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At least 163 records · Page 9Linked to original sources
PubMed2005

Better prepared than synthesized: Adolf Butenandt, Schering Ag and the transformation of sex steroids into drugs (1930-1946).

This paper follows the trajectory of sex steroids in 1930s Germany as a way to investigate the system of research which characterized the development of these drugs. Analyzing the changing relationship between the pharmaceutical company Schering and the Kaiser Wilhelm Institute für Biochemie headed by Nobel Prize winner Adolf Butenandt, the paper highlights the circulation of materials, information and money as much as the role of patents in shaping the study of sex steroids. Semi-synthetic analogs and metabolic pathways thus emerged as shared bio-industrial assets. This collaborative work participated in a more general 'internalization' of biology, which took place in pharmaceutical firms during the 1920s and 1930s as a strategy to standardize and develop biologicals. The construction of the hormone market was also based on Schering's collaboration with a selected group of clinicians who worked out the wide-range of indications associated with these 'natural' drugs. The paper finally shows how the wartime scientific and industrial mobilization in Nazi Germany marginalized the study of sex steroids and led to the dismantling of the KWIB-Schering network.

Academies and Institutes↗
PubMed1988

Who's afraid of the dentate line? The Whitehead hemorrhoidectomy.

Between January 1, 1970 and January 1, 1980, 1,002 hemorrhoidectomies, of which 356 were modified Whitehead procedures, were performed at a University of Illinois-affiliated hospital. Follow-up data were obtained from 295 of these patients, with times ranging from 5 to 12 years. Five patients experienced postoperative contractures. Of these, three required a second procedure and one required a third. There were no cases of fecal incontinence or rectal seepage. After review of the literature, I concluded that (1) the poor record of the Whitehead hemorrhoidectomy is due to the confusing and oftentimes misleading terminology of the anorectal anatomy found in early texts, and (2) this technique, or one of its modifications, is a viable treatment option for patients with circumferential, prolapsing, mixed hemorrhoids.

Anal Canal↗
PubMed2004

[Andrea Cesalpino and systemic circulation].

Although since the publication of the De motu Cordis in 1628 the majority of historians have considered William Harvey the discoverer of the blood circulation, a minority of authors have tried to show that the laurels belong instead to Andrea Cesalpino (c.1520-1603). Over the years,an endless number of points and opinions on the two sides of the question have been advanced and debated; the consensus today, however, is that Harvey deserves the credit and that Cesalpino's contribution was negligible. In an attempt to clarify the issue, the author has translated de novo, from the original Latin, all the passages of Cesalpinoconcerning the circulation and has reviewed the criticisms leveled at his ideas on the subject. The results are surprising on two accounts: first, the conclusion seems inescapable that this author, several decades before Harvey, had a clear general understanding of the circulation of the blood;second, the dismissal of Cesalpino's contribution was (and is) based on misunderstandings and misinterpretations.These, in turn, were the result, for the most part, of two factors: a) critics often did not read all the pertinent passages(possibly because his Latin prose is tedious and sometimes unclear); b) some passages were inaccurately translated. As for who discovered the circulation, it depends on how we define "discovery".

Animals↗
PubMed1997

The women of Salerno: contribution to the origins of surgery from medieval Italy.

Medicine in medieval Europe benefited from Greek, Arabic, Hebrew, and Latin influences. Because of geographic and other favorable conditions, many of these cultural contributions synergized to form the Medical School at Salerno around 900 AD. Somewhat uncharacteristically, women physicians played a part in the advances that came from this school. Among the contributions associated with the School of Salerno were (1) textbooks of anatomy, obtained mainly from porcine dissections, (2) insistence on certification and training for physicians, (3) application of investigative thinking and deduction that led to important advances such as the use of healing by secondary intention, (4) the first textbook about women's medicine, and (5) the first recorded female medical school faculty member named Trotula de Ruggiero or Trocta Salernitana. The women physicians of Salerno contributed to a textbook that gained wide acceptance and distribution throughout Europe. The textbook, called De Passionibus Mulierium, was first published about 1100 AD and was a prominent text until a significant revision by Ambrose Paré's assistant in the early 1600s. Paré was the preeminent anatomist of his time, and many of his important anatomic and surgical considerations were directly and indirectly derived from the work of the women of Salerno. The advances first recorded, taught, and implemented by the women of Salerno are an interesting and important part of our surgical heritage.

Anatomy↗
PubMed1993

The blindness of John Milton.

John Milton (1608-1674) has often been regarded as the greatest poet of his time, yet he did not compose his most famous work, Paradise Lost, until after he had become blind in both eyes. On the basis of clues in Milton's writings, several possible diagnoses have been advanced to explain his loss of vision. Herein the evidence for and against each theory is presented.

Blindness↗
PubMed1985

Dante and medicine.

Explore the source record for details and available documents.

History, Medieval↗
PubMed1997

Tips of the slongue: the enduring legacy of W.A. Spooner.

Slips of the tongue are common and often amusing phonic errors. Although surely not the first speaker to make such transpositions, W.A. Spooner (1844-1930) was well known for them and was the source of the eponym, "Spoonerism." Several of his noted slips are presented along with a whimsical obstetric presentation.

England↗
PubMed1998

A selective history of groin hernia surgery in the early 19th century. The anatomic atlases of Astley Cooper, Franz Hesselbach, Antonio Scarpa, and Jules-Germain Cloquet.

One of the most important eras in the evolution of groin hernia surgery is that of the early 19th century. It was a time when cadaver dissections and diverse clinical studies culminated in a more thorough anatomic understanding of the inguinal canal. For reasons cloaked in permanent historical uncertainty, the style of hernia textbook publishing also dramatically changed at the turn of the 19th century when sumptuous anatomical atlases, exemplified by those of Astley Cooper, Franz Hesselbach, Antonio Scarpa, and Jules-Germain Cloquet, began to appear. Characterized by the presence of numerous detailed engravings these texts were expensive to publish and often had limited print runs. The publishing history and clinical impact of these now rare hernia tomes are analyzed in this article.

Anatomy, Artistic↗