alkaloids were found in physiological samples. The balance trials demonstrated a significantly decreased protein digestibility for the most highly supplemented diet.

Animal Feed↗
PubMed1988

Influence of some ergot alkaloids on the cerebral reduced glutathione.

Dose-related changes of the reduced glutathione were evaluated in forebrains from male Wistar rats aged 10 months after chronic i.p. treatment for two months with the ergot alkaloids dihydroergocristine and dihydroergocriptine. The results indicate that, within a specific dose-range, the concentration of the cerebral reduced glutathione may be modified by exogenous intervention.

Animals↗
PubMed1998

Separation of ergot alkaloids and their epimers and determination in sclerotia by capillary electrophoresis.

Capillary electrophoresis has been shown to be a very useful analysis technique for secondary metabolites of plants. In the present study a method is described for the qualitative and quantitative determination of ergot alkaloids and their epimers. The extraction from the biological matrix yields recoveries of 50-97%, depending on the individual alkaloid. Using a mixture of 20 mM beta-cyclodextrin (CD), 8 mM gamma-CD, 2 M urea and 0.3% (w/w) poly(vinyl alcohol) to phosphate buffer at pH 2.5 the simultaneous separation of all analytes was achieved. A 37 cm (30 cm) fused-silica capillary, at a voltage of 25 kV and a temperature of 20 degrees C, was used for the analysis. Overall analysis time for the separation was 12 min. The limit of detection of the alkaloids using UV detection at 214 nm can be improved 30-fold to about 9.10(-8) M when laser-induced fluorescence detection is applied.

Buffers↗
PubMed1980

[Acute changes in intracerebral vascular resistance after application of dihydrogenated ergot alkaloids (author's transl)].

Measurements of total cerebrovascular resistance (CVR) before and after administration of dihydrogenated ergot alkaloids are performed using a decoupling extracorporeal bypass system in rabbits. From the experiments there is clear evidence that the application of dihydroergotoxine-mesylate (28 micrograms/ml intracarotid.) or dihydroergocristine-methansulfonate (Decme, DHEC, 27 micrograms/ml) is followed by a significant drop in total CVR during 5--6 min. In addition, DHEC shows other, more differentiated effects within the cerebrovascular system. At comparable concentrations within the cerebrovascular system, the vasodilatory effect of DHEC seems to be a function of the initial CVR before administration of the drug (range of the initial CVR-values: 1.1--2.0 kPa-min/ml). During very low initial CVR-values (CVR less than 1.1. kPa-min/ml) the application of DHEC is followed by an increase in CVR. There are indications that DHEC acts as a vasoconstrictor in the cerebral vascular bed if the initial CVR-values are quite low. This bivalent effect of DHEC on CVR may cause favourable redistributions of regional blood flow under certain circumstances (e.g., if focal hypoperfusion is combined with perifocal hyperemia).

Animals↗
PubMed1980

Effect of bromocriptine, ergotamine and other ergot alkaloids on the hormone secretion and growth of a rat pituitary tumour.

The effect of bromocriptine on hormone secretion and the growth of the prolactin- and growth hormone (GH)-secreting rat pituitary tumour of the GH3 cell line has been compared with that of ergotamine and other ergot alkaloids. Bromocriptine in doses ranging from 1 to 20 mg/kg had no effect on tumour growth or on the excessive secretion of GH by the tumour; prolactin concentrations were reduced only by the highest dosage of the drug. Similarly the tumour was resistant to the administration of ergocryptine, ergocornine and the synthetic ergolines, lergotrile and CH 29-717. In contrast, ergotamine reduced secretion of both GH and prolactin and considerably inhibited the growth of the tumour. Experiments in vitro showed that ergotamine inhibited DNA synthesis of the tumour cells and decreased hormone secretion. It was concluded that ergotamine had a direct inhibitory action on the GH3 cell tumour which was not mediated through the dopaminergic mechanisms.

Animals↗
PubMed1979

Effect of ergot alkaloids on serum prolactin in non-psychotic organic brain syndrome of the elderly.

A compound of ergot alkaloids (Hydergine-Sandoz) or placebo was given to sixty elderly nursing home patients with non-psychotic organic brain syndrome. Subsequent to 12 weeks of treatment, the mean serum prolactin of the drug was significantly lower than that of the placebo group. No correlation was found between changes in prolactin and changes in behavior using Sandoz Assessment of Clinical Status Rating Form-Geriatric [SCAG]. It may be that a higher dose of Hydergine with an accompanying greater drop in prolactin would be required to observe this effect.

Aged↗
PubMed1983

Vascular effects of ergot alkaloids: a study on human basilar arteries.

Postmortem examinations on human basilar arteries were performed in vitro by recording isometric tension from spiral strips in tissue baths at 37 degrees C. Antagonism of 5-HT by ergotamine, dihydroergotamine and methysergide was of the non-competitive type, that of noradrenaline was either absent (i.e. ergotamine) or considerably weaker. In addition each ergot alkaloid acted as a partial agonist in the following order of efficacy: ergotamine greater than dihydroergotamine greater than methysergide, producing pD2 values of 9.30, 9.60 and 7.10 respectively. Evidence is provided that the stimulant activity of ergotamine is mediated through 5-HT receptors. The present results are compared to those obtained on isolated human vein strips as well as to those on canine blood vessels.

Basilar Artery↗
PubMed1982

Conformational analysis of the ergot alkaloids ergotamine and ergotaminine.

Conformational analyses by 1H NMR and potential-energy calculations are reported for the ergot alkaloids ergotamine and ergotaminine, both as free bases and as the protonated species. In the neutral forms in CDCl3. two strong intramolecular hydrogen bonds fix the molecules in folded conformations, but the protonated species adopt a more extended conformation, with a single intramolecular hydrogen bond. Of the 24 alternative conformations available to ergotamine, the most likely biologically active species in environments with low dielectric constants, e.g., the presumed ergotamine binding site, is the folded, hydrogen-bonded conformation observed for the neutral molecule in CDCl3 solution.

Chemical Phenomena↗