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PubMed1997

Clinical and biologic features of the AIDS dementia complex.

Human immunodeficiency virus type 1 infection is frequently associated with complications of the nervous system, involving all levels of the neuraxis. Many of these represent focal disorders, such as toxoplasmosis, lymphoma, and progressive multifocal leukoencephalopathy. This article reviews the salient clinical and biological features of these disorders.

AIDS Dementia Complex↗
PubMed1993

Psychiatric aspects of acquired immunodeficiency syndrome (AIDS)/human immunodeficiency virus (HIV) infection and sexually transmitted disease (STD): an overview.

The purpose of this paper is to give an overview of the psychiatric aspects of acquired immunodeficiency syndrome (AIDS)/human immunodeficiency virus (HIV) infection and sexually transmitted disease (STD) under the following subheadings: AIDS-related complex, AIDS hypochondriasis, AIDS dementia complex, AIDS and increased risk of suicide, psychiatric aspects of STD, and implications for the management of patients. The psychiatric aspects of HIV infection and AIDS include problems of adjustment to a diagnosis with a stigma and the threat of death, reactive depression and potential risk of suicide, personality disorder, AIDS-related complex (ARC), and AIDS-related dementia. The paper gives an overview of clinical, neuropathological and psychopathological experience in other countries with relevant examples from Papua New Guinea if available. STDs are mentioned because HIV transmission in Papua New Guinea is mostly by heterosexual means. The paper concludes by emphasizing the psychiatric principles of management of HIV-infected/AIDS/STD patients, which include pharmacotherapy but are always based on supportive psychotherapy and counselling.

Adult↗
PubMed1989

Spongiform encephalopathy in AIDS dementia complex: report of five cases.

We describe the morphological findings in the brain of five AIDS patients who died with a clinical diagnosis of dementia. We have found a spongiform change (small rounded vacuoles) in different parts of the brain and a similar but morphologically different sponginess, the status spongiosus, characterized by looser and coarser microcystic cavitations of the grey matter in which the tiny cysts and vacuoles are enmeshed by glial fibrils. At the ultrastructural level, round and oval clear spaces, divided by septae into several smaller ones, appeared in the neuropil. The pathogenesis of the majority of the vacuoles and cavitations is not clear yet but a focal loss of cortical neurons was evident and furthermore some of the vacuoles were identified as remnants of dendrites. The light and electron microscopic findings can not be interpreted as artefacts or as a simple edema of the brain and also can not be explained by the different infective complications. We have found spongiform alterations in all cases of clinically diagnosed dementia and therefore it seems obvious that these findings are quite frequent in AIDS dementia.

Acquired Immunodeficiency Syndrome↗