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Results for “Connective Tissue Cells”

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At least 163 records · Page 9Linked to original sources
PubMed1992

High levels of xanthine oxidoreductase in rat endothelial, epithelial and connective tissue cells. A relation between localization and function?

The localization of xanthine oxidoreductase activity was investigated in unfixed cryostat sections of various rat tissues by an enzyme histochemical method which specifically demonstrates both the dehydrogenase and oxidase forms of xanthine oxidoreductase. High activity was found in epithelial cells from skin, vagina, uterus, penis, liver, oral and nasal cavities, tongue, esophagus, fore-stomach and small intestine. In addition activity was demonstrated in sinusoidal cells of liver and adrenal cortex, endothelial cells in various organs and connective tissue fibroblasts. Xanthine oxidoreductase produces urate which is a scavenger of oxygen-derived radicals. Because the enzyme is found in epithelial and endothelial cells which are subject to relatively high oxidant stress, it is postulated that in these cells xanthine oxidoreductase is involved in the antioxidant enzyme defense system. In addition, a possible role for the enzyme in proliferation and differentiation processes is discussed.

Adrenal Cortex↗
PubMed1995

Cementum specific components which influence periodontal connective tissue cells.

We have isolated two polypeptides from cementum one of which promotes the growth and the other the attachment of periodontal cells. One polypeptide, the cementum derived growth factor (CGF), was extracted from healthy human and bovine teeth by 1 M CH3COOH and purified by heparin-affinity chromatography and HPLC. The CGF is a 23 kDa polypeptide which is mitogenic to fibroblasts and smooth muscle cells. It is active alone, but its activity is highly potentiated by plasma-derived serum or EGF. It induces classical mitogenic signaling events, which include Ca++ mobilization, inositol phosphate hydrolysis, activation of phosphokinase C (PKC) and transcription of cellular protooncogenes c-fos and jun-B. The magnitude and pattern of activation of signaling events and their susceptibility to PKC inhibitors and pertussis toxin indicated that the CGF may be a distinct molecular species. The CAP is a 55 kDa polypeptide which promotes the attachment and spreading of fibroblasts, smooth muscle cells, bone cells and endothelial cells, but not epithelial cells. Antibodies to CAP immunostain cementum, but not other tissues. Root surfaces bind CAP. The CGF and CAP do not appear to be present in adjacent periodontal structures. Our data show that the CAP and CGF selectively interact with periodontal cell populations and affect their biological activities, and thus may influence the formation and regeneration of periodontal connective tissues.

Animals↗
PubMed1978

[Immunofluorescent study of the origin of connective tissue cells in xenogenic radiation chimeras under normal conditions and in aseptic inflammation].

The origin of elements of the focus of aseptic inflammation and the normal subcutaneous connective tissue in the xenogenic (mouse-rat) radiation chimaeras was investigated by means of indirect Coons method with antiserum to the rat bone marrow cells. The cells of the imflammation focus (leucocytes, macrophages, fibroblasts or fibroblast-like cells, polynuclear giant cells of foreign bodies), as well as leucocytes, macrophages and some fibroblasts of the normal subcutaneous connective tissue, were shown to take their origin from the transplanted bone marrow cells of the donor.

Animals↗