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PubMed1995

A quantitative ranking of the Biomedical Informatics serials.

We have developed a quantitative serial ranking system based on multiple citation analysis techniques, library use statistics, expert opinion, and selected distinguishing publication characteristics. Evaluation criteria categories include: average Science Citation Index (Impact Factor, Immediacy Index, Total citations) rankings from 1987 to 1992; citation source counts of multiple "core" biomedical informatics publications; a questionnaire sent to American College of Medical Informatics Fellows; publication delay; distinguishing characteristics (e.g., subscription cost, total circulation, year established, places indexed, affiliation with a professional society, major biomedical resource library holdings); and the total number of interlibrary loan requests to the U. S. National Library of Medicine. The top serials were Computers and Biomedical Research, MD Computing, Methods of Information in Medicine, Medical Decision Making and Computers in Biology and Medicine.

Abstracting and Indexing↗
PubMed1972

Reference books and computerized information services: partners in librarianship.

As a basis for thoughts on the roles of reference books and computerized information services in general, a comparison is made of the value to medical libraries of a comprehensive reference tool (the new dual media publication Biomedical Research in Progress) and a comprehensive information center file (the Smithsonian Science Information Exchange, the national resource for information on research in progress). It is concluded that a detailed reference tool which is physically present for library users has several advantages, in particular the provision of both detailed and comprehensive retrieval of all biomedical research information at substantially less annual cost and with faster access time than is possible with comparable questions put to an information center. On the other hand, the information center is able to provide more up-to-date material in more flexible combinations. The recommendation is made that medical libraries avoid treating the comprehensive reference tool and the computerized information file as alternatives and instead view both as necessary and complementary to each other.

Computers↗
PubMed2002

Community animal health services for improving household wealth and health status of low income farmers.

BACKGROUND: Community animal health services in low income countries aim to improve the health of animals. They are thought to directly improve the wealth and health or livelihood of their owners. These services have been promoted since the 1970s by aid organizations. OBJECTIVES: To summarize reliable research of community animal health services on indicators for household wealth and health. SEARCH STRATEGY: We searched the Cochrane Infectious Diseases Group specialized trials register (up to May 2002); the AGRIS database (January 1975 to April 2002); STN SIGLE database (January 1976 to 2002); CAB database (January 1973 to January 2002); AGRICultural OnLine Access (US National Agricultural Library; accessed 30 April 2002); MEDLINE (PubMed; 1966 to April 2002); the Science Citation Index (2000 to April 2002); and checked the reference lists of articles. We searched 24 relevant web sites and contacted 22 organizations between July and September 2000. SELECTION CRITERIA: Individual, cluster and quasi-randomized controlled trials, and controlled before and after studies: comparing community animal health services with no community animal health services, or with an alternative animal health service. DATA COLLECTION AND ANALYSIS: We independently assessed studies for inclusion in the review. We contacted study authors for additional information. MAIN RESULTS: No studies met the inclusion criteria. Subsidiary analysis of excluded studies indicate a need for methodological rigor in evaluating programmes. REVIEWER'S CONCLUSIONS: No studies met the inclusion criteria. Reports that draw on observational data show insufficient rigor to conclude benefit. Given the amount of money and time invested in this area, these observations need to be confirmed by well-designed trials using pragmatic outcomes.

Animal Husbandry↗
PubMed2004

Antibiotic prophylaxis in clean and clean-contaminated ear surgery.

BACKGROUND: Ear surgery may be performed in the treatment of chronic otitis media, ossicular chain disorders, tympanic membrane perforations and otitis media with effusion. Postoperative infection in ear surgery may result in: Wound infections Infection of the middle ear or mastoid resulting in discharge from the ear canal Failure of the tympanic membrane to close Labyrinthitis due to infection in, or adjacent to, the inner ear These complications may be associated with discomfort and inconvenience for the patient, an increase in morbidity and an increase in the costs of medical care. OBJECTIVES: The objective of this review was to assess the effects of local and/or systemic antibiotics for preventing complications such as postoperative discharge, graft failure and labyrinthitis in patients undergoing clean or clean-contaminated ear surgery. SEARCH STRATEGY: We searched MEDLINE (searched January 1966 to December 2002), EMBASE (searched January 1980 to December 2002), the Science Citation Index, The Cochrane Central Register of Controlled Trials (CENTRAL) (Cochrane Library, Issue 4 2002); the Cochrane Acute Respiratory Infections Group and Cochrane Ear, Nose and Throat Group Specialised Registers and proceedings of scientific meetings. The date of the last search was December 2002. We also contacted investigators in the field (Govaerts, Antwerp). Bibliographies of identified articles were screened for further relevant trials. No language restriction was applied. SELECTION CRITERIA: Randomised or quasi-randomised trials involving: PARTICIPANTS: patients undergoing clean or clean-contaminated types of ear surgery. Skull base surgery was excluded. INTERVENTION: any regimen of local and/or systemic antibiotic prophylaxis administered at or around the time of surgery compared to placebo, no antibiotic, or an alternative intervention group. OUTCOME MEASURES: infection, discharge, graft failure, labyrinthitis, adverse effects of prophylaxis. DATA COLLECTION AND ANALYSIS: When possible, investigators were contacted for additional information on data and methodological issues. At least two reviewers independently extracted data and assessed trial quality. MAIN RESULTS: Eleven studies were included in the review. The methodological quality of the trials was fair to good. However, most studies presented insufficient detail on methodological data. Although definitions of outcome measures were heterogeneous, pooling of results was possible. There were no significant differences between antibiotic prophylaxis groups and control groups in terms of reduction of postoperative infections, graft failures, draining outer ear canals and adverse drug effects. REVIEWERS' CONCLUSIONS: There is no strong evidence that the large scale use of prophylactic of antibiotics in clean and clean-contaminated ear surgery is helpful in reducing postoperative complications such as wound infection, discharge from the outer ear canal, labyrinthitis and graft failure.

Adult↗
PubMed2006

Alpha-glucosidase inhibitors for people with impaired glucose tolerance or impaired fasting blood glucose.

BACKGROUND: Alpha-glucosidase inhibitors (AGIs) reduce blood glucose levels and may thus prevent type 2 diabetes and cardiovascular disease in patients with impaired glucose tolerance. These possible effects, and the effects on quality of life, plasma lipids and body weight, have never been investigated in a systematic literature review and meta-analysis. OBJECTIVES: To assess the effects of alpha-glucosidase inhibitors in patients with impaired glucose tolerance (IGT) or impaired fasting blood glucose (IFBG), or both. SEARCH STRATEGY: We searched The Cochrane Library (Clinical Trials database, formerly known as CENTRAL), PUBMED, EMBASE, Web of Science, LILACS, databases of ongoing trials, reference lists of relevant reviews, and we contacted experts and manufacturers. Date of last search was February 2006. SELECTION CRITERIA: Randomised controlled trials of at least one-year duration in patients with IGT or IFBG, or both, comparing AGI monotherapy with any other intervention. DATA COLLECTION AND ANALYSIS: Two reviewers read all abstracts, assessed quality and extracted data independently. Discrepancies were resolved by consensus or by the judgement of a third reviewer. MAIN RESULTS: We included five trials (2360 participants), all investigating acarbose, that included patients with IGT or patients 'at increased risk for diabetes' (n = 1). Study duration was one, three (n = 2), five and six years. One study was at low risk of bias and four studies at high risk of bias. Except for the outcome incidence of type 2 diabetes in acarbose versus no treatment (two studies), meta-analyses were not possible. Data from the study at low risk of bias suggests that acarbose decreases the occurrence of type 2 diabetes (NNT = 10), cardiovascular events (NNT = 50, based on 47 events, study not initially powered for this outcome), post-load blood glucose (-0.6 mmol/L, 95% CI -1.0 to -0.3) and body mass index (0.3 kg/m(2), 95% CI -0.1 to -0.5). No statistically significant effects were observed on mortality, other morbidity, glycated haemoglobin, fasting blood glucose, lipids and blood pressure. The effects on the incidence of type 2 diabetes were confirmed in two studies at high risk of bias (OR 0.2, 95% CI 0.1 to 0.6). Adverse effects were mostly of gastro-intestinal origin (OR 3.5, 95% CI 2.7 to 4.4). AUTHORS' CONCLUSIONS: There is evidence that acarbose reduces the incidence of type 2 diabetes in patients with IGT. However, it is unclear whether this should be seen as prevention, delay or masking of diabetes. Acarbose may prevent the occurrence of cardiovascular events, but this finding needs to be confirmed in more studies.

Acarbose↗
PubMed2005

Scientists in the swamp: narrowing the language-practice gap in community psychology.

As a confluence of unique values and activities, the collective practice of community psychology is difficult to characterize in a simple way. Increasingly, however, professional contexts are laden with pressure to define any practice--from library work to medical interventions--in the orderly, compact language of traditional science. This trend has historically been resisted in the field by those sensing a fundamental lack of fit between the fluid, emergent aspects of community psychological practice and the fixed, precise language of classic science. In response to this "language-practice gap," some have attempted to adapt the traditional language of science to better fit the field's practice, while others have explored alternative languages of practice seemingly more indigenous to the messy "swamp" of actual communities. While the former effort leaves some theoretical contradictions intact, the latter tends to discount scientific identity entirely. This paper proposes a potential step forward by resituating questions of disciplinary language and identity within a current philosophical discourse where the nature of social science itself remains sharply contested. This suggests shifting attention away from "should we be a science?" to "what kind of science might we be after all?"; in turn, alternative languages may be re-cast as legitimate contributors to a kind of science more authentic to human communities--even a viable "science in the swamp." One such language-philosophical hermeneutics--is presented as a particularly valuable supplement to traditional science. Illustrations highlight ways that hermeneutics may advance the formal language of the field towards a closer fit of what actually happens in practice, while preserving and even bolstering the empirical rigor and scientific identity of the field.

Community Mental Health Services↗
PubMed2006

Books for free? How can this be? - A PubMed resource you may be overlooking.

The NCBI (National Center for Biotechnology Information) at the National Institutes of Health collects a wide range of molecular biological data, and develops tools and databases to analyse and disseminate this information. Many life scientists are familiar with the website maintained by the NCBI (http://www.ncbi.nlm.nih.gov), because they use it to search GenBank for homologues of their genes of interest or to search the PubMed database for scientific literature of interest. There is also a database called the Bookshelf that includes searchable popular life science textbooks, medical and research reference books and NCBI reference materials. The Bookshelf can be useful for researchers and educators to find basic biological information. This article includes a representative list of the resources currently available on the Bookshelf, as well as instructions on how to access the information in these resources.

Biological Science Disciplines↗
PubMedDate not supplied

[Is running associated with premature degenerative arthritis of the hip? A systematic review].

AIM: The study was performed to investigated correlations between running and degenerative arthritis of the hip, according to the principles of evidence-based medicine. METHOD: The database Medline, the Cochrane Library, the centre for Evidence Based Medicine in Oxford and the sports science database Spolit, Spofor and Spowis were scanned systematically for the keywords "arthritis, osteoarthritis, degenerative, hip, sports, running, jogging, walking". RESULTS: 10 retrospective case control studies and 3 prospective studies were included for further analysis. The clinical examinations reported in the prospective studies did not reveal a significant difference between runners and non-runners. In one study a slightly increased risk for signs of arthritis at the X-ray was found in runners below 50 years with a very high mileage. No increased risk for degenerative arthritis was reported in most of the retrospective studies. A few authors of retrospective studies reported a slightly to moderately increased risk. The pooled estimate of the included studies showed a slightly increased risk for degenerative arthritis in runners (pooled OR 1.24 95 % CI 0.87-1.85). However, the increased risk did not reach a level of statistical significance. The graphic analysis of the data with the technique of the funnel plot gives an OR of 1.04. CONCLUSION: There is no evidence that running is associated with an increased risk for degenerative arthritis of the hip. There is no evidence for a different risk in men and women.

Case-Control Studies↗
PubMed2006

Sequencing Medicago truncatula expressed sequenced tags using 454 Life Sciences technology.

BACKGROUND: In this study, we addressed whether a single 454 Life Science GS20 sequencing run provides new gene discovery from a normalized cDNA library, and whether the short reads produced via this technology are of value in gene structure annotation. RESULTS: A single 454 GS20 sequencing run on adapter-ligated cDNA, from a normalized cDNA library, generated 292,465 reads that were reduced to 252,384 reads with an average read length of 92 nucleotides after cleaning. After clustering and assembly, a total of 184,599 unique sequences were generated containing over 400 SSRs. The 454 sequences generated hits to more genes than a comparable amount of sequence from MtGI. Although short, the 454 reads are of sufficient length to map to a unique genome location as effectively as longer ESTs produced by conventional sequencing. Functional interpretation of the sequences was carried out by Gene Ontology assignments from matches to Arabidopsis and was shown to cover a broad range of GO categories. 53,796 assemblies and singletons (29%) had no match in the existing MtGI. Within the previously unobserved Medicago transcripts, thousands had matches in a comprehensive protein database and one or more of the TIGR Plant Gene Indices. Approximately 20% of these novel sequences could be found in the Medicago genome sequence. A total of 70,026 reads generated by the 454 technology were mapped to 785 Medicago finished BACs using PASA and over 1,000 gene models required modification. In parallel to 454 sequencing, 4,445 5'-prime reads were generated by conventional sequencing using the same library and from the assembled sequences it was shown to contain about 52% full length cDNAs encoding proteins from 50 to over 500 amino acids in length. CONCLUSION: Due to the large number of reads afforded by the 454 DNA sequencing technology, it is effective in revealing the expression of transcripts from a broad range of GO categories and contains many rare transcripts in normalized cDNA libraries, although only a limited portion of their sequence is uncovered. As with longer ESTs, 454 reads can be mapped uniquely onto genomic sequence to provide support for, and modifications of, gene predictions.

Base Sequence↗
PubMed2006

Increasing recruitment to randomised trials: a review of randomised controlled trials.

BACKGROUND: Poor recruitment to randomised controlled trials (RCTs) is a widespread and important problem. With poor recruitment being such an important issue with respect to the conduct of randomised trials, a systematic review of controlled trials on recruitment methods was undertaken in order to identify strategies that are effective. METHODS: We searched the register of trials in Cochrane library from 1996 to end of 2004. We also searched Web of Science for 2004. Additional trials were identified from personal knowledge. Included studies had to use random allocation and participants had to be allocated to different methods of recruitment to a 'real' randomised trial. Trials that randomised participants to 'mock' trials and trials of recruitment to non-randomised studies (e.g., case control studies) were excluded. Information on the study design, intervention and control, and number of patients recruited was extracted by the 2 authors. RESULTS: We identified 14 papers describing 20 different interventions. Effective interventions included: telephone reminders; questionnaire inclusion; monetary incentives; using an 'open' rather than placebo design; and making trial materials culturally sensitive. CONCLUSION: Few trials have been undertaken to test interventions to improve trial recruitment. There is an urgent need for more RCTs of recruitment strategies.

Culture↗
PubMed1993

[Not Available].

Explore the source record for details and available documents.

Archives↗
PubMedDate not supplied

[Visibility of scientific journals and initiatives to improve the diffusion of spanish publications].

The conceptual change which has been produced in the transmission of technology knowledge among the scientific community is examined. The international and national systems to organize, store and retrieve the scientific production as referential data bases like Medline, PubMed, Latin American and Caribbean Health Sciences (LILACS) and Spanish Health Sciences Bibliographic Index (IBECS) are listed. The initiative called the Virtual Health Library (VHL) developed by BIREME/PAHO/WHO, especially SciELO (Scientific Electronic Library Online) the electronic publication model, that gather collections of scientific publications--full text--, with high quality is detailed.

Language↗
PubMed1983

A clinical information consultation service at a teaching hospital.

The library and the department of medicine at the University of Texas Health Science Center at San Antonio cooperated in a three-month pilot project to test a clinical information consultation service that provides patient care information to house staff members in the clinical setting. Evaluation indicated that users were highly satisfied with the service. Results of our pilot project seem to show that a clinical information consultation service can be an efficient and cost-effective means to provide information in a patient-care setting.

Hospitals, Teaching↗
PubMed1996

Michael S. Brown, MD and Joseph L. Goldstein, MD. 1985 Nobel laureates in medicine.

When Michael S. Brown, MD and Joseph L. Goldstein, MD first met as interns at the Massachusetts General Hospital in 1966, they could hardly have imagined that their careers would continue to be intertwined some 30 years later. It was shortly following their arrival as clinical associates at the National Institutes of Health in 1968 that the pair developed an interest in abnormalities of cholesterol metabolism. Bolstered by epidemiologic data that showed elevated cholesterol levels in many patients with myocardial infarction, Brown and Goldstein, who relocated to the University of Texas Southwestern Medical Center in 1972, began a search for receptors important in cholesterol homeostasis. These studies, performed in their early stages while juggling clinical duties at Parkland Hospital, culminated in a series of scientific achievements which merited among other honors the Hazen Award in 1982, the Lasker Award in 1985, and the Nobel Prize in Medicine in 1985. Today, as Regental Professors of the University of Texas, Brown and Goldstein head a laboratory group which continues to test the cutting edge of medical research. Although impressed with the pace of technological advances in biology, the declining role of clinically oriented physicians in biomedical research troubles the pair. Interviewed in their library in Dallas, Brown and Goldstein spoke about the complicated balance of science, medicine, and education necessary to produce another generation of successful investigators.

Cholesterol↗
PubMed1997

The risk factors of death from the acetaminophen poisoning with antipyretic-analgesic drugs in Japan.

Since adverse effects rarely occur with the therapeutic doses of acetaminophen, it is commonly used as a mild antipyletic and analgesic. However, overdosage of acetaminophen causes fatal hepatic failure and acute renal failure. Therefore, we evaluated the risk factors for death among the reported cases of acetaminophen poisoning in Japan, which were obtained from Japan Science and Technology Corporation, Information Center for Science and Technology (JICST) on-line service in the Kyushu University Library. In a univariate analysis, the death rate of patients with hepatic failure (23.3% vs 0%, p = 0.04), disseminated intravascular coagulation syndrome (DIC) (38.1% vs 5.3%, p = 0.001) or plasma exchange treatment (33.3% vs 7.9%, p = 0.01) was significantly greater than those without it while a multivariate analysis revealed that DIC (with vs without; odds ratio = 23.04, 95% confidence interval = 2.80-189.75) and the treatment with plasma exchange (with vs without; odds ratio = 14.77, 95% confidence interval = 1.44-151.52) were independent risk factors. These results suggest that DIC and hepatic failure, especially requiring plasma exchange, were poor prognostic factors. In addition, about seventeen percent of the cases with less than 5 g of acetaminophen ingestion were death cases although the acute lethal adult dose is shown 13-25 g in western countries. This suggests that its acute lethal dose may be low in Japan, which may be partly due to the additional adverse effect of other drugs used in the mixed compounds while acetaminophen alone is used in western countries. An intensive treatment should be recommended for the acetaminophen poisoning patients regardless of the ingested dose.

Acetaminophen↗
PubMed2002

Science's signal transduction knowledge environment: the connections maps database.

Knowledge environment (KE) describes the collection of electronic networking tools that have been and continue to be developed by AAAS and Stanford University libraries. Knowledge environments use practical, production-quality tools to systematize the consensus knowledge within a scientific domain and facilitate users' access to that knowledge. Science's Signal Transduction Knowledge Environment (STKE) is the first in this new concept in electronic publishing that combines the traditional, albeit electronic, publishing of articles, such as reviews, perspectives, and protocols, with tools for organizing and collating information in the cross-disciplinary field of signal transduction. One of the major tools developed for the STKE is the Connections Map database and the software (called CMADES [Connections Maps Authority Data Entry Software]) created to facilitate data entry by Pathway Authorities. The Connections Maps are a graphical representation of a database of information about the molecules involved in cellular signaling cascades. CMADES automates many of the functions involved in adding data into the Connections Maps database, such as references and descriptors, as well as allowing the Authorities to indicate the relationships between the components in the pathway through the use of a graphing tool. CMADES and the Connections Maps represent evolving tools that assist the Authorities in systemizing information regarding a particular system at the organism- and cell-specific level and the canonical level, as well as provide the STKE user with organized and expert-supplied information about signal transduction pathways.

Biology↗