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At least 1,603 records · Page 89Linked to original sources
PubMed1998

Making the move from nurse to nursing informatics consultant.

Health care is unique among industries because of the human component involved. That fact, coupled with the unique nursing qualities--critical thinking, caring, attention to detail, accountability and the ability to direct others--makes nurses highly suited o be information system consultants. This article will discuss the health care trends driving the demand for nurse consultants, where and when their skills can be applied, the pros and cons of the entrepreneurial life and What's required to entry consulting.

Career Mobility↗
PubMed2000

Informatics issues in large-scale sequence analysis: elucidating the protein kinases of C. elegans.

With the availability of the nearly complete genomic sequence of C. elegans, the first multicellular organism to be sequenced, molecular biology has definitely entered the postgenomic era. Annotation of the genomic sequence, which refers to identifying the genes and other biologically relevant sections of the genome, is an important and nontrivial next step. A first-pass annotation will be necessarily incomplete but will drive further biological experiments, which in turn will help to annotate the genome better. Given the scale of the genome sequence analysis, it is clear that the annotation should be automated as much as possible without sacrificing the quality of analysis. In this work, we outline our approach to identifying the protein kinases of C. elegans from the genomic sequence. We describe new tools we have developed for analysis, management and visualization of genomic data. By developing modular and scalable solutions, this study has provided a framework for future analysis of the Drosophila and human genomes.

Animals↗
PubMed2006

Proteome informatics II: bioinformatics for comparative proteomics.

The present review attempts to cover the most recent initiatives directed towards representing, storing, displaying and processing protein-related data suited to undertake "comparative proteomics" studies. Data interpretation is brought into focus. Efforts invested into analysing and interpreting experimental data increasingly express the need for adding meaning. This trend is perceptible in work dedicated to determining ontologies, modelling interaction networks, etc. In parallel, technical advances in computer science are spurred by the development of the Web and the growing need to channel and understand massive volumes of data. Biology benefits from these advances as an application of choice for many generic solutions. Some examples of bioinformatics solutions are discussed and directions for on-going and future work conclude the review.

Algorithms↗
PubMed2002

A strategy for examining complex mixtures of deoxyoligonucleotides using ion-pair-reverse-phase high-performance liquid chromatography, matrix-assisted laser desorption ionization time-of-flight mass spectrometry, and informatics.

Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) and ion-pair-reverse-phase high-performance liquid chromatography (IP-RP HPLC) techniques were combined to determine the sequence identity of short single-stranded deoxyoligonucleotides. This methodology is demonstrated using a commercially available multiplex set of eight primer pairs. The primer pairs were separated and collected by IP-RP HPLC. Partial sequence information for IP-RP HPLC fractions was obtained from analyzing exonuclease digestion products by MALDI-TOF MS. IP-RP HPLC, MALDI-TOF MS, exonuclease digests, and a simple computational algorithm provide an integrated strategy for determining the sequence of short nucleic acid oligomers.

Algorithms↗
PubMed2001

Analysis of complex decision-making processes in health care: cognitive approaches to health informatics.

Decision making by health care professionals is often complicated by the need to integrate ill-structured, uncertain, and potentially conflicting information from various sources. In this paper cognitive approaches to the study of decision making are presented within the context of a variety of complex health care applications. In recent years it has become increasingly accepted that in order to build information systems that can support complex decision making it will be necessary to more fully understand human decision-making processes. Methodological approaches are described that aim to explicate the decision making and reasoning skills of subjects as they perform activities involving the processing of complex information. The paper begins by presenting the theoretical foundations for cognitive analyses of decision making, including discussion of major approaches to the study of decision making in a range of real-world domains, including medicine. Applications of cognitive approaches are then illustrated, including a description of a study in which subjects were asked to "think aloud" in providing treatment decisions for complex medical cases. The resulting protocols were then analyzed for subjects' use of decision strategies and problems in reasoning. Extension of cognitive approaches to the study of group decision-making processes is also described. Recent approaches are discussed which borrow from advances in the study of human-computer interaction and which utilize video analysis of decision-making activities involving information technologies. Using these approaches it has been found that health care information systems, such as computerized patient record systems, may have inadvertent effects on human decision making. Implications of a cognitive approach to improving our understanding of complex decision making are discussed in the context of developing appropriate computer-based decision support for both individuals and groups.

Cognitive Science↗
PubMed1998

Informatics for mouse genetics and genome mapping.

Bioinformatics has become an essential part of biological research. The rapid pace of technology development and the ability to carry out biological experimentation in large scale require computerized systems for data management, analysis, and display. Experimentation with the mouse, a major model organism of the Human Genome Initiative, has intensified the need for bioinformatics tools for mouse mapping and genome analysis. This article describes the Mouse Genome Database in the United States, a primary resource for mouse genomic data, as well as resources at the Mammalian Genetics Unit in the United Kingdom and the Animal Genome Database of Japan. Internet addresses are provided for major genetic and physical mapping resources, major genome data sites, and resources of molecular information.

Animals↗
PubMed2006

Lipid mediator informatics-lipidomics: novel pathways in mapping resolution.

Lipidomics, the systematic decoding of lipid-based information in biosystems, is composed of identifying and profiling lipids and lipid-derived mediators. As currently practiced, lipidomics can be subdivided into architecture/membrane lipidomics and mediator lipidomics. The mapping of structural components and their relation to cell activation as well as generation of potent lipid mediators and networks involves a mass spectrometry-computational approach so that interrelationships and complex mediator networks important for cell homeostasis can be appreciated. Cell membranes are composed of a bilayer that contains phospholipids, fatty acids, integral membrane proteins, membrane-associated proteins, sphingolipids, and so on. The membrane composition of many cell types has been established. The components' organization and effect on cell function remains to be established, however, and is a quest for lipidomics. Here, we review liquid chromatography tandem mass spectrometry-based lipidomic analyses to address bioactive lipid mediators in signaling pathways and the roles of lipid-derived mediators in resolution of inflammation.

Animals↗
PubMed2005

Informatics and mass spectrometry challenge.

For the first time this year, we would like to invite you to participate in the Analytical Challenge, which is a series of puzzles to entertain and challenge our readers. We hope that you not only find this feature stimulating but that it provides you with points of further interest for your work and study. And please note: there is a prize to be won (a Springer book from our catalogue up to a value of 75 Euros).These Analytical Challenges are published every two months. Two years ago, we first began with a series of spectroscopy challenges by Ernö Pretsch and Renato Zenobi, which may still be viewed on the 'Springer' chemistry website www.springeronline.com. Mass spectrometry is the topic in the present challenge. Please read on...

Journal Article↗