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Workshop 5 (synthesis): water pollution abatement as related to ecosystem protection.

Water pollution exerts major stress on water systems and the challenge is to ensure security in river basins for both water-dependent activities and for the aquatic ecosystems. The workshop focused on protection of good ecological status, quality criteria, priorities for action, and on achievement of sustainable improvements. The three keynote speakers presented the concept applied in the EU Water Framework Directive, the need for a multi-stakeholder collaboration in order to reach a good ecological status of waters and a concrete example of interactive planning of water protection measures in a transboundary lake. The additional paper presentations addressed specific pollution problems in catchments, the effect of environmental user fees and ecosystem indicators.

Ecology↗

A study on the prevalence of chronic bronchitis in workers exposed to smoke and irritant fumes in a railway workshop.

In the present study 108 full time workers employed in various sections of a railway workshop and exposed to smoke and irritant fumes, and 45 matched control subjects from local administrative staff were investigated to find prevalence of chronic bronchitis. In all 18 (16.7%) workers and 4 (8.9%) control subjects had clinical evidence of chronic bronchitis. Peak expiratory flow rate less than 300 L/min was observed in 54.6% workers and 2.2% control subjects. A significantly higher prevalence of chronic bronchitis was seen in workers. The advancing age, smoking and duration of exposure had significant influence on prevalence of chronic bronchitis.

Adult↗

Incorporating bioterrorism training into dental education: report of ADA-ADEA terrorism and mass casualty curriculum development workshop.

Numerous areas have been identified in which the dental profession may be called upon to assist in the event of a major terrorism attack. In order to successfully fulfill these roles, dentists and dental students must be adequately prepared. Dental schools play a vital role in this preparation. Participants in an ADA-ADEA workshop reached consensus that all dental students should be trained in a core set of competencies enabling them to respond to a significant bioterrorism attack, help contain the spread of the attack, and participate in surveillance activities as appropriate upon direction of proper authorities. Further emergency response training should be available to individuals interested in gaining additional knowledge and skills to assist in response to an attack. Participants also concluded that, where possible, training should be seamlessly implemented into the current curriculum without the addition of new courses; however, the group also recognized the possible need for alternative models at some dental schools. Challenges to implementing bioterrorism training into the dental school curriculum include regional variation, management of the basic science curriculum, and financial considerations. The development of an exportable training package will be considered and funding sources explored in moving forward with the development of a curriculum.

American Dental Association↗

Teaching suturing in a workshop setting: a comparison of several models.

OBJECTIVES: Suturing is taught in workshops using a variety of models. The purpose of this study is to compare the resemblance to human skin of four models commonly used to teach suturing: pig skin, beef tongue, hot dog and latex glove. METHODS: 5 centimeter biconvex incisions were made in each of the models and closed by 50 physician study volunteers comprised of 33 board-certified physicians and 17 resident physicians. They rated each model on a scale of 1 to 4, where 4 closely resembles human skin and 1 does not resemble human skin. RESULTS: The following mean ratings were given by study volunteers: beef tongue 3.5 +/- 0.5, pig skin 3.2 +/- 0.8, latex glove 1.6 +/- 0.7, hot dog 1.4 +/- 0.6. CONCLUSION: Beef tongue and pig skin were rated highest by study volunteers. However, pig skin is much cheaper than beef tongue. Pig skin is the best inexpensive model for teaching skin suturing of the four models studied.

Animals↗

[Ageing rate in workers of mechanic workshops of machinery construction industry in Armenia].

Studies of biologic age formation and ageing rate in workers of mechanic workshops revealed that able-bodied population grew old demographically. That is proved by absent age group of 20-29 years and increased share of able-bodied workers older than 50. Young workers aged 30-39 appeared the most vulnerable for occupational hazards--they demonstrated increased ageing rate and maximal excess of biologic age over chronological age and due biologic age.

Adult↗

[A workshop on the high risk group and the preventive oncology of renal cell carcinoma].

A workshop on the high risk group and the preventive oncology of renal cell carcinoma was held in Kyoto on September 7, 1990. The following subjects were presented: 1. Cohort study of renal cell carcinoma (Dr. Hirayama). 2. Pathoepidemiological study on the background of occurrence of renal cell carcinoma (Dr. Aoki). 3. Case-control study on renal cell carcinoma (Dr. Watanabe). 4. Geographic distribution of renal cell carcinoma in Japan (Dr. Minowa). 5. Pathological findings of small renal cell carcinoma (Prof. Yatani). 6. Pathoepidemiological study on occurrence of renal cell carcinoma (Dr. Tsuchihashi). 7. Clinical evaluation of small renal cell carcinoma (Dr. Masuda). 8. Clinical (biological) characteristics of renal cell carcinoma (Dr. Satomi). 9. Mass screening program for renal cell carcinoma on private urological clinic (Dr. Mishina). 10. Early stage detection of renal cell carcinoma (Dr. Ohe). 11. A review on the literature of epidemiology for renal cell carcinoma (Dr. Nakagawa). Possible risk factors reported for renal cell carcinoma were as follows: 1) Work in petroleum-related and dry-cleaning industries were positive risk. A predominant lifetime occupation as a professional was negative risk. 2) Milk or coffee consumption and use of artificial sweeteners were positive. Drinking of alcohol was negative. 3) Obesity was positive. 4) Personal history of cancer was positive. 5) Cigarette smoking was positive. 6) Exposure to radiation or hydrocarbon was positive. 7) Use of estrogen, diuretic and pain relievers was positive. 8) History of myocardial infarction, hypertension and diabetes mellitus was positive.

Carcinoma, Renal Cell↗

Management of chronic hepatitis C in HIV-co-infected patients--results from the First International Workshop on HIV and Hepatitis Co-infection, 2nd-4th December 2004, Amsterdam, Netherlands.

About 30% of HIV-positive individuals are concomitantly infected with HCV within the United States and Europe. Approximately 50 to 90 % of persons who acquired HIV from injecting drugs are co-infected with HCV. In these dually infected individuals the presence of each viral infection may impact the natural course of the other one, and worsening of associated liver disease and complications within this population are frequent. The management of chronic hepatitis C (cHC) in HCV-HIV-co-infection has become a major challenge, as possible interactions with antiretroviral therapy (ART), increased risk of special side effects, as well as compromises in adherence of patients, who already take several drugs, have to be taken into account. Treatment strategies to fight HCV-infection have been essentially ameliorated during the past three years in using pegylated interferon alpha (PegIFN alpha) combined with ribavirin (Rbv). There is hope that the beneficial therapeutic outcome in HCV-mono-infected individuals may be at least partly translated into successful treatment of dually infected patients too. However, the stepwise amelioration of therapeutic options and strategies does actually not yet result in equal anti-HCV response rates for co-infected compared to HCV-mono-infected persons. The 1st International Workshop on HIV and Hepatitis Co-infection 2004, was initiated to face the severe clinical problems which arise from viral hepatitis and HIV dual infection. The organising committee was headed by J. K. Rockstroh, University of Bonn, Germany, as chair and M. Sulkowski, John Hopkins University, USA, as co-chair of the meeting, in which more than 300 researchers and physicians from various European and US locations participated. This report summarizes some results on epidemiology, pathogenesis, viral interactions, and treatment of chronic hepatitis C in HIV-infected individuals.

AIDS-Related Opportunistic Infections↗

Cognition, interaction and ageing: an Internet workshops exploratory study.

Gerontology is known more and more as an interdisciplinary and functional knowledge. Geriatrics as one of its branches intends to make possible longevity with health. World population ageing occurs along with important economical and social inequalities for elder people, which are likely to be more affected by deficiencies (physical and/or cognitive) than younger groups. With the purpose of minimizing these deficiencies, Internet Workshops were accomplished, with a retired group of senior persons. This research was developed to bring together principles of Human-Computer Interaction, informatics, accessibility and gerontology in order to promote Digital Inclusion to this growing population and a methodology to virtual cognitive rehabilitation.

Aged↗

Juvenile rheumatoid arthritis and HLA: report of the Park City III workshop.

The workshop held during the Park City Meeting was directed toward developing a consensus about HLA associations in juvenile rheumatoid arthritis (JRA). Most agreement was achieved in pauciarticular JRA where the strongest associations were with the HLA-DRB1 alleles as is also the case in IgM rheumatoid factor positive polyarticular disease. In addition, HLA-DP associations are being identified although roles for linked genes are still possible. The critical nucleotides among HLA genes are not known; however, disease specific mutations have not been shown.

Alleles↗

Structure and function of nuclear receptors--EMBO workshop. 25-27 May 1999, Villefranche-sur-Mer, Nice, France.

This was the second in a bi-annual series of workshops held in Europe, supported by the European Molecular Biology Organization (EMBO), dealing with nuclear receptor (NR) structure and function. Exciting, novel information was presented on both the structure and functionality of NRs, whose members are increasingly recognized as families of ligand-regulable transcription factors with a major impact on a variety of (patho)physiological phenomena, ranging from the regulation of cell growth and death to cholesterol homeostasis and drug metabolism. There is no doubt that NRs are of interest to researchers who are trying to understand the molecular events involved in the corresponding signaling pathways and drug companies involved in drug design.

Journal Article↗

Types of Glaucoma and recent trends applied in treatment: Observations from a Glaucoma Training Workshop in the Gambia.

OBJECTIVES: To determine types of glaucoma seen and the recent trends applied in treatment, a retrospective non-comparative case-series study was conducted in the Eye Unit of the Royal Victoria Hospital, Banjul, The Gambia. METHODS: The records of the 88 patients(145 eyes) seen during the glaucoma training workshop(organised by Prof.James Standefer, a clinical ophthalmologist from Minneapolis, U.S.A.) which held between 3rd and 14th of September, 2001, were analysed for types of glaucoma and treatment given. All but one patient who was a baby underwent the following tests: visual acuity measurement using the illiterate E-Chart with multiple optotypes; tonometry using the Schiotz tonometer with the 5.5g weight; oblique flashlight test; Van Herrick's estimation of the angle depth; pupillary reactions to light; Slitlamp biomicroscopy; gonioscopy using the 4-mirror pressure gonioprism; fundoscopy using the +78D Volk lens and confrontational visual field analysis. RESULTS: 27 eyes did not have definite glaucoma. Out of the remaining 118 eyes, 65(55.08%) had POAG;17(14.41%)ACG out of which 8 were CACG and 2 acute ACG. 8 eyes had pseudoexfoliation of the lens capsule with or without glaucoma. In the frail and elderly, guttae Timoptol 0.5% was given once daily. 27 eyes had trabeculectomy; all were with releasable sutures and intraoperative application of 5-Fluorouracil. 3 eyes had laser trabeculoplasty and 5, diode laser transscleral cyclophotocoagulation. CONCLUSIONS: POAG was the commonest type of glaucoma seen. Pseudoexfoliation of the lens capsule with or without glaucoma and ACG are not very rare in The Gambia. In the frail and elderly, guttae Timoptol 0.5% was given once daily and none at all in painless glaucoma-blind eyes. Trabeculectomy with releasable sutures and intraoperative application of 5-FU has a very satisfactory pressure-lowering effect. KEYWORDS: glaucoma; treatment; the Gambia.

Gambia↗

Inflammation Research Association--ninth international conference. Chemokines, signal transduction and new drugs workshops. 1-5 November 1998, Hershey, PA, USA.

The Inflammation Research Association (IRA) is an industry-led organization which was founded 18 years ago to foster communication between industrial scientists working within the broad field of inflammation. The biennial International Conferences focus on disease mechanisms and therapeutics. The meeting was divided into invited symposia in the morning, poster sessions after lunch and evening parallel workshops. On the whole, the quality and novelty of the work presented was below that of previous years and the number of registrants was reduced from the previous conference at around 370. The most interesting areas covered in this meeting were signal transduction, chemokines and the symposium on new drugs for inflammatory and allergic disease.

Journal Article↗

Current understanding and therapy of asthma workshop summary.

The prevalence of asthma has increased globally in the past 2 decades. To address this critical issue, a workshop on "Current Understanding and Therapy of Asthma" was recently held in Beijing, as a part of the 10th International Conference of the Society of Chinese Bioscientists in America (SCBA). Several pertinent topics were addressed by leading experts from China, Taiwan, Japan and the US, which include epidemiology, the molecular genetic mechanism, pathogenesis, treatment and prevention of asthma. This article highlights the issues presented and discussed in this ground-breaking symposium emphasizing this important public health problem in the Chinese population.

Anti-Inflammatory Agents↗

Psoriasis: severity assessment in clinical practice. Conclusions from workshop discussions and a prospective multicentre survey of psoriasis severity.

Psoriasis treatment is highly individualized. Although a standardized assessment of psoriasis severity for clinical practice may be theoretically advantageous for the purposes of determining treatment, the relevance of currently available research tools in clinical practice is uncertain. Our objectives were to ascertain in workshop discussions and through a prospective survey the relevance of standard severity measures in clinical practice with regard to choice of treatment. Although there was agreement on the possible structure of an algorithm for the treatment-related definition of psoriasis severity, consensus on the cut-off levels for the PASI and %BSA that would indicate a switch in treatment mode could not be reached. The lack of agreement prompted a prospective survey of 112 patients with psoriasis from 10 countries. This survey used a formal questionnaire asking for the PASI and %BSA scores, the patient's self assessment score (VAS ranging from 0 to 10), location of the psoriatic lesions and disease phase. Severity scores from 20 patients pre-selected for inclusion in a trial of a biological agent were included for comparison. Severity scores were analysed in relation to the choice of treatment (topical or systemic, which included phototherapy and combination) suggested by the treating physician.PASI scores differed significantly between the treatment groups (topical vs systemic, p=0.009); however, there was large overlap in the range of PASI scores between the groups. The same was true for VAS scores (topical vs systemic, p=0.035). %BSA scores were not significantly different between treatment groups. There was a large overlap for both the topical and systemic treatment groups with the biologicals group for the range of both the PASI and %BSA scores. A standardized protocol for the evaluation of psoriasis severity based on established severity scores (PASI, %BSA) appears to be unrealistic in day-to-day clinical practice. In clinical practice, a host of factors must be evaluated alongside possible metric measures. This requires experience and the specialized medical education of those involved in the treatment of patients with psoriasis.

Humans↗