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At least 163 records · Page 9Linked to original sources
PubMed1989

[A rare complication of ulcerative colitis: Bowen's disease in perianal condyloma acuminatum].

Discharging, itching perianal pointed condyloma acuminatum in a 35 years old male patient who had been suffering from ulcerative colitis for 20 years. Two years following its development the condyloma was excised. Histological examination revealed in the perianal condyloma in situ cancer, characteristic of Bowen's disease. With electronmicroscopic examination the tumor cells were found to be keratinocytes of medium differentiation. Virus could not be detected in the tumor cells. The author was the first to describe in the literature the development of perianal Bowen's disease on the ground of ulcerative colitis. On the basis of literary data the author emphasizes the importance of the radical removal and regular control.

Adult↗
PubMed1987

[A comparative study of sensitivities of immunocytochemistry, koilocytosis and transmission electron microscopy in detecting HPV in the cervical condyloma and intraepithelial neoplasia as compared to DNA hybridization].

The sensitivity in detection of human papillomavirus (HPV) by immunocytochemistry, histological observation of koilocytosis and electron microscopy with reference to the results of Southern blot DNA hybridization were reviewed in 41 lesions (37 patients) of cervical and vaginal condylomata acuminata and intraepithelial neoplasia. HPV DNA was demonstrated in all but one lesion of moderate dysplasia (98%). HPV capsid antigens were demonstrated by immunocytochemistry in approximately 60% of the lesions of condyloma and mild dysplasia. Koilocytosis was present in approximately 90% of the lesions of condyloma and mild dysplasia as well. But the rate of HPV detection by immunocytochemistry and by observation of koilocytosis declined markedly in severe lesions; immunocytochemistry was positive in 22% and koilocytosis was present in 60% in the lesions of moderate dysplasia: positive in 17% and 33% respectively in the lesions of severe dysplasia: 0% and 20% respectively in the lesions of CIS. Intranuclear virus-like particles were observed in all of 8 lesions subjected to electron microscopy. The negative findings of immunocytochemistry and koilocytosis in advanced cervical intraepithelial neoplasia (CIN) have very little significance in relation to the actual presence of HPV in these lesions, although they may be useful in detecting HPV in condyloma acuminatum and mild dysplasia (over 50%).

Antigens, Viral↗
PubMed1987

The management of genital condylomas in pregnant women.

Genital condylomas complicating pregnancy pose several management problems for the obstetrician, including the issues of mechanical difficulties in women with large lesions and possible viral transmission to the fetus during delivery. Although respiratory papillomatosis is infrequent, this complication can be catastrophic and produce significant long-term morbidity in affected children. Hence, we believe that condylomas in pregnancy should not be ignored. In view of the precision, high success rate, and low risk of complications, CO2 laser surgery appears to offer the best option in patients with extensive condylomas and those whose disease proves resistant to simpler therapies.

Condylomata Acuminata↗
PubMed1979

Condyloma acuminatum of the lip: report of case.

This case exemplifies the clinical and histomorphologic manifestations of a moist wart (condyloma acuminatum) and emphasizes the possibility of oral condylomas in patients with anogenital condyloma acuminatum.

Adult↗
PubMed1986

[Bowenoid papulosis and its relation to Bowen's disease and atypical condyloma].

All the 5 sexual partners of male patients suffering from bowenoid papulosis and bearing the HPV 16 genome showed cervical lesions induced by HPV. 2 of them proved to be noncondylomatous infections, 3 cases were cervical condylomas, and 2 patients revealed severe dysplasia or carcinoma in situ (CIS). 3 out of 4 women suffering from multicentrical pigmented Bowen's disease of the vulva showed plain condylomas of the cervix, with severe dysplasia or CIS in 2 cases and slight dysplasia in one case. Thus bowenoid papulosis as well as multicentrical pigmented Bowen's disease of the vulva are high risk factors for cervical HPV infection and carcinoma, both for the patients themselves and their sexual partners. Atypical pigmented genital condylomas induced by HPV 6 also bear a risk for cervical HPV infection of the sexual partners. Malignant transformation, however, seems to depend on the type of the infecting virus (mainly HPV 16).

Bowen's Disease↗
PubMed1986

Intralesional recombinant alpha-2 interferon for the treatment of patients with condyloma acuminatum or verruca plantaris.

We conducted a multicenter double-blind study comparing human recombinant intralesional alpha-2 interferon (IFN) and placebo in 237 patients with the clinical diagnosis of condyloma acuminatum or verruca plantaris. A single wart on each patient was injected with 0.1 mL containing 10(6) IU of IFN, 10(5) IU of IFN, or placebo three times weekly for three weeks, and the response to treatment was followed up for 12 weeks. Among 91 of the 114 patients with condyloma acuminatum who completed the study, complete clearing of the treated wart occurred in 16 (53%) of 30 patients receiving 10(6) IU of IFN compared with six (19%) of 32 receiving 10(5) IU of IFN and four (14%) of 29 receiving placebo. In the group of 100 patients with plantar warts, there was no apparent benefit associated with interferon administration. Seven patients (3%) had treatment discontinued due to adverse reactions. Intralesional alpha-2 IFN is of benefit in the treatment of a single condyloma; its role in the treatment of multiple lesions remains to be clarified. Its role in the treatment of verruca plantaris, where no response was seen, also remains to be clarified.

Adult↗
PubMed1979

[Condyloma acuminata].

A review of the clinical features and therapeutic possibilities of condyloma acuminatum is presented on the ground of the ten-year experience of the authors. A giant condyloma simplex with benign clinical behaviour and typical histologic pattern and a case of epithelioma starting from a condyloma simplex and leading to the amputation of the penis are described.

Adult↗
PubMed1984

Condyloma acuminatum in Rochester, Minn., 1950-1978. I. Epidemiology and clinical features.

From 1950 through 1978, condyloma acuminatum was diagnosed in 746 residents of Rochester, Minn (246 male and 500 female subjects). With the number of cases increasing almost every year until 1975, the mean annual incidence rate reached 106.5 per 100,000 population in the period 1975 through 1978, apparently the highest reported to date. Among age groups, the rate was highest in the 20- through 24-year-old group. Female patients contracted the infection at a higher rate and at a younger age than male patients. Anal condyloma occurred in one third of the male subjects studied and recurrent condyloma in 30% of the male subjects. More female than male patients had lesions at multiple locations.

Adolescent↗
PubMed1983

Malignant transformation in an anal condyloma acuminatum.

A 61-year-old man had malignant transformation of an anal condyloma acuminatum, demonstrated by light and electron microscopic studies. Intranuclear virus-like particles were seen in the benign condylomatous koilocytotic cells but these were absent in the malignant cells. Multinucleation, syncytial giant cells and nuclear atypia in a condyloma acuminatum are considered features of in-situ carcinomatous change. Anal condyloma acuminatum requires wide excision and thorough examination of anorectal canal in order to exclude hidden disease, which will predispose to recurrence. Homosexuality is considered a predisposing factor. The authors stress the importance of histopathologic examination of all anorectal warts to exclude malignant change.

Anus Neoplasms↗
PubMed1993

[A case report of condyloma acuminatum of urethral meatus in a boy].

A 4-year-old boy was referred for treatment of papillary tumor at the urethral meatus. He was well until December 1990, when his mother noticed a tumor at the urethral meatus. The tumor was resected elsewhere. However, a similar tumor was noted again at the urethral meatus in May, 1991. The patient was admitted on September 16, 1991. Retraction of the phimotic foreskin revealed a well-demarcated papillary mass, approximately 2 x 2 mm in diameter, at the urethral meatus. There were no tumors on foreskin or glans. Under general anesthesia endoscopy was performed to locate other tumors at the urethra and bladder. No tumors were found elsewhere. Then the meatal tumor was resected surgically. Pathology was condyloma acuminatum. There was no recurrence one year after surgery. We also reviewed 24 boys with condyloma acuminatum, including 13 boys with a solitary condyloma at the urethral meatus, reported in Japan.

Child, Preschool↗
PubMed1993

Polymerase chain reaction in detection of human papillomavirus DNA and types of condyloma acuminata.

Sections from 88 paraffin-embedded tissues identified histopathologically as condyloma acuminata were assayed for the presence of human papillomavirus (HPV) types 6, 11, 16, 18 and 33 using polymerase chain reaction followed by specific hybridization. HPV DNA sequences were found in all tissues of condyloma acuminata. HPV type 6 was present in 71 tissues, type 11 in 16, and type 16 in 2. One man was doubly infected with HPV types 6 and 16. No HPV types 18 and 33 were found. We conclude that condyloma acuminata is mainly produced by HPV types 6 and 11.

Base Sequence↗
PubMed1997

Aggressive giant condyloma acuminatum associated with oncogenic human papilloma virus: a case report.

Malignant transformation has been described in 30% of cases of giant anorectal condyloma acuminatum. The authors report on a 33-year-old man who was heterosexual and HIV negative and who had a giant anal condyloma. Despite aggressive therapy with multiple fulgurations, interferon alpha and isotretinoin, an invasive squamous cell carcinoma of the rectum developed. An abdominoperineal resection was done followed by radiotherapy and chemotherapy, but this treatment regimen was unsuccessful in controlling the progression of his carcinoma. Human papillomavirus (HPV) serotyping in tumoral tissue was positive for HPV types 11 and 16. In patients with giant anorectal condylomas associated with oncogenic HPV, the course of the disease may be aggressive, so they may benefit from early surgical and medical intervention.

Adult↗
PubMed1996

Overexpression of the proto-oncogene c-jun in association with low-risk type specific human papillomavirus infection in condyloma acuminata.

Infection with different types of human papillomavirus (HPV) is associated with neoplasia at different anatomic sites. The "low-risk" HPVs (LR-HPV) are responsible for benign genital lesions such as condyloma acuminata. In order to clarify the tumorigenic mechanism of LR-HPV, the HPV infection status was investigated and the expression of the c-jun proto-oncogene in different HPV-related skin and genital lesions analyzed. Of the 17 condyloma specimens analyzed by Western blotting, 13 cases (76.5%) exhibited overexpression of the c-jun gene. All 13 cases harbored high copy numbers of the LR-HPV genome with an average of 926 copies per cell, whereas the other four cases had an average of 12 copies of LR-HPV per cell (P < 0.001). Further typing of HPV by Southern blotting revealed that HPV-6 and HPV-11 infections predominated in c-jun positive cases. The c-jun protein was detected much less frequently in cervical cancers (three of 29, or 10.3%) and skin warts (one of 10), and was not detected in five genital polyps or in five normal cervical tissues. These findings suggest a type 6/11-specific induction of c-jun gene expression in HPV-related neoplastic lesions.

Animals↗
PubMed1987

Sensitivity of the cytologic diagnosis of cervical condyloma in comparison with HPV-DNA hybridization studies.

The cytologic diagnosis of cervical condyloma is based on criteria developed over the last 10 years. It has now become possible to document the presence of human papilloma virus (HPV) DNA directly in cervical swabs by the highly sensitive technique of DNA filter hybridization in situ. The purpose of this article is to evaluate critically the empirically established cytologic criteria of condyloma by comparing them with HPV-DNA hybridization studies in the same material. The results of this study indicate that "classic" koilocytosis and dyskeratocytosis are not highly sensitive criteria for the presence of HPV infection, identifying only 15% of the HPV-DNA-positive cases correctly. In an attempt to improve the sensitivity of the cytologic diagnosis of HPV infections, a panel of nine "nonclassic" criteria was evaluated. The five most valuable signs were "mild koilocytosis," mild dyskeratocytosis," hyperchromatic nuclei, bi- and multinucleation, and cleared cytoplasm. Using these criteria in combination, statistically discriminant analysis could correctly identify 84% of the HPV-positive group.

Condylomata Acuminata↗
PubMed1990

Rates of condyloma and dysplasia in Papanicolaou smears with and without endocervical cells.

A retrospective study of 36,853 Papanicolaou smears recorded in our laboratory during the latter half of 1988 was undertaken to assess the effect of the absence or presence of columnar endocervical cells on the detection rate of cervical condyloma acuminatum and squamous dysplasia. We found that condyloma was diagnosed only slightly more frequently in smears with endocervical cells than in those without. However, cervical intraepithelial neoplasia was detected 2.3 times more frequently in smears with endocervical cells. The disparity in detection rate increased with higher grades of dysplasia. A significant difference in detection rate was maintained in all age groups except teenagers and patients 60 yr old and above. This suggests that smears lacking endocervical cells are less sensitive in screening for dysplasia and should be repeated when clinically appropriate.

Adolescent↗
PubMed1995

Prospective study on the development of antibodies against human papillomavirus type 6 among patients with condyloma acuminata or new asymptomatic infection.

The development over time of antibodies to human papillomavirus type 6 (HPV 6) was studied prospectively in a group of 26 condyloma patients receiving multiple treatments, as well as in 17 healthy subjects with a new HPV 6 infection. The condyloma patients provided serum samples during 2-12 visits over a period of 1-20 months, and the levels of IgA, IgG and IgM antibodies to HPV 6, 11 and 16 capsids, and to HPV 6-derived peptide antigens were determined. Among the capsid antibodies, the IgG and IgA responses against HPV 6 were the most prominent, whereas IgM was detected only in a few patients. During follow-up, seroconversion to HPV capsids was found in six patients and antibody peaks disappeared during follow-up in nine patients. There was no association between serology and cure of the wart. One hundred twenty subjects who reported multiple sexual partners, but found negative for HPV DNA at multiple anogenital and oral sites, provided serum samples and swabs for HPV DNA analysis at 2-7 visits during 4-74 months. Seventeen subjects acquired HPV 6 DNA and were included in the study. Serum IgA, IgG and IgM antibodies to HPV 6 capsids were induced concomitantly with the acquisition of viral DNA (P = 0.02, 0.002 and 0.006, respectively), and declined again when the viral DNA was no longer detectable. In conclusion, antibodies to HPV 6 did not predict the clinical course of condylomatous disease, but appear to be useful mainly as epidemiological markers of viral exposure.

Adult↗
PubMed1983

Giant condyloma acuminatum (Buschke-Lowenstein tumor) involving a pilonidal sinus: a case report and review of the literature.

Giant condyloma acuminatum or Buschke-Lowenstein tumor has been reported to involve many areas about the perineum. The majority of previous documentations have implicated the coronal sulcus, prepuce, and fossa navicularis of the penis as the most likely foci to support growth. Authors have contributed multiple cases of perianal and rectal involvement as well as rare reports of inguinal, bladder, and endocervix-low uterine segment tumors. A case of giant condyloma acuminatum involving a chronic pilonidal sinus overlying the sacrum is described. Wide surgical extirpation was found to be a curative means of management.

Condylomata Acuminata↗
PubMed1994

Demonstration of URR-duplication variants of human papillomavirus type 6 in paraffin-embedded tissue sections of one condyloma acuminatum and one Buschke-Loewenstein tumour.

Human papillomavirus type 6 (HPV 6) induces condylomata acuminata and laryngeal papillomas. Occasionally, HPV 6 may also be found in low-grade verrucous carcinomas. In some tumours, genetic analysis revealed the presence of HPV 6 variants with rearrangements, mostly DNA duplications, within the upstream regulatory region (URR). In this study, we analysed 98 formalin-fixed, paraffin-embedded condylomata acuminata obtained from 54 patients for the presence of URR-duplication variants of HPV 6. HPV 6 DNA could be amplified by polymerase chain reaction (PCR) from 40 samples. One condyloma acuminatum contained a HPV 6 genome with rearranged URR. Analysis using restriction enzyme cleavage suggested a DNA duplication within the URR of approximately 200 bp, spanning the Hpa II site at nt 7863 and the Dde I site at nt 7843 but not involving the Rsa I site at nt 7633. In addition, we analysed the distribution of the already characterized URR-duplication variant HPV 6AC1B within different paraffin-embedded tissue sections of a Buschke-Loewenstein tumour. No correlation could be demonstrated between the presence of the rearranged genome and malignant histological changes. This result and the demonstration of an URR-duplication variant in a typical condyloma acuminatum suggest that duplications within the URR of HPV 6 are not directly related to malignant progression of HPV 6-induced tumours.

Base Sequence↗