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PubMed1991

Mismatched double-stranded RNA, Ampligen (poly(I): poly(C12U), demonstrates antiviral and immunostimulatory activities in HIV disease.

Mismatched double-stranded RNA (Ampligen) has broad spectrum antiviral and immunomodulatory activities. These activities generate stabilization or improvement in three important surrogate markers of HIV disease progression. Patients with HIV disease treated with Ampligen do not become positive for p24 antigen, in contrast to patients treated with AZT or placebo. Viral burden can also be decreased in patients receiving Ampligen/AZT therapy. In vitro studies indicate that both AZT sensitive and AZT resistant viruses can be inhibited by Ampligen alone and are synergistically inhibited by Ampligen in combination with AZT. The immunomodulatory effects of Ampligen are manifested as a stabilization of CD4 counts. When Ampligen is combined with AZT, an increase in CD4 count is seen. Furthermore, a return or increase in delayed type hypersensitivity to mumps, Candida, and trichophyton was seen in approximately 70% of patients treated with Ampligen. The activity of Ampligen in HIV disease is due to its multifunctional activity as an antiviral and immune stimulating agent. The antiviral effect directly inhibits HIV-infection and other viruses which have been implicated in HIV disease acceleration and progression. The immunomodulatory activity can stabilize, increase, or restore immune function. This enhanced immune function can also lead to the further inhibition of additional infections associated with disease progression. Thus, Ampligen has multiple mechanisms of action against HIV disease.

Adjuvants, Immunologic↗
PubMedDate not supplied

[Study of dynamic properties of water in poly(A) and poly(U) solutions by proton magnetic resonance].

Proton magnetic relaxation in aqueous solutions of polyadenylic and polyuridylic acids in the temperature range (10-80 degrees C) and acidities (pH 3-9.7) has been investigated. Activation energies of water molecule diffusion and proton exchange, as well as the velocities of these processes have been determined. It is established that from the point of view of magnetic relaxation, the state of single helices resulted from the thermal conformation transition, are not equal to the state obtained by the change of the pH of solution; it refers both to the secondary structure of the chains and the dynamical behaviour of the biopolymer hydrate layers.

Chemical Phenomena↗