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[The use of transvenous destruction of the atrioventricular junction for correcting hemodynamic disorders caused by ventricular-atrial conduction].

The authors studied disorders of central and intracardiac hemodynamics occurring in electrostimulation of the ventricles attended by retrograde stimulation of the cardia. The experiments were conducted on 8 anesthetized dogs in whom, after disclosure of intact ventriculoatrial conduction, transvenous destruction of the atrioventricular junction was performed. Clinical study was carried out in 12 patients with continuous electrostimulation of the ventricles which caused retrograde stimulation of the atria, and in 19 patients with supraventricular tachyarrhythmia who were subjected to transvenous endocardial destruction of the atrioventricular junction. Due to the development of severe hemodynamic disorders in electrostimulation of the ventricles attended by retrograde stimulation of the atria the last named condition should be changed to ventriculoatrial dissociation which promotes growth of contractile activity and stroke volume of the left ventricle. Transvenous destruction of the atrioventricular junction is a reliable method for blocking retrograde conduction.

Animals↗

Effects of N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate on the ventriculo-atrial conductivity of accessory pathways.

The purpose of this study was to examine the effects of N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate (SUN 1165), a newly developed antiarrhythmic agent belonging to class Ic, on the ventriculoatrial (VA) conductivity of accessory pathways and paroxysmal supra-ventricular tachycardia (PSVT). Twelve patients with accessory pathways were examined by standard electrophysiologic technique before and after a single oral dose of SUN 1165 (100 mg). 1 h after administration, SUN 1165 blocked VA conduction of the accessory pathway in six of twelve patients and prevented the induction of PSVT in six of seven cases. In the cases in which VA block did not occur, the VA interval prolonged (from 178 +/- 7 to 190 +/- 11 ms, p less than 0.05), and the effective refractory period of VA conduction was also increased (from 273 +/- 10 to 318 +/- 15 ms. p less than 0.05). SUN 1165 also prolonged the conduction time in normal conduction systems (AH and HV intervals and QRS duration), but the degree of the prolongation was moderate and not dangerous. There was no adverse effect. These results indicate that SUN 1165 is a potent and safe antiarrhythmic agent, and useful for preventing or stopping PSVT by blocking or depressing VA conduction through accessory pathways.

Administration, Oral↗

[The function of retrograde (ventricular-atrial) conduction in Wolff-Parkinson-White syndrome patients].

Functional characteristics of the retrograde conduction in the WPW syndrome were studied in 68 patients by means of electrophysiological examination of the heart. The retrograde conduction via the Kent bundle was characterized by constant time of the atrioventricular conduction. The latent WPW syndrome with the accessory pathway blocked in the anterograde direction and functioning in the retrograde direction only was detected in 22 cases. A possible successive relationship of the classical and latent WPW syndrome was shown. Higher functional possibilities of the accessory pathway for the retrograde conduction were revealed in comparison with the anterograde conduction.

Adolescent↗

[Relation between intra-atrial conduction and disorders of sinoatrial, atrioventricular and intraventricular conduction (according to selectively intensified ECG findings)].

The differentially intensified ECG was recorded from the chest surface to determine the intraatrial conductivity in patients with chronic coronary heart disease. The parameters of the differentially intensified ECG were compared with the indices of intraatrial conductivity on the intracavitary electrogram. Disorders of intraatrial conductivity were also compared with impairments of conductivity in other sites of the conductivity system of the heart. A total of 154 patients with chronic coronary heart disease (aged 38 to 77 years) and with disorders of conductivity in various sites of the heart were examined. Intraatrial conductivity disorders were detected in 77.8% of patients with the syndrome of pacemaker weakness, in 46.5% of patients with atrioventricular block of degree II and III and in 82.1% of patients with block of the peduncles of His's bundle.

Adult↗