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PubMed1992

Influence of a serotonin- and dopamine-rich diet on platelet serotonin content and urinary excretion of biogenic amines and their metabolites.

Using high-performance liquid chromatography and gas chromatography, we reevaluated the 24-h influence of a serotonin- and dopamine-rich diet on platelet serotonin and serotonin, 5-hydroxyindoleacetic acid (5-HIAA), and major catecholamine metabolites in the urine of 15 healthy adults. Although there were significant responses in urinary free serotonin and catecholamine metabolites, their concentrations did not exceed the upper limits of the reference ranges for any of the participants. For urinary 5-HIAA, pronounced effects were observed within 2-4 h. After 6-8 h, results for 11 participants exceeded the upper limit of the reference range. The median recovery of dietary serotonin as urinary 5-HIAA was 20% and subject to a large range (1-50%). There was no significant change in platelet serotonin. We conclude that, using specific analytical methods, no dietary restrictions need be imposed to diagnose catecholamine (metabolite)-producing tumors. For diagnosis of carcinoids on the basis of urinary 5-HIAA it is appropriate to completely abstain from serotonin-containing foods for greater than or equal to 12 h before testing. Platelet serotonin is a more sensitive marker for carcinoids that produce only small amounts of serotonin, and is unaffected by dietary serotonin.

Adult↗
PubMedDate not supplied

[Deamination reaction of biogenic amines and other nitrogen compounds during the long-term influence of ethylenediamine in an experiment on rats].

Activity and substrate specificity of monoamine oxidase (MAO) were studied in tissues of rats inhaling low concentrations of ethylene diamine for a long time. While the activity of MAO-A (serotonin as a substrate) was decreased in brain, functions of the enzyme were altered: the enzyme acquired the ability to deaminate glucosamine, which is not a substrate of MAO under normal conditions. Ethylene diamine-dependent modification of MAO was responsible for alterations of the enzyme catalytic properties involved in oxidation of substances with specific biochemical functions. A new drug diethon as well as ionol, pyrazidole and ascorbic acid were used in attempts to normalize the MAO properties; ionol proved to be the most effective compound. Detection of alterations in the MAO catalytic properties, developed after influence of the chemical factor at very low concentrations but without symptoms of toxicosis, may be used as a sensitive test for evaluation of early steps of ethylene diamine-produced intoxication. Ionol may be used for pathogenetic prophylaxis of ethylene diamine caused intoxication.

Amination↗
PubMedDate not supplied

[Effect of biogenic amines on glycogen degradation in isolated rat hepatocytes].

Serotonin and tyramine affected dissimilarly the enzyme activity involved in degradation of glycogen in isolated rat hepatocytes. Serotonin inhibited hydrolytic enzymes acid alpha-glucosidase, alpha-amylase and amylo-1,6-glucosidase but activated phosphorylase inducing a decrease of glycogen content in cells. Tyramine inhibited acid alpha-glucosidase and amylo-1,6-glucosidase, did not affect the alpha-amylase and phosphorylase activities and increased content of glycogen in cells. Tyramine may be used as stimulator of glycogen accumulation in liver cells.

Animals↗