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Results for “ACETYLSALICYLIC ACID”

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PubMed1992

[Fibrinolytic complexes of low-molecular heparin and acetylsalicylic acid].

Complexes of low-molecular heparin with acetylsalicilic acid was formed in vitro when the weight ratio of components was 1:1, 1:5 and 5:1, respectively. All the complexes possessed fibrinolytic and anticoagulating activities. The complex possessed the highest activity when the ratio of heparin to acetylsalicilic acid was 5:1. This complex at a dose 1 mg/200 g of rat weight had the largest thrombolytic effect on the experimental fresh thrombus.

Animals↗
PubMed1992

Effects of acetylsalicylic acid, chlormethine and glucose on cow's mammary gland.

It was found that 100 ml of 5% glucose solution, 200 ml of acetylsalicyclic acid or 200 ml of chlormethine introduced into udder quarter caused a temporary irritation of mammary gland in healthy cows after a single intramammary inlocation. The changes in milk manifested by an increase of somatic cells number, serum albumins level and LDH activity, and decreased lactose content disappeared after 48-60 hours.

Animals↗
PubMed1992

Concentrations of antibiotics in alveolar milk after intramammary inlocation of their different doses together with glucose, acetylsalicylic acid or chlormethine.

After intramammary introduction of penicillin (600 th. i.u.), streptomycin (0.5 g), cloxacillin (0.5 g), neomycin (0.5 g), erythromycin (0.5 g) and cefoperazone (0.25 g) in 100 ml of 5% glucose solution the antibiotics' concentrations in the alveolar milk remained for 24 hours or longer on the level higher than MIC in relation to staphylococci and streptococci isolated from cows mastitis. In the first 24 hours the growth of antibiotic activity was little influenced by chlormethine supplement. While addition of ASA increased concentration and prolonged the time of antibiotics remaining on the therapeutic level.

Animals↗
PubMed1992

[The use of acetylsalicylic acid as a platelet antiaggregant].

PURPOSE: To comprove the efficiency of acetyl salicylic acid (ASA) as platelet antiaggregant drug, a 100 mg/day dose base. METHODS: Two hundred and fifty-eight patients were studied between 1988 and 1990. Platelet functions were measured using an aggregometer plus ADP 5 as platelet aggregation inductor. RESULTS: Two groups were studied: 1st group, using ASA (111 patients), 91 hypoaggregants; 2nd group, not using ASA (147 patients), 120 normals, 12 hypoaggregants and 15 hyperaggregants. From the 2nd group, 91 had another evaluation under the use of ASA and showed a clear effect of the drug. CONCLUSION: The use of aspirin, 100 mg/day dose, is enough to reduce platelet antiaggregation.

Adolescent↗
PubMedDate not supplied

Indobufen vs acetylsalicylic acid plus dipyridamole in long-term patency after femoropopliteal bypass.

To compare the effects of indobufen (INB) with those of ASA+dipyridamole (DP) on graft patency, 113 patients undergoing femoropopliteal bypass surgery were randomly and blindly assigned to treatment with INB 400 mg daily or with ASA 900 mg daily plus DP 225 mg daily. Treatment started 2 days before surgery and lasted for 12 months. All patients underwent two angiographic examinations: the first early after surgery (mean 6 days) and the second at the end of the study (mean 368 days). The 1 year cumulative patency rate for INB was 60% higher but not statistically different from the ASA-DP group (53.2%). The relative risk (INB/ASA+DP) calculated by the Mantel-Haenszel test was 0.86 (confidence limits 0.54-1.35). Only the site of operation (above-knee or below-knee) has a significant prognostic value on the fate of the graft.

Aged↗