Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Color Vision”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,603 records · Page 89Linked to original sources

[Suggestions for the design of a modern anomaloscope].

Three variants of a new anomaloscope principle are described. This principle is distinguished by the fact that for generation of the mixed color and the reference color three interference filters with narrow band widths are used instead of an expensive dispersion prism. In the first variant the brightness of the mixed color field and the reference field is determined by three detectors (silicon diodes) and kept constant taking the relative spectral response into consideration. The degree of anomalous color vision present is indicated digitally by a microprocessor whose interface also permits data processing equipment to be connected. The second variant uses only one detector which sequentially pulses the three light sources and distributes the results to different signal channels for further processing. In the third variant, measurement is performed in the same way as in the second variant but with only one light source. Fiber optic bundles illuminate of the mixed color and reference fields and also permit adaptation of the eye to neutral. In this case additional optical attenuators are required to keep the luminance of the fields constant. An advantage shared by all three variants is that they have virtually no moving parts, employing monochromatic filters and cemented prism blocks with high-quality electronics. This has made it possible to produce a compact, rugged and efficient new-generation anomaloscope, which renders the considerable calibration and maintenance work previously necessary superfluous.

Color Perception↗

[Cerebral achromatopsia without prosopagnosia, alexia, object agnosia].

A 62-year-old woman was admitted for a disorder of color vision. This cerebral achromatopsia was isolated, without prosopagnosia, alexia, object agnosia. MRI showed bilateral temporo-occipital infarcts, including lingual and fusiform gyrus. Neuropsychological examination and topographic hypotheses are discussed.

Color Perception↗

The absence of the Ives effect in a deuteranope.

Ives found that when monochromatic stimuli are matched to white by flicker photometry, they are not equal in brightness to the white by direct comparison, and the discrepancy is minimal for yellow but is increased for longer and shorter wavelengths. On the two sides of yellow, the colors are more saturated, and Ives postulated that brightness involves the sum of a chromatic component and an achromatic component and that the chromatic component varies with the saturation. In the case of a deuteranope, one would expect a vigorous chromatic response for yellow and blue stimuli but a poor response for the neutral part of the spectrum. The Ives effect is virtually nonexistent for subject SR, who is a deuteranope. In terms of the zone theory of color vision, this would mean that the blue-yellow chromatic channel contributes little or nothing to brightness. In a normal observer, the blue-yellow mechanism can be isolated by using blues and yellows depurified with white, but in this case the Ives effect is found to exist.

Adult↗

Nomograms for the assessment of Farnsworth-Munsell 100-hue test scores.

Although the Farnsworth-Munsell 100-hue test is a sensitive means of evaluating congenital and acquired color vision deficiencies, using the data it provides involves complex calculations. We have developed two nomograms that permit the clinician to determine quickly and easily whether a given score is normal for the patient's age and whether the difference between fellow eyes is within the normal range.

Adult↗

[Molecular genetic findings in patients with congenital cone dysfunction. Mutations in the CNGA3, CNGB3, or GNAT2 genes].

PURPOSE: This study compares clinical and molecular genetic findings in patients with congenital cone dysfunction. METHODS: In this study 28 patients underwent a basic ophthalmologic examination. Except for a 1-year-old boy, color vision, perimetry, and full-field ERG (ISCEV standard) were evaluated in all patients. Blood samples were taken for molecular genetic analysis of the CNGA3, CNGB3, or GNAT2 genes. RESULTS: Two patient groups could be distinguished: patients without and with residual cone function in the ERG. In 14 of 17 patients without cone function, mutations in one of the three genes were detected, and except for one patient mutations in both alleles could be determined. In these patients, visual acuity was reduced to 20/400 and color discrimination was absent. In 2 of 11 patients with residual cone function, mutations in one allele of the CNGB3 gene were detected. It is of interest that 6 of 16 patients with mutations perceived their disease as progressive; in three of them we could determine a progression. Only in 4 of 16 patients was the ocular fundus normal. The other patients with mutations presented with central pigment irregularities, attenuated vessels, or pale optic disk. CONCLUSION: In patients with congenital cone dysfunction without cone function in the ERG, an analysis of the CNGA3, CNGB3, or GNAT2 gene is advisable. In contrast, patients with residual cone function did not show clear association with mutations in one of the three genes. In patients with mutations, retinal alterations and nystagmus are frequent. In contrast to the designation of these disorders as stationary, in some patients with mutations in the CNGA3 and CNGB3 gene slow progression was observed.

Adolescent↗

[Polymyalgia induced by topical minoxidil].

Topical minoxidil, used in the treatment of baldness, has been commercially available since 1987. Its systemic side effects are rare. We observed an as yet unreported "polymyalgia syndrome" in four otherwise healthy males whose sole medication was topically applied minoxidil. They experienced fatigue, weight loss and severe pain in the shoulders and pelvic girdle, suggesting connective tissue disease. Three patients had a transient rise in liver enzymes, while other laboratory analyses remained normal. Tritanomaly was detected in two patients who underwent systematic color vision testing. All symptoms disappeared after withdrawal of minoxidil. Rechallenge was positive once in one patient and twice in another. The mechanism of this side effect remains to be determined.

Administration, Topical↗

Visual dysfunction in workers exposed to a mixture of organic solvents.

The aim of this study was to investigate the relationship between the workers occupationally exposed to a mixture of organic solvents and their visual functions. Here the visual functions included color vision (CV), visual contrast sensitivity (CS) and visual evoked potentials (VEP). Test subjects were 182 workers at 53 furniture factories in the same industrial area of Japan. As control, a group consisted of 96 workers without exposure to any organic solvent was also tested. Exposure assessments were made both by the environmental concentration and biological monitoring. CV and CS tests were carried out for all the subjects. VEP was measured for 21 exposed subjects who were considered to have impaired CV and CS. In the results, the color confusion index (CCI) values of the exposed subjects were significantly higher than that of the age-matched controls (P<0.01). Their CS values were significantly lower than those in the controls at spatial frequencies of 6 and 12 cycles per degree (cpd) (P<0.01 and <0.05, respectively). A significant correlation between the concentration of urinary methylhippuric acid and contrast sensitivity was found by a multiple regression analysis (P<0.05). CCI showed a negative correlation at all spatial frequencies of CS in a simple regression analysis, no abnormal data were found by the VEP test in the exposed subjects who were found to have impaired CV and CS. The results suppose that a low concentration of the mixed organic solvents might affect the retina and optic nerve. However, it needs to be further researched if such an impact affects the Brodmann's areas of visual cortex in the brain.

Adult↗

Visual handicaps of mentally handicapped people.

Recent literature concerning visual handicaps of mentally handicapped people was reviewed. Topic areas considered were etiology and epidemiology, visual acuity, color vision, and educational techniques. The material considered indicated that a large proportion of mentally handicapped people are affected by some form of visual handicap and the extent to which further specialization of care and training techniques is required in order to limit the extra disadvantages imposed by such defects.

Adolescent↗

Visual results of a long-term trial of a low-arginine diet in gyrate atrophy of choroid and retina.

Visual function has been serially assessed in two gyrate atrophy patients who have had long-term reduction of plasma ornithine concentrations by a low-arginine diet. One patient demonstrated subjective and objective improvement after 15 months of treatment. In addition to improvements in dark adaptation thresholds, enlargement of visual fields, and a more normal electroretinogram, there was marked improvement in cone function as measured by color vision. There has been no change noted in the second patient. These results suggest that reduction of plasma ornithine may be beneficial in gyrate atrophy patients and that the high ornithine concentrations characteristic of this disorder play some role in the pathophysiology.

Adult↗

[X-linked blue cone monochromatism. A familial case report].

CLINICAL CASE: A family affected by X-linked blue cone monochromatism is presented. There are 4 male affected individuals and 9 female carriers. DISCUSSION: The diagnosis of blue cone monochromatism is based on severely affected color vision with preserved blue function, poor visual acuity, nystagmus, nearly absent photopic ERG, and a family pedigree compatible with X-linked inheritance. The female carriers showed normal visual function and ocular motility. It is important to be familiar with non progressive cone dysgenesis in order to make a genetic diagnosis of the illnesses in this group.

Adult↗

Toxic optic neuropathy after concomitant use of melatonin, zoloft, and a high-protein diet.

Melatonin is a neuromodulating hormone found in the pineal gland and retina. It is involved in light-dark circadian rhythms and mediates retinal processes in a manner antagonistic to that of dopamine. Zoloft (sertraline) is an antidepressant drug that blocks the reuptake of serotonin at the neural synapse. Serotonin is the natural precursor of melatonin. A 42-year-old woman sought treatment for visual acuity loss, dyschromatopsia, and altered light adaptation. Neuro-ophthalmologic examination was otherwise normal except for evolving bilateral cecocentral scotomas. She had taken Zoloft for 4 years and began a high-protein diet with melatonin supplementation 2 weeks before onset of visual symptoms. Visual acuity and color vision improved within 2 months after melatonin and the high-protein diet were discontinued. Combined use of melatonin, Zoloft, and a high-protein diet may have resulted in melatonin/dopamine imbalance in the retina, manifesting as a toxic optic neuropathy. Physicians and patients should be alerted to this potential drug interaction.

Adaptation, Ocular↗

Measuring short-wavelength-sensitive cone discrimination thresholds using pseudoisochromatic figures displayed on a color monitor.

PURPOSE: To simplify the testing of short-wavelength-sensitive (SWS) cone function in the clinic. METHODS: SWS-cone discrimination thresholds were measured along the tritan axis using pseudoisochromatic figures displayed on a color monitor. A circular 6 degrees field, containing spatially discrete patches of varying sizes and luminances, was presented on a background. A subset of patches formed the target patch in the shape of a C. Eight subjects with normal color vision reported the direction of the gap in the C using a cursor controlled by a joystick. DATA: were expressed in units of SWS-cone trolands. RESULTS: SWS-cone discrimination threshold increased slowly as the SWS-cone trolands of the starting chromaticity increased. The dependence of the threshold on the SWS-cone activation level was similar to literature reports of chromatic discrimination measured with conventional paradigms. CONCLUSIONS: The advantages of this method: (a) It is a simple intuitive task for patients. (b) The paradigm can be implemented with an 8-bit/gun color monitor. (c) The test avoids the need to define equiluminance for the individual patient before the color test is administered. This method can provide a useful technique for measuring SWS-cone function in a clinical population.

Adult↗

Differential diagnosis of congenital tritanopia and dominantly inherited juvenile optic atrophy.

To determine whether congenital tritanopia and dominantly inherited juvenile optic atrophy (DIJOA) are the same clinical entity, we used electroretinograms of the blue-sensitive cone system (blue cone ERGs), comparing those of two patients with congenital tritanopia from two pedigrees with those of four patients with DIJOA from two pedigrees. The examinations also included visual acuity and visual field tests, fundus examination, the dark-adaptation test, and several color vision tests. The blue cone ERG confirmed a difference between the two groups; it was unrecordable in the patients with congenital tritanopia but within the normal range in those with DIJOA. We believe that congenital tritanopia and DIJOA are distinct disease entities and that the blue cone ERG is a key factor in the differential diagnosis.

Adult↗

Pigmented paravenous retinochoroidal atrophy. Discordant expression in monozygotic twins.

We studied a 43-year-old woman affected with pigmented paravenous retinochoroidal atrophy and her unaffected monozygotic twin. The affected twin had stable visual acuity (20/25), typical fundus findings, markedly constricted visual fields, abnormal color vision, and an abnormal electroretinogram, all consistent with pigmented paravenous retinochoroidal atrophy. Results of examinations and studies in her twin were entirely normal. Fingerprinting for DNA performed on the twins strongly supported monozygosity. Our findings suggest that either our patient did not inherit pigmented paravenous retinochoroidal atrophy or that an unusual (nonmendelian) genetic mechanism occurred.

Adult↗

Bull's-eye maculopathy and negative electroretinogram.

The authors studied four patients with a bull's-eye maculopathy and otherwise normal fundus. A single-flash electroretinogram (ERG) with an intense white light stimulus in the dark showed a normal a-wave but reduced b-wave amplitude (negative ERG). Other findings common to all four patients were initially normal visual acuity, subsequent progressive decrease in visual acuity, mild to moderate deficiency of color vision, normal peripheral visual field, relatively well preserved cone ERG, normal 30-Hz flicker ERG, normal EOG, near emmetropia and selective involvement in males. Cone dystrophy, retinitis pigmentosa, congenital retinoschisis, congenital stationary night blindness, and Batten's disease were excluded. The correlation between this disease and benign concentric annular macular dystrophy is discussed.

Adult↗

Association and dissociation of visual functions in a case of bilateral occipital lobe infarction.

A severe restriction of the visual field was observed in a patient suffering a bilateral occipital lobe infarction. Soon after the lesion, the visual field had an angle of approx. 4 degrees. Some recovery was observed within the following months. Within the restricted visual field, several visual functions were tested. Increment threshold, for instance, was found to be one log unit higher than would normally be expected. Color vision was completely lost soon after the lesion, but some recovery was later observed. Although binocular interaction was demonstrated by the interocular transfer of after-effects, the patient never experienced steropsis. He also seemed unable to recognize faces. Dsepite the small visual field, optokinetic nystagmus could be elicited. A notable slowing down of visual analyses was observed in experiments on visual reaction time, on the inversion of the Necker cube, and on binocular rivalry. The complete loss of certain functions like steropsis or face recognition in contrast to a quantitative reduction of other functions like visual acuity or color perception can be discussed in the light of two conceptual models of perceptual processing. One model suggests the representation of different visual functions within one neuronal network, each function represented by a different number of neurons or a different algorithm within the network. The second model suggests a spatial segregation of different visual functions in different cortical areas that receive input from one common structure, presumably the striate cortex.

Aged↗