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Clinical features predictive of successfully weaning from spectacles those children with accommodative esotropia.

PURPOSE: It has been reported that most children with accommodative esotropia are not able to discontinue spectacle wear as they become older. We conducted a prospective study to determine which factors are predictive of successfully weaning children from spectacles. METHODS: Beginning in 1995, children with fully accommodative esotropia with a baseline refractive error of + 1.50 to + 5.00 diopters (D) were gradually weaned from their hyperopic correction. Patients with amblyopia or who had previously undergone strabismus surgery were excluded. Children were weaned in 0.50 D increments until spectacles were discontinued or they developed esotropia, asthenopia, or decreased vision. A multivariate analysis was performed to assess the association between successful weaning and various clinical characteristics. RESULTS: Twelve of 20 children (60%) were successfully weaned from spectacles. Spectacles were prescribed at a mean age of 4.2 +/- 1.5 years, and weaning was initiated at a mean age of 8.0 +/- 1.1 years. The spherical equivalent of the least hyperopic eye when spectacles were prescribed was 2.99 +/- 1.06 D. The clinical characteristic most clearly associated with successful weaning was the refractive error at the time glasses were prescribed. Whereas 10 of 11 (91%) patients with < 3 D of hyperopia were weaned from spectacles, only 2 of 9 (22%) patients with 3 to 5 D of hyperopia were successfully weaned from their spectacles (P =.005). CONCLUSIONS: Many children with fully accommodative esotropia can be weaned out of spectacles during the grade school years. The degree of baseline hyperopia appears to be one of the best predictors of success.

Accommodation, Ocular↗

[Use of a scanning laser tomograph to evaluate the optic disc of the normal eyes].

We evaluated the optic disc in 77 eyes of 77 normal volunteers using a scanning laser tomograph (Heidelberg Retina Tomograph: HRT, version 1.11). Particular attention was paid to age, refractive error, and disc size. The topographic parameters included: cup area, C/D area ratio, rim area, cup volume, rim volume, mean cup depth, maximum cup depth, cup shape measure, height variation contour, mean RNFL thickness, and RNFL cross section area. There was a significant decline in mean RNFL thickness and RNFL cross section area with increase in age (p < 0.05). The mean and maximum cup depths were significantly deeper in myopic eyes (p < 0.05). Large discs had large values of cup area, C/D area ratio, rim area, cup volume, mean cup depth, cup shape measure (p < 0.01), and maximum cup depth (p < 0.05). Large discs had small values of mean RNFL thickness and RNFL cross section area. Rim volume was independent of age, refractive error, or disc area.

Adult↗

Associated factors for age related maculopathy in the adult population in China: the Beijing eye study.

BACKGROUND: To evaluate factors associated with the prevalence of age related maculopathy (ARM) in the adult Chinese population. METHODS: The Beijing Eye Study, a population based prevalence study, included 4439 out of 5324 subjects from a rural area and an urban region of greater Beijing, aged 40+ years and invited to participate (response rate 83.4%). Fundus photographs were graded using the Wisconsin Age-Related Maculopathy Grading system. The following parameters were graded: drusen size, drusen type, and the area covered by drusen; pigmentary abnormalities; geographic atrophy; and exudative ARM. RESULTS: Fundus photographs were available for 8655 eyes of 4376 (98.6%) subjects. Early age related macular degeneration (ARD), late ARD, and exudative ARD, respectively, were present in 1.4%, 0.20%, and 0.10% of the subjects. In a binary logistic regression analysis, early ARM was statistically associated with age (p<0.001; 95% CI: 1.04 to 1.08), hyperopic refractive error (p = 0.008; 95% CI: 1.04 to 1.28), rural region (p<0.001; 95% CI: 0.17 to 0.49), and lower level of education (p = 0.01; 95% CI: 1.07 to 1.65). Early ARM was not significantly associated with the optic disc size (p = 0.42), and size of beta zone of peripapillary atrophy (p = 0.28), the self reported diagnosis of diabetes mellitus (p = 0.39; OR: 1.37; 95% CI: 0.66 to 2.85), amount of cortical cataract (p = 0.72), subcapsular cataract (p = 0.98), nuclear cataract (p = 0.26), sex (p = 0.23), cataract surgery (p = 1.0; OR: 0.96; 95% CI: 0.13 to 6.95), glaucomatous optic nerve damage (p = 0.77; OR: 0.62; 95% CI: 0.15 to 2.52), and history of smoking (p = 0.66; OR: 1.14; 95% CI: 0.65 to 2.00). CONCLUSIONS: Hyperopic refractive error besides age was the single most important risk factor for ARM in adult Chinese. Other associated factors were rural region and lower level of education.

Adult↗

Computerized corneal topography and its importance to wavefront technology.

PURPOSE: To review the development and application of corneal topography in refractive surgery. METHODS: Review of the literature and discussion of recent developments in corneal topography and wavefront technology. RESULTS: Analysis of corneal topography provides critical information for the preoperative examination of patients before refractive surgery and for the evaluation and treatment of patients with complications after surgery. CONCLUSIONS: Corneal topography will continue to be a critical diagnostic modality for refractive surgery. Even with the advent of wavefront analysis designed to detect refractive error and aberrations of the eye, it will be necessary to have detailed corneal topographic information to understand the contribution the cornea makes to vision so that custom alteration of that surface can be used to optimize vision. This will be true of the normal eye, but it will be of special importance in eyes with abnormalities that were induced by corneal surgery.

Cornea↗

Visual field changes after laser in situ keratomileusis.

PURPOSE: To determine whether laser in situ keratomileusis (LASIK) affects the central 30-degree visual field. SETTING: University-based ophthalmology practice. METHODS: This nonrandomized clinical trial comprised 14 normal patients (27 eyes) scheduled to have LASIK for myopia or myopic astigmatism. Automated static perimetry was performed before and 6 months after surgery using the Octopus 1-2-3 perimeter and the Dynamic-32 test strategy. Patient data included sex, age, preoperative and postoperative refractive errors, preoperative and postoperative best corrected visual acuity, preoperative corneal thickness, programmed optical zone, programmed total ablation diameter, and duration of microkeratome suction. All surgery was performed using the same Alcon LADARVision 4000 excimer laser. The main outcome measures were the mean sensitivity (MS) change in the central 15-degree visual field and the MS change in the 15- to 30-degree visual field. A multivariate analysis of the MS change as a function of preoperative clinical parameters was performed. RESULTS: There was no significant change in the MS in the central 15-degree visual field; between 15 and 30 degrees, there was a statistically significant decrease of -0.82 dB +/- 1.40 (SD) (P=.01, 2-tailed t test). The decline in MS was positively correlated with refractive error and corneal thickness; it was negatively correlated with the programmed optical zone diameter. CONCLUSIONS: Automatic static perimetry can detect decreased sensitivity in the midperipheral visual field after myopic LASIK. It may be a useful quantitative subjective test for measuring the effects of future improvements in surgical technique on vision quality.

Adult↗

Correlation between a disc hemorrhage and peripapillary atrophy in glaucoma patients with a unilateral disc hemorrhage.

PURPOSE: To investigate the correlation between a disc hemorrhage and peripapillary atrophy in glaucoma patients with a unilateral disc hemorrhage. METHODS: The 44 glaucoma patients (7 with primary open-angle glaucoma and 37 with normal-tension glaucoma) with a unilateral disc hemorrhage from June 1997 to November 2002 were selected randomly and included sequentially. The topographic measurements were performed using Heidelberg Retina Tomograph (HRT) within 3 months of detecting the disc hemorrhage. The zone beta parameters of the peripapillary atrophy were analyzed by the Atrophy Zone Analysis software. The intraocular pressure, refractive error, visual field parameters, and optic disc parameters were compared between both eyes. Univariate and multivariate regression analysis were performed. RESULTS: The area, angular and radial extent of the zone beta, and the ratio of the zone beta area to the disc area were significantly greater in the hemorrhagic eyes than in the contralateral eyes (P < 0.001). The prevalence of peripapillary atrophy was significantly higher in the hemorrhagic eyes (84%) than in the contralateral eyes (66%) (P = 0.034, chi2 test). The rim area and the rim volume of the hemorrhagic eyes were significantly smaller than those of the contralateral eyes (P = 0.02, < 0.001, respectively). In multivariate regression analysis, the peripapillary atrophy area was the independent significant factor associated with disc hemorrhage (P = 0.03, Odds Ratio = 1.51). The refractive error, intraocular pressure, Mean Deviation (MD), and Corrected Pattern Standard Deviation (CPSD) of the visual fields in both eyes were similar. CONCLUSION: The area and extent of the peripapillary atrophy was significantly greater and more prevalent in the eyes with a disc hemorrhage than in the contralateral control eyes. Peripapillary atrophy is closely associated with a disc hemorrhage in glaucoma patients irrespective of small neuroretinal rim area and volume.

Aged↗

Vision screening of preschool children in Jeddah, Saudi Arabia.

OBJECTIVE: To determine the prevalence of Amblyopia and other refractive errors and to identify the factors associated with these disorders. METHODS: The study was carried out in Jeddah, Kingdom of Saudi Arabia, in 1999, on children enrolled in governmental kindergartens during the academic year 1419-1420H. Children were screened for Amblyopia, any child who failed to pass the screening examination, was referred to the ophthalmologist for complete examination. A 95% confidence interval was used to describe the prevalence of eye disorders. RESULTS: The number of children referred to the ophthalmologists was 102. Out of this figure, 70% of children kept their appointment. Seventy-two children had decreased visual acuity of 20/30 or worse. The final diagnoses were as follows: Amblyopia in 8 cases, which, give a prevalence rate of 1.3% (95% confidence intervals: 0.4-2.3); refractive errors in 50 cases (69%); strabismus in 4 cases (6%), duane syndrome in 2 cases (3%); and 8 children (11%) were completely normal. The positive predictive value of visual screening examination was 89%. We found no significant correlation between Amblyopia and the risk factors mentioned in the literature. CONCLUSION: Vision screening is very important and recommended to be carried out as part of periodic health examination for pre school children. It is cost effective, highly sensitive, acceptable and easy to be administered.

Amblyopia↗

Wavefront analysis in post-LASIK eyes and its correlation with visual symptoms, refraction, and topography.

PURPOSE: To evaluate the information assessed with the LADARWave wavefront measurement device and correlate it with visual symptoms, refraction, and corneal topography in previously LASIK-treated eyes. PARTICIPANTS: One hundred five eyes (58 patients) of individuals who underwent LASIK surgery were evaluated. DESIGN: Retrospective, noncomparative case series. MAIN OUTCOME MEASURES: Complete ophthalmologic examination, corneal topography, and wavefront measurements were performed. Correlations were made between the examinations and symptoms. METHODS: Wavefront measurements were assessed with the LADARWave device. Manifest, cycloplegic refraction, and topographic data were compared with wavefront refraction and higher order aberrations. Visual symptoms were correlated to higher order aberrations in 3 different pupil sizes (5-mm, 7-mm, and scotopic pupil size). Pearson's correlation coefficient and generalized estimating equations were used for statistical analysis. RESULTS: In post-LASIK eyes, wavefront refraction components were poorly correlated to manifest and cycloplegic components. The comparison between manifest, cycloplegic, and wavefront refraction with total amount of higher order aberrations showed no strong correlation. The comparison between topography and manifest, cycloplegic, and wavefront refraction did not show strong correlation. Visual symptoms analysis showed correlation of double vision with total coma and with horizontal coma for the 5-mm and 7-mm pupil size; correlation between starburst and total coma for the 7-mm pupil size; and correlation of double vision with horizontal coma, glare with spherical aberrations and with total aberrations, and starburst with spherical aberrations for the scotopic pupil size. Scotopic pupil size had a positive association with starburst and a negative association with double vision. CONCLUSIONS: The LADARWave wavefront measurement device is a valuable diagnostic tool in measuring refractive error with ocular aberrations in post-LASIK eyes. A strong correlation between visual symptoms and ocular aberrations, such as monocular diplopia with coma and starburst and glare with spherical aberration, suggest this device is valuable in diagnosing symptomatic LASIK-induced aberrations. Horizontal coma was correlated with double vision, whereas vertical coma was not.

Adult↗

Clear corneal cataract surgery and the correction of myopia, hyperopia, and astigmatism.

PURPOSE: Advances in cataract removal using topical anesthesia through a clear corneal microincision have created a new opportunity to fully correct refractive errors at the time of cataract surgery. This study was undertaken to assess the effectiveness of keratolenticuloplasty (KLP), the simultaneous modification of the cornea at cataract removal to create emmetropia with lens implantation. METHODS: Data were analyzed for 690 consecutive cataract procedures performed between March 1993 and March 1995, with follow-up of 12 to 24 months. Each patient underwent cataract removal with topical anesthesia, clear corneal incision fashioned as an arcuate keratotomy to correct pre-existing astigmatism, intercapsular phacoemulsification, and microinjection of a single-piece elastic intraocular lens (IOL) into the capsular bag to correct spherical error. RESULTS: Preoperative best-corrected visual acuity was worse than 20/50 in all patients; 58% were myopic, 32% were hyperopic, and 57% had astigmatism of greater than 1 diopter (D). Postoperatively, spectacle independence was achieved with uncorrected visual acuity of 20/40 or better in 87% of eyes. The sphere was fully corrected in 78%, within 1 D in 17%, and within 2 D in 5%. No patients were overcorrected. The cylinder was fully corrected in 72%, within 1 D in 26%, and within 2 D in 2%. Of those with residual astigmatism, there was no significant postoperative shift in cylinder axis. There were no sight-threatening complications. All patients were able to resume normal unrestricted activities within 24 hours of undergoing the procedure. CONCLUSIONS: The KLP technique can correct spherical and astigmatic refractive errors, helping individuals become free of eyeglasses after clear corneal cataract surgery.

Adult↗

Role of light emitted by incandescent or fluorescent lamps in the development of myopia and astigmatism.

BACKGROUND: The purpose of our study was to determine if the development of refractive errors night be associated with exposure to light emitted by incandescent or fluorescent lamps. MATERIAL/METHODS: 3377 students from elementary schools, junior high schools and high schools were examined, aged 6-19 years. Visual acuity was measured, and retinoscopy was performed after cycloplegia. The parents of all students examined completed a questionnaire concerning the child's exposure to light emitted by incandescent or fluorescent lamps before the age of two. The data was analyzed using the chi-squared test. RESULTS: Sleeping till the age of two with a room light turned on leads to an increase in the occurrence of myopia (P<0.01). It was also found that light emitted by fluorescent lamps leads to more frequent occurrence of astigmatism (P<0.01). CONCLUSIONS: Disturbance of the daily light/dark cycle over the time during which refraction develops may disrupt emmetropization and lead to refractive errors.

Adolescent↗

Modulation of scleral DNA synthesis in development of and recovery from induced axial myopia in the tree shrew.

Visually modulated scleral extracellular matrix remodelling is associated with the development of, and recovery from, induced axial myopia in the tree shrew, a commonly used mammalian model of refractive error development. The involvement of scleral cell proliferation in this process was investigated using [3H] thymidine. Tree shrews were monocularly deprived of pattern vision, using translucent occluders, or the retinal image was optically defocused, using negative lenses, over a period of 5 days. A further group was monocularly deprived for 5 days, then allowed 3 days of binocular recovery. A control group of binocularly open animals was employed to establish normal parameters. On the final day of the experimental period, [3H] thymidine was administered by intraperitoneal injection, then optical and biometric measures were taken and tissue samples collected for assay. Incorporation of [3H] thymidine into cellular DNA was measured in proteinase K digests, following precipitation with trichloroacetic acid. After 5 days, significant amounts of myopia were present in the treated eyes of both form-deprived [-7. 0+/-0.7 Dioptres (D), group mean+/-s.e.m.; P<0.01] and lens-defocused animals (-6.2+/-0.9 D;P<0.01). After 3 days of recovery, 50% of the refractive error had been compensated for, predominantly through shortening of the vitreous chamber in the treated eye. Reduced levels of [3H] thymidine incorporation were observed in sclera from both groups of myopic animals (form-deprived, -34.3+/-9.9%;P<0.05 and lens-defocus, -32.8+/-4.5%;P<0.005). Increased levels of [3H] thymidine incorporation were found in the sclera of recovering animals (+144.0+/-43.2%;P<0.05). The results show that changes in regulation of cell proliferation, during the development of myopia, are visually mediated and inversely related to the direction of change in ocular size. This implies that alterations in the scleral fibroblast population are involved in the modulation of scleral matrix turnover during myopia development.

Animals↗

Radiotherapy for subfoveal neovascularisation associated with pathological myopia: a pilot study.

BACKGROUND/AIM: Limited treatments are available for this disease process. A pilot study was performed to determine the toxicity and efficacy of external beam radiotherapy for subfoveal neovascular membranes and subretinal haemorrhage associated with pathological myopia. METHODS: A randomised, prospective study was carried out on 39 patients with subfoveal neovascularisation associated with high myopia. 20 patients underwent radiotherapy and the remaining 19 were observed as a randomised comparison group. All patients were followed up for at least 24 months. Subfoveal choroidal neovascular membranes (CNVMs) were treated with a single lateral 6 MV photon beam to a dose of 10 Gy in five fractions over 5-7 days. Post-treatment measurements included corrected visual acuity, area of CNVM, and occurrence of radiotherapy related complications, and adverse reactions. To assess changes of area of CNVM, the initial (pretreatment) size of the CNVM was set to 100%, and all post-treatment measurements were normalised relative to the initial size. RESULTS: No significant acute morbidity was noted. There was no significant difference in age, sex, refractive error, visual acuity, and area of CNVM at baseline between the treatment group and control group. The mean change of the size of the CNVM for 2 years was 155% (SD 156%) in the treatment group and 249% (124%) in the control group. The increase in the size of CNVM in the treatment group was significantly smaller than that in the control group (p = 0.0452). In the treated eyes, the visual acuity before and 1 and 2 years after radiotherapy were 0.111 (22.2/200), 0.091 (18.2/200), and 0.086 (19.2/200), respectively. In the control eyes, visual acuity before and 1 and 2 years after the start of the follow up were 0.141 (34.2/200), 0.089 (17.8/200), and 0.063 (12.6/200). The patients in the treatment group showed no significant change for 2 years, and those in the control group showed a significant decrease in the visual acuity (p = 0.0033). The changes of logMAR of visual acuity for 2 years after the start of the follow up were +0.019 (0. 443) in the treatment group and +0.347 (0.374) in the control group. There was a statistically significant difference between them (p = 0. 0173). Multiple regression analysis on the treatment group showed that the most significant predictive variable for the visual acuity 2 years after the treatment was the combination of pretreatment visual acuity and refractive error. CONCLUSIONS: Radiotherapy appeared to have a favourable treatment effect in eyes with subfoveal neovascular membranes and haemorrhage associated with pathological myopia. Further investigation is needed to evaluate the efficacy of radiotherapy for subfoveal neovascularisation associated with pathological myopia.

Aged↗

Laser refractive surgery: technological advance and tissue response.

Photorefractive keratectomy (PRK) and laser assisted in situ keratomileusis (LASIK), using an excimer laser, are the currently popular techniques of correcting refractive errors. Since these techniques work by selective ablation of corneal stroma, the tissue healing response plays a great role in the ultimate outcome of surgery. Also, various methods of wound healing modulation can be used to achieve better results. While these procedures do lead to a decrease in dioptric power and increase in unaided visual acuity, higher visual functions like contrast sensitivity can sometimes be compromised after the surgery.

Corneal Injuries↗

Principles of modern low vision rehabilitation.

Low vision rehabilitation is a new emerging subspecialty drawing from the traditional fields of ophthalmology, optometry, occupational therapy, and sociology, with an ever-increasing impact on our customary concepts of research, education, and services for the visually impaired patient. A multidisciplinary approach and coordinated effort are necessary to take advantage of new scientific advances and achieve optimal results for the patient. Accordingly, the intent of this paper is to outline the principles and details of a modern low vision rehabilitation service. All rehabilitation attempts must start with a first hand interview (the intake) for assessing functionality and priority tasks for rehabilitation, as well as assessing the patient's all-important cognitive skills. The assessment of residual visual functions follows the intake and offers a unique opportunity to measure, evaluate, and document accurately the extent of functional loss sustained by the patient from disease. An accurate assessment of residual visual functions includes assessment of visual acuity, contrast sensitivity, binocularity, refractive errors, perimetry, oculomotor functions, cortical visual integration, and light characteristics affecting visual functions. Functional vision assessment in low vision rehabilitation measures how well one uses residual visual functions to perform routine tasks, using different items under various conditions, throughout the day. Of the many functional vision skills known, reading skills is an obligatory item for all low vision rehabilitation assessments. Results of assessment guide rehabilitation professionals in developing rehabilitation plans for the individual and recommending appropriate low vision devices. The outcome from assessing residual visual functions is detection of visual functions that can be improved with the use of optical devices. Methods for prescribing devices such as image relocation with prisms to a preferred retinal locus, field displacement to primary gaze position, field expansion, and manipulation of light are practiced today in addition to, or instead of, magnification. Correction of refractive errors, occlusion therapy, enhancement of oculomotor skills, and field restitution are additional methods now available for prescribing devices leading to rehabilitation of visual functions. The outcome from assessing residual functional vision is detection of functional vision that can be improved with the use of vision therapy training. After restoration of optimal residual visual functions is achieved with optical devices, one can follow with training programs for restoration of lost vision-related skills. If an optical dispensary is available where prescribing of low vision devices routinely take place, this will help ensure familiarity and specialization of the dispensary and staff with low vision devices and their special dispensing requirements. The dispensing of low vision devices is an opportunity to introduce the device to the patient, train the patient in the correct use of the device for the task selected, and create a direct and continuous connection with the patient until the next encounter. Following assessment, prescribing, and dispensing of devices, a low vision practitioner, ophthalmologist or optometrist, is responsible for recommending and prescribing vision therapy training to improve residual functional vision. An attempt to present a template for a comprehensive modern low vision rehabilitation practice is made here by summarizing scientific developments in the field and stressing the multidisciplinary involvement required for this kind of practice. It is hoped that this paper and other initiatives from colleagues, the public, and government will promote and raise awareness of modern low vision rehabilitation for the benefit of all.

Humans↗

Extreme hyperopia is the result of null mutations in MFRP, which encodes a Frizzled-related protein.

Nanophthalmos is a rare disorder of eye development characterized by extreme hyperopia (farsightedness), with refractive error in the range of +8.00 to +25.00 diopters. Because the cornea and lens are normal in size and shape, hyperopia occurs because insufficient growth along the visual axis places these lensing components too close to the retina. Nanophthalmic eyes show considerable thickening of both the choroidal vascular bed and scleral coat, which provide nutritive and structural support for the retina. Thickening of these tissues is a general feature of axial hyperopia, whereas the opposite occurs in myopia. We have mapped recessive nanophthalmos to a unique locus at 11q23.3 and identified four independent mutations in MFRP, a gene that is selectively expressed in the eye and encodes a protein with homology to Tolloid proteases and the Wnt-binding domain of the Frizzled transmembrane receptors. This gene is not critical for retinal function, as patients entirely lacking MFRP can still have good refraction-corrected vision, produce clinically normal electro-retinograms, and show only modest anomalies in the dark adaptation of photoreceptors. MFRP appears primarily devoted to regulating axial length of the eye. It remains to be determined whether natural variation in its activity plays a role in common refractive errors.

Animals↗

Posterior pole retinal thickness measurements by the retinal thickness analyzer in healthy Chinese subjects.

PURPOSE: To assess retinal thickness at the posterior pole in healthy Chinese subjects with the retinal thickness analyzer (RTA). METHODS: Retinal thicknesses at the posterior pole and fovea were measured by the RTA in 331 eyes of 178 healthy Chinese subjects. Retinal thicknesses as a function of sex, age, refractive errors, and axial length were also evaluated. RESULTS: The average thickness of the foveal area +/- SD was 158.6 +/- 24.8 microm, the average thickness of the perifoveal region (600-2,500 microm from fovea) +/- SD was 174 +/- 25.2 microm, and the average thickness of the posterior pole region (600-6,000 microm from fovea) +/- SD was 171.9 +/- 25.3 microm. There was no significant difference in retinal thicknesses of the foveal, perifoveal, and posterior pole regions in either right or left eyes or as a function of different spherical equivalents. Moreover, there was no significant difference of foveal thickness between males and females. Greater retinal thicknesses of the foveal, perifoveal, and posterior pole regions were associated with age of older than 40 years and axial length of < 24 mm, and greater perifoveal and posterior pole thicknesses were found for females. Furthermore, there were no significant correlations between age, refractive errors, and axial lengths with retinal thicknesses. CONCLUSION: Retinal thicknesses of the posterior pole region differed by age, axial length, and sex, but there was no effect of laterality or different spherical equivalents. The RTA is a fast and noninvasive technology to assess retinal conditions with thickening or thinning in the fovea and posterior pole.

Adult↗

Outcome of surgery on infants younger than 1 month with congenital glaucoma.

PURPOSE: To determine the visual outcomes and surgical and anesthetic complication rates of patients with newborn glaucoma operated within 1 month of age. DESIGN: Retrospective, consecutive, noncomparative case series. PARTICIPANTS: All children with newborn glaucoma who underwent surgery between January 1990 and December 2000 were included. METHODS: The medical records of 25 consecutive patients (47 eyes) who underwent primary combined trabeculotomy and trabeculectomy either bilaterally in a single session or unilaterally were reviewed retrospectively. Outcomes were evaluated using Kaplan-Meier survival analysis. MAIN OUTCOME MEASURES: Clinical outcome assessment included corneal clarity, intraocular pressure (IOP), bleb characteristics, visual acuity, refractive errors, and identification of surgical and anesthetic complications. RESULTS: The mean follow-up was 3.1+/-1.8 years (range, 9.5 months-7.4 years). The mean preoperative IOP was 26.9+/-5.2 mmHg (range, 14-42 mmHg). At the final follow-up visit, the mean IOP was 14.5+/-3.8 mmHg (range, 8-28 mmHg). The percentage reduction in IOP was 43.3+/-21.5 (P<0.0001). Twelve-, 24-, and 36-month survival rates for complete success for IOP control were 89.4%, 83.6%, and 71.7%, respectively, which were maintained for 7 years of follow-up. After surgery, complete clearance of corneal edema was achieved in 66% of the eyes. Data on visual acuity was available for 19 patients. Final best spectacle-corrected visual acuity was 20/40 or better in the better eye in 5 patients (26.3%), 7 patients (36.8%) obtained 20/60 or better in the better eye, 8 patients (42.1%) achieved final visual acuity of less than 20/60 to 20/200 in the better eye (low vision), and four patients obtained less than 20/400 visual acuity in the better eye (blind) according to World Health Organization criteria. However, there was no eye with absent perception of light in the better eye. Myopia (mean spherical equivalent, 4.6+/-3.2 diopters) was the most common refractive error, present in approximately half of the eyes (n = 23; 53.8%). There were no significant intraoperative or postoperative complications in any patient. Anesthesia-related complications developed in 2 patients; however, they were resuscitated successfully. CONCLUSIONS: Primary combined trabeculotomy-trabeculectomy offers a viable surgical option in infants that have cloudy corneas at birth as a result of congenital glaucoma. It is associated with a favorable visual outcome and a low rate of anesthetic complications in an Indian population.

Cornea↗

[Predictability of amblyopia in ametropic children. Apropos of 96 cases].

PURPOSE: The aim of this cross-sectional retrospective study was to analyze the predictability of amblyopia in children with myopic and hyperopic unilateral and bilateral ametropia. MATERIALS AND METHODS: One hundred and sixty two eyes of 96 children, (mean age: 8.6 years), were included in this work. Mean visual acuities and significant refractive errors were estimated for all the cases. The frequency of amblyopia and strabismus was studied in cases without amblyopia and in cases with medium and high grade amblyopia. RESULTS: Mean visual acuities were significantly higher in cases of bilateral myopia (p < 0.001) and hyperopia (p < 0.05) compared with unilateral ametropia. The frequency of myopic eyes (p < 0.01), eyes with high grade of myopia (p < 0.002) and anisomyopic eyes (p < 0.001) was significantly higher in cases of high amblyopia compared with cases without amblyopia. Strabismus (p < 0.05) were also significantly more frequent in cases of high amblyopia as well as in cases of myopic eyes (p < 0.01). Moreover, in the group of high amblyopia, 6 cases (6/7) had developed an intolerance for contact lenses. CONCLUSIONS: The risk of developing high grade amblyopia appeared significantly associated with unilateral medium and high level myopia. Strabismus and difficulties with good correction of anisometropia by contact lenses or spectacle appeared to be predisposing factors. This observation would suggest the indication of refractive surgery might be useful in these particular cases. To conclude, this study emphasizes the importance of early treatment of ametropia to reduce the incidence of amblyopia in children.

Amblyopia↗