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At least 163 records · Page 9Linked to original sources
PubMed1984

Nuclear DNA cytophotometry in prostate carcinoma.

Eighty patients with prostate carcinoma underwent fine-needle aspiration biopsy for cytologic grading and DNA-single-cell fluorescence photometry before and at 6-month intervals after endocrine treatment. The histograms of DNA values showed single peaks and bimodal and scattered distributions which correlated to the different tumor grades before therapy. The DNA values were significantly different from the controls with benign prostatic hypertrophy. After start of therapy, regressive changes of the DNA-histograms were increases of diploid and hypodiploid DNA values and disappearance of secondary peaks. Progressive changes were increased scattering of DNA values and appearance of secondary peaks. Progressive changes in the histograms were closely related to clinical remission and stable disease, but related poorly to clinical progression. The survival correlated with the pretherapeutic DNA-histograms and with the DNA-median, third-quartile, and maximum parameters.

DNA, Neoplasm↗
PubMed1977

Influence of changes in composition of the cerebrospinal fluid on the secretory activity of the subcommissural organ in Rana esculenta. A quantitative histochemical and autoradiographic study by means of scanning cytophotometry.

The effects of injection into the brain ventricle of noradrenaline dissolved in amphibian Ringer's solution, and of amphibian Ringer's solution alone on the secretory activity of the subcommissural organ (SCO) of Rana esculenta were studied. The parameters used were: the amount and mean concentration of secretory material within the SCO stained by aldehyde fuchsin (AF), the amount and mean concentration of radioactive material within the SCO labelled by 35S-cysteine, and the growth rate of the Reissner's or liquor fibre (LF). A significant influence on the amount of secretory material in the SCO was found to be exerted by the injection of amphibian Ringer's solution alone. This influence can be explained as an inhibition of the release of secretory material by the SCO. Injection of noradrenaline dissolved in amphibian Ringer's solution appeared to have a smaller inhibitory effect. Noradrenaline may be presumed to have only slightly stimulated the secretory activity of the SCO.

Animals↗
PubMed1985

DNA cytophotometry on atypical glands in stomach carcinogenesis of dogs induced by N-methyl-N'-nitro-N-nitrosoguanidine.

Microspectrophotometric measurement of the DNA content of cell nuclei was performed on the lesions (including atypical glands) in gastric carcinogenesis of 15 male beagle dogs, which had been induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The distribution patterns of DNA content were classified into three types: normal, subnormal, and abnormal. The histograms of the distribution in normal and regenerative glands were a normal type and subnormal type, respectively, while adenocarcinoma showed an abnormal distribution type. In atypical glands, the distribution patterns in autopsy cases were subnormal and abnormal types. When sequential endoscopic observation of the angulus of the stomach in dog No. 3 was carried out, atypical glands were found in an ulcer in the early stage of MNNG administration and a precancerous lesion in the late stage after termination of MNNG. The atypical glands in the early stage were of the subnormal type, while the atypical glands in the late stage were of the abnormal type. According to the results, these two types-subnormal and abnormal - of distribution of DNA content on the atypical glands may be related to regeneration and subsequent development of cancer, respectively.

Adenocarcinoma↗
PubMed1980

Demonstration of 2n spermatids in carriers of the "sex reversed" factor in the mouse by Feulgen cytophotometry.

The "Sex Reversed" factor (SXY) leads to development of XX males. The condition is transmitted by XY-Sxr males. The testes of XY-Sxr carriers are characterized by patches of defective spermatogenesis with meiotic failure and appearance of extraordinary large spermatids. In the present study DNA content of the large spermatids is determined by Feulgen DNA measurement using a scanning cytophotometer. The large spermatids in XY-Sxr testes are shown to be 2n.

Animals↗