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At least 1,585 records · Page 88Linked to original sources
PubMed2005

The proton-transfer compounds of strychnine with achiral salicylic acids: strychninium 3,5-dinitrosalicylate and the strychninium 5-nitrosalicylate bis(5-nitrosalicylic acid) adduct.

In the crystal structures of the proton-transfer compounds of strychnine with 3,5-dinitrosalicylic acid, namely strychninium 3,5-dinitrosalicylate, C21H23N2O2+.C7H3N2O7-, (I), and 5-nitrosalicylic acid, namely strychninium-5-nitrosalicylate-5-nitrosalicylic acid (1/1/2), C21H23N2O2+.C7H4NO5-.2C7H5NO5, (II), protonation of one of the N atoms of the strychnine molecule occurs and this group is subsequently involved in intermolecular hydrogen-bonding interactions. In (I), this is four-centred, the primary being with an adjacent strychninium carbonyl O-atom acceptor in a side-to-side interaction giving linear chains. Other interactions are with the phenolate and nitro O-atom acceptors of the anionic species, resulting in a one-dimensional polymer structure. In (II), the N+-H interaction is three-centred, the hydrogen bonding involving carboxyl O-atom acceptors of the anion and both acid adduct species, giving unique discrete hetero-tetramer units. The structure of (II) also features pi-bonding interactions between the two acid adduct molecules.

Journal Article↗
PubMed1991

Steady-state pharmacokinetics of enteric coated 5-amino-salicylic acid tablets in healthy volunteers and in patients with Crohn's disease or ulcerative colitis.

An Eudragit-L coated oral 5-aminosalicylic acid (5-ASA; mesalazine) product (Mesasal), has been formulated to deliver 5-ASA to the distal small bowel and colon for the treatment of inflammatory bowel disease. The purpose of this study was to compare the pharmacokinetic profile of this product at steady-state between healthy volunteers and two different patient groups with inflammation of either the small or the large bowel. Two carefully selected groups of patients, nine with Crohn's disease restricted to the small intestine and ten with total ulcerative colitis and one group of ten healthy volunteers received two 250 mg Mesasal tablets three times daily for 10 days to reach steady-state. Plasma 5-ASA and acetyl-5-ASA concentrations were followed for 48 h and urinary excretion for 72 h. There was a great variation in most pharmacokinetic parameters within each group and no significant differences were noticed between the groups. The location of the inflammatory process probably does not influence the pharmacokinetics of 5-ASA in any significant way in patients with either Crohn's disease in the small bowel or total ulcerative colitis.

Adolescent↗
PubMed1979

The interaction of varying doses of dipyridamole and acetyl salicylic acid on the inhibition of platelet functions and their effect on bleeding time.

1 In normal volunteers maximum reductions in platelet functions, collagen aggregation, adhesion and PF4 availability, were achieved using combined doses of 50 mg three times daily dipyridamole + 180 mg ASA or 75 mg three times daily dipyridamole + 120 mg ASA daily. 2 These doses did not prolong the bleeding time. 3 A synergistic effect has been demonstrated with 25 mg dipyridamole three times daily and 60 mg ASA. 4 At higher doses the effects on platelet functions were additive up to the maximal response. 5 The effect of low doses of ASA on platelet function was cumulative. 6 As lower doses of ASA in the combination studied inhibit platelet functions maximally without altering the bleeding time and probably without inhibiting prostacyclin, we suggest that these combinations of dipyridamole and ASA merit consideration in future clinical trials.

Adult↗
PubMed1981

Prostaglandin E2 in gastric mucosa and its role in the prevention of ulcers induced by acetyl salicylic acid in cats.

Gastric mucosa of the cat generates PGE2 activity at a significantly higher concentration in the antral 59.25 +/- 7.42 ng/g) than in the oxyntic (28.06 +/- 4.50 ng/ml) gland area. Intravenous (i.v.) infusion of histamine 80 micrograms/kg/h) or intragastric (i.g.) instillation of 0.1 N HCl (4 mEq/h) for 3 h significantly decreased the generation of PGE2 in antral and fundic mucosa, but did not result in the formation of gastric lesions. Aspirin (ASA) given i.v. or i.g. for 3 h caused a further fall in the generation of PGE2 in the mucosa and when combined with i.v. histamine or i.g. HCl, it caused almost complete disappearance of PGE2 activity and the formation of antral ulcers in all tested cats. Exogenous PGE2, given i.v. in a dose (30 micrograms/kg/h) reducing histamine-stimulated (80 micrograms/kg/h) acid secretion by about 50%, prevented almost completely the formation of gastric ulcers induced by a combination of ASA plus i.v. histamine or i.g. HCl. This study indicates that the gastric mucosa generates PGE2 which is capable of preventing gastric ulcers induced by ASA combined with histamine or mucosal acidification.

Animals↗
PubMed1984

A comparative study of benzydamine hydrochloride 0.15% w/v ('Difflam' Oral Rinse) and acetyl salicylic acid as analgesics following tonsillectomy.

The efficacy of 'Difflam' Oral Rinse and soluble aspirin in the post-operative management of tonsillectomy in adult patients has been compared. Whilst aspirin proved slightly more effective in relieving pain and discomfort of swallowing, 'Difflam' Oral Rinse was superior in the relief of earache, in promoting the healing of the tonsil bed and in the duration of necessity of treatment. It is therefore suggested that the two preparations might be taken concomitantly to provide quick, as well as long-lasting, pain relief.

Adolescent↗