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At least 163 records · Page 9Linked to original sources

Sleep disruption in the course of chronic levodopa therapy: an early feature of the levodopa psychosis.

Sleep disruption is a common complaint in levodopa-treated parkinsonian patients. A survey of 100 parkinsonian patients revealed prominent sleep complaints in 74%. Sleep complaints were unrelated to patient age and the duration of disease but increased in prevalence with longer periods of levodopa therapy. Sleep abnormalities tended to increase in severity with continued treatment and insomnia tended to be followed by daytime somnolence, altered dream events, and episodic nocturnal vocalization and myoclonus. While dyskinetic side effects and on-off syndrome were encountered in patients with and without sleep complaints, 98% of patients experiencing psychiatric side effects also reported sleep disruption. It is suggested that sleep-related symptoms constitute an early stage of levodopa-induced dopaminergic psychiatric toxicity in the parkinsonian population. Clinical and experimental observations suggest that serotonergic mechanisms are important in this symptom complex.

Aged↗

Unconscious fantasy: developmental and self-psychological considerations.

The authors view unconscious fantasy from the perspective of self psychology as a significant addition and emendation of the classical framework. A selective review of the pertinent literature is presented, followed by clinical material illustrating the contribution of self-psychological concepts to the understanding of unconscious fantasy formation.

Child, Preschool↗

A prominent role for amygdaloid complexes in the Variability in Heart Rate (VHR) during Rapid Eye Movement (REM) sleep relative to wakefulness.

Rapid eye movement sleep (REMS) is associated with intense neuronal activity, rapid eye movements, muscular atonia and dreaming. Another important feature in REMS is the instability in autonomic, especially in cardiovascular regulation. The neural mechanisms underpinning the variability in heart rate (VHR) during REMS are not known in detail, especially in humans. During wakefulness, the right insula has frequently been reported as involved in cardiovascular regulation but this might not be the case during REMS. We aimed at characterizing the neural correlates of VHR during REMS as compared to wakefulness and to slow wave sleep (SWS), the other main component of human sleep, in normal young adults, based on the statistical analysis of a set of H(2)(15)O positron emission tomography (PET) sleep data acquired during SWS, REMS and wakefulness. The results showed that VHR correlated more tightly during REMS than during wakefulness with the rCBF in the right amygdaloid complex. Moreover, we assessed whether functional relationships between amygdala and any brain area changed depending the state of vigilance. Only the activity within in the insula was found to covary with the amygdala, significantly more tightly during wakefulness than during REMS in relation to the VHR. The functional connectivity between the amygdala and the insular cortex, two brain areas involved in cardiovascular regulation, differs significantly in REMS as compared to wakefulness. This suggests a functional reorganization of central cardiovascular regulation during REMS.

Adult↗

Once-a-day HAART: dream or reality?

A constant and nearly absolute adherence is required to ensure a successful long-lasting outcome of highly active antiretroviral therapy (HAART). Pill burden and regimen complexity are important contributors to adherence problems. The most significant treatment-related strategy to improve adherence may be the reduction in the number and frequency of pills to be taken every day. If one accepts the concept that once-daily therapy is likely to benefit patients, then the issue turns to whether we have adequate drugs to implement once-daily HAART. There is quite a difference between using a once-a-day drug within an HAART regimen and designing an HAART regimen that is dosed once daily. To date, studies that explore the feasibility of once-a-day HAART regimens are still few, mostly exploratory, not controlled, and performed in a limited number of patients. However, most data are consistent one with the other, and evidence on the utility of such regimens is growing. Once-daily therapy cannot be the answer to all the questions that complex and life-long therapies give rise to, but it could be a further choice that can meet the needs of many patients. The range of once-daily options is expanding rapidly, and the patients' request for easier therapies that are respectful of their lifestyle could be fulfilled.

Anti-HIV Agents↗

"The scenes themselves which lie at the bottom of the story:" Julius, circumcision, and the castration complex.

In this paper I developed a description of Freud's childhood environment and the events surrounding the life of his brother Julius. I examined some of Freud's dreams, letters, and theoretical writings for clues regarding the effect of his early traumatic life events related to Julius. As Alice Miller (1990) suggests, "... how fruitless historical research can be if the psychological significance of external events is not taken into consideration" (p. 9). Miller (1981) also remarks, "... every childhood's conflictual experiences remain hidden and locked in darkness, and the key to our understanding of the life that follows is hidden away with them." I offer this analysis with the expectation of opening a search for the key; that identifying and interpreting Freud's own repressed material will lead to a fuller understanding of the prehistory of psychoanalysis and lend perspective to the meaning of his theories.

Anxiety, Castration↗

Why people see things that are not there: a novel Perception and Attention Deficit model for recurrent complex visual hallucinations.

As many as two million people in the United Kingdom repeatedly see people, animals, and objects that have no objective reality. Hallucinations on the border of sleep, dementing illnesses, delirium, eye disease, and schizophrenia account for 90% of these. The remainder have rarer disorders. We review existing models of recurrent complex visual hallucinations (RCVH) in the awake person, including cortical irritation, cortical hyperexcitability and cortical release, top-down activation, misperception, dream intrusion, and interactive models. We provide evidence that these can neither fully account for the phenomenology of RCVH, nor for variations in the frequency of RCVH in different disorders. We propose a novel Perception and Attention Deficit (PAD) model for RCVH. A combination of impaired attentional binding and poor sensory activation of a correct proto-object, in conjunction with a relatively intact scene representation, bias perception to allow the intrusion of a hallucinatory proto-object into a scene perception. Incorporation of this image into a context-specific hallucinatory scene representation accounts for repetitive hallucinations. We suggest that these impairments are underpinned by disturbances in a lateral frontal cortex-ventral visual stream system. We show how the frequency of RCVH in different diseases is related to the coexistence of attentional and visual perceptual impairments; how attentional and perceptual processes can account for their phenomenology; and that diseases and other states with high rates of RCVH have cholinergic dysfunction in both frontal cortex and the ventral visual stream. Several tests of the model are indicated, together with a number of treatment options that it generates.

Alcoholism↗

Psychoanalytic psychotherapy in Japan: the issue of dependency pattern and the resolution of psychopathology.

In this paper, I have tried to describe some of the characteristics of psychoanalytic psychotherapy in Japan in terms of dependency patterns in the psychotherapeutic relationship and the resolution of psychological problems. In the beginning of my paper I described problems concerning the professional network of psychiatry and psychotherapy in Japan and looked at the general attitude of the people toward this type of therapy. Then I briefly mentioned the attraction of traditional folk healing practices and outlined two of the academically acknowledged psychotherapies which originated in Japan. I have also presented characteristics of psychoanalytic psychotherapy practice in conjunction with those Japanese psychotherapies, discussing them in terms of the following issues: 1. General differences in psychoanalytic psychotherapy as contrasted to Naikan and Morita therapies and problems in psychoanalytic treatment that result from these differences. 2. Symptom resolution patterns in psychoanalytic treatment in Japanese patients and in relation to dream interpretation. 3. The cultural pattern of transference and how this relates to the Buddhistic figure of Kannon. 4. The Ajase Complex, a model of maternal transferential issues and an interpretation of objected-relations among the Japanese, namely the importance of forgiveness as a resolution of guilt and resentment. 5. The Amida Complex, a model of the cultural pattern of countertransference and the feeling of omnipotence and need for praise in the therapist. 6. Some complications and characteristics of a patient's perception of psychoanalytic interpretation. 7. The patient's perception of the psychoanalytic psychotherapist.

Attitude of Health Personnel↗

Who killed Laius?: On Sophocles' enigmatic message.

Using Laplanche's basic conceptualisation of the role of the other in unconscious processes, the author proposes a reading of Sophocles' tragedy, Oedipus the King, according to basic principles of dream interpretation. This reading corroborates contemporary literary perspectives suggesting that Sophocles' tragedy may not only convey the myth but also provide a critical analysis of how myths work. Important textual inconsistencies and incoherence, which have been noted through the centuries, suggest the existence of another, repressed story. Moreover, the action of the play points to enigmatic parental messages of infanticide and the silencing of Oedipus's story, as well as their translation into primordial guilt, as the origins of the tragic denouement. Oedipus's self-condemnation of parricide follows these enigmatic codes and is unrelated to, and may even contradict, the evidence offered in the tragedy as to the identity of Laius's murderers. Moreover, Sophocles' text provides a complex intertwining of hermeneutic and deterministic perspectives. Through the use of the mythical deterministic content, the formal characteristics of Sophocles' text, mainly its complex time perspective and extensive use of double meaning, dramatise in the act of reading an acute awareness of interpretation. This reading underscores the fundamental role of the other in the constitution of unconscious processes.

Adult↗

Erotic horror: desire and resistance in the psychoanalytic situation.

The emotions experienced during a sexualized transference are, though genital, hardly pleasurable. The phrase erotic horror describes something of what most patients find the experience to be like. Accordingly, I set forward the hypotheses that in direct proportion to the intensity of its need, the erotic transference is a form of negative transference deriving from past object relationships with exciting but frustrating objects; genetically, erotic transferences can be related not only to the oedipal phase but also to preoedipal phases of development, can refer to actual or fantasied seductions by either or both parents, and can involve both sexual and aggressive drives; the patient can also be an exciting but frustrating object to the analyst, evoking inevitable countertransference feelings in the analyst pertaining to both contemporary and past objects; the factor that most limits the elucidation of the patient's erotic transference is not the desire of the patient but the desire of the analyst; and only the correct interpretation, whether spoken or silently understood, mitigates the frustrated desire and resistance of both patient and analyst.

Adult↗

Patients' reactions to the birth of a male analyst's child.

After the author informed his patients he planned to be absent for one week, approximately one month hence, nearly all his patients correctly assumed that his wife was pregnant. The birth of the analyst's child revived conflicts concerning younger siblings. Male patients seemed to respond to the reactivation of oedipal conflicts by a transference intensification of their paternal identifications. Female patients reacted more negatively and more dramatically. For them, the birth of the analyst's child signified a defeat of both their positive and negative oedipal wishes. The author compares and contrasts his findings with the literature on the pregnant analyst.

Countertransference↗

Daimonic elements in early trauma.

This paper explores some of the 'daimonic' elements of unconscious mentation that emerge both in dreams and in the transference/countertransference field with early-trauma patients and illustrates these with an extended clinical example. An archaic and typical (archetypal) 'trauma complex' is articulated (with diagram) as a bi-polar structure consisting of divine child protected and/or persecuted by an inner 'guardian angel'. Sources of this structure and its mythological inner objects are traced to trauma at the stage of what Winnicott calls 'unintegration' and to flooding by disintegration anxiety at a time before nascent ego-structure has formed. In an extended case example, the author shows how the patient's traumatized innocence and desire for a new start, thwarted by self-attacking defences, pulls him into playing the inflated role of her guardian angel, leading to re-traumatization in the transference. Working through is seen as the necessary disillusionment and humanization of these daimonic structures as they are projected, suffered, and transmuted by the analytic partners in the stormy process of psychotherapy.

Adult↗

Some thoughts on the psychoanalytic situation.

This article develops ideas set out in a previous study on the "archaic matrix of the Oedipus complex" versus the fully developed Oedipus complex (their similarities and their differences), applying these to a study of the psychoanalytic situation. The central hypothesis is that there is a correspondence between the psychoanalytic situation and the structure of the mental apparatus. The author supposes that our perception of the world is intimately linked to the primary maternal relationship, to our wish to fuse with the mother once more, and to the accompanying fear such a wish inspires. To deal with this we create enclaves where the regressive wish can be satisfied without fear of ego dissolution. The author suggests that the psychoanalytic situation is one such enclave. She examines its specific features in the light of the structure of the mental apparatus as she defines it.

Adult↗

[Mechanisms of dream-sleep-wakefulness cycle].

For the occurrence of each state of sleep (slow wave sleep, paradoxical sleep) there are two neuronal networks. The first one called executive is responsible for the sleep phenomenology; the second called permissive is for the triggering of sleep. Wakefulness depends on a very complex system (10 structures) including the permissive networks which inhibit sleep. Sleep onset is thought as a blockade of the waking state by an antiwake network synthesizing hypnogenic factors. Such a regulation allows to suggest that insomnia is a wake trouble depending on a revisited therapy.

Animals↗