Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “ADRENALECTOMY”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,585 records · Page 88Linked to original sources
PubMed1991

[Specific binding of H3-GABA by synaptic membranes of hypothalamus and hippocampus in rats after adrenalectomy and administration of hydrocortisone and corticosterone].

It has been shown that single hydrocortisone administration increased 3H-GABA binding by hypothalamic synaptic membranes. ACTH administration enhanced binding in both studied brain structures. Multiple hydrocortisone administration did not effect 3H-GABA binding by hypothalamic and hippocampal membranes, while multiple ACTH administration caused the decrease in mediator binding by hypothalamic membranes and increased its level in hippocampal membranes. Adrenalectomy did not change 3H-gaba binding and single hydrocortisone administration to adrenalectomized rats increased 3H-GABA binding only by hypothalamic synaptic membranes.

Adrenalectomy↗
PubMed2006

Adrenalectomy for bilateral and recurrent pheochromocytoma: increased intraoperative risk?

Adrenalectomy for pheochromocytoma is per se associated with a specific intraoperative cardiovascular risk caused by catecholamine secretion during manipulation of the tumor. Bilateral or multiple, and recurrent chromaffine tumors are special subentities with a potentially more intensified and longer surgical preparation. The aim of our study was to examine these effects on hemodynamic changes compared with those observed for primary, solitary tumors. Of the 82 studied interventions between February 1992 and May 2005, 58 were seen to involve primary, unilateral tumors, 17 involved bilateral (1 trilateral) findings, and there were 7 cases of recurrency. The hemodynamic changes related to primary, solitary pheochromocytomas revealed a higher frequency of intraoperative blood pressure crises (37%) compared with the comparative groups (11.8% in bilateral and 0% in recurrent tumors), as well as higher maximum pCO2 values noted. The intraoperative blood loss was more pronounced in interventions involving recurrencies. Aside from an appropriate preliminary therapy using an alpha-blocker and the careful surgical preparation of the adrenal gland, the different hemodynamic changes possibly may be related to the presence of smaller tumors in bilateral pheochromocytoma, as well as being based upon the already existent ligature of the draining vein in the event of recurrent procedures. The extent to which the adrenergic effect of the increased maximum pCO2 value plays a role on the development of higher maximum blood pressure values and more frequent intraoperative blood pressure crises continues to remain unclear.

Adrenal Gland Neoplasms↗
PubMed2005

Recurrent lymphocytic hypophysitis in a woman 27 years after subtotal adrenalectomy for hypercortisolism possibly of autoimmune origin.

Lymphocytic hypophysitis commonly occurs in females in peripartum period but several unusual presentations have been reported. Here we report a rare case of recurrent lymphocytic hypophysitis in a woman who had subtotal adrenalectomy for hypercortisolism 27 years back. Polyglandular autoimmune endocrinopathy with an uncommon combination of Cushing's syndrome and recurrent hypophysitis is a strong possibility in this case. Treatment with steroids has been found to have beneficial effect.

Adrenalectomy↗
PubMed2006

[Laparoscopic adrenalectomy for the adrenal gland metastasis from hepatocellular carcinoma].

We present a case of a 70-year-old man with an anamnesis of intra-cerebral bleeding that resulted in right half of the body paralysis and right diaphragm paralysis, The present clinical history indicated hepatocellular carcinoma (HCC) caused by hepatitis C and liver cirrhosis during a regular hospital visit, and the patient had a total of 4 TAEs enforced from three years before. A 4 x 3.5 cm neoplasm at the left adrenal was detected by CT inspection this time. The diagnosis was a metastatic adrenal gland tumor from HCC. Since HCC is controlled by TAE, the metastatic lesions were not found in other organs and were isolated, of 10 cm or less in size. Hence, laparoscopic adrenalectomy was performed in March, 2006. He started having a meal from the 2nd day after the operation. He left the hospital on the 9th day. Pathologial diagnosis was a metastatic adrenal gland tumor from moderately differentiated hepatocellular carcinoma. When observing the adaptation standard strictly to the high-risk case, it was thought that the metastatic tumor extraction under laparoscopic surgery could become a low stress cure in consideration of QOL being useful as a local treatment for cancer.

Adrenal Gland Neoplasms↗
PubMed1976

Technique of adrenalectomy for metastatic cancer of the breast.

The transabdominal approach to adrenalectomy offers many advantages in the patient with metastatic cancer of the breast who is likely to respond to an ablative operation. Information derived in the course of laparotomy is important in planning for adjunctive chemotherapy, and oophorectomy can be carried out through the same incision when indicated. The vena cava can be plicated in patients who are considered to be at riak for thromboembolic phenomenom.

Adrenalectomy↗
PubMed1991

Effects of adrenalectomy on brain weight, body weight and weight of certain endocrine organs in rats.

Albino rats, both males and females were adrenalectomized (Adx.), either on the eleventh or the twenty fifth day after birth and the body weights recorded daily until the sixtieth day when all the animals were sacrificed. Brain (cerebrum and cerebellum), pituitary, thyroid and gonads were weighed post mortem. Body weights decreased in all the Adx. animals, the decrease being statistically significant in the male rats Adx. on day 11 (p less than 0.05). Both cerebrum and cerebellum recorded a significant increase in weight in both the male Adx. groups, whereas pituitary, thyroid and gonads showed a significant decrease. Changes observed in 25 day Adx. female rats were not statistically significant. Thus, adrenalectomy in the young rats appears to have differential effects on the somatic, neural and endocrine growth.

Adrenal Glands↗
PubMed1991

[Should adrenalectomy be performed systematically as part of radical nephrectomy for renal cancer? Review of 119 cases].

Systematic histological examination of 119 operative specimens of radical nephrectomies performed for renal cell carcinoma revealed adrenal invasion in 6 cases (5.04%). Preoperative computed tomography visualised the adrenal lesions with a sensitivity of 100%. Adrenal involvement was due to either contiguous invasion (3 cases) or metastatic spread (3 cases). Other visceral or lymph node metastases were detected in every case. The mean survival of patients with an adrenal lesion was 16.5 months. These data and those reported in the literature suggest the value of systematic adrenalectomy as part of radical nephrectomy.

Adrenalectomy↗
PubMedDate not supplied

[Blood pressure in patients after unilateral adrenalectomy for aldosterone producing adrenal adenoma].

Forty five patients (35 women and 10 men) who underwent adrenalectomy for aldosterone-producing adrenal adenoma were followed up for 5.7 +/- 4.7 years (1-17 years). Stable normalization of blood pressure was noted in 27 (60%) patients. In 16 patients the primary hypertension and in 1 patient the second adrenal adenoma were diagnosed after surgery. Statistically significant decrease in daily excretion of adrenaline and noradrenaline with the urine, reduced adrenaline/noradrenaline ratio and reduced catecholamines and their metabolites ratio were noted in the operated patients in comparison to healthy volunteers indicating catecholamines metabolism disorders. Surgical treatment of adrenal adenoma besides normalization of blood pressure diminishes biochemical abnormalities. Development of the primary blood hypertension may be expected in some patients.

Adenoma↗
PubMedDate not supplied

[Content of free amino acids in rabbit tissues as affected by adrenalectomy and administration of hydrocortisone and ACTH].

Adrenalectomy is accompanied by a decreased content of free amino acids in muscules and blood plasma by an increased content of certain amino acids in the liver. A single injection of hydrocortisone to adrenalectomized animals increases the content of amino acids in muscles and lowers their total content in the liver; a single injection of ACTH lowers the total content of amino acids in the liver and blood plasma "Substitutive therapy" by hydrocortisone essentially increases the content of amino acids in the liver, muscles and blood plasma. Under conditions of the experiment the least changes in the content of amino acids were found in the brain tissue.

Adrenalectomy↗
PubMedDate not supplied

[On 14C-nicotinate penetration into cellular and subcellular structures of animals following adrenalectomy and hormone administration].

The experiments on the Wistar line rats and mongrel dogs showed that gravitational overloading, surgical and chemical adrenalectomy, injections of certain hormones and actinomycin D affect essentially the permeability of blood cells and liver mitochondria to 14C nicotinic acid. An assumption is advanced that the transport of 14C nicotinic acid to biological structures occurs with participation of complex mechanisms, the function of which is regulated by hormones and is coupled with the processes of protein synthesis.

Adrenalectomy↗
PubMed1990

[Is it necessary to combine the surgical treatment of kidney adenocarcinoma with ipsilateral adrenalectomy?].

We analyzed a series of 202 renal adenocarcinomas, 164 of which were submitted to radical nephrectomy. Pathological analyses of 150 adrenal glands revealed ipsilateral adrenal metastasis in 4 cases, 3 of these coexisting with other distant metastases. The primary tumors in these 4 cases were highly undifferentiated and in the advanced local tumor stage; the only case with solitary adrenal metastasis survived 15 months. The present study and data reported in the literature indicate that ipsilateral adrenalectomy should be performed in addition to radical nephrectomy only in renal tumors of the upper pole, those localized at other sites but whose size indicate the possibility of tumor spreading to the adjacent adrenal gland, or when a suspicious mass in the adrenal gland is evidenced by the preliminary workup or during surgery.

Adenocarcinoma↗
PubMed1990

Effect of pinealectomy on mitotic activity of adrenal cortex in rats subjected to unilateral adrenalectomy.

The effect of pinealectomy on the adrenal growth in unilaterally adrenalectomized rats was studied by evaluation of the mitotic activity of adrenocortical cells on the fifth and tenth day after operation. It was found that pinealectomy resulted in an about double increase of mitotic index on the 5th day after unilateral adrenalectomy, and on the 10th day the stimulatory effect of pinealectomy became less significant.

Adrenal Cortex↗
PubMed1990

Adrenalectomy reverses the impaired pyrogenic responses to interleukin-beta in obese Zucker rats.

Interleukin-1 is an important endogenous pyrogen which stimulates thermogenesis in normal animals by a central action which is dependent on release of corticotrophin releasing factor (CRF). Central injection of murine recombinant interleukin-1 beta (IL-1 beta, 5 ng) in conscious lean (+/?) Zucker rats produced significant increases in resting oxygen consumption (VO2, 26 per cent), colonic temperature (1.3 degrees C) and thermogenic activity (mitochondrial GDP binding) of brown adipose tissue (BAT, 24 per cent). In contrast, genetically obese (fa/fa) Zucker rats showed nonsignificant changes in VO2 (4 per cent), temperature (0.5 degrees C) and BAT activity (0 per cent). Bilateral surgical adrenalectomy (ADX) dramatically enhanced the effects of IL-1 beta on VO2 (45 per cent) body temperature (1.8 degrees C) and BAT activity (44 per cent) in obese mutants, but only slightly increased responses in lean rats. These data suggest that impaired responses to IL-1 beta in obese mutants may be due to inhibitory actions of glucocorticoids on either prostaglandin synthesis or CRF release within the hypothalamus.

Adrenal Cortex Hormones↗
PubMed1979

[Cyclic nucleotide content in the adipocytes of rats with spontaneous genetic hypertension. Variations revealed by adrenalectomy].

The basal content of cAMP and cGMP in isolated adipose cells of rats with spontaneous genetic hypertension (SHR) was studied. No differences were found between SHR rats and animals with normal pressure in the content of cyclic nucleotides. Adrenalectomy changes essentially the content of cAMP and cGMP in the adipocytes, reducing the cAMP/cGMP ratio in the cells to about one half; the content of cAMP and cGMP is greater in the adipocytes of adrenalectomized SHR rats than in those of adrenalectomized animals with normal pressure.

Adipose Tissue↗
PubMed1990

Postoperative toxic shock syndrome following adrenalectomy: a case report.

This report describes a fatal case of toxic shock syndrome following surgical procedure of adrenalectomy. Toxic shock syndrome is a severe multisystemic illness associated with Staphylococcus Aureus infection. The disease is usually associated with menstruation and tampon usage. However, it has recently been reported in the postoperative period following simple surgical procedures. The surgical wound does not usually appear infected. The syndrome is associated with specific strains of Staphylococci producing the toxic shock syndrome toxin 1 (TSST-1), that mainly contributes to the illness. The major clinical signs are: fever, diarrhea, cutaneous rash and hypotension. Toxic shock syndrome requires early recognition and prompt aggressive symptomatic treatment based essentially on fluids administration, appropriate intravenous antibiotics and corticosteroids.

Adrenalectomy↗
PubMed1990

[Anesthetic management of adrenalectomy in a patient with aldosteronism complicated with hypertrophic cardiomyopathy].

We had a rare patient for adrenalectomy who had aldosteronism complicated with hypertrophic cardiomyopathy (HCM). It has been suggested that aldosteronism could be the cause of HCM. The association is not clear in this case, but there is a possibility that myocardial hypertrophy was deteriorated with hypertension caused by aldosteronism. Two important points of the anesthetic management of a patient with HCM are (1) to prevent direct or reflex increases in contractility, and (2) to maintain adequate preload and afterload. In a case complicated with aldosteronism, there is a risk that a significant increase in peripheral vascular resistance following the manipulation of the adrenal gland would aggravate left ventricular pressure load, resulting in a marked decrease in cardiac output. Therefore, in such a case, vasodilators which are said to be poorly tolerated in a patient with HCM might be considered to facilitate the anesthetic management, provided that the vascular system is kept appropriately full. In this case, we employed enflurane-oxygen-nitrous oxide with fentanyl to keep deep levels of general anesthesia. Nitroglycerin (NTG) was used when arterial pressure increased suddenly with the manipulation of the adrenal gland. The effect of NTG is not definitely convincing since blood pressure returned to normal after adrenal excision. But the fact that pulmonary capillary wedge pressure decreased with infusion of NTG suggests improvement of hemodynamic function.

Adrenalectomy↗
PubMed1990

[Functional testing of the immunotoxicity of the phenoxyalkane acid mecoprop in rats and prevention of immunotoxic effects by adrenalectomy].

Mecoprop caused in former toxicological examinations time and dose dependent changes of structural components of the immune system. By investigation of humoral and cell immunity was to test, if functional parameter are also influenced by the substance. Mecoprop decreased the delayed hypersensitivity as parameter of cell immunity. The haemagglutination titer against sheep erythrocytes was not influenced by the substance. But the decrease of IgG-concentration in the serum shows also an effect of Mecoprop on the humoral immunity. Adrenalectomy was carried out to test, if there is an indirect mechanism of the action on the immune system, which is mediated by the activity of adrenals. The results show a nearly complete elimination of substance effects in adrenalectomized animals.

2-Methyl-4-chlorophenoxyacetic Acid↗
PubMed1988

Effect of the body temperature upon central administration of substance P--the role of adrenalectomy and GABA-activation.

The change in the body temperature of rats when substance P (SP) is centrally administered is studied by using preimplanted cannules in the preoptic anterior part of the hypothalamus, both in norm and after adrenalectomy, as well as the change of this effect upon preliminary central administration of the GABAA-agonist muscimol. Substance P causes a rise in the temperature, which was significantly less manifested in the adrenalectomized animals. When the animals were pretreated with muscimol in a dose not affecting the temperature when applied independently, the SP-induced rise in the temperature was significantly less manifested in the nonadrenalectomized rats compared with the effect of independent SP administration to nonadrenalectomized animals, though significantly more pronounced compared with the effect of independent administration of SP to adrenalectomized rats. These results suggest the existence of an interaction between the GABA-ergic and the SP-ergic systems and the role of the suprarenal gland for the SP-induced hyperthermia.

Adrenalectomy↗