Rhizopus necrotizing cellulitis in a preterm infant: a case report and review of the literature.
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The possibility of life-threatening complications arising from cervico-facial infections is well known. Deep cervical infections, however, rarely spread to the mediastinus. Organisms responsible for these infections usually include either aerobic or anaerobic microorganisms, whose synergistic activity provokes virulence and contributes to the violent nature of infection. Prompt recognition is vital if appropriate treatment is to be given. Initial management of deep-neck infections consists in intensive parenteral antibiotic therapy. Nevertheless, in spite of antibiotic therapy, mortality due to suppurative mediastinitis remains high. The Author emphasizes the importance and gives priority to surgical drainage and debridement, another fundamental part of treatment.
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The tuberculin skin test is one of the most widely used diagnostic aids ever developed and remains the only technique of detecting Mycobacterium tuberculosis infection other than actually culturing the organism. False-positives are an acknowledged problem, especially among health care workers (HCW), in whom rescreening can raise more questions than answers. A HCW presented with a severe response to an annual screening test and was retested 6 weeks later with normal results (non-reactive). Causes of false-positives (not including cross-reactivity) are discussed. Readers of the purified protein derivative reaction need to consider alternative explanations for a significant response than infection with tuberculosis, given the medical history and nature of response.