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At least 1,585 records · Page 88Linked to original sources
PubMed1989

The Hoffmann reflex from the flexor pollicis longus of the thumb in left-handed subjects: spinal motor asymmetry and supraspinal facilitation to Cattell's intelligence test.

The spinal motor asymmetry was studied in left-handers. Hand preference was assessed by Geschwind scores (GS), and hand skill by peg moving task, the reflex responses were recorded from the long flexor muscle of the thumb. The H-reflex could be elicited by averaging during cortico-spinal facilitation (voluntary isometric force). The Cattell's Culture Fair Intelligence Test was used to assess the individual differences in mental abilities. H-reflexes were found to be significantly larger on the left than the right side. The amplitude of H-reflex increased linearly with force applied to transducer by the thumb. This facilitation was more pronounced for the left than the right reflexes. Removal of the visual visual input caused facilitation in H-reflex (supraspinal disinhibition). Post-activation potentiation was also observed in H-reflex. There was a positive linear correlation between the degree of left-hand preference (-GSs) and left-hand skill. The correlation for the right-hand skill was not significant. There was a linear correlation between the degree of left-hand preference and the right minus left hand skill. There was an inverse correlation between left-hand skill and H-reflex from left. The correlation for the right side did not reach the 5% significance level. The force-reflex relation did not show any significant change to IQ for the right H-reflex. The left H-reflexes were significantly larger in subjects with high IQ than those with low IQ. The regression line and its slope for the force-reflex relation on the left was found to be higher in subjects with high IQ than those with low IQs. There was a positive linear relationship between IQ and H reflex from left. The correlation for the right side was not as pronounced as that for the left side. The left minus right H reflex was also positive linearly correlated with IQ. These results provide further evidence for the psycho-motor hypothesis (Tan. 1988b) as well as the spinal motor asymmetry to handedness. It was suggested that lateralization of cognitive and motor functions would be essential to create subjects with high psychomotor capacity.

Adolescent↗
PubMed1991

The relationships between nonverbal intelligence and the strength of left-hand preference in left-handers to sex and familial sinistrality.

The relationship between the strength of left-handedness and spatial reasoning ability was studied in left-handed male and female subjects with and without familial sinistrality (FS). The degree of left-handedness was assessed by the Edinburgh Handedness Inventory. The spatial reasoning ability was measured by Cattell's Culture Fair Intelligence Test. It was found that there was a negative linear correlation between nonverbal IQ and the strength of left-handedness in females with and without FS, a quadratic relationship in male left-handers without FS and a positive linear correlation in male left-handers with FS. These results indicate that the brain may exhibit different patterns of cerebral organization in left-handers to sex and FS. It was concluded that the "crowding" hypothesis may apply only to a subgroup of left-handers, i.e., females with a greater bilaterality of cognitive functions than males.

Adolescent↗
PubMed1999

[Birth weight as a predictor of young men's intelligence. A historical cohort study].

The objective was to examine the relation between birth weight and cognitive function in young adult life. The study includes 4300 Danish conscripts born between 1973 and 1975, and the main outcome measure was the mean score in the Børge Prien IQ test at drafting. The score is the number of correct answers to 78 questions and it correlates with full scale intelligence quotient (IQ). Data on birth weight were collected from the birth registry. The mean score in the Børge Prien test increased from 39.9 at a birth weight of < or = 2500 g to 44.6 at a birth weight of 4200 g after adjustment for gestational age and length at birth, maternal age and parity, and other variables. Above a birth weight of 4200 the test score decreased slightly. Birth weight is associated with cognitive performance in young adult life and factors that interference with foetal growth may influence adult cognitive performance.

Adolescent↗
PubMed1976

The Peabody Picture Vocabulary Test as a measure of intelligence in children with palatal problems.

The Peabody Picture Vocabulary Test and the Wechsler Intelligence Scale for Children were administered to 33 children with palate problems. The correlations between PPVT and Wechsler IQ's ranged from .45 to .50 indicating that the Peabody is only a moderately good predictor of WISC scores in this population and suggesting that its utility in cleft palate children is limited. Additional data on the PPVT-WISC relationships are also presented and discussed.

Adolescent↗
PubMed2002

Stimulation seeking and intelligence: a prospective longitudinal study.

The prediction that high stimulation seeking 3-year-olds would have higher IQs by 11 years old was tested in 1,795 children on whom behavioral measures of stimulation seeking were taken at 3 years, together with cognitive ability at 11 years. High 3-year-old stimulation seekers scored 12 points higher on total IQ at age 11 compared with low stimulation seekers and also had superior scholastic and reading ability. Results replicated across independent samples and were found for all gender and ethnic groups. Effect sizes for the relationship between age 3 stimulation seeking and age 11 IQ ranged from 0.52 to 0.87. Findings appear to be the first to show a prospective link between stimulation seeking and intelligence. It is hypothesized that young stimulation seekers create for themselves an enriched environment that stimulates cognitive development.

Achievement↗
PubMed1999

[Experimental study on anti-oxygen and promoting intelligence development of Codonopsis lanceolata in old mice].

The water labyrinth test and determining lipid peroxide (LPO) contents were used to assay the effects of Codonopsis lanceolata on promoting intelligence development and lipid peroxide. The results showed that latent period of old mice in water labyrinth was statistically shorten and the number of mistake of old mice was visibly reduced by drinking extraction of Codonopsis lanceolate 4 g/kg and 8 g/kg. These indicated that mice drinking extraction of Codonopsis lanceloata learned faster that those of drinking water. The contents of LPO in red blood cell and brain of mice and rate drinking extraction of Codonopsis lanceolata were significantly reduced, the activities of superoxide dismutase (SOD) in serum of rat drinking extraction of Codonopsis lanceolata were visibly increased. These presents that the extraction of Codonopsis lanceolata has the role of promoting learning and memory of old animal, its mechanism might be increasing SOD activity and decreasing LPO level.

Animals↗
PubMed2006

[Intelligence of hemiplegic children: an association with epilepsy and the laterality of the lesion].

We studied thirty-one children with hemiplegia to elucidate the relationship of intelligence, the laterality of a lesion, and epilepsy, in these children. We investigated the influences of the age at the onset of the seizures, the number of anti-convulsants, and the duration of medication, on the DQ/FIQ. The results indicated a significantly higher DQ/FIQ and VIQ for right hemiplegic children than for left hemiplegic children. But the PIQ of the patients with either a left or right hemiplegia was not significantly different. A significantly higher DQ/FIQ, VIQ, and PIQ was also revealed for the children without epilepsy. In addition, there was also a tendency that the DQ/FIQ of children who suffered from epilepsy before the age of one year was lower than that of children who suffered from epilepsy after the age of one year. The present results provide evidence which supports the crowding hypothesis.

Age of Onset↗
PubMed1994

Do infant and early childhood tests predict intelligence quotients better than maternal characteristics?

The sensitivity, specificity, and predictive values of infant and early childhood testing for subsequent intelligence tests at 3 and 5 years of age were assessed and compared to the sensitivity, specificity, and predictive value of maternal education for the same. The study was based on prospective surveillance of a population of infants attending the Maternal and Child services in western Jerusalem. The sensitivity, specificity, and predictive value of the 9- and 24-month tests were low, thus leading to labeling of false positives and inadequate detection of those with developmental delay. Maternal education was shown to be the single best predictor for intellectual performance on the 3- and 5-year test in the above analysis, as well as in a multivariate model where the 9- and 24-month tests, maternal education, origin, birth order, and sex were introduced as independent variables. It is recommended to take a detailed history, listen to parents' complaints, and use developmental testing selectively for children suspected to have problems, and not to apply developmental tests as a routine for all children in well-child care.

Child↗
PubMed1994

[Problems in auditory perception and verbal and nonverbal intelligence].

The connection between auditory perception and verbal/nonverbal cognitive achievements were studied in a sample of 300 clients of the school counselling service in the district of Neuss. Nearly 46% of the pupils do have problems with the auditory perception; these pupils do have lower test-results in overall intelligence, especially in verbal cognitive achievements. It is concluded that tests concerning the auditory perception should be used more often.

Adolescent↗
PubMed1984

Wechsler Adult Intelligence Scale performance. Cortical localization by fluorodeoxyglucose F 18-positron emission tomography.

We compared local cerebral glucose metabolism, as determined by positron emission tomography following administration of fluorodeoxyglucose F 18, with Wechsler Adult Intelligence Scale (WAIS) scores in 22 right-handed persons. Five study subjects were normal volunteers and the remainder had Alzheimer's disease. Subtest scores within the verbal IQ group or the performance IQ group were generally highly interrelated; there was usually no correlation between the verbal and performance subtests. The cortical distribution of regions in which glucose metabolism was most closely associated with verbal subtest scores generally centered in the left parasylvian area. In contrast, scores on the performance subtests mainly localized to the right posterior parietal region. Most WAIS subtests thus appeared to evaluate primarily either verbal or visuospatial cognitive functions and either left parasylvian or right posteroparietal cortical activity.

Aged↗
PubMed1992

Mechanisms of interhemispheric transfer and patterns of cognitive function in acallosal patients of normal intelligence.

We investigated interhemispheric transfer and cognitive function in two boys with normal intelligence in whom agenesis of the corpus callosum was identified following minor head trauma. In patient 1, magnetic resonance imaging scan showed agenesis of the corpus callosum and absent anterior commissure. Results of visual interhemispheric transfer tasks suggested degradation in transfer of information to the left hemisphere. Results of a tactile interhemispheric transfer task suggested degradation of access to the right hemisphere. In patient 2, magnetic resonance imaging scan showed agenesis of the corpus callosum and enlarged anterior commissure. Results for both visual and tactile interhemispheric transfer tasks were normal. Dichotic listening tests showed a slight left ear advantage in both patients. These results support the hypothesis that hypertrophy of the anterior commissure is an important mechanism of functional compensation in agenesis of the corpus callosum. However, the relative subtlety of deficits in patient 1 and results of dichotic listening tests support use of other mechanisms as well. No consistent pattern of cognitive deficits was observed.

Agenesis of Corpus Callosum↗
PubMed1992

Very low birth weight and growth to age 8 years. II: Head dimensions and intelligence.

The occipitofrontal circumference was measured in all available children in the following cohorts at ages 2, 5, and 8 years: group 1, consisting of 79 children with birth weight between 500 and 999 g; group 2, with 111 children with birth weight between 1000 and 1499 g; and group 3 with 56 children with birth weight greater than 2500 g; all were white with no signs of moderate or severe cerebral palsy. National Center for Health Statistics reference values indicated substantially more children with an occipitofrontal circumference lower than the 10th percentile, particularly at age 2 years, compared with Nellhaus reference data. Occipitofrontal circumference was the head measurement best correlated with the Full Scale IQ on the Wechsler Intelligence Scale for Children-Revised. Dolichocephaly, often seen in very-low-birth-weight children was unrelated to IQ, and correction of occipitofrontal circumference for dolichocephaly was rarely of clinical importance.

Analysis of Variance↗
PubMed2002

A cohort study of behavioral problems and intelligence in children with high prenatal polychlorinated biphenyl exposure.

BACKGROUND: In 1978, about 2000 persons in Taiwan were poisoned when their cooking oil was contaminated during manufacture with heat-degraded polychlorinated biphenyls, which are toxic, very widespread pollutant chemicals. The chemicals cannot be metabolized or excreted, and 8 of the first 39 children born to affected women died. When examined in 1985, 117 surviving children were found to have ectodermal defects, developmental delay, and disordered behavior. We have continued to observe the children. METHODS: From 1992 through 1995, 118 children born between 1978 and 1985 (during or after their mothers' exposure) and 118 matched neighborhood control children had cognitive function measured yearly with the Wechsler Intelligence Scale for Children-Revised and behavioral problems measured with the Achenbach Child Behavior Checklist and the Rutter Child Behavior Scale A. RESULTS: The exposed children scored 3 points (P =.05) lower than control children for IQ; 3 points (P =.002) higher on the Child Behavior Checklist (an effect size similar to the sex difference); and 6 points (P<.001) higher on the Rutter scale (3 times the sex difference). Birth year x exposure interactions, testing whether children born long after the exposure were as affected as those born soon after, were small and not significant. Age x exposure interactions, testing whether the children improved relative to control children as they got older, were significant only for the Rutter scale. CONCLUSIONS: Prenatal exposure to these compounds produces long-lasting cognitive and behavioral damage, but there is some evidence of recovery.

Adolescent↗
PubMed1996

Molecular-intelligence correlations in young fragile X males with a mild CGG repeat expansion in the FMR1 gene.

Several mechanisms can explain the occurrence of full-mutation fragile X males with an IQ level above -2 SD below mean, also called "high-functioning fragile X males." Incomplete methylation of the CpG island at the 5' end of the FMR1 gene is one of these mechanisms. The present study describes the physical and behavior phenotypes in 7 fragile X boys with CGG repeat insertions in the FMR1 gene between 600-2,400 base pairs. The degree of methylation at the FMR1-associated CpG island ranges in peripheral blood lymphocytes from 0-95%. Subjects with a low degree of methylation at this site have mild or absent physical characteristics of the fragile X syndrome, while subjects with a high degree of methylation at this site have more severe physical characteristics. In this range of CGG repeat insertion (600-2,400 base pairs), the degree of methylation at the FMR1-associated CpG island is a good predictor of intelligence, while CGG repeat insertion length is not.

Adolescent↗
PubMed1996

Total anonychia congenita and microcephaly with normal intelligence: a new autosomal-recessive syndrome?

We report on 3 sibs (2 boys and a girl) with a previously apparently unrecognized combination of anonychia congenita and microcephaly with normal intelligence. The shape of the head is normal. Other anomalies include clinodactyly of the fifth fingers and bilateral single transverse palmar creases. Skeletal survey was normal in the 2 older children. These children and their first-cousin Iranian parents have widely spaced teeth. The children's first cousin also has total anonychia congenita and apparently small head. We review anonychia congenita, and conclude that the presently reported family with a "new autosomal-recessive disorder" provides further evidence of the heterogeneity of this condition.

Abnormalities, Multiple↗
PubMed1997

Autosomal dominant microcephaly with normal intelligence, short palpebral fissures, and digital anomalies.

We describe a family segregating an autosomal dominant mutation producing a syndrome comprising microcephaly with normal intelligence and short palpebral fissures together with variable signs including thumb hypoplasia, shortness of the middle phalanges of the second and fifth fingers, small feet, a gap between the first and second toes, and mild syndactyly of the toes or fingers. A characteristic radiologic finding in our family is thinning of the proximal end of the first metacarpal and shortening of that metacarpal. The severity of these findings was asymmetric in our patients. This syndrome is similar to patients described by Brunner and Winter [1991: J Med Genet 28: 389-394], Feingold [1975: Synd Ident 3:16-17, 1978: Hosp Prac 13:44-49], and König et al. [1990: Dysmorphol Clin Genet 4:83-86].

Child, Preschool↗
PubMed2000

The use of artificial intelligence technology to predict lymph node spread in men with clinically localized prostate carcinoma.

BACKGROUND: The current study assesses artificial intelligence methods to identify prostate carcinoma patients at low risk for lymph node spread. If patients can be assigned accurately to a low risk group, unnecessary lymph node dissections can be avoided, thereby reducing morbidity and costs. METHODS: A rule-derivation technology for simple decision-tree analysis was trained and validated using patient data from a large database (4,133 patients) to derive low risk cutoff values for Gleason sum and prostate specific antigen (PSA) level. An empiric analysis was used to derive a low risk cutoff value for clinical TNM stage. These cutoff values then were applied to 2 additional, smaller databases (227 and 330 patients, respectively) from separate institutions. RESULTS: The decision-tree protocol derived cutoff values of < or = 6 for Gleason sum and < or = 10.6 ng/mL for PSA. The empiric analysis yielded a clinical TNM stage low risk cutoff value of < or = T2a. When these cutoff values were applied to the larger database, 44% of patients were classified as being at low risk for lymph node metastases (0.8% false-negative rate). When the same cutoff values were applied to the smaller databases, between 11 and 43% of patients were classified as low risk with a false-negative rate of between 0.0 and 0.7%. CONCLUSIONS: The results of the current study indicate that a population of prostate carcinoma patients at low risk for lymph node metastases can be identified accurately using a simple decision algorithm that considers preoperative PSA, Gleason sum, and clinical TNM stage. The risk of lymph node metastases in these patients is < or = 1%; therefore, pelvic lymph node dissection may be avoided safely. The implications of these findings in surgical and nonsurgical treatment are significant.

Acid Phosphatase↗