Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Biogen”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,585 records · Page 88Linked to original sources
PubMedDate not supplied

[The effect of cyclic nucleotides on the sensitivity of early mouse embryos to biogenic monoamine antagonists].

The effect of lipophilic cAMP analogs on the sensitivity of preimplantation mouse embryos of two strains to cytotoxic serotonin and adrenalin antagonists was studied. Dioctanoyl-cAMP significantly decreased the sensitivity of embryos to inmecarb and cyproheptadine: experimental embryos developed to the stage of morula or blastocyst, in contrast to control embryos incubated without this protector. A somewhat weaker effect was observed in experiments with propranolol: embryos incubated in the propranolol-containing medium after the addition of dioctanoyl-cAMP were capable of one to two cleavage divisions. 8-bromomonobutyryl-cAMP partially suppressed the inhibitory effect of cyproheptadine and did not affect the sensitivity of embryos to propranolol. These data suggest cAMP involvement in the regulatory activity of neurotransmitters in the early mouse embryos.

Animals↗
PubMed1992

Biogenic amines and the activity of the hypothalamo-pituitary-ovarian axis in ewes.

An important feature of communication between the central nervous system and the pituitary-ovarian axis is the pattern of pulsatile discharge of hypothalamic luteinizing hormone releasing hormone (LHRH). The discharge of LHRH is under control of noradrenergic, dopaminergic, and serotoninergic systems of the brain. These systems intervene between external and internal signals (e.g. photoperiod and gonadal steroids) and LHRH output. In the ewe, noradrenaline, dopamine and serotonin of the brain are implicated in the control of LHRH output, and hence luteinizing hormone (LH) release, during both the anoestrous and breeding seasons. These amines are involved in steroid-dependent and steroid-independent regulation of LHRH/LH discharge. An interplay of inhibitory versus excitatory influences of these amines on LHRH/LH release appears to govern the pattern of LHRH/LH output during the annual reproductive cycle and the ovulatory cycle. A concise overview of this topic will be provided.

Anestrus↗
PubMed1976

[Cerebrospinal fluid metabolism of biogenic amines in Huntington chorea].

CSF metabolites of dopamine (HVA), norepinephrine (MHPG) and serotonine (5HIAA) in 9 patients affected by Huntington's Chorea before and after therapy with phenotiazine derivatives (Fluphenazine) have been studied. A close relationship seems to exist between therapeutical results and CSF HVA modifications: improvement of choreatic movements is associated with marked increase in CSF HVA values. Biochemical bases of Huntington's Chorea are discussed.

Adult↗