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Radiographic features of the jaws and teeth in thalassaemia major.

OBJECTIVES: This investigation aimed to compare the radiographic changes and root and crown-body lengths of the mandibular first permanent molar in a group of thalassaemic patients with a control group, matched for age and sex. METHODS: Panoramic radiographs of 50 thalassaemic patients and 50 controls were examined for the presence of radiological changes. Crown body and root lengths were determined using the method of Seow and Lai. The average lengths were calculated and compared between the two groups. RESULTS: The mean crown-body and root lengths of the mandibular first molar of patients with thalassaemia major were 9.58+/-0.83 mm and 11.89+/-1.33 mm, while those for the control group were 10.45+/-0.78 mm and 12.78+/-1.67 mm, respectively. A significant difference (P<0.05) was found between the mean crown-body and root values of the two groups. A significant difference (P<0.05) was also found between thalassaemic patients and controls in the occurrence of spiky-shaped roots, root and crown lengths, taurodontism, attenuated lamina dura, enlarged bone marrow spaces, small maxillary sinuses, faint inferior alveolar canal and thin cortex of the mandible. CONCLUSIONS: While thalassaemia major may not be associated with the occurrence of either vascular canals or prominent antegonial notch, spiky-shaped and short roots, taurodonts, attenuated lamina dura, enlarged bone marrow spaces, small maxillary sinuses, absence of inferior alveolar canal and thin cortex of the mandible were found to be reliable diagnostic criteria for thalassaemia major.

Adolescent↗

Dubowitz syndrome: report of a case with emphasis on the oral features.

Dubowitz syndrome is a rare condition in which the affected individual presents with dysmorphic facial features and manifests growth retardation. Although the condition is well reported in the medical literature, the dental manifestations have not been discussed in great detail. Some of the dental features reported include macrodontia, hypodontia, delayed eruption, and midline diastema. The purpose of this case report was to describe a young Chinese patient with Dubowitz syndrome with specific oral features.

Child↗

Local hemostasis after tooth extraction in patients with abnormal hemostatic function. Use of human fibrinogen concentrate.

Tooth extraction was carried out in 405 patients with various hemostatic disorders due to thrombocytopenia, chronic liver disease, hemophilia A and B, von Willebrand's disease and oral anticoagulants. Human fibrinogen concentrate was used as local hemostatic agent. Prophylactic replacement therapy (platelets or plasma concentrates) and antifibrinolytic agents were not administered. Oral anticoagulants were not discontinued. Minor postextraction bleeding occurred only in severe hemophilia A and occasionally in the oral anticoagulant group.

Blood Coagulation Disorders↗

[A rare case of congenital dentin dysplasia in a child aged 8 years].

In the reported case the authors observed a considerable mobility of all milk teeth and permanent teeth. The degree of this mobility varied. The crowns of milk and permanent teeth had a normal size, shape and colour. All teeth were unresponsive to thermal and electric stimulation. Radiological examination showed a nearly complete lack of roots and complete absence of pulp chambers and root canals. This was confirmed by histological examinations demonstrating that the inner part of the teeth in the crown and root was filled with hard masses which in light microscopy resembled newly forming compact bone with Haversian structures. The absence of resorption sinuses in the rudimentary roots was noted. Paediatric examination failed to demonstrate any abnormalities.

Child↗

Normal and abnormal dental development.

Teeth are vertebrate organs that arise from complex and progressive interactions between an ectoderm, the oral epithelium and an underlying mesenchyme. During their early development, tooth germs exhibit many morphological and molecular similarities with other developing epithelial appendages, such as hair follicles, mammary and salivary glands, lungs, kidneys, etc. The developing mouse tooth germ, which is an experimentally accessible model for organogenesis, provides a powerful tool for elucidating the molecular mechanisms that control the development of these organs. Dentition patterning also provides a unique model for understanding how different shapes of teeth arise in different regions of the jaws. We review here the main signalling networks mediating the epithelial-mesenchymal interactions involved in tooth morphogenesis and patterning.

Animals↗

Anomalies in the permanent dentition and other oral findings in 29 individuals with Laurence-Moon-Bardet-Biedl syndrome.

This paper reports a clinical and roentgenological examination of the teeth, jaws and saliva of 29 Scandinavian individuals with Laurence-Moon-Bardet-Biedl (LMBB) syndrome, whose cardinal signs are retinal dystrophy, polydactyly, obesity, hypogenitalism and mental retardation. All subjects had at least three of these signs, including retinal dystrophy. Compared with normal subjects, the group had statistically significantly higher frequencies of hypodontia, small teeth and short roots. In addition, the saliva showed a buffering capacity higher than normal. In conclusion, there seem to exist disturbances of both dental and skeletal formation in the LMBB syndrome.

Adolescent↗