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PubMedDate not supplied

Gene therapy: theoretical and bioethical concepts.

Gene therapy holds great promise. Somatic gene therapy has the potential to treat a wide range of disorders, including inherited conditions, cancers, and infectious diseases. Early progress has already been made in the treatment of a range of disorders. Ethical issues surrounding somatic gene therapy are primarily those concerned with safety. Germline gene therapy is theoretically possible but raises serious ethical concerns concerning future generations.

Adenoviridae↗
PubMed1985

When organs match and health beliefs don't. Bioethical challenges.

This paper addresses the problems that psychologically unprepared individuals may experience when the socioethnic aspects of their health belief systems are not addressed in the decision-making process for renal transplantation. Case studies of two Hispanic adolescents are presented. A cognitive behavioral therapeutic approach that specifically concentrates on changing health beliefs related to organ transplant is recommended to help maximize the probability of a successful transplant. Past assumptions by psychosocial transplant teams that make self-esteem the primary basis on which to predict transplant or therapeutic outcome are challenged. The exchange of scientific cognition modifying strategies to address health beliefs that are deleterious to biologic and psychologic survival are recommended as a critical part of biomedical engineering practice for the next decade.

Adolescent↗
PubMed2002

Attitudes to bioethical issues: a case study of a screening project.

Commonly expressed in theoretical discussions about ethical problems in the context of epidemiology and screening is the need for more data. A study was carried out involving 21 explorative interviews with participant and nonparticipant mothers in a neonatal research screening project in progress in Sweden, ABIS (All Babies in Southeast Sweden). The respondents were asked, by way of open-ended questions, to give their opinions about certain ethical issues: informed consent; reasons for joining/declining; surrogate decision; the collection, analysis and storage of written and "live" material (biobanks); intervention etc. The ethical implications mentioned in the literature mostly concern the risk of creating distress and anxiety (anxiety and possible stigmatisation in respect of positive or false-positive results, worry about material collected and stored, distress caused by blood sampling procedures, etc.). Our results do not support the idea that the risks are substantial. The respondents rather indicate an attitude of benevolence--they are positive both to the current research on children, to the material they contribute (both written material and "biomaterial"), to possible results and intervention plans. On the other hand the participants expressed concern about the storage of material and the right to be informed of any screening/project results. Further studies in this field are needed and would be of help in theoretical discussion, the work of ethical committees and the designing of, for example, screening and research projects.

Anxiety↗