Introduction to living history--biography of Arthur Barclay Chapman.
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When the study of human inheritance became a topic of scientific interest more than 100 years ago, brain function and mental disease immediately attracted the interest of researchers. Psychiatric genetics was dominated from its early beginnings by the question of nature and nurture. Today this problem can be quantitatively approached with odds ratios and attributable risks for certain genotypes. The false doctrine of eugenics and its practical application by the Nazi regime paved the way for the development of a prevailing anxiety in society that psychiatric genetics might lead to stigmatisation or even a revitalization of eugenics. The major challenge for the field, however, stems from the attitudes of fellow geneticists who doubt that genetics can ever contribute to an understanding of brain function and mental disease. Whereas genetically complex traits are being successfully pinned down to the molecular level in other fields of medicine, psychiatric genetics still awaits a major breakthrough. Although mental disorders are harder to tackle than any other complex disease the concepts developed and the methods available today are powerful enough to predict a bright future of the field.
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At the time of his death in 1972 at 44 years, Alex E. Krill had an established reputation as an authority on the topic of inherited retinal and choroidal dystrophies. He lived to see the publication of the first volume of his two volume textbook on Hereditary Retinal and Choroidal Diseases but perished in an airline crash before the completion of the second volume of this text. Although Dr. Krill had completed a substantial portion of the material for this second volume, the publication of a second volume would unlikely have resulted without major additional efforts from two of his colleagues Drs. Desmond Archer, Belfast, Northern Ireland, and August Deutman, Nijmegen, the Netherlands. This work is a testimonial to the scope of Alex Krill's knowledge of various retinal disorders and their proper investigation and classification by electrophysiologic and psychophysical procedures. It is also a lasting tribute to his memory by two generous and devoted colleagues.
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