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The future of biomedical support: Web technology provides additional tools for today's BMET.

Biomeds have been and will continue to be on the cutting edge of health care technology. Whether it is working on the latest diagnostic imaging equipment, handling the network cabling for the IT department in a large hospital or repairing an infrared TV remote that fell out of a patient's bed, the BMET is able to work with many different and ever changing technologies. By taking advantage of some of the new Web-based technologies and combining them with the existing biomedical training and support programs currently available, today's BMET will be well prepared to meet the changes in health care technology.

Biomedical Engineering↗

Conventional and proteomic technologies for the detection of early stage malignancies: markers for ovarian cancer.

Our understanding of the tumor microenvironment continues to evolve and allows for the identification of biomarkers that should detect the presence of early stage malignancies. Recent advances in computational analysis and biomedical technologies have come together to elucidate signatures associated with cancer and that are capable of identifying unique tumor-specific proteins. Within the tumor microenvironment, we continue to characterize the proteophysiology of the different steps associated with tumor progression. The urgent need for biomarkers accurately detecting early-stage epithelial ovarian cancer has prompted us, and others, to engage in a search for specific peptide signatures that may discriminate transformed cells from those of the normal ovarian microenvironment. This endeavor also provides new insights into the biology of the disease, which may not only be applicable to detection but may also help to initiate new therapies and optimize patient care.

Biomarkers, Tumor↗

The Wentworth Center for Clinical Engineering: a collaborative and interactive venture.

A program has been developed in Boston to bring together hospital and industrial biomedical engineers, BMETs, CEs, nurses, physicians, the Massachusetts Medical Devices Society, academic engineering technologists, and students. This program is headquartered at the Center for Clinical Engineering at the Wentworth Institute of Technology, and is designed to serve and support the interests of the participants for educational, professional, networking and interdisciplinary activities. Because of the availability of engineering technology programs at Wentworth, and the willingness of local professionals to participate, a comprehensive and unique program has been developed to train BMETs and CEs. This program emphasizes hands-on electronic technology, biomedical lectures and laboratories, management lectures and in-hospital preceptorships under the supervision of BMETs, CEs, biomedical directors and nurses.

Biomedical Engineering↗

The Council of Europe's instruments on biomedical research: how is conflict of interest addressed?

Conflict of interest is an issue that has been put in the spotlight by the commercial application of the new biomedical technologies. This paper presents the approach of the Council of Europe and the binding legal instruments to deal with this problem. The main focus is on the Convention on Human Rights and Biomedicine, and its draft additional Protocol on Biomedical Research.

Biomedical Research↗

Life extension research: health, illness, and death.

Scientists, bioethicists, and policy makers are currently engaged in a contentious debate about the scientific prospects and morality of efforts to increase human longevity. Some demographers and geneticists suggest that there is little reason to think that it will be possible to significantly extend the human lifespan. Other biodemographers and geneticists argue that there might well be increases in both life expectancy and lifespan. Bioethicists and policy makers are currently addressing many of the ethical, social, and economic issues raised by life extension research. However, the emphasis on philosophical argument supporting or condemning efforts to increase human longevity means that much less attention is currently being given to the factors that might play a role in generating interest in efforts to increase human longevity. This analysis considers three factors that might play a role in heightening public interest in efforts to develop biomedical technologies capable of retarding or reversing aging processes. While discussions of life extension research can seem quite futuristic and impractical, there are some powerful existential factors that might well generate considerable public support for life extension strategies if effective biomedical interventions emerge. Rather than providing philosophical justifications supporting or condemning efforts to increase human longevity, this essay seeks to promote a better understanding of the factors generating contemporary interest in prolonging life and postponing death.

Attitude↗

[Basic problems of staff training in medical engineering management at the N.E, Bauman Moscow State Engineering University].

The topicality of staff training in medical engineering management in the sphere of medicine and medical engineering is dictated by that the substantiated and flexible strategy in purchasing foreign medical equipment and drugs and supporting purely Russian biomedical technologies must be one of the first steps of health public reforms in Russia. As early as 1992, the N. E. Bauman Moscow State Engineering University was the first that organize to train staff in business and management in biomedical engineering and health public. The accumulated experiment was put in the development of new curricula by the supplementary education system. Interdisciplinary training in medical engineering marketing and management was organized, thus providing both additional education for specialists having complete and incomplete higher education who received diplomas of a management bachelor or master and through training of students who got diplomas of an engineer and diplomas of a management bachelor at the international level.

Biomedical Engineering↗

Embryonic stem-cell research and the moral status of embryos.

Stem-cell research has the potential to significantly advance our knowledge of cell differentiation with the promise of exciting and innovative therapeutic applications for otherwise incurable genetic and degenerative disorders. The issue has been the subject of debate in federal and state parliament as research of embryonic stem cells and their application have come under intense scrutiny. Scientists and medical practitioners are highly skilled in the technical aspects of biomedicine but are decidedly less comfortable with ethics. The place of novel and controversial biomedical technology is commonly left to an ad hoc and complex process whereby social acceptability eventually becomes the final arbiter. Utilitarianism is a popular ethical approach that attempts to weigh all the known and anticipated merits and pitfalls. The scientific background of biomedical professionals, the vast explosion of information, and specialization and subspecialization, have all contributed to a reductionistic view of life and ethics. The 'sanctity of life' doctrine is altogether quite different, as secular and religious advocates appear inflexible and unyielding to the logical propositions of utilitarianism and reductionism or to the consensus of democracy. These four major ethical approaches are discussed with reference to the embryonic stem-cell research debate.

Embryo Research↗

Gas and vapor delivery.

Technology for gas and vapor delivery has not changed substantively in decades. Technology possessing greater precision and reliability has been in use by nonmedical industries to regulate gas flows and to vaporize liquids. Adaptation of existing technology to the needs of anesthesia delivery systems requires stimulus from the anesthesia community and commitment from the anesthesia device industry. No insurmountable problems are evident, but the perennial problem of inertia has prevented progress consistent with that seen in other fields of biomedical technology.

Anesthesia, Inhalation↗

Treatment of patients who have type 1 diabetes mellitus: physiological misconceptions and infusion pump therapy.

BACKGROUND: This article reviews the unique physiology of patients who have type 1 diabetes mellitus (insulin-dependent diabetes mellitus, or IDDM); allays some common physiological misconceptions; and updates dental practitioners on the emerging technology of insulin infusion pump therapy, now available to patients who have type 1 diabetes mellitus. DESCRIPTION: The authors review the physiology of stress and describe the dawn phenomenon. They also describe insulin infusion pump therapy, as well as its advantages and disadvantages, to familiarize dentists with new technologies in caring for patients who have diabetes. Emergencies that may present themselves as a result of these advances in biotechnology are discussed. CLINICAL IMPLICATIONS: Dental practitioners who treat patients who have IDDM need to have a solid foundation in the basic medical sciences and emerging biomedical technology as they each relate to diabetes. Practitioners must become familiar with infusion pump therapy, not only for cases of medical emergencies, but also to customize treatment for patients who have diabetes. Practitioners also need to remain up to date in the rapidly changing realm of caring for people who have diabetes.

Acute Disease↗

Patients' voices: the powerful sound in the stem cell debate.

Millions of patients may benefit from the applications of stem cell research, although there is disagreement about whether public funds should be used to develop the science. Patients have been key to winning political support. Acting as advocates, they have contended that public investment will speed the research and bring accountability to biomedical technology. A political dispute about the new research, which holds the potential for cures to devastating diseases and to foster healthy aging, shows the need to respect public sensibilities and to court public approval, as well as the importance of involving patients in debates where the methods of biomedical discoveries and ethical beliefs collide.

Bioethics↗

Medical ethics in the Islamic Republic of Iran.

Recent trends in biomedical technologies have been associated with increasing discussion about ethical aspects of the new knowledge in many societies, including the Islamic Republic of Iran. Medical ethics has a long history in our country, and great Iranian physicians laid special emphasis on teaching and practising traditional ethics. In recent decades, great strides have been made in biomedical ethics, especially in the fields of education, research and legislation. We present a brief history of medical ethics in our country. Current activities and topics of future plans are also discussed.

Abortion, Induced↗

Effective terminal sterilization using supercritical carbon dioxide.

Gentle alternatives to existing sterilization methods are called for by rapid advances in biomedical technologies. Supercritical fluid technologies have found applications in a wide range of areas and have been explored for use in the inactivation of medical contaminants. In particular, supercritical CO(2) is appealing for sterilization due to the ease at which the supercritical state is attained, the non-reactive nature, and the ability to readily penetrate substrates. However, rapid inactivation of bacterial endospores has proven a barrier to the use of this technology for effective terminal sterilization. We report the development of a supercritical CO(2) based sterilization process capable of achieving rapid inactivation of bacterial endospores while in terminal packaging. Moreover, this process is gentle; as the morphology, ultrastructure, and protein profiles of inactivated microbes are maintained. These properties of the sterilization process suit it for possible use on a wide range of biomedical products including: materials derived from animal tissues, protein based therapies, and other sensitive medical products requiring gentle terminal sterilization.

Carbon Dioxide↗

Ambulatory anesthesia: past, present, and future.

Ambulatory anesthesia has become recognized as an anesthetic subspecialty, with formal postgraduate training programs. With increasing clinical experience, it is possible to determine which patients will derive the greatest clinical benefit from ambulatory surgery. Further expansion of the specialty of ambulatory anesthesia and surgery is likely to occur in the near future. The rate of expansion of ambulatory anesthesia will probably vary from country to country, depending on local needs, the level and availability of ancillary home health-care services, and economic considerations. Many recently developed drugs have pharmacological profiles that make them ideally suited for use in the ambulatory setting. Although these new drugs are valuable additions to the anesthesiologist's armamentarium, their cost is obviously higher than the drugs they were designed to replace. Given the changing pattern of health-care reimbursement, it is incumbent upon all practitioners to carefully examine the impact of new drugs and techniques on the quality of ambulatory anesthesia. It is obvious that these more rapid and shorter-acting anesthetic, analgesic, and muscle relaxant drugs have facilitated the early recovery process, thereby allowing our surgical colleagues to perform more extensive surgical procedures on an ambulatory basis. Future studies of new drugs and techniques for ambulatory anesthesia need to focus not only on subjective improvements for the patient during the perioperative period, but also on the overall cost-effectiveness of the care provided. These studies must compare the increased cost of new treatments with the potential financial savings resulting from earlier hospital discharge, reduced consumption of supplemental drugs, and earlier return to work. Recent pharmacological and technological advances in anesthesia and surgery allow outpatients with complex medical problems to undergo a wide variety of diagnostic and surgical procedures on an ambulatory basis. Increasingly, anesthesia practitioners as well as pharmacy and therapeutic committees are demanding evidence that new drugs and medical devices are superior to existing products--that they work better, have fewer adverse effects, and enhance efficiency, thereby reducing healthcare costs. As new biomedical technology is introduced to facilitate the perioperative management of patients (e.g., computerized anesthesia information management systems), evidence that these systems enhance our ability to provide high-quality, cost-effective health care will assume greater importance. The challenge that all practitioners face is to provide high-quality ambulatory anesthesia care at a reduced cost.

Adult↗

Quality in management of biomedical equipment.

The project described in this paper concerns the assurance of quality in biomedical equipment management. The project commenced in 1988 with the establishment of the Clinical Engineering Department at the General Hospital of Bolzano, which was entrusted with the task of managing all biomedical equipment installed within its health institutions. To ensure the systematic and organic management of biomedical technology, new technical and administrative procedures were introduced. The results achieved have been validated both through a detailed analysis of staff replies to a specific questionnaire and on the basis of several objective indicators, such as maintenance costs and equipment breakdown times.

Biomedical Engineering↗

Research ethics and the development of medical biotechnology.

Commercial funding is of most importance for the development of new biomedical technologies such as xenotransplantation. The dependence of such funding may, however, carry certain risks from an ethical point of view. In this article some of these risks are exemplified and it is argued that the adherence to basic research ethical norms are of vital importance for the field of xenotransplantation to develop properly.

Animals↗

Reconsidering the status of anorexia nervosa as a western culture-bound syndrome.

Based on Ritenbaugh's 1982 definition, this essay reconsiders the status of anorexia nervosa as a Western culture-bound syndrome (CBS). It argues that anorexia nervosa, in its culturally reconstructed fat phobic form, is no longer bound to specific Western localities. Instead, it may be conceived as being grounded in the transnational culture of 'modernity', characterized by an internationalised socio-economic stratum now found in many rapidly urbanising parts of the world, and composed of increased affluence, as well as the globalization of fat phobia and diffusion of biomedical technology. Although the treatment implication of Ritenbaugh's CBS concept may appear to be misplaced from the clinician's pragmatic perspective, its salience for clarifying the interaction of individual and cultural concerns in self-starvation, as well as for fostering a needed self-scrutiny in psychiatry, is affirmed. A critique of the dialectical relationship between culture and psychopathology is then put forward. This addresses the apparently conflicting role of anorexia nervosa in enacting as well as combating the cultural pursuit of thinness, and ends by highlighting the inadvertent influence of the biomedical establishment in propagating the condition with measures intended, ironically, for preventing it.

Acculturation↗

You have an idea, now what?

The innovation process is often more important than the original idea, particularly when the ultimate goal is to improve patient care through technologically advanced products. Many physicians have great ideas; unfortunately, many of these great ideas are never translated to patient care improvements because of a misunderstanding of "the next step." In many cases, the next step is a step backward to understand the real clinical problem: "the clinical need." With the clinical need in hand, the most efficient path to a product for improved patient care can then be derived. Often, the most efficient pathway involves an appreciation of many issues, including intellectual property, regulatory pathways, finance, and clinical trial strategies. The integration of these issues underlies innovation in biomedical technology.

Commerce↗