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[Strength training with superimposed vibrations].

To examine the effects of strength training with superimposed vibrations ten subjects trained over a period of six weeks (three sessions per week) one leg with back squats and superimposed vibrations and the other leg with traditional squats. In each training session participants performed 4 sets with 8-12 repetitions. Before and after the training period maximum strength and rate of force development were measured. The results show that both training modes induced comparable and statistical significant increases in maximum strength (vibration training +6.5%, traditional training +6.2%. The slight increases in rate of force development in both groups didn't reach statistical significance. As a consequence it seems that strength training with superimposed vibrations for the leg extensor chain is not superior to a traditional training mode.

Adult↗

Amide I vibrational circular dichroism of dipeptide: Conformation dependence and fragment analysis.

The amide I vibrational circular dichroic response of alanine dipeptide analog (ADA) was theoretically investigated and the density functional theory calculation and fragment analysis results are presented. A variety of vibrational spectroscopic properties, local and normal mode frequencies, coupling constant, dipole, and rotational strengths, are calculated by varying two dihedral angles determining the three-dimensional ADA conformation. Considering two monopeptide fragments separately, we show that the amide I vibrational circular dichroism of the ADA can be quantitatively predicted. For several representative conformations of the model ADA, vibrational circular dichroism spectra are calculated by using both the density functional theory calculation and fragment analysis methods.

Amides↗

Dynamics of water probed with vibrational echo correlation spectroscopy.

Vibrational echo correlation spectroscopy experiments on the OD stretch of dilute HOD in H(2)O are used to probe the structural dynamics of water. A method is demonstrated for combining correlation spectra taken with different infrared pulse bandwidths (pulse durations), making it possible to use data collected from many experiments in which the laser pulse properties are not identical. Accurate measurements of the OD stretch anharmonicity (162 cm(-1)) are presented and used in the data analysis. In addition, the recent accurate determination of the OD vibrational lifetime (1.45 ps) and the time scale for the production of vibrational relaxation induced broken hydrogen bond "photoproducts" ( approximately 2 ps) aid in the data analysis. The data are analyzed using time dependent diagrammatic perturbation theory to obtain the frequency time correlation function (FTCF). The results are an improved FTCF compared to that obtained previously with vibrational echo correlation spectroscopy. The experimental data and the experimentally determined FTCF are compared to calculations that employ a polarizable water model (SPC-FQ) to calculate the FTCF. The SPC-FQ derived FTCF is much closer to the experimental results than previously tested nonpolarizable water models which are also presented for comparison.

Deuterium↗

Molecular vibrational energy flow and dilution factors in an anharmonic state space.

A fourth-order resonance Hamiltonian is derived from the experimental normal-mode Hamiltonian of SCCl2. The anharmonic vibrational state space constructed from the effective Hamiltonian provides a realistic model for vibrational energy flow from bright states accessible by pulsed laser excitation. We study the experimentally derived distribution PE(sigma) of dilution factors sigma as a function of energy. This distribution characterizes the dynamics in the long-time limit. State space models predict that PE(sigma) should be bimodal, with some states undergoing facile intramolecular vibrational energy redistribution (small sigma), while others at the same total energy remain "protected" (sigma approximately 1). The bimodal distribution is in qualitative agreement with analytical and numerical local density of states models. However, there are fewer states protected from energy flow, and the protected states begin to fragment at higher energy, shifting from sigma approximately 1 to sigma approximately 0.5. We also examine how dilution factors are distributed in the vibrational state space of SCCl2 and how the power law specifying the survival probability of harmonic initial states correlates with the dilution factor distribution of anharmonic initial states.

Chemistry, Physical↗

Vibrational energy relaxation of azide in water.

Vibrational lifetimes of the asymmetric stretch fundamental of azide anion in normal and heavy water have been measured experimentally, with results in the range of a few picoseconds. This is an interesting problem for theoretical study because of the competition between intramolecular (relaxation to the other excited vibrational states of azide) and purely intermolecular (relaxation to azide's ground vibrational state) pathways. In addition it is important to understand the origin of the solvent isotope effect. Building on the seminal work of Morita and Kato [J. Chem. Phys. 109, 5511 (1998)], the authors develop a simple model based on a two-dimensional description of the azide stretching vibrations. A novel aspect of their theory is the use of an "on-the-fly" optimized quantum mechanical/molecular mechanical approach to calculate the system-bath coupling. Their theoretical lifetimes are in good agreement with experiment for azide in both normal and heavy water. They find that the predominant relaxation pathway is intramolecular. The solvent isotope effect arises from the different librational frequencies in normal and heavy water.

Azides↗

Comparison between thyroplasty type I and arytenoid rotation: a study of vocal fold vibration using excised human larynges.

The purpose of this paper was to compare the vibration of the vocal fold submitted to Isshiki thyroplasty type I (TPI) to that of the contralateral one adducted by the arytenoid rotation (AR) technique. The vocal folds of ten human fresh excised larynges were medialized by TPI on one side and by rotation of the arytenoid on the contralateral side. Laryngeal vibration was artificially produced and was recorded by videostroboscopy. The images were subjectively and objectively analyzed. Subjective analysis included periodicity of vibratory cycles, features of the mucosal wave present on the TPI side, amplitude of vibration, and profile of free border of each vocal fold during the opening phase. Objective analyses were carried out on frame-by-frame digitalized images to determine amplitudes of vibrations and phase differences between the folds in three glottic regions (anterior, middle, and posterior). Subjective analysis revealed regular periodicity in 100% of the larynges, a decrease in the mucosal wave on the TPI side in 70%, reduction in amplitude in 30%, and a sigmoid profile of the free border on the TPI side in 80%. Objective analysis showed mean amplitude in the posterior glottic region on the TPI side significantly larger than that on the arytenoids rotation side and phase asymmetry in 90% of the larynges.

Arytenoid Cartilage↗

Vibrational population relaxation of carbon monoxide in the heme pocket of photolyzed carbonmonoxy myoglobin: comparison of time-resolved mid-IR absorbance experiments and molecular dynamics simulations.

The vibrational energy relaxation of carbon monoxide in the heme pocket of sperm whale myoglobin was studied by using molecular dynamics simulation and normal mode analysis methods. Molecular dynamics trajectories of solvated myoglobin were run at 300 K for both the delta- and epsilon-tautomers of the distal His-64. Vibrational population relaxation times of 335 +/- 115 ps for the delta-tautomer and 640 +/- 185 ps for the epsilon-tautomer were estimated by using the Landau-Teller model. Normal mode analysis was used to identify those protein residues that act as the primary "doorway" modes in the vibrational relaxation of the oscillator. Although the CO relaxation rates in both the epsilon- and delta-tautomers are similar in magnitude, the simulations predict that the vibrational relaxation of the CO is faster in the delta-tautomer with the distal His playing an important role in the energy relaxation mechanism. Time-resolved mid-IR absorbance measurements were performed on photolyzed carbonmonoxy hemoglobin (Hb(13)CO). From these measurements, a T(1) time of 600 +/- 150 ps was determined. The simulation and experimental estimates are compared and discussed.

Carbon Monoxide↗

Mechanical bases of frequency tuning and neural excitation at the base of the cochlea: comparison of basilar-membrane vibrations and auditory-nerve-fiber responses in chinchilla.

We review the mechanical origin of auditory-nerve excitation, focusing on comparisons of the magnitudes and phases of basilar-membrane (BM) vibrations and auditory-nerve fiber responses to tones at a basal site of the chinchilla cochlea with characteristic frequency approximately 9 kHz located 3.5 mm from the oval window. At this location, characteristic frequency thresholds of fibers with high spontaneous activity correspond to magnitudes of BM displacement or velocity in the order of 1 nm or 50 microm/s. Over a wide range of stimulus frequencies, neural thresholds are not determined solely by BM displacement but rather by a function of both displacement and velocity. Near-threshold, auditory-nerve responses to low-frequency tones are synchronous with peak BM velocity toward scala tympani but at 80-90 dB sound pressure level (in decibels relative to 20 microPascals) and at 100-110 dB sound pressure level responses undergo two large phase shifts approaching 180 degrees. These drastic phase changes have no counterparts in BM vibrations. Thus, although at threshold levels the encoding of BM vibrations into spike trains appears to involve only relatively minor signal transformations, the polarity of auditory-nerve responses does not conform with traditional views of how BM vibrations are transmitted to the inner hair cells. The response polarity at threshold levels, as well as the intensity-dependent phase changes, apparently reflect micromechanical interactions between the organ of Corti, the tectorial membrane and the subtectorial fluid, and/or electrical and synaptic processes at the inner hair cells.

Animals↗

Influence of vibration to the neck, trunk and lower extremity muscles on equilibrium in normal subjects and patients with unilateral labyrinthine dysfunction.

To investigate the role of proprioceptors of different skeletal muscles in postural control, in normal subjects and patients with unilateral labyrinthine dysfunction (ULD), the effect of vibration on these muscles was studied by postulography. The subjects comprised 59 normal subjects and 12 patients with ULD due to resection of acoustic tumours. Sagittal body sway was observed during vibration to the triceps surae, tibialis anterior and upper dorsal neck muscles. No significant change in sway was observed in the frontal plane in normal subjects. Significant differences between normal subjects and patients were found on stimulation of the muscle groups of triceps surae and biceps femoris during vibration. In patients with ULD, vibration to the dorsal neck muscles caused a deviation towards the diseased side. It can be speculated that the upper dorsal neck muscle plays an important role in maintaining the body balance in the frontal plane in patients with ULD. On the other hand, the lower extremity muscles, especially the muscles on the dorsal side of the body, play a significant role in adjusting the standing posture in the sagittal plane.

Adult↗

Effects of lidocaine on basilar membrane vibration in the guinea pig.

The effects of lidocaine on basilar membrane (BM) vibration and compound action potential (CAP) were studied in guinea pigs in order to elucidate the site of lidocaine action in the cochlea. BM vibration was measured with a laser Doppler vibrometer through an opening made in the lateral bony wall of the scala tympani at the basal turn. Ten min after local administration of lidocaine (250 microg) into the scala tympani, the velocity of BM vibration and the CAP amplitude decreased significantly at around the characteristic frequency of the stimulus sound (p < 0.05). The maximum decreases were 4 dB in the velocity of the BM vibration and 40 dB in the CAP amplitude. In contrast, such changes were not observed after i.v. injection of lidocaine (1.5 mg/kg). These results suggest that when lidocaine is administered locally in the cochlea it acts not only on the cochlear nerve but also on the outer hair cells.

Administration, Topical↗

Whole-body vibration of locomotive engineers.

Vibration of the seat and the body of a diesel locomotive and an electric locomotive were measured while driving on the railways of Eastern Finland. At the speed of 120 km/h for the diesel locomotive and 140 km/h for the electric locomotive (the greatest permissible speeds) the vibration of the seat was tangent to the "fatigue-decreased proficiency boundary" of the international standard ISO 2631/1(1) in the side-to-side direction in one-third octave bands of 1-1.6 Hz. The frequency response measurements between the body of the locomotive and the seat indicated that the seat did not reduce side-to-side vibration of the body at low frequencies where the vibration was most harmful.

Finland↗

Reducing whole-body vibration and musculoskeletal injury with a new car seat design.

A new car seat design, which allows the back part of the seat (BPS) to lower down while a protruded cushion supports the lumbar spine, was quantitatively tested to determine its effectiveness and potentials in reducing whole-body vibration (WBV) and musculoskeletal disorders in automobile drivers. Nine subjects were tested to drive with the seat in: 1) the conventional seating arrangement (Normal posture); and 2) the new seating design (without BPS (WO-BPS) posture). By reducing contact between the seat and the ischial tuberosities (ITs), the new seating design reduced both contact pressure and amplitude of vibrations transmitted through the body. Root-mean-squared values for acceleration along the z-axis at the lumbar spine and ITs significantly decreased 31.6% (p < 0.01) and 19.8% (p < 0.05), respectively, by using the WO-BPS posture. At the same time, vibration dose values significantly decreased along the z-axis of the lumbar spine and ITs by 43.0% (p < 0.05) and 34.5% (p < 0.01). This reduction in WBV allows more sustained driving than permitted by conventional seating devices, by several hours, before sustaining unacceptable WBV levels. Such seating devices, implemented in large trucks and other high-vibration vehicles, may reduce the risk of WBV-related musculoskeletal disorders among drivers.

Acceleration↗

Reduced muscle strength in abduction of the index finger: an important clinical sign in hand-arm vibration syndrome.

Muscle strength in extrinsic and intrinsic hand muscle was assessed in 21 patients with hand-arm vibration syndrome. Twenty-one age-matched healthy workers served as controls. Grip and pinch strength was significantly reduced in the vibration-exposed group (18%; p = 0.006 and 18% p = 0.007, respectively) as well as strength of palmar abduction of the thumb (28%; p < 0.0001) and radial abduction of the index finger (37%; p < 0.0001) while abduction strength in the little finger was not significantly reduced (7%). We postulate that the reduced manipulative skill and impaired dexterity of the hand, which often is associated with vibration syndrome, is not only of sensorineural origin but may also be an effect of reduced intrinsic muscle strength. Reduced strength in abduction of the index finger is an important indicator of intrinsic muscular dysfunction in subjects who use hand-held vibrating tools.

Analysis of Variance↗

Vibrational analysis of phosphorothioate DNA: II. The POS group in the model compound dimethyl phosphorothioate [(CH3O)2(POS)]-.

The results of Raman and Infrared (IR) spectroscopic investigations on the vibrational modes of dimethyl phosphorothioate (DMPS) anion, [(CH3O)2(POS)]-, are reported. Ab initio calculations of the vibrational modes, the IR and Raman spectra and the interatomic force constants of DMPS were performed. A normal mode calculation was performed and the results were used to calculate the potential energy distribution for the vibrational modes. This analysis shows that in DMPS the P-S stretching mode has a frequency of about 630 cm-1 and an angle bending mode involving the sulfur atom has a frequency of about 440 cm-1. The proposed vibrational mode assignments will serve as marker bands in the conformational studies of phosphorothioate oligonucleotides which play a central role in the novel antisense therapeutic paradigm.

DNA↗

Vibration of the temporomandibular joints with normal radiographic imagings: comparison between asymptomatic volunteers and symptomatic patients.

In order to estimate the effect of a background noise during temporomandibular joint (TMJ) vibration analysis, 40 recordings from sensors not attached to subjects and sensors attached to subjects without any jaw movement were evaluated. Both of them showed very small energy density, close to 0, throughout 0 to 600 Hz and flat frequency distributions. To evaluate the vibration energy of asymptomatic TMJs with normal joint anatomy and symptomatic TMJs with normal arthrographic imagings, 20 TMJs from 10 clinically normal and asymptomatic volunteers with bilateral normal TMJ computerized tomography (CT) scanning (N-control) were analyzed at four mandibular positions. Results from intercuspal position and maximal opening were identical to the background noise. Results from closing and opening phase showed higher energy, especially below 150 Hz, than the background noise. Surface vibrations of 83 TMJs from patients with arthrographically normal imagings but having symptoms (NID) showed significantly higher energy than the N-control group above 300 Hz. When the total vibration energy (I(T)) is used to set the threshold for the separation of internal derangement, at I(T) = 2.06, the diagnostic specificity for the NID group is 75%, while the diagnostic sensitivity is 82.4% for internal derangement. At the same time, 98.3% of the N-control group was involved below the threshold.

Adult↗

Diagnostic accuracy of TMJ vibration analysis for internal derangement and/or degenerative joint disease.

Lower joint arthrography and videofluoroscopy were used to diagnose 297 joints from temporomandibular disorders (TMD) patients. The surface vibrations of the temporomandibular joints (TMJs) were recorded by electrovibratography and a parameter set was derived through frequency analysis. Total vibration energies were used as the primary separating threshold for abnormal joints. The following conditions were statistically discriminated by multi-variate analyses: I) meniscal displacement with reduction; II) meniscal displacement with a partial disk reduction; III) meniscal displacement without reduction; and IV) degenerative joint disease and/or perforation of the disk. Using the total vibration energy as a threshold, the diagnostic sensitivity for the abnormal joints was 82%, while the diagnostic specificity for the joints with no evidence of internal derangement was 75%. Discriminant analysis for the above-mentioned four conditions revealed a diagnostic sensitivity of 79.0%, 85.7%, 77.1% and 76.3% for conditions I, II, III and IV, respectively. The diagnostic specificity was 76.2%, 79.9%, 59.0% and 77.9% for conditions I, II, III and IV, respectively. It was concluded that vibration analysis of the TMJ could be clinically useful as a screening examination for TMD patients.

Discriminant Analysis↗

Independent responses of Pacinian and Non-Pacinian systems with hand-transmitted vibration detected from masked thresholds.

This study was designed to identify psychophysical channels responsible for the detection of hand-transmitted vibration. Perception thresholds for vibration (16, 31.5, 63 and 125 Hz sinusoidal for 600 ms) at the distal phalanx of the middle finger and the whole hand were determined with and without simultaneous masking stimuli (1/3 octave bandwidth Gaussian random vibration centered on either 16 Hz or 125 Hz for 3000 ms, varying in magnitude 0 to 30 dB above threshold). At all frequencies from 16 to 125 Hz, absolute thresholds for the hand were significantly lower than those for the finger. Changes in threshold as a function of masker level were used to estimate the thresholds of three psychophysical channels (i.e. P, NP I, and NP II channels). Increased vibrotactile sensitivity of the hand compared to the finger seems to be not entirely due to increased spatial summation via the Pacinian system (P channel); non-Pacinian system (NP I and NP II channels) also contributed to perception. Differing transmission of vibration between the hand and the finger may have also influenced the thresholds.

Adolescent↗

Impact of blast induced transitory vibration and air-overpressure/noise on human brain--an experimental study.

Human response to blast induced ground vibration and air-overpressure/noise is a major concern of current mining activity. This is because the fact that mines are fast transgressing the habitats and people are getting educated. Consequently the response of humans is changing and expectedly will increase in days to come with no viable and economic alternative to blasting--an essential component of mining. The response of humans can be purely physiological or psychological in nature or combination of both depending upon the situation and conditions of mining. Where physiological response is documented in terms of effects on ears and lungs there is a meager amount or no literature available regarding effects of blasting on the brain. Moreover, the studies on transitory phenomenon like the effects of blasting on humans are rare in comparison to the whole body vibration studies. This study was designed to address the issues as a precursor to a major initiative. The preliminary investigations conducted with the monitoring of EEG responses of humans to vibration and air-overpressure/noise due to blasting revealed that there is no major response of the brain to transitory vibrations and noise.

Adult↗