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How accurate are endoscopic estimates of size?

The accuracy of polyp size estimations in clinical studies is not known. This study was designed to evaluate how well endoscopists can estimate the size of objects at endoscopy. Observations were made by six attending gastroenterologists, six gastroenterology fellows, and seven untrained medical residents. Ball bearings ranging in size from 3 mm to 19 mm were randomly inserted into a latex colon model, and size was estimated while being viewed with a video colonoscope with and without the aid of an open biopsy forceps. Estimated size correlated well to actual size (R ranged from 0.78 to 0.93), although the mean estimates were consistently lower (13% to 29%) than the actual size for all groups, with and without forceps. The use of forceps did not improve the estimates. Exactly correct estimates occurred in 8%; errors of as much as 110% were recorded. The 12 mm bearing was estimated to be less than 10 mm half of the time. We conclude that endoscopists frequently underestimate the size of objects viewed at the time of endoscopy. There was no difference in the performance of experienced gastroenterologists, fellows in training, or untrained residents. This study indicates that better methods of training and for determining size are needed. Research that depends on endoscopic estimates of polyp size may be biased.

Analysis of Variance↗

Endoscopic measurement of lesion size: improved accuracy with image processing.

Endoscopic measurement of lesions is of great importance in the design and performance of clinical trials, as, for example, in studies of ulcer disease. Endoscopes are constructed with wide-angle lenses that significantly distort the image by creating a relative compression of points in its periphery. We have recently developed a computer program to correct the distortion of the wide-angle lens. We sought to determine the accuracy of the currently used open-biopsy forceps measurement technique and compare it to that of an image-processing technique designed to correct image distortion. The overall error of the open-biopsy forceps technique using an in vitro ulcer model was under-estimation of lesion size by 41.8% +/- 23.3%. When image processing was used to correct distortion, error was significantly decreased to 1.8% +/- 2.2% (p < 0.05). In vivo measurements were made using an inserted object of known size (coated chewing gum). The mean error of the forceps technique in vivo was 26.5% +/- 5.7% (under-estimation of size), which improved significantly to an error of 2.8% +/- 3.2% (p < 0.05) with the image-processing technique. We conclude that image processing significantly enhances the accuracy of measurement at endoscopy.

Biopsy↗

Acceptability of shade differences in metal ceramic crowns.

STATEMENT OF PROBLEM: Application of technology that quantify color and color differences is currently used in esthetic restorative materials research. However, parameters for the size of perceptible and acceptable color differences in metal ceramic crowns have not been determined. PURPOSE: The CIELAB colorimetric system was used to study the relationship between instrumentally measured color differences (delta E) and human observer assessment of color differences in metal ceramic crowns. MATERIAL AND METHODS: Subjects were shown pairs of metal ceramic crowns whose color difference varied from indistinguishable to obvious. The subjects attempted to discern a difference in each pair's color and indicated the clinical acceptability of the shade difference between the crown pairs. RESULTS: Correlations between instrumental and visual assessment of color differences in these crown pairs did not agree in all dimensions of color space. Thresholds acceptability of color differences were 1.1 delta E units for red-varying crowns and 2.1 delta E units for yellow-varying crowns. Thresholds for perceptibility judgments were significantly lower than thresholds for acceptability judgments. CONCLUSIONS: Acceptability thresholds were found to be dependent on chromaticity. Observers were more sensitive and critical of crowns whose color differed in redness as opposed to crowns whose color differed to the same extent in yellowness.

Chi-Square Distribution↗

Disruption of estimation of body-scaled aperture width in Hemiparkinson's disease.

A group of patients with left-sided symptoms of Parkinson's disease (LPD) was compared with a group of patients with right-sided symptoms (RPD) and with a group of healthy age-matched controls on body-scaled judgements of aperture width. Participants judged whether or not they would fit through a life-sized schematic doorway shown on a large screen. A staircase technique was used to find the door width for which 50% of the judgements were positive. The ratio between this measure and the width of the participant's body at the shoulders (the aperture to shoulder - A/S ratio) was calculated. The A/S ratio was approximately 1.5 in the LPD group, approximately 0.9 in the RPD group, and approximately 1.1 in the control group, suggesting that the visual representation of the doorway (or that of its relationship to perceived body-size) is compressed in LPD (and perhaps expanded in RPD). The A/S ratios were invariant with viewing distance (0.6 or 1.5 m), the contrast polarity of the display (white on dark, or vice versa) and the doorway surround (blank, or vertical or horizontal stripes). The findings are discussed with reference to the neural representation of external space and of the body, and to the motor problems of Parkinson's disease.

Aged↗

Local-global processing in Alzheimer's disease: an examination of interference, inhibition and priming.

Impairments of memory, praxis, gnosis, language and executive functioning are well documented in Alzheimer's disease (AD). Functions, such as attention, however, have only recently been systematically investigated. We used Navon-type stimuli (large "global" digits composed of smaller "local" digits) to assess 12 AD participants' plus age-matched controls' ability to focus and alter the scale of their spatial attention. In the first experiment, participants responded to either the global or local characters within a block, ignoring characters at the other spatial scale. Healthy young adults (n=12) demonstrated the normal 'global precedence' effect on this task. In contrast, participants with AD and their age-matched controls were significantly faster on the local task than on the global task, suggesting in these groups a 'local precedence' effect. This consisted of both a local advantage and a local-on-global interference effect. In a second experiment, participants searched for designated targets which occurred unpredictably at either the local or global spatial scale. Participants with AD were significantly slower and more error-prone than older controls. In addition, participants with AD showed a greater cost in reaction time (RT) when required to switch spatial scales on consecutive trials, compared to no switch responses at the same spatial scale on consecutive trials. Thus, AD may impair the ability to process global figures, due perhaps to involvement of posterior parietal areas. Further, participants with AD were poor at inhibiting irrelevant stimuli and at inhibiting attentional allocation to an irrelevant spatial scale, which may relate to prefrontal pathology.

Adult↗

Object motor representation and reaching-grasping control.

The following two competing hypotheses were tested in the present study. Is grasp guided by multiple representations of a single object, each of which codes a different grasp motor act according to the physical properties of that item? Conversely, is grasp guided by a single representation that codes all the possible affordances enabled by the object? Subjects reached different objects, but the object part used by subjects to grasp them was identical. In experiments 1 and 2, two familiar objects (fruits) which varied for size and shape were presented. Subjects grasped their stalks whose size and shape were equal. In experiments 3-7 the presented objects were geometrical solids, which varied, respectively, for weight, volume, intrinsic height, centre of mass and shape. Nevertheless, in all experiments the object portion where subjects' fingers grasped it had the same physical features. Finally, experiment 8 was a control experiment in which subjects reached and grasped equal handles of bells of the same shape, but different size. Volume, shape, and familiarity of the object influenced the grasp kinematics, even if the features of the grasped object part did not change. Variation in intrinsic object height and weight influenced final reach kinematics. Variation in centre of mass influenced neither grasp nor reach kinematics. Data are discussed in support of the hypothesis that a single object motor representation, which codes all the object affordances, is involved in grasp kinematic implementation.

Adult↗

Cognitive estimation in patients with probable Alzheimer's disease and alcoholic Korsakoff patients.

Cognitive estimation is an important function in daily living. In early studies it was proposed that estimation deficits are associated with frontal lobe damage and executive dysfunctions. In this study, we assessed Alzheimer patients and patients with alcoholic Korsakoff's syndrome with a newly developed cognitive estimation task. We compared their performance with respect to different dimensions of estimation ('size', 'weight', 'quantity', and 'time') and to various error types. Compared to healthy controls, both patient groups were strongly impaired in all tested estimation dimensions, with Alzheimer patients performing generally worse than Korsakoff patients, except for the dimension "time". Alzheimer as well as Korsakoff patients produced so-called 'bizarre errors' and errors in the choice of the correct unit of measurement. In both patient groups cognitive estimation correlated highly with general knowledge. The production of bizarre errors and unit errors correlated with general knowledge as well as with working memory and executive functions. Results support the main assumptions of a model of cognitive estimation, described in the discussion, that specific parts of the semantic memory system as well as executive functions, in form of a plausibility check of the generated answer, are involved in the process of cognitive estimation.

Aged↗

Eye-movement patterns do not mediate size distortion effects in hemispatial neglect: looking without seeing.

Over the last decade a range of studies have shown that some patients with hemispatial neglect subjectively underestimate the size of objects presented in their contralesional hemispace. Recently, it has been suggested that the effect is simply due to either hemianopia [Brain 124 (2001) 527], or the combination of neglect and hemianopia [Neurology 52 (1999) 1845]. In the current study we asked right hemisphere lesioned patients with and without neglect and hemianopia as well as healthy controls to judge either two horizontal or vertical lines presented simultaneously in right and left hemispace and monitored their eye movements. Three out of the six patients showed the predicted size distortion effect for horizontal lines. We found no evidence that the effect was mediated by eye movements. The two neglect patients who showed the strongest left side underestimation showed symmetrical (left, right) scanning of the lines both in terms of number of fixations and fixation time, yet they still failed to judge the relative size veridically. In addition, we did not find strong evidence for a link with hemianopia. We therefore propose that the effect reflects a computational/representational failure of processing for horizontal extent.

Aged↗

When does the Titchener Circles illusion exert an effect on grasping?. Two- and three-dimensional targets.

This study used the Titchener Circles illusion to investigate the functional dissociation of the dorsal visuomotor and ventral perceptual systems. In order to investigate the visual requirements for an action to be driven by the dorsal stream, two-dimensional (2D) and three-dimensional (3D) targets were compared. Thirteen subjects made visual open loop manual estimations or grasping actions towards 2D and 3D versions of the illusion. No illusion effect was found for immediate grasping, but the illusion did influence manual estimation, irrespective of whether the target was 2D or 3D. It is suggested that the underlying representations used to drive grasping actions towards 2D targets are fundamentally the same as those used to drive natural grasping actions. While stereoscopically specified depth may be important to the dorsal visuomotor system, it does not appear to be necessary in order for an action to be based on dorsal representations. It is suggested that an action must be goal directed in order for that action to be driven by dorsal stream processes.

Adolescent↗

Contributions of the left and right cerebral hemispheres to line bisection.

Thirty-one right-hemisphere lesioned (RHL) patients, 11 left-hemisphere lesioned patients (LHL) and 10 normal controls (NC) bisected lines in three spatial location and four directional cuing conditions. The error direction and error size were analyzed as separate and combined variables. Seventy-seven percent of RHL patients and 45% of LHL patients made abnormally large errors in line bisection. Right-hemisphere lesioned patients were more sensitive to spatial location and directional cuing than NC subjects. In contrast, LHL patients were less sensitive to either condition than NCs. The error direction and error size emerged as dissociable components of line bisection. Right-hemisphere lesioned patients and NC subjects bisected lines consistently to one side of the true center. Left-hemisphere lesioned patients bisected lines equally often on both sides of the true center. Both RHL and LHL patients made larger absolute bisection errors than NC subjects, but the RHL patient's errors were larger than those of the LHL patients. We propose that the greater sensitivity of RHL patients to spatial location and directional cues and the directional consistency of their bisection errors represent contributions of the intact left cerebral hemisphere to line bisection. In contrast, the LHL patient's unrestrained ability to orient to both ends of the line reflects a contribution of the intact right cerebral hemisphere to line bisection. The failure of both groups to accurately bisect lines reflects a common visuospatial processing deficit that is more pronounced following RHLs than LHLs.

Aged↗

Cognitive and perceptual influences on visual line bisection: psychophysical and chronometric analyses of pseudoneglect.

Perceptual and cognitive influences on line bisection were isolated using a tachistoscopic forced-choice paradigm. Pretransected lines were presented for 150 msec at four orientations ([symbol: see text],-,/ and [symbol: see text]). Subjects made either 'left-right' (for -,/, and [symbol: see text] lines) or 'above-below' (for [symbol: see text],/and [symbol: see text] lines) discriminations in response to each line stimulus, depending upon perceived transector location relative to veridical line midpoint. Median response time and point of subjective equality (P.S.E.) were computed for each treatment condition. P.S.E.s in 'left-right' conditions were significantly left of veridical; response time maxima were similarly displaced. Azimuthal pseudoneglect was greatest for horizontal lines. P.S.E.s in 'above-below' conditions were displaced above veridical, and response time maxima were similarly displaced. Altitudinal pseudoneglect was greatest for negative diagonal lines [symbol: see text]. Azimuthal pseudoneglect significantly exceeded altitudinal pseudoneglect. 'Left-right' responses (mean = 478.3 msec) were significantly faster than 'above-below' responses (mean = 504.6 msec). We conclude that scanning eye and/or gross limb movements do not account for pseudoneglect, and that a significant component must be purely perceptual. Chronometric and psychometric measures of pseudoneglect are in remarkable agreement. The effects of altitudinal and azimuthal pseudoneglect are neither separable nor additive, suggesting the existence of independent mechanisms governing the allocation of spatial attention to objects of differing orientation. The slopes of the psychometric functions for lines of cardinal orientation are significantly steeper than for diagonal lines, which may reflect a processing conflict between these putatively independent mechanisms at diagonal line orientations. Decision context significantly modulates the magnitude of pseudoneglect for physically identical stimuli, perhaps reflecting the selective differential engagement of the vertical or horizontal attentional mechanisms. There are significant individual differences in line bisection performance, even in a very homogeneous sample of strongly right-handed subjects.

Analysis of Variance↗

A distortion of perceived space in patients with right-hemisphere lesions and visual hemineglect.

In twelve patients with left visuospatial hemineglect following acute right hemisphere cerebrovascular accident (CVA), and in twelve normal controls, we used a matching task to investigate judgement of the length of lines. Their task was to choose which of three lines of different length matched a separate single line. On each trial, the lines were all vertical or all horizontal. The set of three lines was presented either to the left or the right of the single line. When the lines were vertical, the choices made both by normal subjects and patients were nearly always correct. However, when the lines were horizontal and the set of comparison lines was on the left, patients mostly selected a line that was longer than the sample on the right, and never chose shorter lines, suggesting that the length of horizontal lines on the left was underestimated. When the set of three lines was on the right, patients chose the correct line more often, but made errors in both directions, i.e. longer or shorter, although shorter lines were chosen more often than longer lines. The rare errors made by normal subjects were in the same directions as those observed in the patients. The results provide further evidence for a non-Euclidean distortion of perceptual space in patients with left sided visuospatial neglect, and suggest that this distortion could be a gross exaggeration of normal performance or a product of diminished spatial attention, or both.

Aged↗

Identification of facial images in peripheral vision.

Contrast sensitivity for face identification was measured as a function of image size to find out whether foveal and peripheral performance would become equivalent by magnification. Size scaling was not sufficient for this task, but when the data was scaled both in size and contrast dimensions, there was no significant eccentricity-dependent variation in the data, i.e. for equivalent performance both the size and contrast needed to increase in the periphery. By utilising spatial noise added to the images we found that in periphery information was utilised less efficiently and peripheral inferiority arose completely from lower efficiency, not from increased internal noise.

Contrast Sensitivity↗

Perceived length in the central visual field: evidence for visual field asymmetries.

Visual performance for judging the length of a simultaneously presented pair of radial lines, reciprocally opposed by 180 degrees at a central fixation point, was assessed for 24 radial positions of test lines, for three viewing conditions (binocular, left and right monocular) and five different standard line sizes (1.43-7.13 degrees ). Generally, the results showed underestimation of the test line. Furthermore, clear visual field asymmetries were observed between the upper versus lower visual fields and the left versus right visual fields with greater underestimation for test lines presented in the lower and right visual fields. Also, asymmetries tended to be strongest along the 30 and 150 degrees radial orientations. Fourier analysis indicated that these asymmetries are mainly described by summing up the f0, f1, f2 and f5 components.

Adolescent↗

Effect of size of attended area on contrast sensitivity function.

Contrast sensitivity functions (CSFs) were measured in the foveal region while subjects simultaneously performed an instantaneous judgment task, which was designed to maintain their attended areas at a constant size. Spatial attention was sustained over areas that were either narrow (Narrow condition) or broad (Broad condition). We observed that the sensitivity at higher frequencies (over 3 cpd) was greater under the Narrow condition than that under the Broad condition, supporting the argument that attention enhances spatial resolution.

Attention↗

Size tuning in the absence of spatial frequency tuning in object recognition.

How do we attend to objects at a variety of sizes as we view our visual world? Because of an advantage in identification of lowpass over highpass filtered patterns, as well as large over small images, a number of theorists have assumed that size-independent recognition is achieved by spatial frequency (SF) based coarse-to-fine tuning. We found that the advantage of large sizes or low SFs was lost when participants attempted to identify a target object (specified verbally) somewhere in the middle of a sequence of 40 images of objects, each shown for only 72 ms, as long as the target and distractors were the same size or spatial frequency (unfiltered or low or high bandpassed). When targets were of a different size or scale than the distractors, a marked advantage (pop out) was observed for large (unfiltered) and low SF targets against small (unfiltered) and high SF distractors, respectively, and a marked decrement for the complementary conditions. Importantly, this pattern of results for large and small images was unaffected by holding absolute or relative SF content constant over the different sizes and it could not be explained by simple luminance- or contrast-based pattern masking. These results suggest that size/scale tuning in object recognition was accomplished over the first several images (<576 ms) in the sequence and that the size tuning was implemented by a mechanism sensitive to spatial extent rather than to variations in spatial frequency.

Analysis of Variance↗

Apparent size of an object remains uncompressed during presaccadic compression of visual space.

It is well known that compression of visual space occurs near the saccade goal when visual stimuli are briefly flashed at various locations on a visual reference just before a saccade. We investigated how presaccadic compression of visual space affected the apparent size of an object. In the first experiment, subjects were instructed to report the apparent number of multiple bars briefly presented around the time of saccade onset. The reported number of four bars began to decline at the 50 ms mark before a saccade and reached a minimum near the saccade onset. This confirms that the compression of visual space occurs just before saccades. In the second experiment, subjects judged the apparent width of a rectangle (a single element) or four bars (four elements) presented just before saccades. The apparent width of the four-bar stimulus was compressed just before saccades, but that of the rectangle stimulus was not compressed. Experiment 3 shows that the width compression of the four-bar stimulus is consistent with the width change predicted by compression of position. These findings indicate that the shape of a single object is not distorted at the saccade goal during presaccadic compression of visual space. In addition, experiment 4 indicates that the apparent width of a flashed stimulus just before saccades depends on the processing of global shape. This extends the definition of a visual object during presaccadic compression of visual space to not only a solid element but also a constellation of multiple elements. Furthermore, the results from these experiments suggest that presaccadic compression of visual space does not prevent object recognition underlying an attentional mechanism in generating saccadic eye movements.

Adult↗

Texture segmentation performance related to cortical geometry.

There are two prevailing explanations for the foveal deficit in texture segmentation reported in previous works. One is based on the spatial and temporal properties of the stimuli, which means in terms of physiology a strong contribution of the Magno-channel. The other one is purely spatial and assigns filters of different bandwidths to each eccentricity in the visual field. We have challenged the first explanation experimentally by using isoluminant stimuli. The central performance drop persisted although the Magno-channel is known to respond weakly to stimuli with low luminance contrast. Therefore, we agreed with the spatial explanation. But instead of the abstract filter theories from previous works we propose a computational neural model assuming local lateral interactions in a cortical map model. The psychophysical performance measures could be directly related to geometric properties of the primary visual cortex concerning its mapping geometry and its intrinsic interaction width. Our model accounts quantitatively for our own psychophysical data as well as for others from literature. In general, we claim that the high foveal retino-cortical magnification maps texture elements too far away from each other for being compared by local processes.

Contrast Sensitivity↗