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At least 1,603 records · Page 89Linked to original sources
PubMedDate not supplied

[Natural remedies and hormone preparations--potential risk for breast cancer patients. A study surveys the use of agents which possibly counteract with the treatment].

We have studied the use of complimentary alternative medicine (CAM) among 233 consecutive breast cancer patients operated on at the Lund University Hospital, Sweden between 2002 and 2004. Questionnaires were administered preoperatively (n = 233), and again 3-6 months post-operatively (n = 167) and one year after surgery (n = 88). At baseline, 14,5% used CAM, 3-6 months post-operatively 14,4% used CAM and one year after surgery 18,2% used CAM. The most common products contained omega-3, garlic, ginseng and roseroot. We identified use of 35 different types of CAM products and seven of these could potentially increase the risk of breast cancer or interact with tamoxifen or aromatase inhibitors: soy, garlic, ginko biloba, echinacea, ginseng, valerian and phytoestrogens (excluding soy). Five and a half percent of the patients used either hormone replacement therapy (HRT) or hormonal contraception at the pre-operative visit, after they had received their breast cancer diagnosis. In conclusion, it is important that doctors discuss the use of CAM and exogenous hormone therapy with their breast cancer patients given the prevalence of these drugs.

Antineoplastic Agents↗
PubMed2006

[Crude drugs for curing internal injury (NeiShang) caused by improper diet or fatigue in "NeiWaiShangBianHuoLun" and "PiWeiLun"].

In "NeiWaiShangBianHuoLun," written by LiGao in the 13th century, internal injury (NeiShang) caused by emotional strain, improper diet and overwork was compared against external injury (WaiShang) caused by exogenous pathogenic factors. A combination of Aurantii Fructus Immaturus and A tractylodis Rhizoma is used for treating the feeling of stuffiness and fullness in the gastric region (Pi) due to improper diet. For treatment of general debility and lassitude due to emotional strain, improper diet and overwork, BuzhongYiqiTang was invented, in which the combination of Ginseng and Astragali Radix is used to activate and reinforce the Qi-deficiency of PiWei (vital energy or digestive function). LiGao recommended the combination of Bupleuri Radix and Cimicifugae Rhizoma for treating loose tissues due to Qi-deficiency, and to assist drugs for replenishing Qi such as Ginseng and Astragali Radix. These uses of crude drugs for curing internal injury (NeiShang) may be useful for treating modern deficiency syndrome in weak children with atopic disposition and persons with postoperative complications.

Diet↗
PubMed1991

[Preliminary study on soilless cultivation techniques of Panax quinquefolium L].

Our experiment has shown 1. Vermiculite with sand (volume 1:1) is a good substrate of soil for American Ginseng. The yield and contents of ginsenoside of American ginseng in this soilless substrate are a little higher than those in ordinary soil. 2. This kind of substrate can be used continuously with fewer occurrences of insect pest and plant diseases and contributes significantly to the reduction of production cost.

Ginsenosides↗
PubMed1990

[Quantitative assay method for total saponins in Panax quinquefolium Api].

This article adopts macro-reticular resins to separate and get rid of water soluble impurities such as carbohydrate in Panax quinquefolium so as to determine its total saponin content by spectrophotometry. This method also yields good results in determining the total saponins in P. ginseng ora solution. For the control or appraise of the quality of preparations containing P. quinquefolium or P. ginseng oral solutions this method has practice value.

Honey↗
PubMed1989

Adaptogenic activity of Indian Panax pseudoginseng.

The crude extract and saponins of Indian pseudoginseng and saponins of Korean ginseng have been studied using a battery of biological tests in rats and mice. Indian pseudoginseng saponins were found to exhibit better activity than the Korean ginseng saponins in several tests employed. The results indicate a need for in-depth study of Indian pseudoginseng as an adaptogenic agent, after cultivation of the plant under controlled conditions.

Animals↗
PubMed1989

[Induction of phenotypic reverse transformation by plant glycosides in cultured cancer cells].

Crude ginsenosides extracted from the root of Panax ginseng C.A. Meyer inhibited the growth and colony forming ability of Morris hepatoma cells in soft agar suspension culture, and stimulate the serum protein synthesis of these cells, thus converting the cell characteristics both functionally and morphologically to those resembling original normal liver cells. We have called such a phenomenon "reverse transformation" or "redifferentiation" which can be regarded as decarcinogenesis. In this report, the results of our recent investigations are presented with particular reference to reverse transformation of B16 melanoma cells induced by ginsenoside Rh2 isolated from the methanol extract of crude ginseng saponin fraction and action mechanisms of ginsenoside Rh2 are also discussed.

Cell Differentiation↗
PubMed1982

[Anti-allergic actions of traditional oriental medicine--actions against types I and IV hypersensitivity reactions].

A study was carried out to examine the effects of 23 kinds of crude drugs and 3 kinds of blended Chinese traditional medicines on Type I and Type IV allergic reactions. Forty eight-hr homologous PCA in rats as a typical model of the Type I reaction using anti-dinitrophenylated ascaris . IgE serum was significantly inhibited by the oral administration of the following drugs: Aqueous extracts: Aurantii F.i., Bupleuri R., Schizandrae F., Scutellariae R., Zizyphi F., and Shohsaiko-to and Methanolic extracts: Asiasari R., Aurantii F.i., Bupleuri R., Ginseng R., Glycyrrhizae R., Magnoliae C., Schizandrae F. and Trichosanthis S., Contact dermatitis in mice as a model of the Type IV reaction caused by picryl chloride was significantly inhibited by the oral application of aqueous extracts of Ginseng R. and Magnoliae C. as well as the powder of Hoelen. The aqueous extract of Saiboku-to also showed an inhibition of the contact dermatitis, and it significantly potentiated the inhibition of contact dermatitis by prednisolone.

Animals↗
PubMed1995

Anticholinergic poisoning due to Chinese herbal medicines.

Serious poisoning may occur following the consumption of Chinese herbal medicines (CHM) containing anticholinergics. The great majority of cases are probably related to the use of yangjinhua, the dried flower of Datura metel L, for treating bronchial asthma, chronic bronchitis, pains and flu symptoms. In some cases the use of CHM contaminated by atropine-like substances or fake herbs were suspected. Some ginseng (Panax ginseng) preparations might have been adulterated with Mandragora officinarum (scopolamine) and other herbs.

Cholinergic Antagonists↗
PubMedDate not supplied

[The role of proteins in the immunomodulating effect of bioginseng products].

Immunomodulating properties of the bioginseng preparations (Panax ginseng), isolated from the cell culture of ginseng calluses, were studied in model experiments of acquired immunodeficiency developed as a result of long-term protein starvation or after vinblastin administration. The following preparations were studied: 1) preparation obtained by means of the cell culture cryoconcentration, 2) ethanol extract of the cell culture, 3) high-molecular protein containing fraction of the bioginseng I. Under conditions of acquired immunodeficiency all the preparations studied were shown to increase the content of antibody producing cells developed in response to sheep erythrocytes administration, while the highest effect exhibited the bioginseng preparation III. These data suggest that proteins are of great importance in the immunomodulating effects of bioginseng preparations.

Adjuvants, Immunologic↗
PubMed1993

[Inductive differentiation effect of ginsenosides on human acute non-lymphocytic leukemic cells in 58 patients].

Ginsenosides are the main active component of Panax ginseng. It has been shown that ginsenosides have antineoplastic, antiaging, immunologic function enhancing and other pharmacological actions. In this article, result of experimental studies showed ginsenosides extracted from stem and leaf of Panax ginseng (GSL) has inductive differentiation effect on all types of acute nonlymphocytic leukemia cells in primary culture. The effect on M5, M4 was most potent, followed by M1, M2 and the least, on M3. Through analysis, it was considered that the inductive differentiation effect of ginsenosides might be due to the comprehensive effect of increasing intracellular cAMP and inducing interferon. Since GSL have some other important actions, therefore, if it could be used as a differentiation inducer in clinical practice or combined with other antineoplastic drugs, it would show co-antineoplastic actions in many aspect.

Adolescent↗
PubMedDate not supplied

[An antimutagenicity study of bioginseng].

We studied antimutagenic properties of bioginseng, a biotechnological product obtained from the callus culture of the ginseng root cells by alcohol extraction (bioginseng-1) and lyophilization (bioginseng-2). We have estimated the frequency of sister-chromatid exchange and chromosome aberrations in the culture of Chinese hamster cells, of chromosome aberrations in cells of the Ehrlich-ICF ascite strain, and of micronuclei in the mouse bone marrow cells. The bioginseng exerted an antimutagenic effect with respect to nitrosomethylurea and cyclophosphamide. The sister-chromatid change in the culture of Chinese hamster cells decreased under the influence of bioginseng due, apparently, to enhanced DNA repair. The most distinct protective effect was observed when ginseng was introduced 2 h prior to the cell treatment with mutagens.

Animals↗
PubMed1993

[Effect of hyperglycemia on insulin release from isolated rat pancreatic islets].

We investigated the long-term (24h) influence of high concentration glucose (26.4mmol/L) on insulin release by culturing collagenase isolated rat pancreatic islets in vitro. The cultured islets were morphologically normal by histological examination. Compared with freshly isolated islets, islets cultured in 26.4mmol/L glucose showed higher basal insulin release (P < 0.05). The effect of high glucose was time dependence. When islets preexposed to high glucose medium for 24h were perfused, the basal insulin release was significantly higher than that of freshly isolated islets, the first-phase glucose stimulated insulin release disappeared, and the second-phase was diminished. Islets cultured in high glucose medium showed increased sensitivity to L-arginine. Long-term high concentration glucose could potentiate the arginine-induced release. When added to the culture medium with 26.4mmol/L glucose, Ginseng saponins markedly increased the responsiveness of islets to glucose stimulation, and augmented the sensitivity of incubated islets to additional Ginseng saponins.

Animals↗
PubMed1993

[Inhibitory effects of oral administration of ginsenoside Rh2 on tumor growth in nude mice bearing serous cyst adenocarcinoma of the human ovary].

We examined the inhibitory effect of the oral administration of ginsenoside Rh2 (Rh2) on tumor growth in nude mice bearing human ovarian cancer cells (HRA). In the first experiment, it was revealed that daily administration of 30 microM Rh2 significantly inhibited tumor growth. In the second experiment, therefore, various concentration of Rh2 (1, 15, 30, 60, 120 microM) were administered every day for 91 days, beginning the day after tumor inoculation. Treatment with Rh2 resulted in a remarkable retardation of the HRA cell tumor growth. In particular, tumor growth in mice treated with 15, 30 and 120 microM Rh2 was significantly inhibited, compared to that in CDDP treated mice as well as in untreated mice. Consequently, 50% survival in nude mice treated with 15, 30 and 120 microM Rh2 was significantly prolonged, compared to that not only in untreated mice but also in CDDP treated mice. No side effect was observed in any mice treated with Rh2. Red ginseng containing Rh2 has been used exclusively, orally administered. In the present study, we considered that oral administration of Rh2, which is a component of red ginseng, has strong inhibitory effects on human ovarian cancer cell growth in nude mice.

Administration, Oral↗
PubMedDate not supplied

Dietary supplement users: demographics, product use, and medical system interaction.

BACKGROUND: Dietary supplements-defined as vitamins and minerals, herbal products, tissue extracts, proteins and amino acids, and other products-are purchased to improve health and prevent disease. Little has been published, however, about the characteristics of either the products or the people who use them. METHODS: Consecutive customers visiting two health food stores during a 15-day period were interviewed by telephone. They were asked about their use of dietary supplements, demographics, and their use of the established health care system. RESULTS: Of the 194 customers contacted, 136 (70.1 percent) completed the survey. Respondents took a total of 805 supplements, most often to prevent a health problem (84.3 percent). Herbal products were most commonly used. Garlic, ginseng, and Ginkgo biloba were the herbs most frequently used. Fifty products were found to have previously reported toxicities, including vitamin A, which 9 customers were taking in megadoses. Most customers were white (94.1 percent), female (75.7 percent), had at least 1 year of college education (70.6 percent), had health insurance (95.6 percent), and had a regular physician (85.3 percent). CONCLUSION: Most of the dietary supplements consumed appear to be safe, but 50 of 805 had previously reported toxicities including megadoses of vitamin A. Garlic, ginseng, and Ginkgo biloba were the most commonly ingested herbs, and the medical literature supports their effectiveness for some conditions in humans. Customers of two health food stores had average to above-average education and took dietary supplements to stay healthy. They used the conventional health care system but did not typically consult their physician about dietary supplements. The pattern of use suggests that physicians might not be adequately addressing preventive and wellness issues in discussions with their patients. Furthermore, physicians might need to learn about dietary supplements so they can communicate with patients about them.

Adult↗
PubMedDate not supplied

Herbal therapy: what every facial plastic surgeon must know.

Herbal medicine (phytomedicine) uses remedies possessing significant pharmacological activity and, consequently, potential adverse effects and drug interactions. The explosion in sales of herbal therapies has brought many products to the marketplace that do not conform to the standards of safety and efficacy that physicians and patients expect. Unfortunately, few surgeons question patients regarding their use of herbal medicines, and 70% of patients do not reveal their use of herbal medicines to their physicians and pharmacists. All surgeons should question patients about the use of the following common herbal remedies, which may increase the risk of bleeding during surgical procedures: feverfew, garlic, ginger, ginkgo, and Asian ginseng. Physicians should exercise caution in prescribing retinoids or advising skin resurfacing in patients using St John's wort, which poses a risk of photosensitivity reaction. Several herbal medicines, such as aloe vera gel, contain pharmacologically active ingredients that may aid in wound healing. Practitioners who wish to recommend herbal medicines to patients should counsel them that products labeled as supplements have not been evaluated by the US Food and Drug Administration and that no guarantee of product quality can be made.

Blood Loss, Surgical↗
PubMed2004

Incidence and severity of potential drug-dietary supplement interactions in primary care patients: an exploratory study of 2 outpatient practices.

BACKGROUND: To explore the incidence and severity of potential interactions between prescription medications and dietary supplements. METHODS: A survey was conducted on dietary supplement use in 458 veteran outpatients currently taking prescription medications. Self-reported dietary supplement use was cross-referenced with each patient's prescription medication list, and potential interactions were identified from several tertiary sources and medical literature searches. RESULTS: One hundred ninety-seven patients (43%) were currently taking at least 1 dietary supplement with prescription medication(s). The most common products included vitamins and minerals, garlic, Ginkgo biloba, saw palmetto, and ginseng. Among these, 89 (45%) had a potential for drug-dietary supplement interactions of any significance. Most of these interactions (n = 84 [94%]) were not serious based on limited available evidence, giving an incidence of 6% (5/89) of potentially severe interactions among patients taking interacting drugs and dietary supplements and 3% (5/197) among patients taking coincident dietary supplements and medications. CONCLUSIONS: Although the use of dietary supplements appears to be very common among patients who also take prescription medications, most potential drug-dietary supplement interactions found were not serious. However, literature support was sparse at best. Health care providers should continue to inquire about dietary supplement use and consider the potential for interactions, regardless of their severity.

Dietary Supplements↗
PubMed2005

Recent trends in use of herbal and other natural products.

BACKGROUND: The benefits of herbal and other natural products (dietary supplements) are increasingly cited in the media. Dramatic increases in use reported during the last decade have led to growing concerns about efficacy and safety. METHODS: To determine which dietary supplements American adults use, whether the prevalence has continued to increase in recent years, and whether popularity of individual supplements has changed, demographic information and details of use of all medicines and dietary supplements in the preceding week were obtained by telephone interview from February 1998 through December 2002 from households in 48 contiguous states and the District of Columbia. Participants included randomly selected residents of households with telephones; compared with 2000 US Census data, participants were representative of the US population. The main outcome measure was the weekly prevalence of dietary supplement use, alone or in a multicomponent product. RESULTS: There were 8470 subjects 18 years or older. The annual prevalence of dietary supplement use increased from 14.2% in 1998-1999 to 18.8% in 2002. Although use did not change among younger subjects, it doubled for men and women 65 years or older. Use of Ginkgo biloba and Panax ginseng declined during the study, while lutein use increased dramatically, because of its addition to multivitamin products. The overall 2002 prevalence excluding lutein use was 13.9%. CONCLUSIONS: The popularity of specific supplements has varied over time and differs according to age and sex. The sharp increase in supplement use in the 1990s appears to have slowed. However, the addition of supplements, such as lutein and lycopene, to mainstream multivitamins has become an important source of exposure.

Adult↗
PubMed2006

Factors associated with dietary supplement use among prescription medication users.

BACKGROUND: We examined the patterns of nonvitamin dietary supplement (NVDS) use among adult prescription medication users in the United States. METHODS: Using the 2002 National Health Interview Survey, we analyzed factors associated with NVDS use and prescription medication use in the prior 12 months with descriptive, chi(2), and logistic regression analysis. RESULTS: In the United States, 21% of adult prescription medication users reported using NVDSs in the prior 12 months. Of the respondents who used both prescription medications and NVDSs in the prior 12 months, 69% did not discuss this use with a conventional medical practitioner. Among adults who used prescription medications in the prior 12 months, the most commonly used supplements included echinacea, ginseng, ginkgo, garlic, and glucosamine chondroitin. Prescription medication users with menopause and chronic gastrointestinal disorders had the highest rates of NVDS use (33% and 28%, respectively), and prescription medication users with coronary heart disease and history of myocardial infarction had the lowest rates of use (12% each). In the adjusted analysis, factors associated with increased use of NVDSs by prescription medication users included being female, being Hispanic, having more years of education, living in the West, lacking medical insurance, and having chronic conditions. Elderly respondents were less likely to use NVDSs. CONCLUSION: One in 4 prescription medication users took an NVDS in the prior 12 months, yet the majority did not share this with a conventional medical professional.

Adult↗