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Monitors of cerebral oxygenation.

None of the monitors of cerebral oxygenation discussed above has proven to be effective enough to have become a standard of care in any given area of medical treatment. As described above, each has specific and well-defined shortcomings that prevent its widespread use. These shortcomings may not be so much a failure of technology as an acknowledgement of the complexity of our goal: a monitor that can divide the entire brain into small, focal, and discrete areas and accurately measure the oxygen tension in each one. Because we are asking for the functional equivalent of 30 or 40 simultaneous PbtO2 probes, it is small wonder that we are not yet satisfied. Of the three monitors discussed here, the greatest potential may lie with the transcranial cerebral oximetry. The cerebral oximeter has the biggest potential for improvement because it holds the most potential for technical advancement. Although, for instance, jugular venous bulb oximetric catheters may become somewhat more accurate, the biggest drawbacks in that monitor's usefulness lie in human anatomy and intracerebral blood mixing, not catheter accuracy. PbtO2 probes, also, have little room for improvement. Although every technology can be refined, the PbtO2 probes are already accurate. The fact that they are an invasive monitor, and a regional one at that, will relegate them to a limited number of cases. Cerebral oximeters hold more potential. Their greatest limitations lie in technical aspects that can be, and hopefully will be, improved upon in terms of computer technology as well as algorithm accuracy. The fact that cerebral oximeters can be used on any patient, at any time, on almost any case, makes it, potentially, truly an ideal monitor for anesthesiologists and intensivists alike. There is no certainty that any of these limitations will be surmounted, at least to the degree necessary to achieve desired accuracy. But there is much to anticipate.

Anesthetics, Inhalation↗

Continuous intrapartum pH, pO2, pCO2, and SpO2 monitoring.

The goal of intrapartum surveillance and its further development is better patient care for both the fetus and the gravida. A normal FHR pattern is usually associated with the delivery of a normal well-oxygenated infant; however, a nonreassuring FHR is not always associated with the delivery of a compromised infant. This situation has led to an increase in unnecessary obstetric interventions in the form of a rising cesarean section rate. Fetal scalp sampling was developed in an attempt to improve the predictive value of electronic FHR monitoring, but because this technique is not widely used, management decisions are frequently made using FHR patterns alone. Much research has been performed in the search for a continuous biochemical measurement of fetal status, including continuous pH, pO2, or pCO2 and various combinations of these methodologies. None of these measurements are used in current clinical practice, mainly owing to technical problems and difficulties associated with the continuous direct measurement of these parameters in fetal blood throughout labor. The promising new field of fetal pulse oximetry has the potential to provide reliable, meaningful, and reproducible data as shown in early cross-sectional studies and more recent longitudinal studies. By identifying developing hypoxia, this technology may reduce the uncertainty associated with electronic FHR monitoring. Fetal pulse oximetry may also provide critical information relating to the detection and management of the hypoxic fetus. Any new method of intrapartum fetal monitoring requires careful evaluation to assess its potential value before its introduction into clinical practice. The use of fetal SpO2 monitoring in the presence of a nonreassuring FHR pattern is being examined in a multicenter randomized controlled trial. This study will address the question of whether supplementary monitoring of fetal SpO2 levels can lead to a reduction in the cesarean section rate for fetal distress. The available data on fetal noninvasive pulse oximetry have been obtained from a combination of well-designed cohort studies (level II-2 evidence) or from earlier multiple time series (level II-3 evidence). The results from the US Multicenter Trial (level I evidence) should provide a significant addition to current evidence. A continuous fetal noninvasive monitor measuring fetal oxygenation directly could lead to an improvement in the sensitivity and specificity of fetal surveillance. This improvement could ultimately result in a reduction in unnecessary interventions by differentiating hypoxic fetuses from nonhypoxic fetuses and, more importantly, may lead to earlier intervention for fetuses in danger of serious compromise.

Acid-Base Equilibrium↗

Intraoperative monitoring of cochlear nerve compound action potential in cerebellopontine angle tumour removal.

Cochlear nerve compound action potential (CNAP) provides a real-time auditory evoked potential. Because of technical difficulty, CNAP monitoring has not been popular during the removal of cerebellopontine angle (CPA) tumour. To clarify the efficiency of intraoperative CNAP monitoring, we designed an intracranial electrode for CNAP monitoring and performed the simultaneous monitoring of CNAP and auditory brainstem response (ABR) in 10 patients undergoing CPA tumour removal in an attempt to preserve hearing. ABR recordings during microsurgical tumour removal were unsatisfactory in 6 patients because of severe artifacts. Reliable CNAP recordings were obtained without artifacts in all 10 patients throughout surgery. Eight patients preserved useful hearing after tumour removal, and the CNAP amplitude reflected the postoperative hearing. The newly designed intracranial electrode enables CNAP monitoring predicting the postoperative hearing more reliably than ABR. CNAP monitoring is efficient to improve the hearing preservation rate following CPA tumour removal.

Action Potentials↗

Comparative evaluation of three end-tidal CO2 monitors used during air medical transport.

The purpose of this investigation on ETCO2 monitoring was to determine if the monitors would function effectively in the aircraft. When compared in a cumulative manner, little difference between the three monitors was noted. The ETCO2 monitor appears to function in the fixed-wing aircraft when transporting critically ill, mechanically ventilated patients. Although this study does not address the accuracy of the ETCO2 monitor during changes in altitude, a base-line reading can be established during flight. Light weight, small size and extended battery life appear to be the criteria most lacking in these three capnographs reviewed in this study. This study demonstrates the compatibility of three capnographs with the aircraft environment. Manufacturers will hopefully continue to develop ETCO2 monitors to meet the space and weight needs of flight personnel in the difficult conditions of the air medical environment.

Aircraft↗

Monitoring of left ventricular ejection fraction with a miniature, nonimaging nuclear detector: accuracy and reliability over time with special reference to blood labeling.

BACKGROUND: The purpose of this study was to determine the accuracy of determinations of left ventricular ejection fraction (LVEF) by a nonimaging miniature nuclear detector system (Cardioscint) and to evaluate the feasibility of long-term LVEF monitoring in patients admitted to the coronary care unit, with special reference to the blood-labeling technique. METHODS AND RESULTS: Cardioscint LVEF values were compared with measurements of LVEF by conventional gamma camera radionuclide ventriculography in 33 patients with a wide range of LVEF values. In 21 of the 33 patients, long-term monitoring was carried out for 1 to 4 hours (mean 186 minutes), with three different kits: one for in vivo and two for in vitro red blood cell labeling. The stability of the labeling was assessed by determination of the activity of blood samples taken during the first 24 hours after blood labeling. The agreement between Cardioscint LVEF and gamma camera LVEF was good with automatic background correction (r = 0.82; regression equation y = 1.04x + 3.88) but poor with manual background correction (r = 0.50; y = 0.88x - 0.55). The agreement was highest in patients without wall motion abnormalities. The long-term monitoring showed no difference between morning and afternoon Cardioscint LVEF values. Short-lasting fluctuations in LVEFs greater than 10 EF units were observed in the majority of the patients. After 24 hours, the mean reduction in the physical decay-corrected count rate of the blood samples was most pronounced for the two in vitro blood-labeling kits (57% +/- 9% and 41% +/- 3%) and less for the in vivo blood-labeling kit (32% +/- 26%). This "biologic decay" had a marked influence on the Cardioscint monitoring results, demanding frequent background correction. CONCLUSION: A fairly accurate estimate of LVEF can be obtained with the nonimaging Cardioscint system, and continuous bedside LVEF monitoring can proceed for hours with little inconvenience to the patients. Instability of the red blood cell labeling during long-term monitoring necessitates frequent background correction.

Erythrocytes↗

Selective use of esophageal manometry and 24-Hour pH monitoring before laparoscopic fundoplication.

BACKGROUND: Preoperative esophageal manometry and 24-hour pH monitoring commonly are used in preoperative evaluation of patients undergoing fundoplication. Here we review our experience with the selective preoperative workup of patients undergoing fundoplication to treat gastroesophageal reflux disease. STUDY DESIGN: A series of 628 consecutive antireflux procedures was reviewed. History and physical examination, upper endoscopy, and upper gastrointestinal videofluoroscopy were obtained preoperatively on all patients; the first 30 patients also underwent esophageal manometry and pH monitoring (routine evaluation group). Thereafter, pH monitoring only was performed for atypical reflux symptoms, and manometry only was performed for a history of dysphagia, odynophagia, or for abnormal motility on videofluoroscopy (selective evaluation group). All patients underwent a laparoscopic floppy Nissen fundoplication, and then endoscopy and fluoroscopy at 3 months and 12 months postoperatively. RESULTS: Eighty-five of the patients in the selective evaluation group (14%) required manometry, and 88 (15%) underwent pH monitoring. Eighteen of the 115 patients who underwent manometry (16%) had evidence of dysmotility. None of these 18 patients had increased dysphagia postoperatively; 8 of 18 reported improvement with swallowing. Five patients in the selective group (0.8%) had persistent postoperative dysphagia caused by technical error (four patients) or with no identifiable cause (one patient). The estimated charge or collection reduction with use of the selective evaluation was 1,253,100 US dollars or 395,000 US dollars, respectively. CONCLUSIONS: Selective use of manometry and pH monitoring was cost effective and safe in this series. Although esophageal manometry and 24-hour pH monitoring might be necessary with abnormal findings on videofluoroscopy or atypical symptoms, in our experience, their routine use is not essential in preoperative evaluation of patients undergoing fundoplication for gastroesophageal reflux disease.

Adolescent↗

Combined monitoring of motor and somatosensory evoked potentials in orthopaedic spinal surgery.

OBJECTIVES: To demonstrate possible advantages of combined (motor and sensory) versus single modality (either motor or sensory) intra-operative spinal cord monitoring and to investigate risk factors for post-operative neurological sequelae. METHODS: Recordings of lower limb motor evoked potentials (MEPs) to multi-pulse transcranial electrical stimulation (TES), and tibial nerve somatosensory evoked potentials (SEPs), were attempted during 126 operations in 97 patients (79 with spinal deformity and 18 with miscellaneous spinal disorders). RESULTS: Combined motor and sensory monitoring was successfully achieved in 104 of 126 (82%) operations. No response to either modality could be recorded in two patients with Friedreich' s ataxia. In 18 patients monitoring was possible in only one modality: SEPs could not be recorded in two patients and MEPs in 16. Significant intra-operative EP changes occurred in one or both modalities in 16 patients; in association with instrumentation in 10 cases, and with systemic changes in 6. After appropriate remedial measures, SEPs recovered either fully or partially in 8/8 patients and MEPs in only 67% (10/15 patients). New deficits were present post-operatively in 6 of the 16 patients with abnormal intra-operative EPs. Normal MEPs at the end of the operation correctly predicted the absence of new motor deficits in all cases. SEPs either remained unchanged or recovered fully after remedial measures in 3 patients with new post-operative motor deficits. Neurological complications were more frequent in patients with miscellaneous spinal disorders and/or pre-existing neurological deficits. No complications occurred in patients with idiopathic scoliosis. CONCLUSIONS: Combined SEPs and multi-pulse TES-MEPs provide a safe, reliable and sensitive method of monitoring spinal cord function in orthopaedic surgery. This method is superior to single modality techniques, both for increasing the number of patients in whom satisfactory monitoring of spinal cord function can be achieved and, for improving the sensitivity and predictivity of monitoring. Combined SEP/MEP methods may enhance the impact of neuromonitoring on the intra-operative management of the patient and favourably influence neurological outcome.

Action Potentials↗

Monitoring depth of anaesthesia: is it worth the effort?

In this review paper, the authors critically analyse the use of a number of depth of anaesthesia monitors in light of the most recent literature and their own clinical experience. There appears to be increasing evidence that anaesthesia depth monitors reduce the incidence of unexpected intraoperative awareness and also that they improve the quality of anaesthesia. Proper use of these monitors necessitates background knowledge about the physiology of the loss of consciousness, the type of variable recorded and processed by the monitoring devices, the factors that might interfere with recording and the limits of use. The information provided by anaesthesia depth monitors is detailed and relationships with clinical practice are established to provide the reader with key features for optimal use of those monitors and correct interpretation of data. Practitioners and patient's knowledge and expectations regarding this matter, as well as the cost-benefit relationship are also discussed.

Anesthesia, General↗

Critical evaluation of factors required to terminate the postclosure monitoring period at solid waste landfills.

Regulations governing the disposal of solid waste in landfills specify that they must be monitored for 30 years after closure unless this period is extended by the governing regulatory authority. Given the wide range of conditions under which refuse is buried, technical criteria, rather than a specific time period, are preferable for evaluation of when it is acceptable to terminate postclosure monitoring. The objectives of this paper are to identify and evaluate parameters that can be used to define the end of the postclosure monitoring period and to present a conceptual framework for an investigation of whether postclosure monitoring can be terminated at a landfill. Parameters evaluated include leachate composition and leachate and gas production. Estimates of leachate production from closed landfills are used to assess the potential environmental impacts of a hypothetical release to surface water or groundwater. The acceptability of gaseous releases should be evaluated against criteria for odors, the potential for subsurface migration, and greenhouse gas and ozone precursor emissions. The approach presented here must be tested on a site-specific basis to identify additional data requirements and regulatory activity that might be required to prepare regulators for the large number of requests to terminate postclosure monitoring expected over the next 20 years. An approach in which the frequency and extent of postclosure monitoring is reduced as warranted by site-specific data and impact analysis should provide an effective strategy to manage closed landfills.

Environmental Monitoring↗

Portable sick house syndrome gas monitoring system based on novel colorimetric reagents for the highly selective and sensitive detection of formaldehyde.

Formaldehyde (HCHO) emitted from the furniture and the walls in the rooms injures the eyes, nose, and respiratory organs and causes allergies, which is called sick house syndrome. We designed and synthesized novel colorimetric HCHO-sensing molecules (KD-XA01 and KD-XA02) which possess an enaminone structure and developed a hand-held instrument to monitor indoor HCHO gas with the use of KD-XA01. These sensing molecules produced speedy color changes from colorless to yellow under mild conditions, which was caused by the fact that the enaminone structure in the reagent reacts with HCHO to give a lutidine derivative. This reaction took place not only in the solution phase but also in the solid phase (surface of the cellulose paper). To take advantage of this phenomena, a handy and rapid monitoring system has been developed for detecting indoor HCHO gas using a highly sensitive and selective detection tablet constructed from the porous cellulose paper that contains silica gel as an adsorbent, KD-XA01, and phosphoric acid under optimum conditions. This instrument detected the surface color change of the tablet from white to yellow, which was monitored as a function of the intensity of the reflected light illuminated by an LED (475 nm). The response was proportional to the HCHO concentration at a constant sampling time and flow rate; 0.05 ppm HCHO, which is under the standard value set by the World Health Organization, was able to be detected in 5 min. The detection limit was 0.005 ppm. This monitoring system was not interfered by carbonyl compounds such as acetaldehyde and acetone, alcohols, hydrocarbons, and typical gases such as carbon monoxide, carbon dioxide, nitrogen dioxide, etc., which contributes to the measurement of correct HCHO concentrations. It was possible to monitor the HCHO gas in the room of a new apartment and school using this instrument; the response values were in good agreement with those obtained by the standard DNPH method. This highly sensitive, selective, and handy HCHO gas monitor is widely applicable and convenient for users who are not specialists in this field.

Air Pollution, Indoor↗

Performance of an electrochemical carbon monoxide monitor in the presence of anesthetic gases.

OBJECTIVE: The passage of volatile anesthetic agents through accidentally dried CO2 absorbents in anesthesia circuits can result in the chemical breakdown of anesthetics with production of greater than 10000 ppm carbon monoxide (CO). This study was designed to evaluate a portable CO monitor in the presence of volatile anesthetic agents. METHODS: Two portable CO monitors employing electrochemical sensors were tested to determine the effects of anesthetic agents, gas sample flow rates, and high CO concentrations on their electrochemical sensor. The portable CO monitors were exposed to gas mixtures of 0 to 500 ppm CO in either 70% nitrous oxide, 1 MAC concentrations of contemporary volatile anesthetics, or reacted isoflurane or desflurane (containing CO and CHF3) in oxygen. The CO measurements from the electrochemical sensors were compared to simultaneously obtained samples measured by gas chromatography (GC). Data were analyzed by linear regression. RESULTS: Overall correlation between the portable CO monitors and the GC resulted in an r2 value >0.98 for all anesthetic agents. Sequestered samples produced an exponential decay of measured CO with time, whereas stable measurements were maintained during continuous flow across the sensor. Increasing flow rates resulted in higher CO readings. Exposing the CO sensor to 3000 and 19000 ppm CO resulted in maximum reported concentrations of approximately 1250 ppm, with a prolonged recovery. CONCLUSIONS: Decrease in measured concentration of the sequestered samples suggests destruction of the sample by the sensor, whereas a diffusion limitation is suggested by the dependency of measured value upon flow. Any value over 500 ppm must be assumed to represent dangerous concentrations of CO because of the non-linear response of these monitors at very high CO concentrations. These portable electrochemical CO monitors are adequate to measure CO concentrations up to 500 ppm in the presence of typical clinical concentrations of anesthetics.

Anesthesia, Closed-Circuit↗

Monitoring of isoflurane and desflurane breakdown: interfering gases and infrared detection.

OBJECTIVE: The reaction of isoflurane, enflurane or desflurane with dried CO2 absorbents produces carbon monixide (CO), a highly toxic gas which cannot be detected by gas monitors typically available in the operating room. Trifluoromethane (CHF3) is produced along with CO when this reaction occurs with isoflurane and desflurane, and can be detected by gas monitors. This study will determine the ability of a modified SAM module (Smart Anesthesia Multigas Module, GE/Marquette Medical Systems, Milwaukee, WI) to identify the presence of CHF3, and provide a clinically useful indirect warning of CO production. METHODS: Isoflurane (1.5%) and desflurane (7.5%) were reacted under clinical conditions with desiccated absorbents resulting in CO production. CO and CHF3 concentrations were measured using gas chromatography. The CHF3 concentrations measured by a modified SAM monitor were compared with the measurements obtained by gas chromatography. Alarm limits set on the SAM monitor were used to warn of the presence of CHF3. RESULTS: A concentration of 0.25% CHF3, as measured by the SAM monitor, corresponds to an average CO concentration of 780 ppm for isoflurane and 1700 ppm for desflurane. Lowering the threshold to 0.05% CHF3 would result in an average CO concentration of 155 ppm CO for isoflurane and 345 ppm CO for desflurane. CONCLUSIONS: We have shown that the SAM module is capable of measuring CHF3 due to anesthetic breakdown. With appropriate changes in the display programming and reference cell spectra the monitor would be able to provide an early warning of CO exposure, although the amount of CO would not be reported.

Anesthesia, General↗

Do asthma patients receive sufficient information to monitor their disease--a nationwide survey in Finland.

OBJECTIVES: The aim of this study was to assess to what extent the principles of asthma monitoring are implemented among Finnish asthma patients and if the patients have received sufficient information to adjust their medication according to asthma symptoms. SETTING: All Finnish asthma patients receiving asthma medication from Finnish community pharmacies during two days in June 1998. MAIN OUTCOME MEASURES: The proportions of asthma patients who monitor their asthma status according to the national guidelines and have received specific instructions on how and when to adjust their asthma medication. RESULTS: Eighty-six per cent of the respondents (86%) monitored their asthma status on a method recommended by the national guidelines. They made Peak Expiratory Flow (PEF) measurements (39% of the respondents), they monitored their symptoms (34%) or both (13%). A smaller proportion of the respondents (58%) were instructed on adjusting their medication according to symptoms. The lowest rates for monitoring the asthma status was found among the elderly (65 years or more) and among those who reported that they had been on medication for longer than 5 years (17% and 13% of the subgroup populations, respectively). The lowest rates for having received specific instructions on adjusting their asthma medication according to symptoms were found among the elderly (36%), among those who reported that they had been on asthma medication less than one year (44%), and among males (54%). CONCLUSIONS: Pharmacists and other health care professionals need to enhance their education activities and their co-operation in training asthma patients to monitor their disease, especially principles of adjusting medication according to symptoms. In this process, especially the training needs of the elderly patients and those who have been using asthma medicines for a long time need to be taken into account.

Adolescent↗

An assessment and monitoring program for birds in the Lower Urubamba region, Peru.

We developed an assessment and monitoring plan for birds in connection with the exploration and potential development of a large natural gas field in the Lower Urubamba drainage of Peru, a project of Shell Prospecting and Development Peru (SPDP). Our objectives were to: (1) inventory the birds in the area, including information on habitat use and abundance, and (2) devise long-term monitoring protocols for birds. We sampled birds through a combination of visual and auditory surveys and mist-netting at 4 well sites and 3 sites along the Urubamba and Camisea rivers. We recorded 420 species during 135 days of field work. We consider the highest priorities for a future monitoring program to be: (1) establish whether edge effects are occurring at well sites, along roads and along the planned pipeline route and determine the significance and extent of these effects and (2) assess the impact of increased human access to the area on game and other exploited species. The remoteness of the area, its rugged terrain and dense vegetation and the lack of trained personnel limit the choice of survey and monitoring methods. We recommend use of mist-netting and transects for monitoring edge effects and use of transects for monitoring game and other exploited species.

Animals↗

Use of the BIS monitor to detect onset of naturally occurring sleep.

OBJECTIVES: Inadvertent sleep episodes are a recognized complication of sleep deprivation. Although such events can be life threatening, no system currently exists to detect and prevent sleep onset. Because sleep shares electroencephalographic similarities with the anesthetized state, we hypothesized that the BIS monitor, a currently available EEG-based monitor of anesthetic depth, would detect the onset of physiologic sleep. To test our hypothesis, we monitored volunteers during the transition from waking to sleep. METHODS: Non-medicated volunteers were asked to lie down in a dark room for 30-minutes and fall asleep while attached to a BIS monitor located outside the room. A laptop computer was used to generate an audio tone inside the room. Speaker volume was adjusted to the lowest level detectable by the awake subject. Testing was begun by activating a computer to play a tone at random intervals. The subject was instructed to click a mouse connected to the computer upon hearing the tone to verify wakefulness. The session was terminated upon loss of response to three consecutive tones or after 30 minutes. Subjects were questioned afterwards regarding their perceptions of sleep during testing. RESULTS: 11 out of 28 self-described good sleepers could not sleep under testing conditions. BIS values for the remaining 17 fell from 96.4 +/- 2.1 to 86.5 +/- 0.79 (p < 0.01) upon sleep onset. All subjects responded to audio stimuli at BIS values >90, and were asleep either by subjective or objective report at BIS values <80. Three subjects retained the mouse-click response despite low BIS scores and subjective descriptions of sleep. CONCLUSION: Although variability in the BIS value marking sleep onset was noted, the BIS monitor detected all episodes of sleep onset in our testing regimen. We conclude that a threshold BIS value can be defined to allow the BIS monitor to detect sleep onset.

Adult↗

Monitoring urban streams: strategies and protocols for humid-region lowland systems.

Governmental mandates and public awareness have forced progressively smaller and less sophisticated agencies and organizations to initiate stream monitoring programs, particularly in urban and urbanizing areas. Yet many of these monitoring efforts lack either a coherent conceptual framework or appropriately chosen methods, and they rely on monitoring techniques that are simply infeasible for these institutional settings. We propose a monitoring strategy, and specific existing monitoring protocols, that will be useful for the management and rehabilitation of streams in urbanizing watersheds. A monitoring strategy must be developed by 1) identifying the management question(s) being addressed, 2) determining the institional level of effort required (and available) to effectively make particular kinds of measurements, and 3) identifying what specific parameters should and can be measured. Only a limited set of parameters show much utility or feasibility in addressing the most common management questions being faced by municipalities in urbanizing, humid-area regions of the United States. These include measures of riparian canopy, bank erosion and bank hardening, and in-stream large woody debris. With some additional expertise useful data can also be included on channel gradient, substrate composition, and pools. Nearly all of the other myriad parameters that have been measured historically on rivers and streams show little apparent value in these watershed and institutional settings.

Cities↗

Establishing the Canadian Community Monitoring Network.

Community-based ecosystem monitoring activities in Canada are increasing in response to a number of factors including: (i) the needs of decision-makers for timely information on local environmental changes; (ii) limited use of government monitoring data and information by decision makers: (iii) government cuts to monitoring programs; (iv) the increasingly recognized need to include stakeholders in planning and management processes; and (v) the desire of citizens to contribute to environmental protection. To date there has been no network coordination of community based monitoring in Canada. This paper reports on the establishment of the Canadian Community Monitoring Network by Environment Canada's Ecological Monitoring and Assessment Network Coordinating Office and the Canadian Nature Federation. Information on research prepared in support of network establishment is presented along with a discussion of the potential of the network.

Animals↗

Validation and calibration of physical activity monitors in children.

OBJECTIVE: This study was designed to validate accelerometer-based activity monitors against energy expenditure (EE) in children; to compare monitor placement sites; to field-test the monitors; and to establish sedentary, light, moderate, and vigorous threshold counts. RESEARCH METHODS AND PROCEDURES: Computer Science and Applications Actigraph (CSA) and Mini-Mitter Actiwatch (MM) monitors, on the hip or lower leg, were validated and calibrated against 6-hour EE measurements by room respiration calorimetry, activity by microwave detector, and heart rate by telemetry in 26 children, 6 to 16 years old. During the 6 hours, the children performed structured activities, including resting metabolic rate (RMR), Nintendo, arts and crafts, aerobic warm-up, Tae Bo, treadmill walking and running, and games. Activity energy expenditure (AEE) computed as EE - RMR was regressed against counts to derive threshold counts. RESULTS: The mean correlations between EE or AEE and counts were slightly higher for MM-hip (r = 0.78 +/- 0.06) and MM-leg (r = 0.80 +/- 0.05) than CSA-hip (r = 0.66 +/- 0.08) and CSA-leg (r = 0.73 +/- 0.07). CSA and MM performed similarly on the hip (inter-instrument r = 0.88) and on the lower leg (inter-instrument r = 0.89). Threshold counts for the CSA-hip were <800, <3200, <8200, and > or = 8200 for sedentary, light, moderate, and vigorous categories, respectively. For the MM-hip, the threshold counts were <100, <900, <2200, and > or = 2200, respectively. DISCUSSION: The validation of the CSA and MM monitors against AEE and their calibration for sedentary, light, moderate, and vigorous thresholds certify these monitors as valid, useful devices for the assessment of physical activity in children.

Adolescent↗