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PubMed1984

Virulence of two strains of Cowdria ruminantium in mice and their use to predict drug activity against heartwater.

A study was made of the infectivity of two mouse-adapted strains of Cowdria ruminantium in mice. The Kwanyanga strain was most virulent in Balb/C mice which died nine days after infection with homogenate of liver from infected mice. CD-1 mice were least susceptible of six strains tested. The du Plessis strain of C. ruminantium was equally virulent in all six mouse strains. The du Plessis strain in CD-1 mice was used as the basis of a drug screen to detect activity against heartwater (C. ruminantium infection) and was highly predictive when active compounds were tested in sheep infected with the Ball 3 strain of C. ruminantium.

Animals↗
PubMed2005

New antimycobacterial S-alkylisothiosemicarbazones.

In connection with a systematic study of antimycobacterial agents against potentially pathogenic strains the series of 12 S-alkylisothiosemicarbazones was evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis, M. kansasii, M. fortuitum, two strains of M. intracellulare and three strains of M. avium. Quinoline-4-carbaldehyde-S-hexyl-isothiohydrazone was found to be more active against potentially pathogenic strains than isoniazide.

Aldehydes↗
PubMedDate not supplied

Heterogeneity of regional nitrogen 13-labeled ammonia tracer distribution in the normal human heart: comparison with rubidium 82 and copper 62-labeled PTSM.

BACKGROUND: Recent reports on 13N-labeled ammonia (13N-ammonia) positron emission tomographic (PET) imaging have suggested a relative reduction of measured tracer activity in the posterolateral wall. Such inhomogeneity of tracer distribution could potentially affect accuracy for detection of disease. The aim of this study was to compare the regional distribution of 13N-ammonia with 82Rb and 62Cu-labeled PTSM (62Cu-PTSM) to identify tracer-specific patterns that may be important in the clinical interpretation of cardiac flow studies. METHODS AND RESULTS: Twenty-eight healthy volunteers underwent PET imaging at rest with either 13N-ammonia (n = 14), 82Rb (n = 8), or 62Cu-PTSM (n = 6). Eight subjects given 13N-ammonia also underwent imaging after adenosine. Activity measured in the posterolateral wall on transaxial images was significantly lower than in the septum for 13N-ammonia, both at rest (p < 0.005) and after adenosine (p < 0.05). No differences were detected for 82Rb or 62Cu-PTSM. The septum/posterolateral wall activity ratios for 13N-ammonia, 82Rb, and 62Cu-PTSM were 1.15 +/- 0.07, 1.00 +/- 0.06, and 0.97 +/- 0.08, respectively (p < 0.001). Regional analysis of image data showed the percent of maximal activity data for 13N-ammonia in the lateral wall to be less than that of other regions (p < 0.001) and in the inferior wall to be greater than in the anterior and lateral walls (p < 0.001). For 62Cu-PTSM, activity in the inferior wall was greater than that in other regions (p < 0.005). No regional differences were detected for 82Rb. CONCLUSIONS: The relatively increased wall activity with 13N-ammonia and 62Cu-PTSM is most likely due to cross-contamination of activity from the liver. The significant reduction in activity in the lateral wall with 13N-ammonia, which persists after adenosine, is most likely related to regional heterogeneity in 13N-ammonia retention and may reflect regional differences in metabolic-trapping mechanisms for 13N-ammonia. Further investigation is required to elucidate the underlying mechanism of this phenomenon. Reduced tracer retention in the lateral wall segment as a normal variant must be considered when evaluating clinical 13N-ammonia PET studies.

Adult↗