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Stress and disease: the missing link. A vasospastic theory. III. Stress, vasospasm and general disease.

The potential importance of vasospasm, with or without consequent thrombosis, as a mechanism in general disease is discussed and the evidence examined in one organ, namely the brain. It is concluded that vasospasm might be important in a number of neurological disorders, including migraine, epilepsy, and even some of the schizophrenia-like illnesses. Repeated ischaemic cell damage from vasospasm is also discussed as a possible factor initiating autoimmune disease and cancer. The similarities between viral transformation and neoplasia have led to the proposition that much cancer might be explained if as a species we have evolved by the gradual build-up of viruses.

Arteries↗
PubMed2006

Temperature increase results in oxidative stress in goldfish tissues. 1. Indices of oxidative stress.

Levels of lipid peroxides (LOOH), thiobarbituric-acid reactive substances (TBARS), protein carbonyls and low- and high-molecular weight thiols were measured in brain, liver, kidney, and white muscle of goldfish, Carassius auratus L., over 1-12 h of high temperature (35 degrees C) exposure followed by 4 or 24 h of lower (21 degrees C) temperature recovery. LOOH and TBARS contents increased during heat shock exposure with a maximal rise of 20-fold for liver TBARS, but both mainly reversed at recovery. Protein carbonyl content was unaffected by heat shock but rose in brain, liver, and kidney during recovery. Low-molecular weight thiol concentrations unexpectedly increased up to approximately 4-fold in brain, kidney and muscle under heat shock and remained high during recovery. Protein thiol contents also rose in liver and muscle during high temperature exposure by 2- and 3-fold, respectively, and decreased to control values or below in all tissues at late recovery. Low- and high-molecular weight thiol levels inversely correlated in liver (R2=0.87) suggesting that the former was used to reduce the latter over the experiment. It is concluded that the redox balance in goldfish tissues is strictly maintained probably contributing to the high tolerance of this species to heat shock.

Animals↗
PubMed2005

Is life stress more traumatic than traumatic stress?

This study explored the definition of a traumatic stressor, as it currently stands in the DSM-IV-TR, and the relationship between this definition and psychological symptomatology. Four hundred and fifty-four college undergraduates completed measures assessing psychopathology and exposure to trauma. Individuals were then divided into two groups, those who reported a traumatic event that was consistent with the DSM Criterion A1 definition and those who reported a traumatic event that was inconsistent with the definition. Surprisingly, the latter group reported significantly greater severity of PTSD symptomatology than those who reported a Criterion A1 PTSD event. In addition, significantly more people in the DSM trauma-incongruent group met criteria for PTSD than those in the DSM trauma-congruent group. Nearly two-thirds of the DSM trauma-incongruent group identified the death or illness of a loved one as their traumatic experience. The results are discussed within the context of the ongoing controversy over PTSD Criterion A1.

Adolescent↗