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An efficient Fourier method for 3-D radon inversion in exact cone-beam CT reconstruction.

The radial derivative of the three-dimensional (3-D) radon transform of an object is an important intermediate result in many analytically exact cone-beam reconstruction algorithms. We briefly review Grangeat's approach for calculating radon derivative data from cone-beam projections and then present a new, efficient method for 3-D radon inversion, i.e., reconstruction of the image from the radial derivative of the 3-D radon transform, called direct Fourier inversion (DFI). The method is based directly on the 3-D Fourier slice theorem. From the 3-D radon derivative data, which is assumed to be sampled on a spherical grid, the 3-D Fourier transform of the object is calculated by performing fast Fourier transforms (FFT's) along radial lines in the radon space. Then, an interpolation is performed from the spherical to a Cartesian grid using a 3-D gridding step in the frequency domain. Finally, this 3-D Fourier transform is transformed back to the spatial domain via 3-D inverse FFT. The algorithm is computationally efficient with complexity in the order of N3 logN. We have done reconstructions of simulated 3-D radon derivative data assuming sampling conditions and image quality requirements similar to those in medical computed tomography (CT).

Algorithms↗

A unified reconstruction framework for both parallel-beam and variable focal-length fan-beam collimators by a Cormack-type inversion of exponential radon transform.

A variety of inversions of exponential Radon transform has been derived based on the circular harmonic transform in Fourier space by several research groups. However, these inversions cannot be directly applied to deal with the reconstruction for fan-beam or variable-focal-length fan-beam collimator geometries in single photon emission computed tomography (SPECT). In this paper, we derived a Cormack-type inversion of the exponential Radon transform by employing the circular harmonic transform directly in the projection space and the image space instead of the Fourier space. Thus, a unified reconstruction framework is established for parallel-, fan-, and variable-focal-length fan-beam collimator geometries. Compared to many existing algorithms, the presented one greatly mitigates the difficulty of image reconstruction due to the complicated collimator geometry and significantly reduces the computational burden of the special functions, such as Chebyshev or Bessel functions. By the well-established fast-Fourier transform (FFT), our algorithm is very efficient, as demonstrated by several numerical simulations.

Algorithms↗

Comparison of potential- and activation-based formulations for the inverse problem of electrocardiology.

Two predominant source formulations for the inverse problem of electrocardiology currently exist. They involve the reconstruction of epicardial potentials or myocardial activation times from noninvasively recorded torso surface potentials. Each of these formulations have their advantages, however, they have not been systematically compared against each other. We present results from a simulation study which compared a number of epicardial potential (Tikhonov, Truncated singular value decomposition (TSVD), Greensite-Tikhonov and Greensite-TSVD), and a myocardial activation time formulation for the inverse problem of electrocardiology. A number of different methods were also used to determine the appropriate level of regularization (optimal, L-curve, zero-crossing, and composite residual and smoothing operator) to apply to each formulation. The simulation study was conducted using an anatomically based boundary element porcine model with a variety of cardiac sources. Varying levels of geometric error were introduced to the system and solutions were computed using each of the inverse algorithms. Results show that under pure Gaussian noise potential-based methods performed best at low noise levels while the activation-based method was less effected by higher noise levels. In the presence of correlated geometric error, the activation-based method out performed the potential methods, with the Greensite-Tikhonov method being the most favored potential-based method when using the L-curve or zero-crossing method to determine the regularization parameter.

Algorithms↗

Conventional and reciprocal approaches to the inverse dipole localization problem of electroencephalography.

Forward transfer matrices relating dipole source to surface potentials can be determined via conventional or reciprocal approaches. In numerical simulations with a triangulated boundary-element three-concentric-spheres head model, we compare four inverse electroencephalogram (EEG) solutions: those obtained utilizing conventional or reciprocal forward transfer matrices, relating in each case source dipole components to potentials at either triangle centroids or triangle vertices. Single-dipole inverse solutions were obtained using simplex optimization with an additional position constraint limiting solution dipoles to within the brain region. Dipole localization errors are presented in all four cases, for varying dipole eccentricity and two different values of skull conductivity. Both conventional and reciprocal forward transfer matrices yielded inverse dipole solutions of comparable accuracy. Localization errors were low even for highly eccentric source dipoles on account of the nonlinear nature of the single-dipole solution and the position constraint. In the presence of Gaussian noise, both conventional and reciprocal approaches were also found to be equally robust to skull conductivity errors.

Action Potentials↗

Improving the performance of linear inverse solutions by inverting the resolution matrix.

This paper proposes a new strategy for improving the localization capabilities of linear inverse solutions, based on the relationship between the real solution and the estimated solution as described by the resolution matrix equation. Specifically, we present two alternatives based on either the partial or total inversion of the resolution matrix and applied them to the minimum norm solution, which is known for its poor performance in three-dimensional (3-D) localization problems. The minimum norm transformed inverse showed a clear improvement in 3-D localization. The strong dependence of localization errors with the eccentricity of the sources, characteristic of this solution, disappears after the proposed transformation. A similar effect is illustrated, using a realistic example where multiple generators at striate areas are active. While the original minimum norm incorrectly places the generators at extrastriate cortex, the transformed minimum norm localizes, for the example considered, the sources at their correct eccentricity with very low spatial blurring.

Algorithms↗

Task-based comparison of inverse methods in magnetoencephalography.

Magnetoencephalography (MEG) provides unique insights into the spatio-temporal dynamics of neural activation in the human brain. Unfortunately, the accuracy with which neural sources can be localized is limited by the highly illposed nature of the inverse problem. A large number of inverse methods have been proposed that deal with this illposedness using a range of different modeling and regularization procedures. Here we describe an objective task-based framework for comparing different inverse methods. Using the free-response receiver operating characteristic (FROC) we compare the performance of matched filters, cortically constrained dipole scanning, and minimum norm imaging methods for the task of detecting focal cortical activation. Our results indicate that the scanning methods outperform matched filters and minimum norm imaging for the case of one and two 2 cm2 patches of cortical activity when the dynamics of the two patches are both strongly and weakly correlated and irrespective of the spacing of the two activated regions.

Algorithms↗

VLSI architectures for computing multiplications and inverses in GF(2m).

Finite field arithmetic logic is central in the implementation of Reed-Solomon coders and in some cryptographic algorithms. There is a need for good multiplication and inversion algorithms that can be easily realized on VLSI chips. Massey and Omura recently developed a new multiplication algorithm for Galois fields based on a normal basis representation. In this paper, a pipeline structure is developed to realize the Massey-Omura multiplier in the finite field GF(2m). With the simple squaring property of the normal basis representation used together with this multiplier, a pipeline architecture is developed for computing inverse elements in GF(2m). The designs developed for the Massey-Omura multiplier and the computation of inverse elements are regular, simple, expandable, and therefore, naturally suitable for VLSI implementation.

Algorithms↗

Inverse halftoning algorithm using edge-based lookup table approach.

The inverse halftoning algorithm is used to reconstruct a gray image from an input halftone image. Based on the recently published lookup table (LUT) technique, this paper presents a novel edge-based LUT method for inverse halftoning which improves the quality of the reconstructed gray image. The proposed method first uses the LUT-based inverse halftoning method as a preprocessing step to transform the given halftone image to a base gray image, and then the edges are extracted and classified from the base gray image. According to these classified edges, a novel edge-based LUT is built up to reconstruct the gray image. Based on a set of 30 real training images with both low-and high-frequency contents, experimental results demonstrated that the proposed method achieves a better image quality when compared to the currently published two methods, by Chang et al. and Meşe and Vaidyanathan.

Algorithms↗

Electrode boundary conditions and experimental validation for BEM-based EIT forward and inverse solutions.

In this paper, we present theoretical developments and experimental results for the problem of estimating the conductivity map inside a volume using electrical impedance tomography (EIT) when the boundary locations of any internal inhomogeneities are known. We describe boundary element method (BEM) implementations of advanced electrode models for the forward problem of EIT. We then use them in the inverse problem with known internal boundaries and derive the associated Jacobians. We report on the results of two EIT phantom studies, one using a homogeneous cubical tank, and one using a cylindrical tank with agar conductivity inhomogeneities. We test both the accuracy of our BEM forward model, including the electrode models, as well as our inverse solution, against the measured data. Results show good agreement between measured values and both forward-computed tank voltages and inverse-computed conductivities; for instance, in a phantom experiment, we reconstructed the conductivities of three agar objects inside a cylindrical tank with an error less than 2% of their true value.

Algorithms↗

Design and analysis of a general recurrent neural network model for time-varying matrix inversion.

Following the idea of using first-order time derivatives, this paper presents a general recurrent neural network (RNN) model for online inversion of time-varying matrices. Different kinds of activation functions are investigated to guarantee the global exponential convergence of the neural model to the exact inverse of a given time-varying matrix. The robustness of the proposed neural model is also studied with respect to different activation functions and various implementation errors. Simulation results, including the application to kinematic control of redundant manipulators, substantiate the theoretical analysis and demonstrate the efficacy of the neural model on time-varying matrix inversion, especially when using a power-sigmoid activation function.

Algorithms↗

Inverse association between periodontitis and respiratory allergies.

BACKGROUND: Periodontitis is an infection with systemic effects and a high prevalence among adults. In the aetiology of allergic diseases the hygiene hypothesis claims that infections in early infancy may protect against allergic diseases. OBJECTIVE: The aim of the present analyses was to investigate the independent relation between periodontitis and respiratory allergies such as hayfever, house dust mite (HDM) allergy and asthma. METHODS: From the Study of Health in Pomerania (SHIP) a total number of 2837 subjects aged 20 to 59 years were included in the analysis. In our study population 326, 111 and 114 subjects were classified as suffering from hayfever, HDM allergy or asthma, respectively. The attachment loss (AL) were measured. Periodontitis was defined according to the percentage of surfaces which exceeded 3 mm AL [healthy: 0-7.7%, mild: 7.8-28.6%, moderate: 28.7-63.9%, severe: >63.9%]. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using logistic regression. RESULTS: After adjustment for confounding factors these analyses revealed inverse associations between periodontitis and hayfever as well as periodontitis and HDM allergy. For increasing AL, a trend of decreasing risk could be observed for hayfever (healthy: reference; mild AL: OR 0.87 [95%-CI 0.6-1.2]; moderate AL: OR 0.80 [95% CI 0.6-1.2]; server AL: OR 0.53 [95% CI 0.3-0.9]; P(trend)=0.01) and for HDM allergy (healthy: reference; mild AL: OR 0.80 [95% CI 0.5-1.3]; moderate AL: OR 0.64 [95% CI 0.3-1.2]; server AL: OR 0.39 [95% CI 0.2-0.9]; P(trend)=0.02). Furthermore, for asthma were observed a slightly inverse association in the full-adjusted model (healthy: reference; mild AL: OR 1.10 [95% CI 0.6-2.0]; moderate AL: OR 0.96 [95% CI 0.5-1.8]; server AL: OR 0.48 [95% CI 0.2-1.0]; P(trend)=0.11). CONCLUSION: There is an inverse association between periodontitis and respiratory allergies. Our results might support the hygiene hypothesis.

Adult↗

Inverse correlation between insulin-like growth factor binding protein-1 and insulin in patients with acromegaly during treatment with the somatostatin analogue octreotide.

OBJECTIVE: Previous reports have shown an inverse relation between IGFBP-1 and insulin levels in healthy men, patients with insulin dependent diabetes mellitus, and insulinoma. We have investigated whether this inverse relation also exists in acromegaly, before and during treatment with octreotide, and whether changes in IGFBP-1 levels relate to GH and IGF-I levels. DESIGN: We studied short-term treatment with octreotide in a double-blind placebo-controlled 14-day clinical trial. PATIENTS: Eighteen patients with acromegaly were studied. MEASUREMENTS: Plasma GH and serum IGFBP-1 levels were measured at hourly intervals from 0700 to 1800 h before randomization (day 0) and on days 4, 6, 8, 14 and 20. Serum insulin was determined at 0700, 0800 and 0900 h, and serum IGF-I at 0700 h. RESULTS: Octreotide increased the daily mean IGFBP-1 level by 43% on day 8 and by 35% on day 14. The IGFBP-1 levels during octreotide were significantly higher (P < 0.05) compared to placebo, 29.9 +/- 3.9 vs 19.9 +/- 1.7 micrograms/l (mean +/- SEM) on day 8, and 28.3 +/- 3.2 vs 19.9 +/- 1.6 micrograms/l on day 14. Octreotide treatment significantly suppressed the insulin levels on all observation days by 40-48% compared to placebo. There was a significant inverse correlation between IGFBP-1 levels and insulin levels, both before treatment and on the last day of treatment (r = 0.79, P = 0.04; r = -0.90, P = 0.02, respectively). GH and IGF-I were significantly decreased in the octreotide group compared to the placebo group during the entire treatment period. The mean of age related standard deviation scores of IGF-I in the octreotide group decreased from a pretreatment value of 6.47 +/- 0.74 to 3.60 +/- 1.20 on day 14. There was no significant correlation between IGFBP-1 levels and levels of GH and IGF-I, either before or during treatment. CONCLUSIONS: Octreotide treatment, in addition to reducing GH, IGF-I and insulin levels, is associated with an increase in IGFBP-1 concentrations in patients with acromegaly, and it is suggested that the rise in serum IGFBP-1 is a consequence of the decrease in insulin secretion.

Acromegaly↗

Effect of visual experience on face processing: a developmental study of inversion and non-native effects.

In adults, three phenomena are taken to demonstrate an experience effect on face recognition: an inversion effect, a non-native face effect (so-called 'other-race' effect) and their interaction. It is crucial for our understanding of the developmental perception mechanisms of object processing to discover when these effects are present in childhood. Three- to 5-year-old Caucasian children (N = 64) were asked to recognize upright and inverted Caucasian and Asian faces. Recognition was tested with a forced-choice procedure. Overall performance improved with age. However, there was an interaction between the inversion and non-native effects that did not change with age between ages 3 and 5: (a) the inversion effect with native (Caucasian) faces was larger than with non-native (Asian) faces, and (b) upright native faces were recognized better than upright non-native faces. These results show that face orientation and morphology constrain face processing in 3- to 5-year-olds. The first 3 years of life during which the brain and the environment interact are sufficient to build a face-processing system that constrains recognition.

Adult↗

Activation of face expertise and the inversion effect.

We used a contextual priming paradigm to examine top-down influences on the face-inversion effect. Adult participants were primed with either faces or Chinese characters and then tested on ambiguous figures that could be perceived as either faces or Chinese characters, dependent on the priming condition. The ambiguous figures differed from one another in their configural information, which is crucial for processing faces but not Chinese characters. The inversion effect was observed in the face-priming condition, but not in the character-priming condition. The present results provide the first direct evidence that top-down activation of the face-processing expertise system plays a crucial role in the face-inversion effect.

Adult↗

Modulation of gamma-aminobutyric acidA receptor-operated chloride channels by benzodiazepine inverse agonists is related to genetic differences in ethanol withdrawal seizure severity.

To determine whether genetic differences in development of ethanol dependence are related to changes in gamma-aminobutyric acidA (GABAA) receptor function, we measured 36Cl- uptake by brain cortical membrane vesicles from withdrawal seizure prone and withdrawal seizure resistant (WSP/WSR) mice treated chronically with ethanol. Muscimol-stimulated chloride flux was not different between WSP and WSR mice before or after ethanol treatment. Also, augmentation of muscimol action by flunitrazepam or inhibition of muscimol action by the inverse agonists Ro 15-4513 (ethyl-8-azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5a]- [1,4]benzodiazepine-3-carboxylate) and methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM) was not different for ethanol-naive WSP and WSR mice. However, chronic ethanol administration enhanced the inhibitory actions of DMCM and Ro 15-4513 on membranes from WSP but not WSR mice. Conversely, chronic ethanol treatment attenuated the action of flunitrazepam on membranes from WSR but not WSP mice, suggesting that the actions of benzodiazepine agonists and inverse agonists are under separate genetic control. These genetic differences in actions of DMCM and Ro 15-4513 indicate that sensitization to benzodiazepine inverse agonists produced by chronic ethanol treatment may be related to development of withdrawal seizures and suggest that differences in the GABA/benzodiazepine receptor complex represent alleles that have segregated during the selection of the WSP/WSR mice.

Animals↗

A longitudinal study of the age dependence of human ocular refraction--III. The mediation of changes from direct to inverse astigmatism examined by means of matrices of transition probabilities.

This study enquires into the manner in which the axis of astigmatism changes in the course of individual refractive histories. Specifically, two related problems are addressed: (1) how is the change from direct to inverse astigmatism mediated, and (2) what is the range of relative proportions of each of four variables (spherical ametropia, direct, inverse and oblique astigmatism) that occur in a sample population so that it can be considered randomly sampled and well distributed? Solutions to both problems are obtained by calculation of the probabilities with which transitions between such variables occur. A moderately sized longitudinal sample is used to demonstrate the new method. One of the conclusions is that the biological strategy for the mutation of the astigmatic axis is multi-faceted and that there is unlikely to be a single cause which can explain the process by which inverse astigmatism is achieved.

Adult↗

The affinities, potencies and efficacies of some benzodiazepine-receptor agonists, antagonists and inverse-agonists at rat hippocampal GABAA-receptors.

The abilities of some benzodiazepine-receptor agonists, antagonists and inverse agonists to modulate the inhibitory potency of the gamma-aminobutyric acid (GABA)A-receptor agonist, isoguvacine, on the CA1 population spike recorded from slices of rat hippocampus, were determined. Concentration-response curves were constructed of the extent to which the benzodiazepine-receptor ligands shifted the isoguvacine concentration-response curve to the left or right. These were compared to their displacement curves of [3H]-Ro15-1788 binding to rat hippocampal membranes under near physiological assay conditions. The above comparisons suggest that the effect on the potency of isoguvacine produced by the benzodiazepine-receptor agonists, diazepam and flunitrazepam, and the partial agonists, Ro16-6028 and Ro17-1812, closely parallels their degree of benzodiazepine-receptor occupancy. Thus, the partial agonists, Ro16-6028 and Ro17-1812, were unable to produce as large a maximum response as the full agonists, diazepam and flunitrazepam. The maximum effects produced by diazepam, flunitrazepam, Ro16-6028, Ro17-1812, the antagonist, propyl-beta-carboline-3-carboxylate, and the inverse agonist, methyl-6, 7-dimethyl-4-ethyl-beta-carboline-3-carboxylate (DMCM), on the potency of isoguvacine in the hippocampal slice corresponded to the change in their affinities produced by the addition of GABA in the radioligand binding studies (GABA-shift). This suggests that the changes in affinity of benzodiazepine-receptor ligands produced by GABAA-receptor activation reflects their ability to modify GABAA-receptor function. The benzodiazepine-receptor antagonists, Ro15-1788 and CGS 8216, had apparent agonist and inverse agonist effects, respectively, on the potency of isoguvacine. These effects occurred at concentrations above those required for saturation of the benzodiazepine-receptor, as labelled by [3H]-Ro15-1788, and were not in agreement with the absence of any effect of GABAA-receptor stimulation in the GABA-shift experiments. This indicates that these events are not mediated by an action at the classical benzodiazepine-receptor site. 6 It is concluded that hippocampal GABAA-receptor function can be allosterically modulated in a manner consistent with the agonist/inverse-agonist model of benzodiazepine-receptor activation, and that compounds exist with varying efficacies throughout this range.

Animals↗

Effects of an intrathecally administered benzodiazepine receptor agonist, antagonist and inverse agonist on morphine-induced inhibition of a spinal nociceptive reflex.

1. The effects of an intrathecally administered benzodiazepine receptor (BZR) agonist (midazolam, up to 50 micrograms), antagonist (flumazenil, Ro 15-1788, 5 micrograms) and inverse agonist (Ro 19-4603, 15 micrograms) on nociception and on morphine-induced antinociception were studied in rats. 2. By themselves, none of these compounds significantly altered pain threshold. 3. The BZR agonist midazolam enhanced the morphine-induced antinociceptive effect whereas the antagonist flumazenil did not alter it. In contrast, the BZR inverse agonist Ro 19-4603 decreased the morphine-induced antinociceptive effect. 4. Naloxone (1 mg kg-1 i.p.) completely reversed all these effects. 5. These results demonstrate that BZR agonists and inverse agonists are able to affect, by allosteric up- or down-modulation of gamma-aminobutyric acidA (GABAA)-receptors, the transmission of nociceptive information at the spinal cord level, when this transmission is depressed by mu-opioid receptor activation.

Animals↗