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PubMedDate not supplied

Apocrine poroma of the breast.

Poromas are sweat gland tumors classically reported to be of eccrine origin. However, it is now recognized that poromas may also be derived from apocrine glands. There are no prior reports of either type of poroma arising on the breast. We report the first case of a poroma of the breast. The lesion was localized to the areola of a 70-year-old woman and mimicked an underlying neoplasm of the breast. Because the histopathology demonstrated apparent continuity of a benign poroma with the infundibula of hair follicles, the diagnosis of apocrine poroma was made. The poroma in this case is of apocrine derivation. This report demonstrates that apocrine poromas should be considered in the clinical differential of acquired lesions on the areola, suggesting an underlying breast tumor. Apocrine poromas that are only partially biopsied may recur. Moreover, since apocrine poromas may potentially develop into apocrine porocarcinomas, analogous to eccrine poromas sometimes transforming into eccrine porocarcinomas, apocrine poromas should be completely excised.

Acrospiroma↗
PubMedDate not supplied

Unusual case of porocarcinoma of the foot with no clinically evident dermatologic manifestations.

Eccrine poromas are solitary nodules that predilect the soles of the foot. Rarely, malignancies may arise within these tumors. When this occurs, the growth is classified as a malignant eccrine poroma, or porocarcinoma. A case of a 39-year-old woman who originally presented with an incidental plantar skin lesion that was later diagnosed as a porocarcinoma is reported. The patient underwent local excision of the lesion and a sentinel node biopsy. At 18 months postoperative there were no signs of recurrence. This case has been presented to demonstrate that skin lesions with minimal abnormalities of skin texture or color, and slight elevation as the only dermatologic manifestation, can represent a malignancy.

Acrospiroma↗
PubMed2004

[Recurrent highly-differentiated eccrine carcinoma of the thumb -- a case report].

The eccrine carcinoma is a rare tumour originating from the sweat glands. They are mainly located in the palm of the hand and the sole of the foot, the digits, the head and the trunk. We report on a now 68-year-old male, who underwent partial amputation of the thumb at the level of the proximal phalanx due to an eccrine carcinoma in 1990. In the following years, three local recurrences were excised. After the exclusion of metastases an amputation at the MP I level was performed at our institution. To restore grip function, we performed a distraction of the first metacarpal bone followed by deepening of the first web space. So far, there are no defined treatment recommendations due to the rarity of the tumor. In some cases, metastatic disease has been reported, and in most cases, a high rate of local recurrence. After diagnostic biopsy, we recommend staging to exclude metastatic spread of the tumor followed by aggressive local surgical treatment.

Acrospiroma↗
PubMed2006

[Malignant eccrine poroma].

INTRODUCTION: Malignant eccrine poroma is a very rare tumour of the sweat glands with high malignancy and presenting with a polymorph clinical and histological picture. CASE REPORT: We describe the case of a 99-year-old patient with a malignant poroma on the buttock. Despite the large size of the tumour, no metastasis was found with standard examination techniques. Radical excision and defect closure with a Limberg flap was performed. RESULT: The healing course was uneventful and without complications. CONCLUSION: The malignant poroma is a tumour of high malignancy which can easily be misdiagnosed because of its different forms of presentation. Radical surgical therapy is the only known effective treatment.

Acrospiroma↗
PubMed2001

Poromas of the head and neck.

BACKGROUND: The "eccrine" poroma is a benign neoplasm previously thought to originate from the eccrine sweat gland. Early studies suggested that these were primarily lesions of the hairless acral surfaces. OBJECTIVE: This article reports the clinical and histologic findings of 10 cases of poroma of the head and neck area. METHODS: The clinical and histologic findings of 10 cases of poroma of the head and neck area are compared with 10 poromas occurring on the extremities. RESULTS: Some poromas demonstrated evidence for apocrine origin. Unlike poromas found on the extremities, head and neck poromas were usually asymptomatic and were never correctly diagnosed clinically. Although 9 of 10 poromas on the extremities occurred in male patients, the head and neck poromas showed no gender predilection. CONCLUSION: Clinicians should be aware that poromas can occur in the head and neck area and may be of apocrine origin.

Acrospiroma↗
PubMedDate not supplied

Eccrine porocarcinoma: a case report.

Eccrine porocarcinoma is a rare malignant sweat gland tumour. Clinical presentation can vary from an indurated plaque to a polypoid ulcerated and bleeding lesion. Diagnosis of eccrine porocarcinoma on clinical observation only is quite impossible. Here we present the case of a 64-year-old female patient with a small reddish nodule of the knee that, on histological evaluation, proved to be an eccrine porocarcinoma.

Acrospiroma↗
PubMed2004

Eccrine porocarcinoma with Bowenoid changes: epithelial membrane antigen is not a useful marker for malignant tumours arising from eccrine gland structures.

A case of eccrine porocarcinoma with Bowenoid changes is reported. We compared the results of immunohistochemical staining for epithelial membrane antigen in the present case with results in Bowen's disease to determine whether the presence of epithelial membrane antigen (EMA) enabled us to differentiate between Bowen's disease and eccrine porocarcinoma with Bowenoid changes. Histologically, the present tumour was characterized by atypical clear cells with Bowenoid changes as well as uniform small cells and intradermal nests with ductal structures. The membrane and cytoplasm of uniform small cells and ductal luminal surfaces were positive for EMA. However, the atypical cells with Bowenoid changes were negative for this. In contrast, tumour cells in Bowen's disease were positive for EMA. Although EMA is known to be a useful marker for some benign tumours derived from eccrine ducts, we found it difficult to distinguish eccrine porocarcinoma with Bowenoid changes from Bowen's disease using immunohistochemical staining for EMA.

Acrospiroma↗
PubMed2006

Malignant eccrine poroma invading the parotid gland.

Malignant eccrine poroma was first described by Pinkus and Mehregon in 1963. Because of the histologic characteristics of the tumor, these authors concluded that the tumor was likely of eccrine origin. Malignant eccrine poroma originates from the intraepidermal ductal portion of the eccrine gland. Like other tumors of skin adnexa, malignant eccrine poroma is a rare tumor. It mostly affects older persons. Clinical diagnosis is difficult, and lesions are often mistakenly identified as squamous cell carcinoma or pyogenic granuloma. We report a case of malignant eccrine poroma invading the parotid gland. A 65-year-old man presented with an ulcerated mass (2x3 cm) below the ear lobule of 3 months' duration. The mass was fixed to the skin and underlying parotid gland. The lesion was treated using a superficial parotidectomy approach including the overlying skin. Simultaneous neck dissection was performed. The diagnosis was malignant eccrine poroma invading the parotid gland.

Acrospiroma↗
PubMed1961

Eccrine poroma.

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Acrospiroma↗
PubMed1993

Squamous differentiation in malignant eccrine poroma.

Squamous differentiation in poral adnexal neoplasms is a rare event. Two cases are presented of malignant eccrine poroma in which areas of squamous differentiation showing the features of squamous cell carcinoma were present. The areas of squamous differentiation were found within the invasive components of the lesions and appeared to result from direct transformation of the poral epithelial cells. A review of the literature on this unusual phenomenon is presented.

Acrospiroma↗
PubMed1994

Three subtypes of poroid neoplasia in a single lesion: eccrine poroma, hidroacanthoma simplex, and dermal duct tumor. Histologic, histochemical, and ultrastructural findings.

A single poroid neoplasm composed of three histologically distinct lesions (hidroacanthomas simplex, eccrine poroma, and dermal duct tumor) is reported. Comparative histologic, histochemical, and electron-microscopic studies revealed that each tumor subtype contained varying proportions of poroid cells, clear cells, and cuticular cells. The major component of all three neoplasms was poroid cells, which, under the electron microscope, were characterized by a few, small, poorly developed desmosomes, and were histochemically characterized by a positive succinic dehydrogenase reaction. The dermal duct tumor was cultured, and showed similar histochemical findings to the in vivo poroid cells. These results suggest that poroid cells play the most important role in the histogenesis of these three neoplasms.

Acrospiroma↗
PubMed1995

p53 protein and proliferating cell nuclear antigen in eccrine poroma and porocarcinoma. an immunohistochemical study.

The expression of p53 protein and proliferating cell nuclear antigen (PCNA) in 18 eccrine poromas and four porocarcinomas was examined by immunohistochemistry. Immunoreactivity for p53 in eccrine poromas was negative in five tumors, < 10% of tumor cells in one (low expresser), 10-50% in seven (moderate expressers), and > 50% in five (high expressers). The duration of the presence before excision of p53-negative poromas was shorter, and the size of these tumors was smaller in comparison with those of p53-positive poromas. Moreover, all high expressers showed some atypical cells in limited areas. Of the four porocarcinomas, three were high expressers and one a low expresser of p53 protein. The low-expresser tumor showed clinically more rapid growth and histologically no poromatous foci in contrast to the high expressers. No significant correlation was found between p53 protein expression and PCNA positive staining in either eccrine poromas or porocarcinomas. However, the percentages of PCNA-positive cells in porocarcinomas were significantly higher than those in poromas, with no overlapping values. These results suggest that the PCNA index is useful in differentiating between poroma and porocarcinoma and that p53 gene mutation may occur in long-standing eccrine poromas and correlate with atypical changes in histology as well as subsequent progression to porocarcinoma.

Acrospiroma↗