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At least 163 records · Page 9Linked to original sources
PubMed1980

[Low diuretic dosage in a beta blocker-diuretic combination].

Thirty outpatients with arterial hypertension were treated for eight weeks with a daily dose of one tablet of Cardiotensin, taken after breakfast. The compound contains 100mg bupranolol, 10mg bemetizide and 20mg triamterene. Drug therapy was preceded by a one-week placebo washout period. Within two weeks of treatment, systolic and diastolic blood pressure had reverted to normal in 26 of the patients. At the end of the observation period, 4 patients still had diastolic pressure values of more than 100 mm Hg. Ergometer stress testing revealed clear-cut diminution of blood pressure and heart rate elevations following the medication. Serum potassium levels were not influenced by the drug. Under the mentioned dose regimen there were no changes in serum uric acid, creatinine, and glucose concentrations. Tolerability was generally good.

Administration, Oral↗
PubMed1992

Diuretic and non-diuretic actions of furosemide: effects of probenecid.

Furosemide causes not only natriuresis, but a rapid (5-10 min) increase in plasma renin activity. The latter has been attributed both to the release of eicosanoids from renal blood vessels and to changes in sodium delivery to the macula densa. Drugs like indomethacin abolish the renin increment and could potentially affect both mechanisms: they inhibit cyclooxygenase but could also compete with furosemide for transport into the tubular lumen, reducing furosemide concentration at its site of action. We studied the effects of probenecid, a weak acid without cyclooxygenase activity, on the responses to furosemide in 20 healthy young men. Each received placebo and low (1000 mg/d) or high (2000 mg/d) doses of probenecid for one week in double-blind, randomized trials, crossover fashion. One hour after the last dose, all participants were given furosemide 0.5 mg/kg intravenously. Probenecid reduced serum uric acid in a dose-dependent manner but did not change platelet thromboxane B2 production. Similarly, there was no change in urine excretion rates of thromboxane B2 or 6ketoprostaglandin F1 alpha, or in baseline or stimulated plasma renin activity. The total natriuresis in 4 h was also unchanged. By contrast, the sodium excretion rate in the first 30 min was reduced after both probenecid regimens while that of later periods was increased. These findings are consistent with the proposed effect of probenecid as reducing furosemide secretion in the proximal tubule, which reduces its concentration at the lumenal surface of the thick ascending limb of Henle's loop, but also prevents its excretion from the body.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗