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At least 163 records · Page 9Linked to original sources
PubMed2005

Bio-sensing on a chip with compact discs and nanofibers.

This paper describes a novel, sensitive detection system for biomolecules (DNA and proteins etc.) that is integrated in a lab-on-a-chip utilizing optical compact discs (CDs) and bio-nanofibers. The new method comprises a microchannel containing CD grating that confines fragments of unique bacterial cellulose fibrils (BC), which have nanometre scale fibers and holes. A maximum of six times higher sensitivity to detect DNA was obtained with this CD and BC system compared to a conventional method. We also demonstrate an effective light-confining effect for biological application with the new method.

Biosensing Techniques↗
PubMed1990

Normative data in quiet, broadband noise, and competing message for Northwestern University Auditory Test No. 6 by a female speaker.

Two descriptive experiments were performed on a version of the Northwestern University Auditory Test No. 6 (NU No. 6) recorded by a female speaker that is included on an audio compact disc recently produced by the Department of Veterans Affairs. In Experiment 1, normative psychometric functions for the female speaker version of the NU No. 6 materials were established on 24 young adults for three monaural listening conditions (in quiet, in 60-dB SPL broadband noise, and in 60-dB SPL competing message). The 60-dB SPL broadband noise shifted the psychometric function for the NU No. 6 words 33 dB, whereas the 60-dB SPL competing message shifted the function only 18-22 dB. In contrast to the slopes of the quiet and noise conditions (4.5%/dB), the slope of the competing message function was more gradual (3.5%/dB). In Experiment 2, comparisons between the psychometric functions for the female and the original male speaker versions of NU No. 6 in quiet and in broadband noise were made on 8 young adults. In comparison to the psychometric functions for the male speaker version of NU No. 6, the functions for the female speaker version of NU No. 6 were displaced between the 10-90% correct points to higher sound-pressure levels by 10-13 dB in quiet and by 12-16 dB in noise. The difference in performance on the two versions of NU No. 6 is attributed to spectral differences between the two sets of materials that produced a calibration anomaly.

Adult↗
PubMed1991

A comparison of the currency of secondary information sources in the biomedical literature. I. Weekly current awareness services.

Three biomedical current awareness products which are distributed on floppy disc, were studied over a period of 3 months. They were monitored for the speed with which primary journal issues were indexed, and for the coverage of the journals which were selected for study. Data on issues of 72 monthly journals (38 North American and 34 European) and nine weekly titles (four from North America and five from Europe) were recorded. The time to elapse between publication date and arrival of hard copy in the British libraries and appearance in secondary sources varied enormously. The findings suggest that monthly journal issues appear in the secondary sources on average 6-7 weeks after publication date and weekly journals appear after approximately 4 weeks. Indexing of North American monthly journals is 1 week ahead of European titles in the two products from the US, but the European service indexed European publications sooner. One product, Current Contents on Diskette, contained all issues included in the 3-month period covered by the study, but Reference Update omitted 9.1% of the issues and Medical Science Weekly 1.6%, including leading biomedical journals.

Abstracting and Indexing↗
PubMed1991

Spondaic word detection and recognition functions for female and male speakers.

The Department of Veterans Affairs recently produced a compact disc of speech audiometry materials. The compact disc, which is available commercially, includes the W-1 spondaic words recorded by a female speaker. Two experiments were conducted. The purposes of experiment 1 were to obtain normative detection and recognition data on the female recording of the spondaic words and to compare the detection and recognition functions for the original male speaker version of the W-1 words. No significant differences were found between the recognition functions for each speaker. The recognition functions for both speakers were displaced to higher sound-pressure levels by 8 dB above the detection functions. Clinically, the two versions of the W-1 spondaic words should produce equivalent results. In experiment 2, slopes of the individual spondaic word recognition functions for the female speaker were obtained from two listeners and are discussed in terms of interstimulus, intertrial, and intersubject variability.

Adult↗
PubMedDate not supplied

Technical note: Rationale, development, use and evaluation of an equipment management and image storage system.

Lack of space and organization have become significant problems in the contemporary business world. Modern industries must eliminate mountains of paper and better organize themselves. With the incorporation of a fully automated equipment management system and image storage system, the Jacobi Medical Center has succeeded in correcting these problems. This technical note shows how the use of computer software and hardware components can be integrated to manage electronic patient care equipment. The adoption of this new technology was applied to equipment maintenance, tracking and record-keeping, thereby accomplishing the aims of space conservation and organization. As the components became more advanced, the technology included computer software products that could store more information and electronically effect a more rapid document retrieval. This will eventually allow for a paperless operation. The latest available equipment management software is supported by an image storage system that may contain important signature documents and outside vendor information. The applicability of these systems to the biomedical engineering field is obvious: (a) space efficiency eliminates folders and files; (b) simultaneous technician access to equipment history; and (c) rapid archive retrieval of data as well as vendor information and safety alerts.

Biomedical Engineering↗
PubMed2004

New version of the TEN test with calibrations in dB HL.

OBJECTIVE: To develop a new version of the threshold-equalizing-noise (TEN) test for the diagnosis of dead regions, with levels calibrated in dB HL rather than dB SPL, and with levels corresponding to the dial readings on the audiometer. DESIGN: The spectral shape of the noise required to give equal masked thresholds at all frequencies, when expressed in dB HL, was derived by two calculation methods and by empirical measurements of the electrical output of audiometers using TDH50 earphones and TDH39 earphones. To reduce the loudness of the noise and to minimize distortion generated in the audiometer and/or earphone, the noise was bandlimited between 354 and 6500 Hz. In addition, the noise was synthesized using a method that leads to a low crest factor (ratio of peak to root-mean-square value). This further reduced audiometer/earphone distortion and allowed higher levels per ERBN; ERBN is the equivalent rectangular bandwidth of the auditory filter at 1 kHz, as determined in young, normally hearing subjects. The test tone frequencies were limited to the range 500 to 4000 Hz. Subjects with normal or near-normal hearing were tested by using a noise level of 60 dB HL/ERBN to assess whether the noise did lead to equal masked thresholds in dB HL for all audiometric frequencies from 500 to 4000 Hz. Thresholds in the TEN were measured by means of manual audiometry with a 2 dB final step size. RESULTS: The mean masked thresholds were almost constant across frequency when expressed in dB HL and were within 0.5 dB of the noise level per ERBN. For a single noise level, the test takes approximately 5 minutes per ear to administer. CONCLUSIONS: The new TEN test has the following advantages over the original version (which used levels calibrated in dB SPL): (1) All levels are expressed in dB HL. Thus, absolute thresholds only need to be measured once. (2) Calibration is such that both the noise level/ERBN and the test tone levels correspond to the values indicated on the audiometer. This makes the test simpler to apply and reduces the likelihood of errors. (3) The noise bandwidth is restricted, and the noise has a low crest factor. This allows the noise level/ERBN to be increased while avoiding distortion, excessive loudness, and possible further damage to hearing.

Adult↗
PubMed2003

The patient's dilemma: prostate cancer treatment choices.

PURPOSE: We summarize the literature addressing factors that influence treatment decisions made by men with prostate cancer. MATERIALS AND METHODS: A MEDLINE search of the English language literature published between 1969 and 2000, using the combined MESH key words "prostatic neoplasms," "patient participation," "Internet" and "decision making," generated 181 abstracts. Only 23 of these publications addressed factors influencing treatment decisions made by men with prostate cancer. Nine additional relevant studies were identified from references in the original 23 articles. Subsequently a search for the term "prostate cancer" using several popular Internet search engines yielded more than 1 million hits. A further search was performed using the key words "prostate cancer" and "prostate" within on-line archives of the United Kingdom television channels BBC, ITV, and channels 4 and 5, and newspapers The Sun, The Daily Mail, The Observer, The Guardian and The Times. RESULTS: When there is poor quality evidence or little professional consensus to support a particular treatment over another, no clinical guidelines regarding treatment are possible. Patients are faced with a series of options, and the data reveal that the process of choosing between these options is based on input from a large number of sources. These sources differ in the way that benefits of treatment are emphasized over harms and vice versa. We identified little evidence regarding which type of input exerts the greatest influence on patients. It may be that the sources associated with the most bias have the greatest influence. CONCLUSIONS: There is a paucity of information on how patients with prostate cancer use different types of input in the treatment decision making process. The physician, as principal caregiver, still appears to have the most direct influence on patient choice. Just how long this status will continue is uncertain.

Compact Disks↗
PubMed2004

A Meaningful Day Group approach to weight gain from antipsychotic medication.

For clients who receive medical treatment for a severe and enduring mental health problem, antipsychotic medication is the first line of treatment. The adverse effects of these medications are well documented and can lead to discontinuation of therapy. The newer atypical antipsychotics would seem to have distinct advantages over more traditional substances but significant weight gain can be experienced. This group is an attempt to capitalize upon psychosocial approaches to this such that outcome may be enhanced. The following is a description of an attempt to implement such a group and to explore the outcome. The group has been devised by one of the manufacturers of atypical antipsychotic medication concerned by the side-effect to their product. The group is formatted on a computer disc ready to use by any mental health professional and freely available.

Antipsychotic Agents↗
PubMed1993

Maleficent magnets and mangled megabytes.

Personal computers have become common-place in physicians' practices and their use in cardiac pacing for programming and follow-up is increasing. The most commonly used media for mass data storage are ferromagnetic. That the toroidal and bar magnets used to activate reed switches pose a threat to such data is well known but the degree of care necessary in handling magnets around storage media, especially the vulnerable floppy diskettes, is not generally appreciated. The basic principles of magnetic data storage discussed herein elucidate the mechanism of data alteration by extraneous magnetic fields. The properties of the surface coatings, the requirements of applicable industry standards, and the field strengths of the pacemaker magnets suggest that data on diskettes should be secure if kept at least 6-7 cm from an isolated pacemaker magnet. Experiments with typical bar and toroidal magnets demonstrated that data recorded on representative diskettes actually remained unaltered until the magnets were placed < 1 cm from the recording surfaces.

Compact Disks↗
PubMed2004

Distance communication transfer of HIV prevention interventions to service providers.

Most acquired immunodeficiency syndrome (AIDS) service providers are in countries with little access to scientific developments relevant to their programs. It is critical to transfer advances from the scientific arena to service providers on a global scale. Human immunodeficiency virus (HIV) prevention organizations in 78 countries were randomized to receive either a control condition or a technology transfer condition with an interactive distance learning computer training curriculum and individualized distance consultation. Of 42 nongovernmental organizations in the technology transfer condition, 29 adopted the science-based program in their communities or trained other agencies to also use it. Advanced communication technologies can create a cost-effective infrastructure to disseminate new intervention models to service providers worldwide.

Communication↗
PubMedDate not supplied

Converting laserdisc video to digital video: a demonstration project using brain animations.

Interactive laserdiscs are of limited value in large group learning situations due to the expense of establishing multiple workstations. The authors implemented an alternative to laserdisc video by using indexed digital video combined with an expert system. High-quality video was captured from a laserdisc player and combined with waveform audio into an audio-video-interleave (AVI) file format in the Microsoft Video-for-Windows environment (Microsoft Corp., Seattle, WA). With the use of an expert system, a knowledge-based computer program provided random access to these indexed AVI files. The program can be played on any multimedia computer without the need for laserdiscs. This system offers a high level of interactive video without the overhead and cost of a laserdisc player.

Audiovisual Aids↗
PubMed2006

Lab on a CD.

In this paper, centrifuge-based microfluidic platforms are reviewed and compared with other popular microfluidic propulsion methods. The underlying physical principles of centrifugal pumping in microfluidic systems are presented and the various centrifuge fluidic functions, such as valving, decanting, calibration, mixing, metering, heating, sample splitting, and separation, are introduced. Those fluidic functions have been combined with analytical measurement techniques, such as optical imaging, absorbance, and fluorescence spectroscopy and mass spectrometry, to make the centrifugal platform a powerful solution for medical and clinical diagnostics and high throughput screening (HTS) in drug discovery. Applications of a compact disc (CD)-based centrifuge platform analyzed in this review include two-point calibration of an optode-based ion sensor, an automated immunoassay platform, multiple parallel screening assays, and cellular-based assays. The use of modified commercial CD drives for high-resolution optical imaging is discussed as well. From a broader perspective, we compare technical barriers involved in applying microfluidics for sensing and diagnostic use and applying such techniques to HTS. The latter poses less challenges and explains why HTS products based on a CD fluidic platform are already commercially available, whereas we might have to wait longer to see commercial CD-based diagnostics.

Biological Assay↗
PubMedDate not supplied

Informatics in radiology (infoRAD): an open source framework for modification and communication of DICOM objects.

A configurable framework has been developed that can receive, modify, and export images in different picture archiving and communication system scenarios. The framework has three main components: a receiver for Digital Imaging and Communications in Medicine (DICOM) objects, a processing pipeline to apply one or more modifications to these objects, and one or more senders to send the processed objects to predefined addresses. The toolbox programming was implemented as an open source project in Java. The processing pipeline uses the concept of configurable plug-ins. One plug-in is user programmable by means of extensible stylesheet language files and allows conversion of DICOM objects to extensible markup language documents or other file types. Input and output channels are the DICOM Storage service, DICOM compact disks-read-only memory (CD-ROMs), and the local file system. The toolbox has been successfully applied to different clinical scenarios, including the correction of DICOM objects from non-Integrating the Healthcare Enterprise (IHE) conform modalities, pseudonaming of DICOM images, and use of the IHE Portable Data for Imaging profile with import and export of CD-ROMs. The toolbox has proved reliability in the clinical routine. Because of the open programming interfaces, the functionality can easily be adapted to future applications.

Computer Communication Networks↗