Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “AMIDES”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 163 records · Page 9Linked to original sources
PubMed1989

Isolation, primary structure and bioactivity of schistoflrf-amide, a FMRF-amide-like neuropeptide from the locust, Schistocerca gregaria.

We have isolated a neuropeptide, related to the Phe-Met-Arg-Phe-NH2 family, from the thoracic nervous system of the locust, Schistocerca gregaria, using a purification system based on the radioimmunoassay of high pressure liquid chromatography fractions. The primary sequence of this locust peptide is Pro-Asp-Val-Asp-His-Val-Phe-Leu-Arg-Phe-NH2. The bioactivities of the native and synthetic neuropeptide are identical in both the locust heart and hindleg extensor-tibiae muscle bioassays.

Amino Acid Sequence↗
PubMed1992

Actions of APGW-amide and GW-amide on identified central neurons of the snail, Helix aspersa.

1. Actions of APGWamide and GWamide have been examined on identified central neurons of the snail, Helix aspersa. 2. In F1 neurons, both APGWamide and GWamide, 0.5-5 microM, reversibly inhibited the amplitude of evoked-IPSPs which were dopaminergic, but had no direct effect on membrane potential, cell firing rate, or dopamine-induced responses. These results indicate that the actions of APGWamide and GWamide in F1 neurons are at presynaptic sites. 3. At concentrations between 0.5 and 10 microM, APGWamide and GWamide had direct postsynaptic effects on F2 neurons. They inhibited the spike activity and hyperpolarized the membrane potential of F2 neurons in a dose-dependent manner with a reversal potential around -85 mV which is close to Ek. 4. In K+ free solution, the inhibitory effects of APGWamide and GWamide were potentiated, while they were reduced by increasing external K+ concentration. Either tetraethylammonium (10 mM) or 4-aminopyridine (500 microM) only partially prevented the inhibition induced by APGWamide and GWamide on F2 neurons. Combination of TEA (5 mM) and 4-AP (250 microM) could abolish this inhibition. However, neither 1 mM La2+ nor 10 mM Co2+ could prevent the inhibitory action of APGWamide and GWamide. This evidence indicates that the postsynaptic inhibition of APGWamide and GWamide on F2 neurons is due to an increase in K+ conductance and that both transient K channel (IA) and delay K+ channel (IK) were affected by these peptides. 4. APGWamide and GWamide exert both presynaptic and postsynaptic effects of Helix neurons, depending on the neuron under study. They are qualitatively and quantitatively similar in their presynaptic or postsynaptic actions.(ABSTRACT TRUNCATED AT 250 WORDS)

Amino Acid Sequence↗
PubMed2002

Reactions of amides with organoaluminum compounds: factors affecting the coordination mode of aluminum amidates.

Factors affecting the coordination mode of an amidato group on aluminum will be presented. The reaction of N-tert-butylalkylacetamide ((t)BuNHCR([double bond]O)) with 1.1 molar equiv of Me(3)Al in refluxing hexane affords a pentacoordinated, dimeric compound [Me(2)Al[eta(2)-(t)BuNC(R)(mu(2)-O)]](2) (3, R = p-(t)Bu-C(6)H(4); 4, R = 2,6-F,F-C(6)H(3); 5, R = Me; 6, R = CF(3); 7, R = p-F(3)C-C(6)H(4)). However, in the presence of 2.2 molar equiv of Me(3)Al, N-tert-butyl-4-tert-butylbenzamide ((t)BuNHC(p-(t)Bu-C(6)H(4))([double bond]O in refluxing hexane gives [Me(2)Al[eta(2)-(t)BuNC(p-(t)Bu-C(6)H(4))(mu(2)-O)]AlMe(3)], 8. In contrast, the reaction of R'NHCR' '([double bond]O) with 1 molar equiv of R(3)Al at room temperature produces tetracoordinated, dimeric, eight-membered ring aluminum compounds [R(2)Al[mu,eta(2)-R'NC(R' ')O]](2) (9, R = Me, R' = 2,6-(i)Pr, (i)()Pr-C(6)H(3), R' ' = Ph; 10, R = Me, R' = (i)Bu, R' ' = Ph; 11, R = Et, R' = Bn, R' ' = Ph; 12, R = Me, R' = Ph, R' ' = CF(3); 13, R = Me, R' = Bn, R' ' = CF(3)). On the other hand, 4'-chlorobenzanilide ((p-Cl-C(6)H(4))NHCPh([double bond]O)) reacts with R(3)Al to produce trimeric, twelve-membered ring aluminum compounds [R(2)Al[mu, eta(2)-(p-Cl-C(6)H(4))NC(Ph)O]](3) (14, R = Me; 15, R = Et). Furthermore, the reaction of 2'-methoxybenzanilide with 1 molar equiv of Me(3)Al in hexane yields a dinuclear aluminum complex [Me(2)Al(o-OMe-Ph)NC(Ph)(O)AlMe(3)], 16.

Journal Article↗
PubMed2005

Deprotonation reactions of zirconium and hafnium amide complexes H2N-M[N(SiMe3)2]3 and subsequent silyl migration from amide -N(SiMe3)2 to imide =NH ligands.

Ammonolysis of previously reported Cl-M[N(SiMe3)2]3 (M = Zr, 1a; Hf, 1b) leads to the formation of peramides H2N-M[N(SiMe3)2]3 (M = Zr, 2a; Hf, 2b) which upon deprotonation by LiN(SiMe3)2 or Li(THF)3SiPh2But yields imides Li+(THF)n{HN(-)-M[N(SiMe3)2]3} (M = Zr, 3a; Hf, 3b). One -SiMe3 group in 3a-b undergoes silyl migration from a -N(SiMe3)2 ligand to the imide =NH ligand to give Li+(THF)2{Me3SiN(-)-M[NH(SiMe3)][N(SiMe3)2]2} (M = Zr, 4a; Hf, 4b) containing an imide =N(SiMe3) ligand. The kinetics of the 3a --> 4a conversion was investigated between 290 and 315 K and was first-order with respect to 3a. The activation parameters for this silyl migration are DeltaH++ = 13.3(1.3) kcal/mol and DeltaS++ = -34(3) eu in solutions of 3a (in toluene-d8 with 1.07 M THF) prepared in situ. THF in the mixed solvent promoted the 3a --> 4a reaction. The effect of THF on the rate constants of the conversion has been studied, and the kinetics of the reaction was 3.4(0.6)th order with respect to THF. Crystal and molecular structures of H2N-Zr[N(SiMe3)2]3 (2a) and 4a-b have been determined.

Journal Article↗