[Change in electrical activity of the cerebral cortex of dogs during formation of a stereotype of motor conditioned reflexes].
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Results from previous studies on monkeys and human subjects have demonstrated that the biceps brachii spinal stretch reflex (SSR) can be operantly conditioned. The extent to which conditioning paradigms influence contralateral SSRs or longer latency responses in the same limb has not been examined. Nine subjects were given 10 training sessions to either increase or decrease the size of their biceps brachii SSR. Group changes were compared to the mean of six baseline (control) sessions. Both groups showed progressive SSR changes over the training sessions. Up-trained subjects increased their SSR responses by an average of 135.3% above baseline, with the last three sessions showing a 237.5% increase, while down-trained subjects reduced their average SSR responses by 43.4%, with a 52.7% reduction over the last three sessions. ipsilateral longer latency responses showed average changes of 68.9% and -68.7% for up- and down-trainers, respectively. As in the case of SSRs, these responses changed progressively over sessions, with a 131.5% increase seen in the last three up-training sessions and an 82.4% reduction over the same period for down-trainers. Correlation coefficients between SSR and longer latency responses were high (R = 0.90, up-trainers; R = 0.87, down-trainers). Contralateral SSR and longer latency responses, measured in the absence of feedback and at least 10 min after ipsilateral conditioning, showed directional changes that were similar to the trained side, but their magnitudes were not as profound. Collectively, these data suggest that unilateral SSR conditioning affects spinal circuits controlling contralateral SSRs and influences longer latency responses.
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Recent research on the role of classical conditioning in homeostatic regulation (Dworkin, 1993; Siegel, Krank & Hinson, 1987) has underscored the potential importance of the work of earlier Eastern-European work on physiological conditioning. The present article is a translation and discussion of a paper on blood glucose conditioning, first published in 1954 by the Russian physiologist M.I. Mityushov. Mityushov was able to demonstrate conditioned hypoglycemia in humans and dogs after using an injection procedure as the CS and intravenous glucose as the UCS. The translation is preceded by a general introduction and followed by a reanalysis and discussion of Mityushov's results.
In cats with a preliminarily learned conditioned avoidance reaction, stimulation of the caudate nucleus inhibited behavioral response by lengthening its latency and reducing the number of conditioned reactions. Intensity of the inhibitory effect did not substantially depend on the localization of electrodes in the head or body of the nucleus and weakened within a few experimental days. D,1-amphetamine (0.5 to 4 mg/kg) and caffeine (10 to 10 mg/kg) suppressed the caudate inhibition, but the action of the drugs was manifested in different ways. The influence of large doses of d,1-amphetamine was characterized by a serious disturbance of behaviour and caudate inhibition of conditioned responses.
Alimentary conditioned response to the sound of turning of the feeding-rack reinforced in 33 and 25 per cent of cases was formed faster in rats with frontal cortical lesion than in intact animals. The results obtained permit to suppose that during integrative brain activity the frontal areas of the cerebral cortex participate in organization of behavior with a high probability of reinforcement.
Conditioned fore-leg movement was elaborated in cats to the electrical stimulation of the ventrolateral thalamic nucleus through one of the two chronically implanted electrodes (1+) and differentiation to a stimulation through the other electrode (2-). Then the signal meaning of the stimuli for the same animals was reversed (1-, 2+). Independently of the electrode through which the positive or differentiation stimulus was applied, the following was observed during the conditioned response: 1) in the biceps EMG a response to the conditioned stimulus was recorded with minimal latency of 8--12 ms; when the conditioned and differentiation stimuli were presented at random, the EMG response to the differentiation stimulation was considerably less pronounced or was totally absent: 2) Short-latency excitatory components of neuronal responses in the motor cortex to conditioned stimuli with a latency less than 6 and 12 ms were greater than the corresponding components of the response to differentiation stimuli.
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