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PubMed2002

Local cerebral glucose utilization after relapse in ethanol drinking in alcohol-preferring (P) rats.

The [(14)C]-2-deoxyglucose ([(14)C]-2-DG) quantitative autoradiographic technique was used to determine rates of local cerebral glucose utilization (LCGU) in discrete brain regions of adult, male alcohol-preferring (P) rats after 2 weeks of ethanol deprivation (E-D), 3 and 14 days of ethanol-relapse drinking (E-R3; E-R14), and in P rats, which were chronically drinking ethanol (E-C) for 8 weeks during daily 3-h scheduled-access sessions to 15% (vol./vol.) ethanol and water, or were ethanol-naive (E-N). The hypothesis to be tested was that ethanol-relapse drinking is initiated to restore changes in functional activity back to their chronic ethanol-exposed state. The LCGU rates were measured 1 h before the scheduled-access session. Mean ethanol intake did not differ among the groups. The LCGU rates were decreased in 41 of 57 regions or subregions examined in E-C rats compared with findings for E-N rats, including subregions of the cerebral cortex, hippocampus, and structures in the mesocorticolimbic and nigrostriatal systems. After 2 weeks of deprivation, LCGU values tended to return toward control values (E-N) in most CNS regions and did not differ significantly from control values in 12 regions or subregions (e.g., parts of the limbic system, cerebral cortex). Compared with LCGU values that recovered toward control levels in the E-D group, ethanol-relapse drinking was associated with decreased LCGU values in (1) 4 of 10 limbic structures, (2) all 6 cerebral cortical regions, (3) 1 of 4 basal ganglia regions, (4) 2 of 7 hippocampus subregions, and (5) 1 of 6 thalamic nuclei. The present results indicate that ethanol-relapse drinking was associated with reduced LCGU rates in most CNS regions that recovered toward control values and suggested to us that ethanol-relapse drinking may be initiated to restore neuronal function to its prior chronic ethanol-exposure state.

Alcohol Drinking↗
PubMed1999

Dose-response relationships between drinking and serum tests in Japanese men aged 40-59 years.

Alcohol intake per Japanese adult has been increasing year by year. To show biological effects of drinking, the dose-response relationships between alcohol use and serum indices were analyzed in 5919 Japanese men aged 40-59 years. The subjects were classified into nine groups: a nondrinking (ND, n = 1827) group and eight drinking (1D-8D) groups, by self-reported drinking habit. The 1D (the lightest drinking, n = 699), 5D (n = 942), and 8D (the heaviest drinking, n = 46) groups consumed alcohol less than 30 g per week, 25-30 g alcohol per day, and 100 g alcohol per day or more, respectively. Ten serum indices, total cholesterol, HDL cholesterol, triglyceride, total/HDL cholesterol ratio, LDL cholesterol, gamma-glutamyl transpeptidase, aspartate aminotransferase, alanine aminotransferase, glucose, and uric acid, were used. The dose-response analysis was statistically controlled for age, body mass index, smoking, and habitual exercise, and showed that drinking, even a small amount of alcohol, always had both beneficial and adverse effects on humans. However, alcohol less than 30 g per day may be tolerable for middle-aged Japanese men, because it improved serum lipids profile but did not induce apparent liver cell damage, hyperglycemia, or hyperuricemia.

Adult↗
PubMed1999

Calcium and magnesium in drinking water and the risk of death from hypertension.

Many studies have demonstrated a negative association between blood pressure and calcium and magnesium levels. This report examines whether calcium and magnesium in drinking water are protective against hypertension. All eligible hypertension deaths (2336 cases) of Taiwan residents from 1990 through 1994 were compared with deaths from other causes (2336 controls), and the levels of calcium and magnesium in the drinking water of these residents were determined. Data on calcium and magnesium levels in drinking water throughout Taiwan have been obtained from the Taiwan Water Supply Corporation. The control group consisted of people who died from other causes and the controls were pair matched to the cases by sex, year of birth, and year of death. Magnesium levels in drinking water were inversely related to the risk of death from hypertension. The adjusted odds ratios (95% confidence interval) for the highest versus lowest quintiles of exposure was 0.63 (0.47 to 0.84). After adjustment for magnesium levels in drinking water, there was no difference between the groups with different levels of calcium. The results of the present study show that there is a significant protective effect of magnesium intake from drinking water on the risk of hypertension. This is an important finding for the Taiwan water industry and human health.

Aged↗
PubMed2000

Psychometric evaluation of the short form inventory of drinking situations (IDS-42) in a community-recruited sample of substance-abusing women.

PURPOSE: We investigated the psychometric properties (factor structure, internal consistency reliability, concurrent validity) of the Short Form Inventory of Drinking Situations (IDS-42) in women substance abusers. METHODS: A sample of 297 substance-abusing women was recruited from the community. The women completed the IDS-42 and the three-factor Drinking Motives Questionnaire (DMQ). RESULTS: Confirmatory factor analyses of IDS-42 items suggested a hierarchical structure for the scale. Eight factors (corresponding to Marlatt and Gordon's eight heavy drinking situations) provided the best model fit at the lower-order level, and three factors (i.e., Negatively Reinforcing vs. Positively Reinforcing vs. Temptation Situations) provided the best model fit at the higher-order level. Lower- and higher-order IDS-42 subscales were shown to possess adequate-to-high levels of internal consistency. The eight lower-order IDS-42 factors demonstrated excellent concurrent validity with conceptually similar DMQ subscale scores. Across the entire sample of female substance abusers, a higher frequency of heavy drinking was reported in Positively Reinforcing Situations and Unpleasant Emotions Situations, as compared to other heavy drinking situations. IMPLICATIONS: Results support the IDS-42's good psychometric properties and demonstrate its utility as a tool in identifying situation-specific antecedents to heavy drinking among women substance abusers.

Adult↗
PubMed1991

The Drinking Problems Index: a measure to assess alcohol-related problems among older adults.

Research on problem drinking among older adults has been hampered by the lack of specialized instruments to assess drinking problems. In this paper, we examine the psychometric properties of a 17-item measure specifically designed to assess drinking problems in this population. The Drinking Problems Index (DPI) exhibits excellent psychometric properties, with an internal consistency reliability estimate of .94, a cross-temporal correlation over a 1-year interval of .66, and cross-sectional correlations with alcohol consumption at two points a year apart of .37 and .42. In addition, the construct validity of the DPI is supported by significant concurrent correlations indicating that persons who have more drinking-related problems experience more depression, have less self-confidence, and participate in fewer social activities. Consistent with the high internal consistency reliability estimate, a factor analysis confirmed that the measure is largely unifactorial. Overall, the findings suggest that the DPI is a reliable and valid instrument for assessing problems associated with drinking in surveys of older persons.

Activities of Daily Living↗
PubMed1994

The effects of parental influences and respondents' norms and attitudes on black and white adult drinking patterns.

A model predicting drinking patterns among adult respondents from parental influences and respondents' norms and attitudes was tested with data from a nationwide survey of 1,947 black and 1,777 white Americans. The results showed that relationships between parental drinking background, respondents' norms and attitudes, and respondents' drinking behavior are identical for blacks and whites. Among both groups, parental influences are indirect and have a moderate influence on the respondents' norms and attitudes, which in turn are the most powerful predictors of drinking behavior. However, racial differences did emerge in the model, and they illustrate that race moderates relationships between social characteristics and norms, parental demographics and parent drinking attitudes and behavior, and respondents' social characteristics and drinking patterns. These differences were traced to religion, social status, and cultural variation between the two groups.

Adolescent↗
PubMed1995

The effects of food and drink on the survival of binephrectomized rats.

Previous studies have shown that the survival time of rats following binephrectomy is between 48 and 120 hours. The aim of the present study was to examine the assumption that the eating and drinking protocol before and after binephrectomy affects the survival time following surgery in male, female and young rats. In this study we used protocols which included various combinations of eating and drinking or their prevention before and after binephrectomy. Survival time was determined by examining the kinetics of death following binephrectomy. Examination of the azotemia and physiological condition of the rat was performed by testing BUN, creatinine, plasma Na and K concentrations as well as the hematocrit. All rats that had eaten and drunk before and after binephrectomy, in various combinations, died within 48 hours. Rats that did not eat or drink before and after binephrectomy died within 72 hours (p < 0.001). Rats that did not eat before and after the binephrectomy but had free access to drink died within 90 hours of the surgery (p < 0.001). From this study it can be concluded that the eating and drinking protocol before and after binephrectomy affects the survival time of male, female and young rats. The effect varies between a survival time of 48 and 90 hours following binephrectomy. A possible explanation for this effect is that the eating and drinking protocol affects the rate of azotemia formation.

Animals↗
PubMed2002

Smoking, alcohol drinking and non-fatal coronary heart disease in Hong Kong Chinese.

PURPOSE: To examine whether smoking, alcohol drinking and other risk factors were associated with non-fatal coronary heart disease (CHD) in Hong Kong Chinese. METHODS: A case control study was carried out with 598 CHD hospital cases (431 men, 167 women) and 1100 community controls (663 men, 437 women). Standardized questionnaires were used and blood lipids were measured using standard methods. RESULTS: Stepwise logistic regression models showed adjusted odds ratios (AOR) of 3.36 [95% confidence interval (CI): 2.35 to 4.81] for smoking and 0.32 (95% CI: 0.22 to 0.45) for alcohol drinking in men, and 6.50 (95% CI: 2.61 to 16.19) and 0.15 (95% CI: 0.08 to 0.30), respectively, in women. The OR increased with decreasing levels of high-density lipoprotein cholesterol (HDL) and increasing levels of triglycerides. No patterns were observed for body mass index (BMI), total and low-density lipoprotein cholesterol (LDL). The protective effect of drinking was observed for different types of drinks and frequency of drinking, although few drank alcohol more than 3 days per week. CONCLUSIONS: Smoking was a strong risk factor and moderate alcohol drinking was a protective factor for CHD, and low HDL and high triglyceride levels were important risk factors in Hong Kong Chinese.

Adult↗
PubMed1997

DSM-IV alcohol dependence and drinking in the U.S. population: a risk analysis.

PURPOSE: This paper examines the relationship between alcohol dependence according to the criteria found in the 4th edition of the Diagnostic and Statistical Manual (DSM-IV) of the American Psychiatric Association and drinking in the U.S. general population. METHODS: The data set under analysis is the 1988 National Health Interview Survey, which interviewed a probability sample of 22,102 adult drinkers in the U.S. household population. The response rate was 86%. RESULTS: Results indicate that there is a linear relationship between DSM-IV dependence and the mean number of drinks consumed per day, or the number of days drinking five or more glasses of alcohol in the past 12 months. Respondents who reported consuming five or more drinks in a day have about six times more chances of being dependent than respondents who did not report such pattern of drinking. Older drinkers are less at risk than younger drinkers. CONCLUSIONS: There is a risk of alcohol dependence at relatively low volumes of consumption. The risk increases gradually with the volume of consumption. An added and higher risk exists when drinkers engage in a pattern of consumption involving the ingestion of five or more drinks per day.

Adolescent↗
PubMed2001

Heavy drinking is associated with more severe psychosocial dysfunction among girls than boys in Finland.

PURPOSE: To investigate social, psychological, and environmental factors related to heavy drinking by 15-year-old Finnish school pupils. METHODS: Each of 240 pupils completed a questionnaire about alcohol use, smoking, and illicit drug use; an Offer Self-Image Questionnaire; an Inventory of Parent and Peer Attachment; and a Psychosomatic Symptoms Questionnaire. Teachers assessed each pupil according to a Social Skills Rating Scale. Academic achievement was assessed on the basis of report grades. RESULTS: Heavy drinking was associated with smoking, trial of drugs, poor social skills in class, and poor school achievement in both boys and girls. In girls, heavy drinking was associated with psychosomatic symptoms and a negative social self-image. Girls who drank heavily also had more difficulty with concentration and externalizing problems and more problems with teachers than those who were abstinent or consumed alcohol moderately. The self-images of boys who drank heavily were more negative than those of alcohol-abstinent boys. In boys, heavy drinking was associated with higher numbers of peer relationships. CONCLUSIONS: Heavy drinking is associated with more severe psychosocial dysfunction among girls than boys. It may be possible to identify girls at school who drink heavily and guide them toward treatment.

Adolescent↗
PubMed2000

Preferred drinking locations of Scottish adolescents.

A sample of Scottish schoolchildren (N=1240) were asked a series of questions about their consumption of alcoholic beverages. Those who had consumed alcohol were asked about the circumstances of their last drinking occasion. That is, what alcoholic drink(s) they consumed, how they obtained this alcohol and where they were when they drank it. This was done with the intention of quantifying the extent of under-age drinking in different settings. The results presented in this paper indicate a continuum of drinking styles between what might be regarded as low-risk and high-risk circumstances. At one extreme, much drinking tended to take place within the family home, usually under parental supervision. At the opposite extreme, other alcohol consumption took place in a variety of public or 'hidden' outdoor locations. Consumption in these latter location types more often resulted in intoxication. Also, more dangerous, high alcohol, large volume beverages (e.g. white cider) tended to be consumed in more risky locations. The implications of these findings are discussed in terms of the potential harm and delinquency that can be associated with adolescent drinking.

Adolescent↗
PubMed2002

Body mass index, tobacco chewing, alcohol drinking and the risk of oral submucous fibrosis in Kerala, India.

OBJECTIVE: While chewing areca nut is considered a risk factor for oral submucous fibrosis, the effects of cigarette smoking, alcohol drinking, and body mass index (BMI) have not been examined; nor are they well established. In this study we investigated the association between BMI, smoking, drinking, and the risk of oral submucous fibrosis. METHODS: We conducted a case-control study within the framework of an ongoing randomized oral cancer screening trial in Kerala, India. Trained health workers conducted interviews with structured questionnaires and oral visual inspections to diagnose oral premalignant lesions. A total of 170 oral submucous fibrosis cases (139 women and 31 men) and 47,773 controls were identified. The odds ratios (OR) and 95% confidence intervals (CI) were calculated by logistic regression in SAS. RESULTS: The adjusted OR for ever-tobacco chewing was 44.1 (95% CI = 22.0-88.2). An inverse dose-response relationship was seen between BMI and the risk of oral submucous fibrosis when both genders were combined (p for trend = 0.0010), with an OR of 0.5 (95% CI = 0.3-0.9) for the highest BMI quartile compared to the lowest. Alcohol drinking may possibly be associated with the risk of oral submucous fibrosis; the adjusted OR for ever drinking was 2.1 (95% CI = 1.0-4.4). Cigarette smoking did not appear to be a risk factor for women or for men. Both smoking and drinking were rare habits among women. CONCLUSION: This study suggested, for the first time, that BMI was inversely associated with the risk of oral submucous fibrosis for both genders when potential confounding factors were adjusted. Our results indicated that alcohol drinking might be a moderate risk factor and confirmed the previous observation that chewing tobacco was a strong risk factor for oral submucous fibrosis.

Adult↗
PubMed2001

Transitioning into and out of large-effect drinking in young adulthood.

As individuals age beyond the college years into young adulthood, many exhibit a tendency to moderate or "mature out of" alcohol involvement. The current study classified effect-drinking statuses in young adults and examined transitions among statuses using latent transition analysis, a latent variable state-sequential model for longitudinal data. At 3 occasions over 7 years (Years 1, 4, and 7), 443 men (47%) and women (mean age of both at baseline = 18.5 years; 51% with family history of alcoholism) responded to 3 past-30-day items assessing drinking and subjective effects of drinking: whether the respondent drank alcohol, felt high, and felt drunk. Latent statuses included abstainers (14% at Year 1), limited-effect drinkers (8%), moderate-effect drinkers (23%), and large-effect drinkers (54%). Respondents with family history of alcoholism were less likely to transition out of large-effect drinking than those without family history. Men exhibited more severe initial effect-drinking statuses and lower transition probabilities into less severe effect-drinking statuses than women.

Adult↗
PubMed1997

Cue exposure in moderation drinking: a comparison with cognitive-behavior therapy.

To date, the published controlled trials on exposure to alcohol cues have had an abstinence treatment goal. A modification of cue exposure (CE) for moderation drinking, which incorporated priming doses of alcohol, could train participants to stop drinking after 2 to 3 drinks. This study examined the effects of modified CE within sessions, combined with directed homework practice. Nondependent problem drinkers who requested a moderation drinking goal were randomly allocated to modified CE or standard cognitive-behavior therapy (CBT) for alcohol abuse. Both interventions were delivered in 6 90-min group sessions. Eighty-one percent of eligible participants completed treatment and follow-up assessment. Over 6 months, CE produced significantly greater reductions than CBT in participants' reports of drinking frequency and consumption on each occasion. No pretreatment variables significantly predicted outcome. The modified CE procedure appears viable for nondependent drinkers who want to adopt a moderate drinking goal.

Adult↗
PubMed1997

Dopamine and sodium appetite: antagonists suppress sham drinking of NaCl solutions in the rat.

Sodium (Na) ingestion in rats depleted of Na is a strong, motivated behavior that is enhanced further when depleted rats are sham drinking. Dopamine plays a critical role in motivation, including reward associated with consumption of palatable tastes. The present studies assessed the role of dopamine in real and sham drinking of NaCl solutions after Na depletion with the diuretic furosemide (10 mg/kg). Dopamine (D2) receptor antagonists were evaluated (Haloperidol [0.1 mg/kg] and raclopride [0.2 mg/kg]), for their effects on sham and real drinking of 0.3 M NaCl. Sham drinking was markedly reduced by both antagonists whereas real drinking was unaffected. These effects did not appear to be due to malaise or suppression of motor behavior because drug-treated animals were able to increase ingestion substantially when offered less concentrated NaCl (0.1 M). These results suggest that the positive motivating properties of NaCl stimulation in depleted, sham-drinking rats are mediated by central D2 receptors.

Animals↗
PubMed1983

Oropharyngeal control of ingestion in rats: acquisition of sham-drinking patterns.

Rats with esophageal fistulas, offered a concentrated glucose solution, sham drank relatively small amounts on the first session. This was true whether or not such a solution was familiar. Intake rose to very high levels over ensuing sham-drinking sessions, a result showing that the initial small volumes were not attributable to fixed properties of the solution itself (e.g., aversiveness, viscosity, or input to "satiety" mechanisms). The gradual acquisition of copious sham drinking was not affected by previous "practice" at sham drinking other commodities; it was not simply an alteration in motor habits. Finally, the gradual acquisition of the sham-drinking pattern did not occur with more dilute solutions; in response to these, sham drinking was copious and continuous from the outset. The following conclusions are made: (a) Rats must learn to respond, by continuous drinking, to the absence of the postingestive inhibition normally produced by concentrated solutions. (It is a separate and open question whether the response to the presence of such inhibitory factors must also be learned.) (b) No such learning is required in the case of more dilute solutions. This is further evidence that controlling factors with differing properties operate at different levels even of the single commodity, glucose in solution.

Animals↗
PubMed2001

Binge drinking in Chinese, Korean, and White college students: genetic and ethnic group differences.

Studies of Asian college students have found that rates of binge drinking are associated with variation in the aldehyde dehydrogenase (ALDH2) gene. Chinese and Koreans have different prevalence rates of the ALDH2*2 allele, alcohol use, and alcoholism. The association of ALDH2 status and ethnic group with binge drinking was examined in 328 Chinese, Korean, and White college students. Ethnic group differences were found, with Whites having the highest rate of binge drinking, followed by Koreans and then Chinese. Among Asian participants, ALDH2 status and ethnicity related to binge drinking in an additive manner. Possessing an ALDH2*2 allele and being Chinese were protective factors, and being White and being Korean without an ALDH2*2 allele were risk factors for binge drinking. These results suggest that ALDH2 status, as well as other factors that differ in Koreans and Chinese, but do not interact with ALDH2, are associated with binge drinking among Asians.

Adult↗
PubMed2001

Differential utility of three indexes of risky drinking for predicting alcohol problems in college students.

This study evaluated the relationship between alcohol-related problems and 3 indexes of risky drinking in college student drinkers: number of drinks consumed per week, frequency of binge drinking, and estimated blood alcohol levels (BALs). Use of 2 independent samples (N1 = 204, N2 = 181) allowed a cross-validation of obtained associations. Results indicated that neither binge drinking frequency nor BAL were more highly related to alcohol-related problems than was weekly drinking. Furthermore, BAL did not provide unique explanatory power in accounting for alcohol-related problems; mixed results were obtained regarding the relationship of binge drinking estimates with problems.

Adolescent↗