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PubMed1984

Carcinogenic activity of condensate from coloquint seeds (Citrullus colocynthis) after chronic epicutaneous administration to mice.

In the Sahelian countries coloquint seed tar is used in traditional medicine. A condensate from the seed of Citrullus colocynthis was obtained in a camel nomad settlement. It contained a large number of polycyclic aromatic hydrocarbons, including known carcinogens [e.g., benzo(a)pyrene, benz(a)anthracene, benzo(b)fluoranthene, benzo(j)fluoranthene]. The dose-related carcinogenic activity of this condensate was established after chronic epicutaneous application to mouse skin. We conclude that the manufacture and use of coloquint tar and related compounds may involve a health hazard and could lead to the development of cancer.

Africa↗
PubMed1990

Distribution of keratinophilic fungi in animal folds in Kuwait.

Soil samples from seventeen animal herds (camels, goats, sheep, cows) were surveyed for the occurrence of keratinophilic fungi. Twenty four species related to eleven genera were recovered on defatted wool baits. Eleven Chrysosporium species were reported in the following order of dominance: C. keratinophilum, C. tropicum, C. indicum, C. queenslandicum, C. pannicola, C. carmichaelii, C. state of Arthroderma curreyi, C. zonatum, C. state of A. cuniculi and Chrysosporium state of Renispora flavissima. The Aphanoascus teleomorph of C. keratinophilum, C. indicum and C. tropicum were frequently reported in soils from cow and sheep folds. Scopulariopsis, Cephaliophora and Sepedonium, although not keratinolytic, were also recorded on wool baits of soils from cow herds which are slightly acidic. The frequency and distribution of these fungi are discussed in relation to animal species and the general ecological conditions of desert soils.

Animals↗
PubMed1985

[Preindustrial man in earth's ecosystems].

Preindustrial man influenced and changed the earth's ecosystems decisively. The disappearance of large animals from all continents (Eurasia, e.g., mammoth; America, e.g., the giant sloths and the giant armadillo) after the Pleistocene was most probably due to a large extent to the early hunters and collectors. Corn-growing and breeding of domestic animals led to the disappearance of their wild forms (e.g., the wild form of today's old world camel is unknown) and the cultivation of huge monocultures. The increasing need for wood resulted in the disappearance of forests almost all over Europe. Specific needs, such as pig-raising or bee-keeping, supported the formation of particular landscapes, e.g., sparsely wooded forests and extensive heathlands. All these factors resulted in extreme soil erosion and the disappearance of nutritionally important minerals from the soil, which was thus severely depleted.

Agriculture↗
PubMed1989

Spectral sensitivity, absolute threshold, and visual field of two tick species, Hyalomma dromedarii and Amblyomma variegatum.

1. The spectral sensitivity in the wavelength range of 340-750 nm was determined by both a behavioral approach based on spontaneous positive phototaxis and the electroretinogram (ERG). 2. Concerning phototaxis the camel tick, Hyalomma dromedarii, showed two sensitivity maxima, one in the UV range (ca. 380 nm) and another in the blue-green range (ca. 500 nm). At higher intensities the relative sensitivity was more pronounced in the UV and at lower intensities more pronounced in the blue-green (reverse Purkinje shift). In the tropical bont tick, Amblyomma variegatum, there was a single sensitivity maximum in the blue range (ca. 480 nm). 3. In the ERG there was a maximum in the blue range (ca. 470 nm) in both species and a weak secondary maximum in the UV in Hyalomma. 4. The absolute sensitivity was very high. The threshold irradiance of phototaxis was as low as 5.2 x 10(6) photons.s-1.cm-2 in Hyalomma and 5.2 x 10(8) photons.s-1.cm-2 in Amblyomma. 5. When the eyes of Hyalomma were covered, the threshold irradiance was still very low, namely 5.2 x 10(8) photons.s-1.cm-2, indicating high absolute sensitivity of the extraretinal photoreceptors. 6. The visual field of the eyes was determined by ERG measurements. In both species the optical axis of each eye, i.e., the center of the visual field, was directed somewhat to the side and above the horizon. In Hyalomma this direction was 35 degrees to the long axis of the animal and 30 degrees above the horizon for natural body posture during walking. In Amblyomma the corresponding angles were 39 degrees and 33 degrees, respectively. The size of the field (at 50% sensitivity) in Hyalomma was relatively small, namely 14 degrees in the horizontal and 25 degrees in the vertical direction, compared with that of Amblyomma with 43 degrees and 49 degrees, respectively. 7. This is the first demonstration in ticks of spectral and absolute sensitivity by the behavioral approach and of the visual field by ERG. The results suggest that tick eyes possess features of both spider eyes and insect ocelli.

Animals↗
PubMed1988

Oxygen binding properties, capillary densities and heart weights in high altitude camelids.

The oxygen binding properties of the blood of the camelid species vicuna, llama, alpaca and dromedary camel were measured and evaluated with respect to interspecific differences. The highest blood oxygen affinity, not only among camelids but of all mammals investigated so far, was found in the vicuna (P50 = 17.6 Torr compared to 20.3-21.6 Torr in the other species). Low hematocrits (23-34%) and small red blood cells (21-30 microns 3) are common features of all camelids, but the lowest values are found in the Lama species. Capillary densities were determined in heart and soleus muscle of vicuna and llama. Again, the vicuna shows exceptional values (3720 cap/mm2 on average in the heart) for a mammal of this body size. Finally, heart weight as percent of body weight is higher in the vicuna (0.7-0.9%) than in the other camelids studied (0.5-0.7%). The possibility that these parameters, measured in New World tylopodes at sea level, are not likely to change considerably with transfer to high altitude, is discussed. In the vicuna, a unique combination of the following features seems to be responsible for an outstanding physical capability at high altitude: saturation of blood with oxygen in the lung is favored by a high blood oxygen affinity, oxygen supply being facilitated by low diffusion distances in the muscle tissue. Loading, as well as unloading, of oxygen is improved by a relatively high oxygen transfer conductance of the red blood cells, which is due to their small size and which compensates the negative effect of a low hematocrit on the oxygen conductance of blood.(ABSTRACT TRUNCATED AT 250 WORDS)

2,3-Diphosphoglycerate↗
PubMed1993

Chromosomal localization of the lysozyme gene cluster in river buffalo (Bubalus bubalis L.).

Lysozyme (LYZ) is an antibacterial enzyme which allows the digestion of bacteria present in tears and saliva. In the true stomach of ruminants LYZ breaks open the bacteria of the foregut, which are subsequently digested by typical mammalian digestive enzymes, allowing the incorporation of nutrients from the bacteria. Southern analysis with a single exon from a cow lysozyme gene revealed that there are about 10 genes in ruminants (Irwin & Wilson 1989), while pig and primates have a single lysozyme gene (Swanson et al. 1991) and camels have two (Irwin et al. 1992). The higher number of LYZ genes in ruminants is believed to be the result of gene duplication associated with the evolution of foregut fermentation (Irwin et al. 1992). Recently, the genomic organization of the lysozyme gene family has been determined in domestic cattle, and, using a cocktail of genomic clones, the lysozyme gene cluster (LYZ/) was assigned to chromosome (Chr) 5, band 23 by fluorescence in situ hybridization (FISH) (Gallagher et al. 1993). In our continued effort to test the genetic homology of conserved chromosome banding regions between cattle and river buffalo, and to extend the river buffalo physical gene map, we have mapped the LYZ/ by FISH and R-banding.

Animals↗
PubMed1978

Comparison of various immunological methods for distinguishing among mammalian pancreatic ribonucleases of known amino acid sequence.

Fourteen mammalian pancreatic ribonucleases of known amino acid sequence were compared by 1 or more of 3 different immunological methods: standard quantitative micro-complement fixation, spot-plate micro-complement fixation, and inhibition of phage inactivation. It was found that, while the results obtained by the 3 techniques were correlated with one another, the standard micro-complement fixation procedure was most versatile, economical of materials, and easiest to execute. The standard MC'F technique was more sensitive than the spot-plate technique to differences in amino acid sequence. The inhibition of phage inactivation method was more sensitive than the standard method for measuring differences among closely related RNases but proved impractical for amino acid differences over 15%; the MC'F method could be extended to at least 30% sequence differences. The standard method, moreover, readily detected the single amino acid difference between dromedary and camel RNases. A linear relationship was found between immunological distance (y) in the MC'F test and percent sequence difference (x) which fit the equation y = 7x. The strength of the correlation between immunological distance and percent sequence difference is consistent with the proposal that a large fraction of the evolutionary substitutions of amino acids in ribonuclease are immunologically detectable. This could be explained either by a multideterminant hypothesis or by a pauci-determinant hypothesis which says that substitutions occurring outside determinants produce small conformational changes influencing determinant reactivity.

Amino Acid Sequence↗
PubMed1995

Serum biochemical values and mineral element contents of tissues in yaks.

Serum biochemical values and the wet weight to dry weight ratios of tissues were determined in yaks in Shandan county of Gansu province. The liver, kidney, heart and muscle contents of seven elements in yaks were also analysed. Most serum biochemical values were similar to those of cattle, camels and sheep, but the calcium concentration was considerably above the normal range for other ruminants. The liver contained the highest concentrations of copper, manganese and cobalt and the kidney of selenium, iron and calcium.

Animals↗
PubMed1990

Amino acid sequences of stomach and nonstomach lysozymes of ruminants.

Complete amino acid sequences are presented for lysozymes c from camel and goat stomachs and compared to sequences of other lysozymes c. Tree analysis suggests that the rate of amino acid replacement went up as soon as lysozyme was recruited for the stomach function in early ruminants. The two lysozymes from goat stomach are the products of a gene duplication that probably took place before the divergence of cow, goat, and deer about 25 million years ago. Partial sequences of three lysozymes from goat tears indicated that (a) the goat tear family of lysozymes may have diverged from the stomach lysozyme family by an ancient duplication and (b) later duplications are probably responsible for the multiple forms of tear and milk lysozymes in ruminants.

Amino Acid Sequence↗
PubMed1983

The foetal thyroid of the dromedary: its relation to body weight and dimensions and to the weight of the Dam's thyroid.

Growth and iodine content of the thyroid glands in relation to body weight, length [total (BCVRT), crown-rump (CR), and curved crown-rump (CVR)], chest circumference (CC), and age were investigated in 83 camel foetuses from 70 to 355 days of gestation (mean gestation length 390 days). Weight and iodine content of the dam's thyroid were also studied. Highly significant (P less than 0.01) correlations of 0.883, 0.797, 0.798, 0.792, and 0.813 were obtained between foetal thyroid weights on the one hand and body weight, BCVRT, CR, CVR, and CC on the other hand. A significant (P less than 0.05) correlation of 0.345 was obtained between weights of the foetal thyroid and dam's thyroid. The relative weight of the foetal thyroid to body weight was 0.045% at 70-99 days of gestation, but decreased to 0.028 (0.023 to 0.036%) in the subsequent stages. Iodine trapping by the foetal thyroid was first detected at 100-129 days of gestation. Total iodine then increased until 310 days, but decreased thereafter. The foetal thyroid has 4 to 25 times higher avidity to iodine accumulation than that of the dam.

Animals↗
PubMed1990

Review of animal mycoses in Australia.

This review covers the available literature on the mycoses of animals in Australia since the last review published in 1967. Of the cutaneous infections, dermatophytoses have been recorded in a wide range of animals: cattle, horses, goats, pigs, sheep, cats, dogs, mice, guinea-pigs, rabbits, a lion, kangaroos, a camel, koalas and wallabies. These infections were caused by several species and varieties of the genera, Microsporum and Trichophyton. Eight agents of ringworms have been recorded in the horse. Two subcutaneous mycoses, phaeohyphomycosis and sporotrichosis have been reported. Phaeohyphomycosis is becoming more common but sporotrichosis is rare having been recorded only once in a cat. The following systemic mycoses have been recorded: adiaspiromycosis, aspergillosis, candidiasis, cryptococcosis, dactylariosis, fusariomycosis, histoplasmosis, miscellaneous mycoses, mycotic abortion and related conditions, zygomycosis, pythiosis, protothecosis and green algal infections. Cryptococcosis has affected 11 different animal species. Mycotic abortion is a serious disease in Victoria. Pythiosis of horses has been extensively studied in northern Australia.

Animals↗
PubMed1989

Serological evidence of Ife virus infection in Nigerian indigenous domestic ruminants.

Serological evidence of Ife virus infection was observed in cattle, sheep, goats and camels in both ecological zones of Sokoto and Kaduna States of Nigeria. The antibody prevalence rates differed between species and between zones, being highest in the guinea savanna. This is the first report of possible Ife virus infection in domestic ruminants.

Animals↗
PubMed1992

Expression of the whey acidic protein in transgenic pigs impairs mammary development.

The whey acidic protein has been found in milk of mice, rats, rabbits and camels, and its gene is expressed specifically in mammary tissue at late pregnancy and throughout lactation. A characteristic of whey acidic protein is the 'four-disulfide-core' signature which is also present in proteins involved in organ development. We have generated six lines of transgenic pigs which carry a mouse whey acidic protein transgene and express it at high levels in their mammary glands. Transgenic sows from three lines could not produce sufficient quantities of milk to support normal development of healthy offspring. This phenotype appears to be similar, if not identical, to the milchlos phenotype exhibited by mice expressing whey acidic protein transgenes. Mammary tissue from post-partum milchlos sows had an immature histological appearance, which was distinct from that observed during normal development or involution. Expression of the whey acidic protein transgene was found in mammary tissue from sexually immature pigs from milchlos lines, but not in sows from lines that appeared to lactate normally. We suggest that precocious synthesis of whey acidic protein impairs mammary development and function. Impaired mammary development due to inappropriate timing of whey acidic protein expression is consistent with the notion that proteins with the 'four-disulfide-core' signature participate in tissue formation.

Aging↗
PubMed1996

Fungal flora and aflatoxin contamination of feedstuff samples in Beida Governorate, Libya.

Fungi of 19 genera, 30 species, and one variety were isolated from 25 samples of sheep-, cattle- and camel feedstuffs collected from different farms in the Beida Governorate, Libya. Aspergillus, Penicillium and Fusarium were the most common genera in the three substrates tested. TLC was used to establish the identity of aflatoxins in the chloroform extract of all samples and the ability to produce aflatoxins by Aspergillus flavus in a synthetic liquid medium. Twenty samples out of 25 tested were naturally contaminated and 21 isolates of A. flavus out of 30 produced at least one of the following aflatoxins: B1; B1, G1; and B1, B2, G1, G2. This is the first report about the natural occurrence of aflatoxins and aflatoxins and aflatoxin-producers of the genus Aspergillus in Libya.

Animal Feed↗
PubMed2005

Molecular structure, binding properties and dynamics of lactoferrin.

Lactoferrin (Lf), a prominent protein in milk, many other secretory fluids and white blood cells, is a monomeric, 80-kDa glycoprotein, with a single polypeptide chain of about 690 amino acid residues. Amino acid sequence relationships place it in the wider transferrin family. Crystallographic analyses of human Lf, and of the Lfs from cow, horse, buffalo and camel, reveal a highly conserved three-dimensional structure, but with differences in detail between species. The molecule is folded into homologous N- and C-terminal lobes, each comprising two domains that enclose a conserved iron binding site. Iron binding and release is accompanied by domain movements that close or open the sites, and is influenced by cooperative interactions between the lobes. Patches of high positive charge on the surface contribute to other binding properties, but the attached glycan chains appear to have little impact on structure and function.

Animals↗
PubMed2002

Stable social aggregations in an Australian lizard, Egernia stokesii.

Social groups in many animal species contain family members, and are maintained by parental care, and then tolerance of related individuals in the group. Lizards rarely show prolonged parental care, and rarely form stable social aggregations, although cohesive groups have been reported in the Australian skink genus, Egernia. A population of Egernia stokesii was surveyed for six seasons on Camel Hill, South Australia. At this site individuals occupied rock crevices for refuges on an isolated rocky outcrop of about 1.5 ha. The population was divided into 17 stable social groups, each containing 2-17 individual lizards. Surveyed juveniles took more than 5 years to reach mature size, and most juveniles and subadults remained in the social group of their parents for that period and longer. There were 2-8 permanent adult members of each group. Group members shared common crevice refuges, basked close together (and sometimes on top of each other) and defecated in common scat piles. There was low mortality after the first 2 years of life, and low dispersal either into or out of the population. Some individuals were "floaters" that did not belong to a social group. Over the study a number of these became established in groups. The social structure of these lizards resembles the family groups reported in many species of birds and mammals where group members help to raise the offspring of relatives. The low level of parental care in lizards suggests that the evolution of this form of social organisation in lizards has resulted from different processes than in other vertebrate taxa.

Aging↗
PubMed1999

Transferrin receptors on the plasma membrane of cultured rat astrocytes.

It is generally accepted that transferrin receptor is located in the endothelial cells of the brain, but its existence in other brain cell types is less established. In this study, a [(125)I]transferrin binding assay was used to determine whether there is transferrin receptor on the membrane of cultured rat cortical astrocytes (type 1) in vitro. The results demonstrated that cortical astrocytes (type 1) in suspension attracted [(125)I]transferrin with a saturable and specific binding. Scatchard and Hill plot analysis showed that the dissociation constant (K(D)) of the binding was about 3.5x10(-8) M and the number of receptors was about 7.1x10(4)/cell. The Hill coefficient was 0.99, approaching 1, indicating the absence of cooperativity. The receptor was specific both for rat and human transferrin. The binding of rat [(125)I]transferrin could be competitively and specifically inhibited by unlabeled iron-saturated rat and human transferrin, and no difference was found between interaction of rat or human transferrin with this receptor. The interaction of duck or camel transferrin with this receptor was found to be very weak. This study provides evidence for the presence of transferrin receptor on the plasma membrane of cultured rat brain astrocytes.

Animals↗
PubMed2001

Hydatidosis: dynamics of transmission.

Hydatidosis is a widespread zoonosis infecting a large number of animals and humans. Echinococcus granulosus has the smallest taenia adult of the cestodes but with the largest larva. Its morphologic and biologic features were identified with DNA analysis. Different strains were separated according to the intermediate hosts: sheep, cattle, pigs, horses, camels. Definitive host are canids, mostly dogs, where the worm grows to adulthood in several months. The eggs are scattered in the pasture by wind and water and are ingested by various hosts. The larvae migrate through the intestinal wall and penetrate the organs, mostly liver and lungs. The eggs survive several days outside, depending on the temperature, but numerous eggs die in nature because they cannot resist desiccation and extreme temperatures. Dissemination is accomplished by dogs. In Turkana (Kenya) the incidence of hydatidosis is high because of the close relationship between the population and dogs and the habit of leaving their dead bodies in the grasslands. In rural areas, the custom of slaughtering sheep at home, among the dogs, is an important dissemination factor. The circumstances of transmission vary according to the country. In Europe the natural life cycle of E. granulosus granulosus involves dogs as the definitive host and sheep as the intermediate host. In northern Europe E. granulosus borealis infects the canids and deer. E. granulosus canadensis infects wolves and reindeer, but there are no human cases. In the endemic Mediterranean area, sheep and dromedaries are the intermediate hosts. In South America, the life cycle of E. granulosus develops among several definitive and intermediate hosts. Hence the dynamics of transmission vary according to the countries with different hosts.

Animals↗