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At least 1,585 records · Page 88Linked to original sources
PubMed1990

[The vascularized pedicled flap of superior gluteal artery to hip bone chip--a new concept in the revascularization of hip necrosis in adults].

The development and introduction of microsurgical technique has made possible completely new concept of revascularisation surgery in femoral head necrosis. The bone graft described in this presentation is a pedicled one from the lateral ilium. In five femoral head necrosis a pedicled corticocancellous pelvic graft, supplied by the deep branch of the superior gluteal artery, was transplanted in the femoral head. In all cases it was possible to lift out the pelvic graft from the same side as the affected hip joint. Contrary to the medial iliac bone graft (deep circumflex iliac artery) the lateral iliac bone graft (deep branch of the superior gluteal artery) is inserted into the femoral head dorsally. Preoperatively and postoperatively performed selective angiographies are necessary and presented. In all cases an unimpeded perfusion could be shown three months postoperatively. Advantages and indications of the pedicled bone graft are discussed.

Adult↗
PubMed1991

[Dorsal technique of vertebral body reconstruction using cortico-cancellous bone chips].

Grafting of cortico-cancellous bone is firmly established in trauma surgery especially as concerns surgical stabilization of the spine. Early references to that procedure can be traced back to Magerl's reports, but it was Daniaux who decisively improved spongiosa reconstruction and published the results. Further modifications were introduced by Thielemann and Holz as well as by Arnold. All techniques applied so far are essentially based on the implantation of cancellous bone. The method presented employs cortico-cancellous grafts.

Bone Transplantation↗
PubMed2006

[DNA-chips in the diagnosis of hematological malignancies].

In hematological malignancies, gene expression profiling using DNA-microarrays led to the discovery of novel lymphoma and leukemia subgroups. The heterogeneous entity of diffuse large B-cell lymphoma could be subdivided into the germinal center B-cell-like and the activated B-cell-like subtype which differ in pathogenesis and clinical behavior. In leukemia, existing entities defined by morphological, cytogenetic, molecular and immunophenotypic criteria were confirmed on the global gene expression level; in addition, new important molecular subgroups could be identified. In retrospective clinical lymphoma and leukemia studies, robust gene expression signatures were discovered that predict the clinical course at the time of diagnosis. Given the huge potential of the DNA-microarray technology, application in the routine diagnostic setting appears possible.

Biomarkers, Tumor↗
PubMed2001

Multiparametric microsensor chips for screening applications.

The identification of drug targets for pharmaceutical screening can be greatly accelerated by gene databases and expression studies. The identification of leading compounds from growing libraries is realized by high throughput screening platforms. Subsequently, for optimization and validation of identified leading compounds studies of their functionality have to be carried out, and just these functionality tests are a limiting factor. A rigorous preselection of identified compounds by in vitro cellular screening is necessary prior to using the drug candidates for the further time consuming and expensive stage, e.g. in animal models. Our efforts are focused to the parallel development, adaptation and integration of different microelectronic sensors into miniaturized biochips for a multiparametric, functional on-line analysis of living cells in physiologically environments. Parallel and on-line acquisition of data related to different cellular targets is required for advanced stages of drug screening and for economizing animal tests.

Biocompatible Materials↗
PubMed2002

Vacuum-soaking of wood chip shiitake (Lentinula edodes) logs to reduce soak time and log weight variability and to stimulate mushroom yield.

Synthetic logs were vacuum-soaked or regular-soaked to determine the effects of soaking on yield and mushroom size, log weight variability and water distribution within the log. Yields (g/log) from substrates vacuum-soaked were higher by 26.7%, 18.6% and 35.8% (mean = 27.2%) for crops I, II and III, respectively, when compared with regular-soaked. However, mushroom size averaged only 11.2 g for vacuum-soaked logs vs 17 g for regular-soaked logs (51.8% larger for regular-soaked). The time required for vacuum-soaking logs was generally less than 3 min, compared with regular-soaking times ranging over 3-15 h. Water tended to accumulate more in the outside zone in the vacuum-soaked logs, compared with regular-soaked logs. Mean moisture contents for crops I and II for outside, middle and interior zones of vacuum-soaked logs were 66%, 47.5% and 42.2%, respectively, while regular-soaked logs for the same zones were 62.4%, 52.1% and 50.9%, respectively. Vacuum-soaked log weights had lower standard deviations than weights for regular-soaked logs in four out of six soaks, indicating a more uniform soaking process.

Crops, Agricultural↗