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PubMed2004

Using nanoparticles to create self-healing composites.

The need for viable materials for optical communications, display technologies, and biomedical engineering is driving the creation of multilayer composites that combine brittle materials, such as glass, with moldable polymers. However, crack formation is a critical problem in composites where thin brittle films lie in contact with deformable polymer layers. Using computer simulations, we show that adding nanoparticles to the polymers yields materials in which the particles become localized at nanoscale cracks and effectively form "patches" to repair the damaged regions. Through micromechanics simulations, we evaluate the properties of these systems in the undamaged, damaged, and healed states and determine optimal conditions for harnessing nanoparticles to act as responsive, self-assembled "band aids" for composite materials. The results reveal situations where the mechanical properties of the repaired composites can potentially be restored to 75%-100% of the undamaged material.

Journal Article↗
PubMed2002

Reliability and measurement error of the BioTonix video posture evaluation system--Part I: Inanimate objects.

OBJECTIVE: To investigate the reliability, concurrent validity, and error of a new video digitizing system for evaluating posture when applied to inanimate objects. DESIGN: Delayed repeated measures of digital images of inanimate objects. SETTING: University laboratory. METHODS: Digital video images of inanimate objects (5 parallelograms) of different sizes and shapes were obtained with the BioTonix postural evaluation system. Three examiners digitized video images of inanimate objects twice; the second data collection was 1 week after the first set. The objects were digitized with both high- and low-resolution settings of the video screen. The Tonix's measurements were statistically compared with the actual object dimensions. Statistical evaluations of reliability and validity were conducted. RESULTS: For distances, both intraclass and interclass correlation coefficients were very high, 0.99 for the estimate. The low- versus high-resolution settings were comparable for distances. For angles, on the low-resolution setting, both intraclass and interclass correlation coefficients were very high: 0.969 and 0.953. On the high-resolution setting, for angles, both intraclass and interclass coefficients were well above 0.99. The difference of the actual size and the means of the digitized measurements of the means were small: at most 1.5 degrees for angles and 3.3 mm for distances. The standard deviations were small, and the confidence intervals were narrow. CONCLUSIONS: Our results demonstrate that the BioTonix's video system has high degrees of reliability and validity. Thus this system would seem suitable for clinical use in the analysis of posture.

Biomedical Technology↗
PubMed2006

Two-photon vibrational spectroscopy for biosciences based on surface-enhanced hyper-Raman scattering.

Two-photon excitation is gaining rapidly in interest and significance in spectroscopy and microscopy. Here we introduce a new approach that suggests versatile optical labels suitable for both one- and two-photon excitation and also two-photon-excited ultrasensitive, nondestructive chemical probing. The underlying spectroscopic effect is the incoherent inelastic scattering of two photons on the vibrational quantum states called hyper-Raman scattering (HRS). The rather weak effect can be strengthened greatly if HRS takes place in the local optical fields of gold and silver nanostructures. This so-called surface-enhanced HRS (SEHRS) is the two-photon analogue to surface-enhanced Raman scattering (SERS). SEHRS provides structurally sensitive vibrational information complementary to those obtained by SERS. SEHRS combines the advantages of two-photon spectroscopy with the structural information of vibrational spectroscopy and the high-sensitivity and nanometer-scale local confinement of plasmonics-based spectroscopy. We infer effective two-photon cross-sections for SEHRS on the order of 10(-46) to 10(-45) cm4 x s, similar to or higher than the best "action" cross-sections (product of the two-photon absorption cross-section and fluorescence quantum yield) for two-photon fluorescence, and we demonstrate HRS on biological structures such as single cells after incubation with gold nanoparticles.

Animals↗