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[Extraction and classification of features of experimental gingivitis. Discriminant analysis of TS 200 data sequences].

This paper represent one of the important index of gingival color to various conditions. Generally the gingival color is very difficult problem to measure, so experimental gingivitis has to be treated by special technique such as Discriminant Analysis in spectrum pattern analysing. On measuring gingiva, Standard Measuring System is used in our department. Tissue Spectrum Analyzer TS-200 is used for measuring gingival color and spectrum pattern. Spectrum patterns are classified by its strength into three categories, that is Normal, Slightly-Redness and Redness. Discriminant Analysis and Graph Analysis (Constellation Graph) showed each group of property. The following results were obtained; Spectrum patterns have two peaks, that is 542 nm and 577 nm. With gingivitis change on three steps, that is Normal, Slightly-Redness and Redness, spectrum powers and difference of absorption in spectrum degrees and brightness is down. With gingivitis change, the Z1 value was obtained by Discriminant Analysis and showed a tendency to sign change from minus to plus. In the result of Discriminant Analysis distinction rate is 97.4% in N Group, 98.5% in SR Group and 100% in R Group. Constellation Graph represented each group of property clearly.

Color↗

Goals for clinical biochemistry analytical imprecision: a graphic approach.

Analytical performance standards for the imprecision of commonly requested clinical biochemistry tests are proposed in the form of goal graphs. The goals delineated in graphic form are a consensus of published performance standards. The graphs define acceptable and unacceptable performance standards for levels of analyte commonly encountered in clinical laboratory practice. The graphic approach allows a flexible presentation of goals that is easy to interpret. The disadvantage of goal graphs is their necessarily empirical foundation.

Bilirubin↗

Trend line influence on visual analysis of single-subject data in rehabilitation research.

Single-subject design and n of 1 randomized clinical trials are being advocated as methods of conducting clinical research in rehabilitation environments. The traditional procedure for interpreting data from such designs is visual analysis. This study examined the effect of including trend lines on the visual judgements made from single-subject data. Twenty-four hypothetical single-subject A-B designs were presented to 20 rehabilitation therapists for visual interpretation. The graphs represented traditional single-subject designs, including a baseline and treatment phase. Trend lines were computed and included in both phases of the design as an adjunct to visual analysis. The interrater reliability of the visual judgements was calculated using the intraclass correlation coefficient and ranged from 0.54 to 0.90. The results suggest that adding trend lines to graphed data presented in single-subject designs can improve the consistency of visual judgements. Implications for using adjuncts to graphing data points in single-subject rehabilitation research are discussed.

Data Interpretation, Statistical↗

A probabilistic and interactive decision-analysis system for unruptured intracranial aneurysms.

OBJECT: The goal in this study was to develop an interactive, probabilistic decision-analysis system for clinical use in the decision to treat or observe unruptured intracranial aneurysms. Further goals were to enable users of the system to adapt decision-analysis methods to individual patients and to provide a tool for interactive sensitivity analysis. METHODS: A computer program was designed to model the outcomes of treatment and observation of unruptured aneurysms. The user supplies probabilistic estimates of key parameters relating to a specific patient and nominates discount rate and quality of life adjustments. The program uses Monte Carlo discrete-event simulation methods to derive probability estimates of the outcomes of treatment and observation. Results are expressed as summary statistics and graphs. Discounted quality-adjusted life years are graphed using survival methods. Hierarchical simulations are used to enable investigators to perform probabilistic sensitivity analysis for one or multiple parameters simultaneously. The results of sensitivity analysis are expressed in graphs and as the expected value of perfect information. The system can be distributed and updated using the Internet. CONCLUSIONS: Further research is required into the benefits of clinical application of this system. Further research is also required into the optimum level of complexity of the model, into the user interface, and into how clinicians and patients are likely to interpret results. The system is easily adaptable to a range of medical decision analyses.

Confidence Intervals↗

[Study on CAM system for dental model].

The purpose of this study was to introduce our newly-developed CAM system for dental model and to examine the shape reproducibility and measurement reliability of the CAM modelling. The system is composed of a measuring unit, which obtains three-dimensional shape information from the dental model using laser scanning, and an engineering workstation, which creates a three-dimensional graph of the dental model. Output module program which can directly process and output the three-dimensional shape data to the wide use modeling systems was developed as the software of this CAM system. Four different CAM models, that, WAX model, STL model, FDM model, and SL model, were made based on the graph of the dental model taken from a mandibular prognathic patient. The measurement reliability of each CAM model were evaluated using a contact three-dimensional measurement unit. All CAM models except a WAX model demonstrated good shape reproducibility without a blind area, suggesting no problem of the three-dimensional shape data and the output module program. Measurement reliability of each CAM model was 0.12 +/- 0.08 mm in graph, 0.25 +/- 0.05 mm in WAX, 0.28 +/- 0.16 mm in SL, 0.31 +/- 0.15 mm in FDM, and 0.39 +/- 0.18 mm in STL. These results suggested clinical feasibility of this system in accordance with electronic storage of medical information.

Computer-Aided Design↗

[The effect of gender on vasomotor function of the vascular endothelium and cardiovascular remodelling during aging].

INTRODUCTION: Aging is correlated with decreased endothelial vasomotor influence, increased carotid intima-media thickness and stiffness, increased left ventricular mass index and increased blood pressure [1-3]. However, these changes are not expressed in the same way in both genders [4, 5]. It seems that females are more protected from cardiovascular changes during aging compared to males [1, 6]. AIM OF THE STUDY: The aim of the study was to evaluate the influence of gender on brachial vasomotor responses (reactive hyperemia test) as well as the correlation with vascular and cardiac remodelling in healthy volunteers of different ages. MATERIAL AND METHODS: The study was carried out on healthy subjects (n = 66; 37 males, 29 females) of different ages (20-82 years) with no history of cardiovascular diseases and diabetes mellitus. All subjects were normotensive, non-smokers with normal blood lipid and glucose values, were not taking any medication at the time of investigation and were asked to refrain from eating and drinking alcohol, coffee or tea 12 hours before the examination. Subjects were divided in two groups (male and female) and 5 age-related groups according to appropriate decade (20-29, 30-39, 40-49, 50-59, and above 60 years). All subjects underwent regular cardiologic examination, ECG recording and cardiac ultrasound in order to exclude valvular diseases, decreased myocardial contractility and ejection fraction. During the study blood pressure and ECG were recorded continuously. Carotid artery intima-media thickness and brachial artery diastolic internal diameter (mm) and blood flow (ml/min) values were measured continuously using high-resolution ultrasound. Brachial artery parameters were measured in baseline condition, during ischaemia and reactive hyperemia (endothelium-dependent relaxation) and after nitroglycerin administration (endothelium independent relaxation, 2 x 400 micrograms, sublingual) [7, 8]. Brachial ischaemia was induced by inflation of a pneumatic tourniquet placed at the forearm to a pressure of 300 mmHg followed by deflation after 3 min. We analyzed changes in peripheral arteries (changes in brachial artery diastolic diameter and flow during 90 sec after cuff deflation), structural changes of carotid artery, functional and structural changes of the left ventricle (19-11). We used cardiac ultrasound (Hewlett Packard Sonos 2500) with a 2.0-2.5 MHz imaging transducer and a 7.0-MHz linear array transducer for vascular measurements. Demographic and clinical characteristics of subjects are presented in Table 1. All results are expressed as mean and S.E.M. Data analysis was done by linear regression analyses, multivariate test (LSD procedure) and Student's T-test. P values less than 0.05 were considered to be significant. RESULTS: Relative changes in brachial artery diastolic diameter in reactive hyperemia in comparison to aging (with gender distribution) are shown in Graphs 1 and 2. Our study showed decrease in brachial vasodilator response to reactive hyperemia during aging (male p < 0.05, female p < 0.001). Data analysis showed a significant difference between age-related groups above 40 years and groups below 30 years of age (p < 0.001). The analysis of carotid intima-media thickness showed increased values during aging in both genders but without statistical significance (Graph 2). Analysis of relationship between carotid intima-media thickness and aging (by gender) showed a good correlation of these parameters expressed by the following formula: intima-media thickness (cm) = 0.0009 x years of age + 0.0139. ANOVA test for age-related groups showed significant correlation (p < 0.01) between all age-related groups except 30-40 vs. 40-50 year group. Student's T-test showed no significant correlation between genders. The relationship between the left ventricular mass index (LVMI) and aging (with gender distribution) is shown in Graphs 3 and 4. The left ventricular mass index was increased during aging

Adult↗

[Radioisotopic examination and diagnosis of dryness of the mouth].

The clinical and sialographic opposition between true xerostomia (with continuous disorders) and paradoxical asialia (with inter-prandial disturbance, but sparing mealtime) led the authors to analyze these patient's scintigraphic scannings. A kinetic study of excretion was carried out with gamma-camera recording of intensity and glandular activity: the information thus obtained was set down in a numerical integration block and dealt with by computer. A graph of activity was plotted for each gland showing: - a phase of ascending concentration followed by a plateau corresponding to excretion at rest; - a phase of excretion provoked by a gustatory stimulus (physiological) with a very rapidly descending graph. It is possible to establish a ratio of glandular activity/blood activity at maximum concentration and maximum excretion. From the graphs thus obtained it is possible to perfectly differentiate true xerostomia (no excretion even with stimulation) from paradoxical asialia (no plateau of excretion at rest, but stimulus effective). A better knowledge of "dryness of the mouth" should enable better adapted therapy.

Diagnosis, Differential↗

[Ultrasound foetal biometry in the town of Ouagadougou, Burkina Faso. Report of a cohort of 126 pregnant women].

PURPOSE: This inquiry on the ultrasound fetal biometry in the town of Ouagadougou aimed to study the fetal growth through the ultrasound biometry in order to compare it with other authors's works and to lay down a local chart. PATIENTS AND METHODS: This prospective study led from March 1997 to April 1998 The follow-up of 126 pregnant women allowed to lay down the graphs of following elements: biparietal diameter, cephalic circumference, transverse abdominal diameter, abdominal circumference and femur. RESULTS: The average age of the subjects was 26 years old+/-0.8 and 52.4% of them belonged to an average socio-economic level. All the studied parameters were closely connected with the age of pregnancy. The DAT and the abdominal circumference presented the greatest correlation (0.998). The comparison of our growth graphs with those of others authors led to notice significant differences as well as with African, European and American graphs. CONCLUSION: There is a need to lay down local charts in order to have a best estimation of the pregnancy age and the fetal growth.

Adolescent↗

[Pseudoarthrosis of the scaphoid bone associated with carpal collapse: factors in choice of surgical approach].

INTRODUCTION: The most common fracture involving the wrist is a fracture of the scaphoid bone [1], and only 5% to 10% of these fractures proceed to nonunion. Although not symptomatic initially, most (if not all) nonunions later produce a painful wrist with impaired function, clinically significant loss of motion, increased weakness and degenerative arthritis. Nonunion of the scaphoid bone should be treated by open reduction and internal fixation. Many surgical procedures have been advocated to achieve union. Most widely used technique for the treatment of scaphoid nonunion was described by Russe [2], but this method may overcome the flexion deformity of the scaphoid and carpal deformities. The ununited scaphoid usually undergoes resorption of the fractures surfaces, principally over the anterolateral aspect of the fracture, so that the scaphoid becomes misshapen. The restoration of the exact length and form is enabled by insertion of a tight-fitting trapezoidal corticocancellous graft, a technique described by Fernandez [11]. AIM: We analysed the results of treatment of scaphoid nonunion utilized by two bone-grafting techniques and pointed out the need of choice of the best operative method. METHODS: From 1977 to 1993, at the Institute of Orthopaedic Surgery and Traumatology in Belgrade, 40 patients were surgically treated for symptomatic nonunion of the scaphoid bone. The mean duration of follow-up was 10.2 years (range, from 6 to 22 years). Eighteen (45%) patients were operated by Fernandez technique and 22 (55%) patients were operated using Russe's technique. Volar approach and Kirschner's wire fixation were performed in both operative methods. We used two rating scales proposed by Cooney [13] to evaluate the results. Objective scale (Table 1a) included the radiographic appearance of the wrist, the range of motion and grip strength. Subjective scale (Table 1b) comprised function, pain perception of a decrease in performance because of limited motion or strength, and satisfaction. These scales were used to compare the objective and subjective results in patients who had postoperatively carpal collapse with the results in patients who had not such deformity. RESULTS: The union rate was 92.5% in both methods. Russe's technique resulted in union in 20 (91%) of 22 cases with two ununited. Fernandez technique achieved union in 17 (94%) of 18 cases. Fracture union was determined by both clinical and roentgenographic examinations. Correction of the lateral interscaphoid angle was obtained in 14 (82%) patients operated by Fernandez technique and 9 (45%) patients operated by Russe's technique. Correction of dorsal tilt of the lunate were achieved in 6 (30%) patients operated by Russe's technique, and 13 (76.6%) patients operated by Fernandez technique. There was a highly significant correlation (p < 0.01) between increased deformity of the scaphoid and extent of carpal collapse (Graph 1). Also, there was significant difference between two operative techniques regarding correction of lateral interscaphoid angle (p < 0.05). Arthrosis of the wrist was present in all patients. We could not demonstrate a significant difference (p > 0.05) between intensity of degenerative changes and increase of lateral interscaphoid angle, but obviously, the large flexion deformity of the scaphoid the worse intensity of degenerative changes (Graph 2). The grip strength significantly increased after Fernandez technique (p > 0.05) (Graph 3), but wrist motion changed a little. The average objective score was 71 points for the patients in whom the lateral interscaphoid angle was 45 degrees or less, and 63 points for those in whom the angle was more than 45 degrees. This difference was significant (p < 0.05), but we could not demonstrate a significant difference between the two groups in terms of the average subjective score. DISCUSSION: In our series, both procedures provided a high union rate [2]. In cases with severe scaphoid shortening and flexion deformity, Russe's procedure has proved to be insufficient to restore anatomic length and correction of carpal alignment [6, 11, 17]. Previous authors have reported that the progression in degenerative changes was slower in patients who had a lateral interscaphoid angle less than 45 degrees [13]. Also, grip strength and range of motion increased in patients in whom flexion deformity of the scaphoid had been corrected [2, 4, 6, 16, 17]. Our study supports these findings, except results regarding the movement. We believe that this was due to postoperative scarring. Discrepancy between the subjective and objective results may have been due to postoperative relief of pain obtained by increased carpal stability or decreased range of motion of the carpal joints due to postoperative scarring. If pain is relieved, patients readily adapt to the functional deficit of decreased range of motion. We concluded that angulatory collapse of the scaphoid resulted in nonunion as well as malunion with secondary functional loss. Recognition and avoidance in acute fractures were important. When recognised late, volar wedge grafting appeared to be a satisfactory method of treatment.

Adolescent↗

Speed of comprehension of visualized ordered sets.

The authors investigated the effects of visual properties of hierarchical graphs on speed of comprehension: planarity (crossing of lines), slopes (orientation of lines), and levels (adjustment of dots). In each of 4 experiments, 30 participants responded to interpretive questions that required comparisons among the elements of the graph. Knowledge provided to participants differed across Experiments 1a, 1b, and 1c; question demands varied in Experiment 2. Analysis of response latencies showed that crossing of lines is the most influential variable independent of orientation, dot adjustment, and question demands. Speed of comprehension decreased with increasing question demands. When question demands were high, orientation of lines also had an effect on speed of comprehension. Preliminary conclusions for the presentation of hierarchical graphs are drawn.

Adolescent↗

[Applications of informatics in anesthesiology: anesthesia graphics].

Computerization has brought radical changes to anesthesiology. Quality of care, management, cost control, training, research, safety and privacy have all improved. The anesthesiologist has been freed from repetitive clerical tasks and is able to make better use of time. A graphic display of anesthesia is only one of the many computer applications available as a consequence of links created among monitoring, continuous infusion and intelligent alarm systems, automatic data collection, network monitoring and the availability of bibliographic information (through Internet connection). The computer graphic display of anesthesia is more precise, legible, complete and reliable (during critical events, in substitutions of anesthesiologists or for research) than the traditional graph. One of the greatest problems of computer graphing today--besides start-up costs--is that of inserting comments on monitoring artifacts, given that the graph is a legally valid medical document.

Anesthesiology↗

[The carotid piezogram in obstetrics].

The carotid piezogram is a very simple test. The graph illustrates the elasticity of the arteries and the peripheral resistance. It is the best way of evaluating the vascular state of the pregnant woman when vascul-renal syndromes occur in pregnancy. The authors have studied three elements in the graph and their modifications resulting from the different types of vasculo-renal syndromes. The piezogram is a valuable test for fetal prognosis: the degree of hypotrophy and the risk of fetal death. Furthermore the piezogram sometimes may be the only alarm signal before the other clinical or paraclinical features for prognosis occur. In any case the piezogram give the best information. Furthermore, it can uncover the rise in peripheral resistance which is the cause of certain fetal hypotrophies when nothing else would point to the vascular system being affected. Often an abnormal piezogram is found for the first time in pregnancy and the graph becomes normal in the months after delivery. Pregnancy may be considered as a "test for vascular function" when vascular functional troubles will show up for a short time, not to declare themselves again for perhaps another ten to twenty years. The piezogram therefore is very valuable as a long-term prognostic tool for the mother.

Arteries↗

Change of nuclear size in monolayer cells from embryonic mouse brain under the influence of cytosine-arabinoside.

The influence of cytosine-arabinoside (ara-C) on the nuclear size of monolayer cells from mouse brains were studied by quantitative analysis with the Quantimet (area measurement) and linear analysis with the Digiscan. Ara C (0,1; 1,0; 10,0 mug/ml) causes a significant nuclear enlargement, depending on the dose of 16%, 30% and 35% respectively and at the same time a decrease in cell density and an inhibition of mitotic activity. The size-distribution graph is altered by ara-C: the graph flattens and widens at the base. Moreover, in the case of 10,0 mug ara-C/ml a pronounced graph shoulder is visible in the small nuclear size region which can be interpreted as a slight accumulation of small nuclei. The nuclear enlargement is possibly due to an accumulation of shortchain polynucleotides.

Animals↗

Measuring client satisfaction with public education II: comparing schools with state benchmarks.

Because the results of the client satisfaction evaluation trials conducted in the state's public schools revealed that levels of client satisfaction differed in significant and meaningful ways between parents and students as well as between types of schools, this research consultancy provided school versus benchmark comparison reports based on groups of generally comparable school types. The state benchmark for each set of comparable schools estimated how easy it was, on average, for the members of the benchmark group (parents or students) to endorse each of the 20 School Opinion Survey Likert-scale items (King and Bond, 2003). The school satisfaction level for each item was calculated by a similar process to estimate how easy it was, on average, for the members of the school sample (parents or students) to endorse that item. Reports to individual schools used easy to interpret Parent/Student Satisfaction Graphs which plotted the Rasch-modeled differences between the state benchmark level and the school level for each item. In very small schools where the small amount of data did not allow for item-by-item graphs to be constructed, overall satisfaction graphs provided one global comparison with the appropriate benchmark to be reported.

Adolescent↗

[Health for All-Italia: an indicator system on health].

The Health for All - Italia information system collects health data from several sources. It is intended to be a cornerstone for the achievement of an overview about health in Italy. Health is analyzed at different levels, ranging from health services, health needs, lifestyles, demographic, social, economic and environmental contexts. The database associated software allows to pin down statistical data into graphs and tables, and to carry out simple statistical analysis. It is therefore possible to view the indicators' time series, make simple projections and compare the various indicators over the years for each territorial unit. This is possible by means of tables, graphs (histograms, line graphs, frequencies, linear regression with calculation of correlation coefficients, etc) and maps. These charts can be exported to other programs (i.e. Word, Excel, Power Point), or they can be directly printed in color or black and white.

Abortion, Induced↗

[The application of nasometer on the analysis of normal and cleft palate speech].

This paper reports the use of for assessment of speech by oronasal acoustic measures. Nasal energy during speech is reflected by nasolance value and graph pattern. The degree of velopharyngeal closure and the situation and movement of other speech organs can be demonstrated. The speech of 120 normal children and 60 preoperation cleft palate patients are studied. The scales of normal value and graph pattern are recorded. Comparing with normal speech, the scale of nasolance value and characteristics of graph pattern of cleft palate speech are obviously changed and may be assessed by this apparatus. The treatment and speech therapy plan can be made with the results obtained by this method as the basis.

Child↗

Analysis of the frequency distribution of tuberculin skin test readings: a tool for the assessment of group contact investigations.

SETTING: The public health tuberculosis control program covering Seattle, Washington, and its surrounding suburban areas. OBJECTIVE: To describe a tool of potential usefulness in the assessment of transmission of tuberculosis in contact investigations of groups, such as co-workers or schoolmates of an infectious case, with a low prior probability of latent tuberculosis infection (LTBI). DESIGN: Tuberculin skin test (TST) readings in mm of the group being tested were graphed and compared with the known frequency distributions of TST readings of populations with and without LTBI, the latter including a fraction with non-specific tuberculin reactivity. RESULTS: Four group contact investigations were analyzed retrospectively with this tool. In two the graphed TST readings of contacts fell within the distribution of a population with LTBI, and suggested that transmission had occurred. In the other two, the graphed readings better fit the distribution of a population with non-specific tuberculin reactivity and suggested that transmission had not occurred. CONCLUSION: This simple tool to facilitate the determination of whether transmission of tuberculosis has occurred, and who should be offered treatment for LTBI in contact investigations of groups of people, deserves further study.

Adolescent↗

Heuristics for chemical compound matching.

We have developed an efficient algorithm for comparing two chemical compounds, where the chemical structure is treated as a 2D graph consisting of atoms as vertices and covalent bonds as edges. Based on the concept of functional groups in chemistry, 68 atom types (vertex types) are defined for carbon, nitrogen, oxygen, and other atomic species with different environments, which has enabled detection of biochemically meaningful features. Maximal common subgraphs of two graphs can be found by searching for maximal cliques in the association graph, and we have introduced heuristics to accelerate the clique finding. Our heuristic procedure is controlled by some adjustable parameters. Here we applied our procedure to the latest KEGG/LIGAND database with different sets of parameters, and demonstrated the correlation of parameters in our algorithm with the distribution of similarity scores and/or the execution time. Finally, we showed the effectiveness of our heuristics for compound pairs along metabolic pathways.

Algorithms↗