Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Bencyclane”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 163 records · Page 9Linked to original sources
PubMed1988

Filterability of human erythrocytes--drug induced prevention of aging in vitro.

Using a computer assisted filtration system, 6 drugs (bencyclane, moxaverine, naftidrofuryl, pentoxyfylline, vincamine, vinpocetine) were tested (versus placebo) to improve filterability of in vitro aged red blood cells (RBC). Up to a concentration of 1 x 10(-7) mol/l all drugs significantly inhibit in vitro aging, indicating an improved of action is still present in RBC incubated with 10 x 10(-8) mol/l naftidrofuryl and pentoxifylline but, comparison in between the compounds reveals no significant difference of action. The data presented confirm the results on the beneficial action of these drugs presented by others. However, direct comparison shows only minor differences in drug potency.

Adult↗
PubMed1985

Effect of cilostazol, a new antithrombotic drug, on cerebral circulation.

The effects on cerebral blood flow and the selectivity of the vasodilating action of cilostazol (6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-qui nolinone, OPC-13013), a new antithrombotic drug, were investigated. In anesthetized dogs, cilostazol increased the venous outflow from the superior sagittal sinus in doses of higher than 10 micrograms/kg i.v. In anesthetized cats, cilostazol was demonstrated by the hydrogen clearance method to cause a dose-dependent increase in blood flow in both the white matter and the grey matter in doses of higher than 10 micrograms/kg/min i.v. The effective dose of cilostazol when compared at ED25 values, which is the dose required to produce a 25% increase in blood flow, was almost equal to that of papaverine and more potent than those of bencyclane and pentoxifylline. Arterial blood gas analysis revealed no significant changes in pCO2, pO2 and pH by intravenous administration of cilostazol. In anesthetized dogs, after intra-arterial administration at a constant perfusion pressure, cilostazol increased the blood flow of the common carotid, internal carotid, vertebral, superior mesenteric and femoral arteries in a dose-dependent manner in doses higher than 1 microgram, and had almost no effect on renal blood flow. High selectivity for the vertebral and femoral arteries was observed.

Anesthesia↗
PubMed1978

The vascular effects of flunarizine as compared with those of other clinically used vasoactive substances.

Flunarizine, a difluoro derivative of cinnarizine, produces a long-lasting inhibition of calcium-induced contractions of isolated vascular preparations of rabbit and rat. In this regard it is slightly more active than cinnarizine and markedly more active than papaverine, naftidrofuryl, bencyclane, cylandelate, dihydroergotoxine, xantinol nicotinate and pentoxifylline; calcium dobesilate does not inhibit the calcium-induced responses. A long-lasting antivasoconstrictor effect was observed also for cinnarizine. This action of flunarizine is selective for calcium channels in vascular tissue, since it has little effect on the calcium-induced response of myocardial preparations of the cat. Flunarizine has no effect on the rhythmic activity of myogenically active blood vessels; it thus shows a further selective activity to calcium channels activated by vasoconstrictor agents and not for those opened by intrinsic changes in membrane permeability. This dual selectivity implies that flunarizine is a useful reference substance in assessing calcium antagonism.

Animals↗
PubMed1979

Regional blood flow determination in rats by the microsphere method during i.v. infusion of vasodilating agents.

The present experiments were performed to gain information on changes in various organ flow rates during i.v. infusion of vasodilating substances. The microsphere method with the reference sample technique was used in rats to measure simultaneously different organ flow rates. The detection of the spheres (non-radioactive) was performed by macerating the tissues and counting samples under the microscope. As only one microsphere-infection per animal was performed, an untreated experimental group served as a control. The cardiac output was measured in a separate series. The effects of isoproterenol, pentoxifylline, bencyclane, acetylcholine, and dihydroergotoxine (mixture of 3 compounds, Hydergin) consisted of flow increases in several organs while the flow in others remained nearly unchanged. Only during the action of sodium nitroprusside the flow values were found decreased or remained unchanged. This substance led to decreased cardiac output, whereas that in the other groups was unchanged or raised. The experiments point to quantitatively different reactions on cardiac output distribution during application of the vasodilating substances tested.

Animals↗
PubMed1984

[Effect of various vasoactive drugs on synaptic transmission in the orthosympathetic ganglia in man].

The effects of the following vasoactive drugs: Bencyclan fumarate, Cetiedil citrate, Cinepazide maleate, Dihydroergocristine methane sulphonate, Nafthydrofuril acid oxalate, Papaverine hydrochloride, Piribedil monomethane sulphonate, Raubasine, Thymoxamine hydrochloride and Xanthinol nicotinate, in concentrations ranging between 0.001 - 2 mM, were tested on the compound action potentials led off from human isolated sympathetic ganglions. The experiments, carried out on 50 isolated lumbar ganglion preparations removed from 23 subjects with arteriopathy of the limbs, indicated that all the drugs are able to impair the synaptic transmission, although at different concentrations. These findings are in favour of the hypothesis that the vasodilatatory effects observed after therapeutic treatment of patients with vasoactive drugs are partially produced by the vasodilatation following the depression of the sympathetic nervous transmission.

Action Potentials↗
PubMed1984

Tracheal phenol red secretion, a new method for screening mucosecretolytic compounds.

A simple method for screening drugs that influence tracheobronchial secretion has been described. After i.p. application of a phenol red solution, part of the dye is secreted into the tracheal lumen. This basal secretion is increased by both parasympathomimetics and sympathomimetics. In addition, expectorants are also capable of increasing tracheal phenol red output. Therefore this method is suitable for the study of drugs that may be capable of influencing tracheobronchial secretion.

2-Hydroxyphenethylamine↗
PubMedDate not supplied

[Effect of no-shpa, halidor, dibazol and euphylline on the fibrinogen content and fibrinolytic activity of blood].

With a single intravenous administration to albino rats of both sexes of nospanum and halidor in a dose of 2 mg/kg and dibazol--in 1 mg/kg produce activation of fibrinolysis, while euphylline in a dose of 12 mg/kg has no effect on this process. A protracted introduction by the subcuataneous route of halidor and nospanum in a dose of 10 mg/kg, of dibazol--in 5 mg/kg and of euphylline intramuscularly in a dose of 24 mg/kg depresses in animals the activity of the proteolytic process. It was found that in vitro nospanum, halidor and dibazol accelerate fibrinolysis, whereas the presence of euphylline in the blood plasma deccelerates this process.

Aminophylline↗
PubMedDate not supplied

[Effect of dibazol, euphylline, No-Spa and galidor on thrombocyte osmotic resistance and blood clot retraction].

The osmotic resistance of thrombocytes and the blood clot retraction are shown to diminish in the presence of nospanum and holidor in the plasma and blood. A double logarithmic relationship between the values characterizing the action on the osmotic resistance of thrombocytes and the blood clot refraction, on the one hand, and concentrations of some of the study substances, on the other, was revealed. With parenteral introduction the fall of the osmotic resistance of thrombocytes and an increase in the amount of the retracted serum were noted to occur with a protracted subcutaneous injection of dibasol (5 mg/kg), whereas euphylline (24 mg/kg) caused only a smaller degree of retraction.

Aminophylline↗