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[Type II multiple endocrine neoplasms (MEN IIB): an unusual cause of constipation. A plea for early thyroidectomy].

We present a 5 year old girl who was diagnosed to have multiple endocrine neoplasia syndrome type IIB (MEN IIB). She presented with serious constipation and had the distinct features of MEN IIB. 100% of the patients with MEN IIB develop medullary thyreoïd carcinoma (MTC). MTC in MEN IIB is known to behave in a very aggressive way. Microscopically MTC was already present in this patient despite of normal calcitonin stimulation tests. Accordingly we plead for a more radical management relating to thyreoïdectomy in MEN IIB.

Child, Preschool↗

[Biofeedback treatment of fecal incontinence and constipation].

In summary, studies published in recent years on biofeedback training in defecation disorders--fecal incontinence and constipation--have presented convincing evidence that this method which derives from psychological learning theory has found clinical importance and relevance. Future research will need to demonstrate the mechanisms involved in its efficacy, the best clinical diagnosis and treatment modalities, and the long term effects of such management.

Adult↗

Total and segmental colon transit time in constipated children assessed by scintigraphy with 111In-DTPA given orally.

Serial colon scintigraphy using 111In-DTPA (2 MBq) given orally was performed in 39 children referred for constipation, and the total and segmental colon transit times were measured. The bowel movements during the study were recorded and the intervals between defecations (ID) were calculated. This method proved able to identify children with normal colon morphology (no. = 32) and those with dolichocolon (no. = 7). Normal children were not included for ethical reasons and we used the normal range determined by others using x-ray methods (29 +/- 4 hours). Total and segmental colon transit times were found to be prolonged in all children with dolichocolon (TC: 113.55 +/- 41.20 hours; RC: 39.85 +/- 26.39 hours; LC: 43.05 +/- 18.30 hours; RS: 30.66 +/- 26.89 hours). In the group of children with a normal colon shape, 13 presented total and segmental colon transit times within the referred normal value (TC: 27.79 +/- 4.10 hours; RC: 9.11 +/- 2.53 hours; LC: 9.80 +/- 3.50 hours; RS: 8.88 +/- 4.09 hours) and normal bowel function (ID: 23.37 +/- 5.93 hours). In the remaining children, 5 presented prolonged retention in the rectum (RS: 53.36 +/- 29.66 hours), and 14 a prolonged transit time in all segments. A good correlation was found between the transit time and bowel function. From the point of view of radiation dosimetry, the most heavily irradiated organs were the lower large intestine and the ovaries, and the level of radiation burden depended on the colon transit time. We can conclude that the described method results safe, accurate and fully diagnostic.

Administration, Oral↗

Radiologic evaluation of constipation and anorectal disorders.

This article has outlined the orderly radiographic approach to evaluating the patient who presents with constipation or other anorectal complaints. Defecography alone provides only a visual record of events taking place during defecation, and it seems likely that further understanding of the pathophysiology will require manometric, electromyographic, and proctographic data in those patients. Defecography is potentially more available than these other techniques because every hospital has a fluoroscopy suite. Studies that relate the proctographic findings with other physiologic studies are underway and necessary. More studies relating pre- and postoperative defecography with clinical results are needed.

Barium Sulfate↗

Constipation: a family-centred approach.

Constipation in childhood is a common problem, causing great concern to parents. Palo Almond describes the problem, its management and the medical, social and psychological issues involved. Greater health visitor input could result in fewer referrals to the consultant paediatrician for treatment, she suggests.

Child↗

Surgical treatment for constipation.

It is evident that the understanding of the pathophysiology underlying the causes of constipation remains incomplete. In some areas, capacity to identify abnormalities has outstripped the ability to treat them. It is hoped that a continuing effort to gather physiologic data from these patients may result in a coherent, physiologic-based treatment approach with maximum therapeutic benefit.

Constipation↗

[Chronic constipation in children; good results of biofeedback training as supplementary therapy].

In two children with refractory constipation biofeedback training was successfully used as a supplementary therapy. In this treatment, a balloon tied to the end of the catheter is inserted into the rectum and inflated with ever-decreasing amounts of air, so as to increase rectal sensibility. In addition, the defaecation pattern is displayed on a monitor. The child learns to control contraction and relaxation of the musculature involved in defaecation.

Anal Canal↗

The aetiology, diagnosis and treatment of constipation and diarrhoea in geriatric patients.

Constipation and, to a lesser extent, diarrhoea, are not uncommon in the elderly and are frequently due to nonorganic causes. Despite this, disturbances in bowel habit always warrant the consideration of possible organic causes. Carcinoma of the colon and endocrine causes are frequently overlooked and rectal examination is mandatory in all patients to exclude rectal carcinoma and faecal impaction. Rectal bleeding, of course, is as alarming a symptom in the elderly as it is in younger people.

Aged↗

Assessing constipation.

This paper discusses the generic view of defaecation and examines the mechanisms contributing to constipation. Although it is recognised that there are specific causes that will require medical intervention, for the purpose of this paper only the general clinical management will be addressed.

Constipation↗

[Chronic idiopathic constipation in adults. Pathogenesis and treatment].

The purpose of this review article is to outline the main factors underlying adult chronic idiopathic constipation (colic substrates, bacterial fermentation, colic peristalsis, perineal anomalies and psychological factors) as well as readily available exploratory methods (colic transit time, anorectal manometry). A review is made of the various therapeutic possibilities, taking into account hygienico-dietetic and pharmacological treatments (mono- or multifactorial laxatives), biofeedback and psychological approaches. The main cases seen in clinical practice are described.

Adult↗

[The surgical treatment of severe chronic constipation].

Materials of surgical treatment of 5 patients are presented who were conservatively treated for severe chronic constipation. This treatment was unsuccessful. Truncal subdiaphragmatic vagotomy with pyloroplasty was fulfilled in 4 patients, in one patient this procedure was accompanied by resection of the sigmoid colon. In all the patients the results obtained were promising.

Adolescent↗

[Laxative effect and tolerance of lactulose administrated in one or two intakes in the treatment of chronic idiopathic constipation. Groupe d'Investigateurs O'Ile-de-France (GIIF)].

OBJECTIVES: The aim of this study was to compare the tolerance and effects of lactulose taken at a daily dose of 20 mg in one or two intakes, in the treatment of idiopathic chronic constipation. METHODS: A total of 121 outpatients (30 men, 91 women, mean age 55) was included in a prospective double blind crossover multicentric study. Patients took lactulose according to two different ways of administration and for two successive 3-week periods. Each period consisted in 2 weeks of adaptation and one week of evaluation. At the end of each period, a global visual satisfactory scale was evaluated as a global index. Patients collected every day the frequency and the aspects of the stools, the quality of exoneration and the existence of digestive symptoms. RESULTS: Number of stools per week (7.29 +/- 3.20 vs 7.08 +/- 3.03), consistency, quality of exoneration, were equivalent whatever the number of intakes and the period of treatment. With one or two intakes, the satisfactory index was the same but significantly better at the end of the second period. With one or two intakes, frequency and intensity of side effects were low and identical. They mostly occurred during the first period. CONCLUSION: Effects and tolerance with one single intake of lactulose (20 g) in the evening and with two intakes, were found to be equivalent. Effect on exoneration persists during the six weeks of administration and then tolerance improves.

Adolescent↗

Abnormalities in the contractile properties of colonic smooth muscle in idiopathic slow transit constipation.

BACKGROUND: The underlying pathophysiology of idiopathic slow transit constipation (ISTC) remains unclear. At present, there is little evidence to implicate a smooth muscle myopathy in the aetiology of this condition. This study compared the effect of cisapride on the cholinergic response of colonic muscle strips from patients with this condition with that of control tissue. METHODS: Isometric tension production was recorded from circular smooth muscle strips taken from five patients undergoing colectomy for ISTC in response to cumulative concentrations of carbachol (100 nmol/1-100 mumol/l) alone and in the presence of cisapride 400 nmol/l. Similar dose-response activity was obtained for a control group consisting of six patients undergoing resection for colorectal carcinoma. RESULTS: In the absence of cisapride, smooth muscle from patients with carcinoma exhibited a significantly lower sensitivity to cholinergic stimulation (agonist concentration required to produce half-maximal activation (EC50) 4.83 mumol/l) than that from patients with ISTC (EC50 1.63 mumol/l, P = 0.036), and also a greater maximal frequency of the oscillatory activity associated with the increase in isometric tension (0.070 versus 0.049 Hz, P = 0.035). Cisapride had no effect on the sensitivity to carbachol of the carcinoma tissue but brought about a significant reduction in the sensitivity of smooth muscle from patients with ISTC (EC50 3.24 mumol/l, P = 0.043). CONCLUSION: These findings indicate that colonic smooth muscle from patients with ISTC is hypersensitive to cholinergic stimulation and suggest the existence of a smooth muscle myopathy in this condition.

Adolescent↗

Preventing constipation in older people.

Laxative misuse is widespread in hospitals and nursing homes throughout the UK. Nurses rarely consider bowel management as central to their role. There is much nurses can do to prevent constipation in their patients/clients.

Aged↗

[Subtotal colectomy with ceco-rectal anastomosis (Deloyers) for severe idiopathic constipation: an alternative to total colectomy reducing risks of digestive sequelae].

PURPOSE: Functional results of total colectomy (TC) and ileorectal anastomosis for colonic inertia are often impaired by postoperative obstruction and diarrhea. In order to avoid these postoperative complications, we propose a subtotal colectomy (STC) preserving the ileo-caecal junction. METHODS: Since 1989, 18 consecutive patients (17 F, 1 M; mean age: 54 years) with intractable constipation underwent TC (n = 6) or STC with caecorectal anastomosis (Deloyers Procedure) (n = 12). Mean preoperative bowel frequency was two movements every month. Colonic inertia was defined as diffuse marker delay during transit study without obstructed defecation on manometry or digitalised rectography. Rectocele (n = 10), rectal (n = 5) and genital prolapse (n = 6) were treated in the same operative time. RESULTS: Postoperative course was uneventful after STC but bowel obstruction, requiring laparotomy, occurred in 3 patients (50%) after TC: enterolysis (n = 2), bowel resection (n = 2). Mean postoperative day stool frequency of TC (4.2 +/- 1.2) was higher than STC (1.2 +/- 0.1). Half of patients after TC needed anti-diarrheal treatment and diet, 33% had rectal evacuation difficulties despite liquid stools, 17% had episodic incontinence, 66% had persistent abdominal pain. Compared to TC, the functional results of STC were significantly better: regular normal transit return without diet or treatment in 75% of cases, 25% had rectal emptying difficulties easily treated by mild laxatives, only 17% had persistent abdominal pain. Postoperative obstruction, diarrhea or fecal incontinence never occurred after STC. CONCLUSION: Compared to TC, STC with Deloyers procedure seems to reduce significantly the postoperative incidence of bowel obstruction, diarrhea and abdominal pain. Expected regular transit return after STC needs a careful selection of patients and simultaneous treatment of ano-rectal and pelvic floor abnormalities frequently associated with colonic inertia.

Adult↗

Antegrade colonic enema (ACE): a new therapeutic approach to chronic constipation.

Continent appendio-cecostomy is a recently developed operation for the therapy of chronic constipation, refractory for other treatment modalities. Two patients are described in whom the operation led to a dramatic improvement of their quality of life. Technical details of the operation are offered as well as some data on the possible mechanism of colonic motility in this pathological disorder.

Adult↗

Clinical and experimental studies on the treatment of senile constipation with shenshen wan.

From August 1988 through February 1991, we have successfully treated 400 cases of senile constipation with self-made Shenshen Wan with a total effective rate of 98%. A group of patients taking Maren Wan served as controls. Clinical practice has proved that Shenshen Wan can not only relax the bowels, but also improve renal function. Furthermore, no side effects whatever were observed after a prolonged administration of the pills.

Aged↗